From Local to Global: Realizing Water Security for Sustainable Development - ...Global Water Partnership
Presentation at the European River Restoration Conference in Vienna on 27 October 2014: "From Local to Global: Realizing Water Security for Sustainable Development", by GWP Executive Secretary Dr. Ania Grobicki.
From Local to Global: Realizing Water Security for Sustainable Development - ...Global Water Partnership
Presentation at the European River Restoration Conference in Vienna on 27 October 2014: "From Local to Global: Realizing Water Security for Sustainable Development", by GWP Executive Secretary Dr. Ania Grobicki.
This presentations explains the main definitions related to flood risk management. and how to assess the Vulnerability of the society towards flood dangers. and flood risk analysis process. and gives some examples of flood risk assessment applications.
Climate Risk Vulnerability Assessment to Support Agricultural ResilienceLeo Kris Palao
CRVA a tool to spatially assess vulnerability to support communities at high risk to climate variability and change thru the provision of climate resilient agriculture (CRA). The project in the Philippines is funded by the Department of Agriculture - System Wide Climate Change Office (DA-SWCCO) to enhance farmer resilience in vulnerable areas. Watch out for the Landscape-CRVA that we are currently piloting in Isabela. This is also funded by DA-SWCCO.
State Action Plan June 2013 Briefing, Doug Beard, USGS National Climate Change and Wildlife. Department of Interior Climate Science Centers and National Climate Change and Wildlife Science Center
Presented by IWMI's Director General, Claudia Sadoff, at the 1st Lancang-Mekong Water Resources Cooperation Forum in Kunming, Yunnan, China, on November 1, 2018.
Determinants of Soil Conservation: An Insight of Tea SmallholdersBRNSS Publication Hub
Soil erosion is one of the most devastating problems in Sri Lanka, which threatens the sustainability of Agriculture. To design future policy and effective outreach, this study examines the factors behind farmers’ decision making attitude of soil conservation. The study was conducted in Ratnapura District. Hundred tea smallholder farmers were selected by following multistage random sampling, and primary data were collected through administrating a pre-tested structured questionnaire. Pearson correlation coefficient was employed between soil conservation attitude which was measured on a scale that consisted of 15 soil conservation measures, and farmers’ socio-economic and other factors considered in the study. Results obtained that age, level of education, income, property size, and, awareness on soil erosion, and associated problems with it were influencing on decision-making attitude of soil conservation while gender was not a significant factor. The study suggested obtaining farmers’ decision-making in soil conservation practices will require the use of various implementation tools such as subsidy, technical assistance, teaching, and extension efforts as well as it should facilitate regional social capital formulation to enable and thrive in the collective decision of soil conservation.
Climate change has been reported as a major challenge to livestock production in the pastoral system through their impacts on forage production, water availability, disease risks and thermal stresses. Consequently, causing declining in livestock production. Among the factors that amplify the effects of climate change droughts are perhaps as the most crucial as they adversely affect pastoral livestock production. Droughts have frequently affected Guji- Borana pastoralists of southern Ethiopia, causing substantial livestock losses, declining agricultural production, and food insecurity.
A range of climate prediction models by have shown that Ethiopia expects a 2°C to 4°C increase in temperature and 10% to 30% increase in precipitation by the end of the century. Use of a large-scale climate trends do not necessarily shows local conditions and has failed to address the local impacts, as well as capability of local communities’ adaption to climate change. Hence, understanding the perception of pastoralists’ on climate change and adaptation response at local level is vital. Furthermore, the adaptive mechanisms suggested by the policy makers based on model output may not often favorable to the local communities’ as it lacks the local and/or traditional human and ecological knowledge. This basic information of the pastoralist’ that has been acquired through extensive observation and practices may easily match with time, location and cultural diversity of the people. This in turn helps the pastoralists better understand the climate change implications and respond to adverse effects strategically.
Overview of Drought Indicators and their application in the context of a Drou...NENAwaterscarcity
Workshop on Operationalizing the Regional Collaborative Platform to Address ‘Water Consumption, Water Productivity and Drought Management’ in Agriculture, 27 - 29 October 2015, Cairo, Egypt
Presentation by Claudia Ringler, Hartwig Kremer and Cheikh Mbow at the UNEA Science Policy Interface, May 19-20
Presentation focuses on the concept of the water, food and energy nexus and its importance within the development context. It also provides a number of cases highlighting nexus issues.
5th International Disaster and Risk Conference IDRC 2014 Integrative Risk Management - The role of science, technology & practice 24-28 August 2014 in Davos, Switzerland
Richard Fuller: Main Conclusions of the Lancet Commission on Pollution and He...THL
Richard Fuller, OAM, Pure Earth - Blacksmith Institute, at Europe That Protects - Safeguarding Our Planet, Safeguarding Our Health EU side event, 3-4 Dec 2019, THL, Helsinki
Impact of Climate Change on Lakes of RajasthanYogeshIJTSRD
Climate change is a global challenge with diverse implications at the national and subnational levels, through impacts on various sectors such as agriculture, water resources, forestry and biodiversity, human health, energy and infrastructure. Such diverse impacts require a range of strategies to be deployed for an effective response and for better preparedness towards climate change. In 2008, a National Action Plan on Climate Change NAPCC for India was released by the Honourable Prime Minister. In view of the criticality of addressing the challenges posed by climate change along with the imperatives of poverty alleviation and economic growth for India, the NAPCC -˜identifies measures that promote development objectives while also yielding co benefits for addressing climate change effectively’. The focus of NAPCC is to improve the understanding of climate science, adaptation, mitigation, energy efficiency and natural resource management and conservation. The NAPCC, further sets eight priority missions to respond to climate change these include National Missions on Solar Energy, Enhanced Energy Efficiency, Sustainable Habitats, Water, Sustaining the Himalayan Ecosystem, Greening India, Sustainable Agriculture and Strategic Knowledge for Climate Change, covering a range of response strategies. Dr. Renu Sharma | Dr. Manesha Mathur "Impact of Climate Change on Lakes of Rajasthan" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43807.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/enviormental-science/43807/impact-of-climate-change-on-lakes-of-rajasthan/dr-renu-sharma
A glance at innovative flood risk management solutions through the provision of index-based insurance, which uses inundation models and remote sensing data, aimed at helping farmers increase their resilience.
This Climate risk management for agricultural water.This File references form two research paper:
1.Agricultural Water Management and Climate Risk
2.Managing Climate Risk
This presentations explains the main definitions related to flood risk management. and how to assess the Vulnerability of the society towards flood dangers. and flood risk analysis process. and gives some examples of flood risk assessment applications.
Climate Risk Vulnerability Assessment to Support Agricultural ResilienceLeo Kris Palao
CRVA a tool to spatially assess vulnerability to support communities at high risk to climate variability and change thru the provision of climate resilient agriculture (CRA). The project in the Philippines is funded by the Department of Agriculture - System Wide Climate Change Office (DA-SWCCO) to enhance farmer resilience in vulnerable areas. Watch out for the Landscape-CRVA that we are currently piloting in Isabela. This is also funded by DA-SWCCO.
State Action Plan June 2013 Briefing, Doug Beard, USGS National Climate Change and Wildlife. Department of Interior Climate Science Centers and National Climate Change and Wildlife Science Center
Presented by IWMI's Director General, Claudia Sadoff, at the 1st Lancang-Mekong Water Resources Cooperation Forum in Kunming, Yunnan, China, on November 1, 2018.
Determinants of Soil Conservation: An Insight of Tea SmallholdersBRNSS Publication Hub
Soil erosion is one of the most devastating problems in Sri Lanka, which threatens the sustainability of Agriculture. To design future policy and effective outreach, this study examines the factors behind farmers’ decision making attitude of soil conservation. The study was conducted in Ratnapura District. Hundred tea smallholder farmers were selected by following multistage random sampling, and primary data were collected through administrating a pre-tested structured questionnaire. Pearson correlation coefficient was employed between soil conservation attitude which was measured on a scale that consisted of 15 soil conservation measures, and farmers’ socio-economic and other factors considered in the study. Results obtained that age, level of education, income, property size, and, awareness on soil erosion, and associated problems with it were influencing on decision-making attitude of soil conservation while gender was not a significant factor. The study suggested obtaining farmers’ decision-making in soil conservation practices will require the use of various implementation tools such as subsidy, technical assistance, teaching, and extension efforts as well as it should facilitate regional social capital formulation to enable and thrive in the collective decision of soil conservation.
Climate change has been reported as a major challenge to livestock production in the pastoral system through their impacts on forage production, water availability, disease risks and thermal stresses. Consequently, causing declining in livestock production. Among the factors that amplify the effects of climate change droughts are perhaps as the most crucial as they adversely affect pastoral livestock production. Droughts have frequently affected Guji- Borana pastoralists of southern Ethiopia, causing substantial livestock losses, declining agricultural production, and food insecurity.
A range of climate prediction models by have shown that Ethiopia expects a 2°C to 4°C increase in temperature and 10% to 30% increase in precipitation by the end of the century. Use of a large-scale climate trends do not necessarily shows local conditions and has failed to address the local impacts, as well as capability of local communities’ adaption to climate change. Hence, understanding the perception of pastoralists’ on climate change and adaptation response at local level is vital. Furthermore, the adaptive mechanisms suggested by the policy makers based on model output may not often favorable to the local communities’ as it lacks the local and/or traditional human and ecological knowledge. This basic information of the pastoralist’ that has been acquired through extensive observation and practices may easily match with time, location and cultural diversity of the people. This in turn helps the pastoralists better understand the climate change implications and respond to adverse effects strategically.
Overview of Drought Indicators and their application in the context of a Drou...NENAwaterscarcity
Workshop on Operationalizing the Regional Collaborative Platform to Address ‘Water Consumption, Water Productivity and Drought Management’ in Agriculture, 27 - 29 October 2015, Cairo, Egypt
Presentation by Claudia Ringler, Hartwig Kremer and Cheikh Mbow at the UNEA Science Policy Interface, May 19-20
Presentation focuses on the concept of the water, food and energy nexus and its importance within the development context. It also provides a number of cases highlighting nexus issues.
5th International Disaster and Risk Conference IDRC 2014 Integrative Risk Management - The role of science, technology & practice 24-28 August 2014 in Davos, Switzerland
Richard Fuller: Main Conclusions of the Lancet Commission on Pollution and He...THL
Richard Fuller, OAM, Pure Earth - Blacksmith Institute, at Europe That Protects - Safeguarding Our Planet, Safeguarding Our Health EU side event, 3-4 Dec 2019, THL, Helsinki
Impact of Climate Change on Lakes of RajasthanYogeshIJTSRD
Climate change is a global challenge with diverse implications at the national and subnational levels, through impacts on various sectors such as agriculture, water resources, forestry and biodiversity, human health, energy and infrastructure. Such diverse impacts require a range of strategies to be deployed for an effective response and for better preparedness towards climate change. In 2008, a National Action Plan on Climate Change NAPCC for India was released by the Honourable Prime Minister. In view of the criticality of addressing the challenges posed by climate change along with the imperatives of poverty alleviation and economic growth for India, the NAPCC -˜identifies measures that promote development objectives while also yielding co benefits for addressing climate change effectively’. The focus of NAPCC is to improve the understanding of climate science, adaptation, mitigation, energy efficiency and natural resource management and conservation. The NAPCC, further sets eight priority missions to respond to climate change these include National Missions on Solar Energy, Enhanced Energy Efficiency, Sustainable Habitats, Water, Sustaining the Himalayan Ecosystem, Greening India, Sustainable Agriculture and Strategic Knowledge for Climate Change, covering a range of response strategies. Dr. Renu Sharma | Dr. Manesha Mathur "Impact of Climate Change on Lakes of Rajasthan" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43807.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/enviormental-science/43807/impact-of-climate-change-on-lakes-of-rajasthan/dr-renu-sharma
A glance at innovative flood risk management solutions through the provision of index-based insurance, which uses inundation models and remote sensing data, aimed at helping farmers increase their resilience.
This Climate risk management for agricultural water.This File references form two research paper:
1.Agricultural Water Management and Climate Risk
2.Managing Climate Risk
Economic Impact Evaluation and Household Adaptation to Extreme Weather Events...Francis Jhun Macalam
Abstract: Bay is one of the municipalities in the province of Laguna that is situated along the coast of Laguna de Bay, and is particularly vulnerable to natural disasters including typhoons and flash floods. Among these, Barangay Dila, San Isidro, and Tagumpay located in low-lying elevation of the Municipality of Bay were not spared by the impacts caused by the disaster. Hence, the study site was conducted in these flood-prone areas of the Municipality. In this study, it highlights the impacts and adaptation of the household to extreme weather events. Specifically, the study aims to identify, quantify, and monetized (whenever possible) the household's impacts of extreme floods and typhoons; described the adaptation actions undertaken by the households; and to evaluate the factors that significantly affect the choice of adaptation activities. The data used in this study was collected through a survey of 90 households. In selecting the household, random sampling was employed using the data that was acquired from the municipality. The selected household heads were interviewed using the structured sample questionnaire. Probit regression was employed to test the significant factors of the choices of adaptation activities of the household. The study revealed that the impacts of extreme weather events on the households of Bay, Laguna could be considered to be ranging from moderate to severe cases depending on the geographical location of the households. Also, households of Bay, Laguna considers the height of flood and distance from bodies of water as significant factors for undertaking adaptation actions.
(PDF) International Journal of Science and Management Studies (IJSMS) Economic Impact Evaluation and Household Adaptation to Extreme Weather Events in the Municipality of Bay, Laguna, Philippines. Available from:
https://www.researchgate.net/publication/343960590_International_Journal_of_Science_and_Management_Studies_IJSMS_Economic_Impact_Evaluation_and_Household_Adaptation_to_Extreme_Weather_Events_in_the_Municipality_of_Bay_Laguna_Philippines [accessed Sep 11 2020].
Presented by Jeremy Bird, Director General of IWMI, at the 1st High Level Scientific Consultation Panel and Ministerial Roundtable for the Adaptation of African Agriculture (AAA) to Climate Change initiative held in Marrakech, Morocco, on September 29 - 30, 2016.
Presented by Giriraj Amarnath at the National Workshop on “Use of Space Based Information for Disaster Management” Colombo, Sri Lanka, November 17, 2014
Presented by Giriraj Amarnath at Asia Water Forum in Manila, Philippines
Research Group Leader: Water Risks and Disasters
International Water Management Institute (IWMI)
October 2, 2018
Presented by IWMI's Luna Bharati at 'Asia water-nomics: More GDP with less water & pollution' session at Stockholm World Water Week, on August 29, 2018.
Climate and weather data to manage associated risks across the agricultural l...DianneDormer1
This presentation was prepared for peer review as part of the fulfillment of the World Bank training on Data For Better Lives 2021. The presentation outlined the successes of a pilot program using climate services to manage risk in the agricultural sector. The second portion explored opportunities for establishing an integrated data management system to support climate and disaster risks planning across key socio-economic sectors. I hope there are lessons for all readers to apply similar thought process in your respective countries and where applicable provide feedback to strengthen this proposal. To get the full effects please view in ppt online or the web version.
Thank you,
Dianne Dormer
The Accelerating Impact of CGIAR Climate Research for Africa (AICCRA) project works to deliver a climate-smart African future driven by science and innovation in agriculture.
AICCRA does this by enhancing access to climate information services and climate-smart agricultural technology to millions of smallholder farmers in Africa.
With better access to climate technology and advisory services—linked to information about effective response measures—farmers can better anticipate climate-related events and take preventative action that help communities better safeguard their livelihoods and the environment.
AICCRA is supported by a grant from the International Development Association (IDA) of the World Bank, which is used to enhance research and capacity-building activities by the CGIAR centers and initiatives as well as their partners in Africa.
About IDA: IDA helps the world’s poorest countries by providing grants and low to zero-interest loans for projects and programmes that boost economic growth, reduce poverty, and improve poor people’s lives.
IDA is one of the largest sources of assistance for the world’s 76 poorest countries, 39 of which are in Africa.
Annual IDA commitments have averaged about $21 billion over circa 2017-2020, with approximately 61 percent going to Africa.
This presentation was given on 27 October 2021 by Mengpin Ge, Global Climate Program Associate at WRI, during the webinar "Achieving NDC Ambition in Agriculture" organized by CCAFS, FAO and WRI.
Find the recording and more information here: https://bit.ly/AchievingNDCs
This presentation was given on 27 October 2021 by Sabrina Rose, Policy Consultant at CCAFS, during the webinar "Achieving NDC Ambition in Agriculture" organized by CCAFS, FAO and WRI.
Find the recording and more information here: https://bit.ly/AchievingNDCs
This presentation was given on 27 October 2021 by Krystal Crumpler, Climate Change and Agricultural Specialist at FAO, during the webinar "Achieving NDC Ambition in Agriculture" organized by CCAFS, FAO and WRI.
Find the recording and more information here: https://bit.ly/AchievingNDCs
This presentation was meant to be included in the 2021 CLIFF-GRADS Welcome Webinar and presented by Ciniro Costa Jr. (CCAFS).
The webinar recording can be found here: https://youtu.be/UoX6aoC4fhQ
The multilevel CSA monitoring set of standard core uptake and outcome indicators + expanded indicators linked to a rapid and reliable ICT based data collection instrument to systematically
assess and monitor:
- CSA Adoption/ Access to CIS
- CSA effects on food security and livelihoods household level)
- CSA effects on farm performance
Presented by Harsh Rajpal, Code Partners Pte. Ltd., on 30 June 2021 at the Asian Development Bank (ADB) Webinar on Sustainable Protein Case Study: Outputs and Synthesis of Results.
Presented by Ciniro Costa Jr., CCAFS, on 28 June 2021 at the Asian Development Bank (ADB) Webinar on Sustainable Protein Case Study: Outputs and Synthesis of Results.
Presented by Marion de Vries, Wageningen Livestock Research at Wageningen University, on 28 June 2021 at the Asian Development Bank (ADB) Webinar on Sustainable Protein Case Study: Outputs and Synthesis of Results.
Presented by Issac Emery, Informed Sustainability Consulting, on 29 June 2021 at the second day of the Asian Development Bank (ADB) Webinar on Sustainable Protein Case Study: Outputs and Synthesis of Results.
Presented by Hongmin Dong and Sha Wei, Chinese Academy of Agricultural Sciences (CAAS), on 28 June 2021 at the Asian Development Bank (ADB) Webinar on Sustainable Protein Case Study: Outputs and Synthesis of Results.
Presented by Lini Wollenberg, CCAFS, on 28 June 2021 at the Asian Development Bank (ADB) Webinar on Sustainable Protein Case Study: Outputs and Synthesis of Results.
Presentation by Han Soethoudt, Jan Broeze, and Heike Axmann of Wageningen University & Resaearch (WUR).
WUR and Olam Rice Nigeria conducted a controlled experiment in Nigeria in which mechanized rice harvesting and threshing were introduced on smallholder farms. The result of the study shows that mechanization considerably reduces losses, has a positive impact on farmers’ income, and the climate.
Learn more: https://www.wur.nl/en/news-wur/show-day/Mechanization-helps-Nigerian-farms-reduce-food-loss-and-increase-income.htm
Presentation on the rapid evidence review findings and key take away messages.
Current evidence for biodiversity and agriculture to achieve and bridging gaps in research and investment to reach multiple global goals.
This presentation was given at an internal workshop in April 2020 and was presented by Le Hoang Anh, Hoang Thi Thien Huong, Le Thi Thanh Huyen, and Nguyen Thi Lien Huong.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...
Mapping multiple climate related hazards in south asia (poster) - final low resolution version
1. Mapping multiple climate-related hazards in South Asia
G. Amarnath1
, N. Alahacoon1
, S. Yoshimoto1
, V. Smakhtin2
and P. Aggarwal3
1
International Water Management Institute (IWMI), Colombo, Sri Lanka
2
United Nations University - Institute for Water, Environment and Health (UNU-INWEH), Ontario, Canada
3
CGIAR Research Program on Climate Change, Agriculture and Food Security (CCAFS), New Delhi, India
RESEARCH
PROGRAM ON
Water, Land and
Ecosystems
Using the ranking procedure, we found that most of the divisions in Bangladesh, and some divisions in India, Sri Lanka, Pakistan and Nepal are extreme-risk areas. Some cities are highly affected by
frequent disasters in spite of their high adaptive capacity, because the adaptive capacities of those cities are not sufficient due to high population densities and significant exposure to the hazards.
www.fsm4.susana.org
Risk is understood as the probability that exposure to a climate-related hazard with a given
vulnerability will lead to negative consequences. Disaster risk reduction includes systematic
efforts to analyze and manage the causal factors of disasters through reduced exposure and
vulnerability to hazards, and improved preparedness for disaster events. In South Asia, interest
in multi-risk assessment has increased during the last decade. The main objectives of this study
were to:
Introduction
map areas exposed to five climate-related hazards: floods, droughts, extreme
rainfall, extreme temperature (heat wave) and sea-level rise;
develop a method for estimating the population exposed to individual natural hazards and
their impacts on agriculture; and
assess the overall vulnerability and risk at the country level based on country-wide, urban and
rural population exposure to these hazards.
For more information, contact Giriraj Amarnath (a.giriraj@cgiar.org)
International Water Management Institute (IWMI)
127 Sunil Mawatha, Pelawatte, Battaramulla, Sri Lanka
Mailing address
P. O. Box 2075, Colombo, Sri Lanka
Tel: +94 11 2880000, 2784080; Fax: +94 11 2786854
Email: iwmi@cgiar.org; Website: www.iwmi.org
Dried tank and damaged crops (Sri Lanka), and flood-affected paddy field (Bihar, India).
Method and approach
Results and discussion
World Bosai Forum/International Disaster and Risk Conference 2017 http://www.worldbosaiforum.com/english/overview/
Conclusion
Reference
Flood – Frequency was obtained from
flood inundation maps based on analyses
of 8-day MOD09A1 reflectance
Drought – Vegetation water stress
NDDI was calculated from
MOD09A1 surface reflectance
Extreme rainfall – Events with
intensity greater than 124.4 mm/
day were classified as ‘extreme’
Heat wave – High temperature
anomaly greater than 6 °C was
distinguished from MODIS-based LST
Sea-level rise – Rate of sea-level rise,
coastal morphology, tidal range, etc. were
integrated
Data used
Hazard Dataset Period Spatial Temporal
Flood MODIS – MOD09A1 2001-2013 500 m 8-day
Drought MODIS – MOD09A1 2001-2013 500 m 8-day
Extreme rainfall APHRODITE and TRMM 1951-2013 11 km Daily
Heat wave MODIS – MOD11C2 2001-2013 5,000 m 8-day
Sea-level rise Tidal gauge data 1930-2013 Points Monthly
resolution resolution
Figure 2. Population exposure to multiple climate hazards in
the eastern part of India and Bangladesh.
Figure 1. Indices of the climate-related hazards calculated in this study: (a) floods, (b) droughts, (c) extreme rainfall, (d) extreme temperature (heat wave), and (e) sea-level rise.
(a) (b) (c) (d) (e)
Figure 4. Hazard rank in comparison with adaptive
capacity (Human Development Index [HDI]).
Multi-hazard risk was calculated as a combination of the individual hazard maps and
population/crop maps with weighting and normalization.
Mappingclimatehazards
This assessment of exposure to climate hazards has implications for country-level adaptation to climate change. It could be used to help
inform decisions about financial aid or how to allocate climate adaptation resources within a country. Additionally, the assessment allows
for comparisons to be made between different countries’ exposure to a particular hazard. The model is designed to be flexible, allowing
exposure assessment methods to be applied to a range of outcomes and adaptation measures, such as economic loss, etc. The approach
can be promoted within the Sendai Framework for Disaster Risk Reduction 2015-2030 to member states for building long-term resilience.
Acknowledgements
This research study was funded by the CGIAR Research Program (CRP) on Climate Change, Agriculture and Food Security (CCAFS);
CGIAR Research Program on Water, Land and Ecosystems (WLE); Ministry of Agriculture, Forestry and Fisheries (MAFF), Japan; and the
International Water Management Institute (IWMI). The contribution made by various government agencies in data sharing and providing
valuable feedback is gratefully acknowledged.
Amarnath, G.; Alahacoon, N.; Smakhtin, V.;
Aggarwal, P. 2017. Mapping multiple climate-related
hazards in South Asia. Colombo, Sri Lanka:
International Water Management Institute (IWMI).
41p. (IWMI Research Report 170).
Figure 3. Sub-national evaluation (a) overall climate hazard map, and (b) climate change
vulnerability map.
(a) (b)
Sendai, Japan
November 25-28, 2017