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Management of Basic Radial
Complications: What to Expect and
How to Get Out of the Woods 
Robert De Larochellière, md, FRCPC
I, Robert De Larochellière, don’t have any 
relevant financial interest to declare.
Adoption of Radial Access and Comparison of Outcomes to Femoral
Access in Percutaneous Coronary InterventionClinical Perspective
Unadjusted rates of the primary outcomes of r-PCI and f-PCI.

Feldman D et al. Circulation 2013;127:2295-2306

Copyright © American Heart Association
Specific transradial complications
Gray's Anatomy of the Human Body, 1918
Radial pulse oxymetry
« In the evaluation of 
hand collaterals, PL 
and OX were found to 
be more sensitive 
than MAT. When 
applied to transradial 
approach screening, 
only 1.5% of patients 
were not suitable 
candidates for the 
transradial 
approach »
Barbeau & al., Am Heart J. 2004 mar; 147(3);489-93 
Acute Hand Ischemia After Radial Intervention in 
Patient with CREST-Associated Pulmonary 
Hypertension: Successful Treatment With Manual 
Thromboaspiration
« Physical examination findings included sclerodactyly, Raynaud phenomenon, and diffuse 
telangiectasias »
« During hospitalization, the patient underwent TR coronary angiography in the context of 
screening  examinations.  The  pre-procedure  evaluation  revealed  a  good  palpable  right 
radial  pulse. No  evaluation  of  ulnar  artery  patency  was  performed.  International 
normalized ratio (INR) was 1.8. This finding along with female gender and small body size 
were perceived to increase the risk of bleeding associated with femoral access »
Taglieri &al., J INVASIVE CARDIOL 2013;25(2):89-91
Radial artery spasm: predisposing factor
Patient related
• Female sex and younger age
• Small body size
• Diabetes mellitus
• Smaller radial artery 
diameter
• Vessel tortuosity
• Anxiety

Procedure related
• Unsuccessful access 
attempts
• Pain
• Vascular trauma (wire)
• Larger sheath
• Number of catheter and 
procedure duration
Radial artery spasm management
• Adequate analgesia & atraumatic puncture
• Sedation (midazolam/narcotic) & warmth
• Smooth wiring of the vessel: size vs support, no force, 
constant motion
• Gentle sheath insertion: small size, good tapering, 
hydrophilic sheath
• Vesssel cocktail: verapamil 2,5-5 mg ± ntg 200 μgm ± 
SQ ntg
• Vessel navigation: J-wire & soft wire, angio guidance & 
visualisation,  gentle loop management, « wire less » 
multipurpose catheter, sheatless catheter
Radial spasm & avulsion

Courtesy of G.Barbeau
Tortuosity, kink and catheter entrapment
Catheter entrapment

Ju-Youn Kim & al., J INVASIVE CARDIOL 2012;24(1):E3-E4
Catheter entrapment

Ju-Youn Kim & al., J INVASIVE CARDIOL 2012;24(1):E3-E4
Avoid catheter entrapment
• Be cautious in tortuous anatomy
• Keep wire within the catheter while torking 
towards the coronary ostia
• Check for kink if lack of distal responsivness to 
manipulation
• Keep the catheter in large vessel if kink
• Gently try to counter the kink and re-wire the 
catheter (0,014/ hydrophylic)
Hematoma, perforation,compartment syndrome
• Anticoagulation state
• Small vessel, small BMI, women,diabetic, 
older patients
• Spasm,tortuosity & remmants radial artery
• Hydrophilic guidewire: perforation with chest 
hematoma reported
Eurointervention, 2013
Hematoma, perforation,vessel occlusive
dissection
Avoidance:
•No force
•Angiographic/fluoroscopy guidance
•0,014 guidewire trough challenging tortuosty and 
straitghtening by pullback
•J wire, Soft wire (Bentson, coronary) , Direct 
« wireless »  4-5 F soft tip multipurpose catheter, 
Balloon assisted tracking
•Carefull with hydrophilic 0,35 wire in the forearm
Courtesy of S.Rinfret
Perforation management
Ongoing procedure
•Soft guide wire under angio guidance
•Low pressure injection to image
•Optimal upsizing of catheter over the wire (6F) to 
assure sealing
•BP cuff  inflation 20 mmhg under SBP after 
catheter passage
•Consider partial (50%) reversal of heparin if 
massive at end of procedure
Perforation management
After procedure
•Angio control (low pressure injection)
•BP cuff inflation to 20mmhg under SBP
•Elastic band
•If low in forearm, consider 2nd compression 
device on artery trajectory
In  our  center,  with  close  to  100K 
radial  procedures,  3  patients  with 
compartment  syndromes  needed 
surgery and had full recovery
Tizon H, Barbeau G, J Interv Cardiol 2008
Radial Arterio-venous fistula

        Dehghani & al., J Med Case Reports. 2013;7(21)
     
Radial artery pseudoaneurysm

Presumed risk factor: oral anticoagulation, inadequate radial compression, 
 hypertension
Management: prolonged compression, thrombin injection under echo guidance,
                          rarely surgery
Heparin and RAO

Spaulding et al

Bernat et al
Courtesy of SV.Rao
Anticoagulation
Patent hemostasis
Rao SV. JACC Intv 2012

UFH 70-100 u/kg

UFH 70 u/kg

UFH 70 u/kg
Or Bivalirudin

UFH 50u/kg

UFH 70-100 u/kg

No

No

No

Yes

Yes

UFH 5000 u

Yes +
Ulnar compression
conclusion
• Specific radial access complications are rare 
and can be anticipated in most instances
• Early recognition and action for vascular 
complication can prevent further clinical 
sequalae
• Radial access is the best mean to accomplish 
the clinical goal of cardiac cath but is not the 
only one to be master and use

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