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Mania and Bipolar disorders
By
DR, SAJJAD ALI
PHARM-D, R.Ph., M.Phil (Pharmacology)
Mania
It is a mental illness marked by periods of
great excitement or euphoria, delusions, and
over activity.
Bipolar disorders
 It is a mental condition marked by alternating
periods of elation and depression
Treatment of Mania
Lithium salts
 Lithium salts are used prophylactically for the
treatment of manic depressive patients
 It is also used for the treatment of manic
episodes and thus considered as mood
stabilizer
Mechanism of action of lithium
 One of the best-defined effects of, lithium is its
action on inositol phosphates.
 Lithium interferes with the resynthesizes of PIP2
(Phosphatidylinositol bisphosphate) leading to its
relative depletion in neuronal membranes of the
CNS.
 Phosphatidylinositol-4,5-bisphosphate (PIP2) is
the membrane precursor of IP3 and DAG
 However, PIP2 level in peripheral membranes are
unaffected
Route of administration of Lithium
 Given orally
 Ions excreted by kidneys
Toxicity :
 Narrow therapeutic index
 Headache
 Dry mouth
 Polydipsia
 Polyuria
 Polyphagia
 GIT disturbances
 Hand tremors
 Dizziness
 Fatigue
 Sedation
Other drugs used for the treatment of
Mania and Bipolar disorders
A. Anti-epileptic drugs
Following anti-epileptic drugs are approved by
FDA for the treatment of mania and bipolar
disordrs
 Carbamazepine
 Valproic acid
 Lamotrigine
B. Atypical anti-psychotics:
 Risperidone
 Olanzapine
 Ziprasidone
 Aripiprazole
 Quetiapine

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Mania

  • 1. Mania and Bipolar disorders By DR, SAJJAD ALI PHARM-D, R.Ph., M.Phil (Pharmacology)
  • 2. Mania It is a mental illness marked by periods of great excitement or euphoria, delusions, and over activity.
  • 3.
  • 4. Bipolar disorders  It is a mental condition marked by alternating periods of elation and depression
  • 5.
  • 6. Treatment of Mania Lithium salts  Lithium salts are used prophylactically for the treatment of manic depressive patients  It is also used for the treatment of manic episodes and thus considered as mood stabilizer
  • 7. Mechanism of action of lithium  One of the best-defined effects of, lithium is its action on inositol phosphates.  Lithium interferes with the resynthesizes of PIP2 (Phosphatidylinositol bisphosphate) leading to its relative depletion in neuronal membranes of the CNS.  Phosphatidylinositol-4,5-bisphosphate (PIP2) is the membrane precursor of IP3 and DAG  However, PIP2 level in peripheral membranes are unaffected
  • 8. Route of administration of Lithium  Given orally  Ions excreted by kidneys Toxicity :  Narrow therapeutic index  Headache  Dry mouth  Polydipsia  Polyuria  Polyphagia  GIT disturbances  Hand tremors  Dizziness  Fatigue  Sedation
  • 9. Other drugs used for the treatment of Mania and Bipolar disorders A. Anti-epileptic drugs Following anti-epileptic drugs are approved by FDA for the treatment of mania and bipolar disordrs  Carbamazepine  Valproic acid  Lamotrigine
  • 10. B. Atypical anti-psychotics:  Risperidone  Olanzapine  Ziprasidone  Aripiprazole  Quetiapine