This document discusses the use of propane (R290) as a refrigerant. It notes that R290 has a very low global warming potential and is an efficient, natural alternative to other refrigerants. However, R290 also has limitations due to its flammability. The document outlines refrigeration system architectures and trends toward lower global warming potential refrigerants. It presents performance data showing the high efficiency of variable speed scroll compressors with R290 over a wide range of speeds. Regulations and standards for R290 are also reviewed. The document concludes that R290 should be a future-proof refrigerant but requires a dedicated compressor design due to safety and reliability considerations stemming from its flammability.