The document outlines the 6 steps of evaluating a novel biomarker for cardiovascular risk from early studies establishing a correlation between the biomarker and disease, to prospective validation in cohort studies, determining incremental predictive value over existing measures, evaluating if the marker changes risk enough to alter treatment, clinical outcomes trials, and finally cost-effectiveness analysis. It specifically discusses the evaluation of coronary artery calcium scoring, which is currently in the planning stages for a large clinical outcomes trial over 6-8 years to complete all 6 steps from initial studies to determining if measuring it improves health outcomes.
SOLACI Chile Congress 2011. Dr.Ajay Kirtane. Drug-Eluting Stents for Multivessel PCI: Indications and Outcomes. Find more presentations on the web site: www.solaci.org/
FOURIER: estudio de eventos cardiovasculares con evolocumab
30/03/2017 18:30h Casa del Corazón, Madrid
http://evolocumab.secardiologia.es
#evolocumab
Se abordarán los siguientes temas:
Presentación de resultados del estudio FOURIER
Interpretación de los datos en el contexto actual
Traslación clínica y aplicabilidad de los resultados
Coloquio y preguntas del público
Coupling is a term commonly used in mechanical engineering.
Coupling between two systems depends on how efficient
is the energy transfer from one to another, without much
losses in overcoming resistance. In cardiovascular system, it
pertains to energy transfer from ventricle to systemic arterial
circulation, for maintenance of organ perfusion, commonly
called as ventricular arterial (VA) coupling (ventricular-arterial
coupling).Best coupled systems, theoretically, have 100%
energy transfer, without any loss, i.e., coupling ratio 1. But,
in practice, VA coupling in adults in resting state varies from
0.6 to 1.2.
Extracorporeal membrane oxygenation assisted cardiopulmonary resuscitation (ECPR) is an effective therapy to improve outcomes for children who experience cardiopulmonary arrest. Survival after ECLS varies between 60% and 75%. For ECPR survival is lower, with 40% to 50% of children surviving ECPR. After ECPR good neurological outcomes are seen in 40% to 60% of children. This contrasts with adult patients where neurological outcomes after ECPR are poor. Given these findings the American Heart Association has included ECPR in their 2015 guidelines for children who experience an in hospital cardiac arrest (IHCA).
SOLACI Chile Congress 2011. Dr.Ajay Kirtane. Drug-Eluting Stents for Multivessel PCI: Indications and Outcomes. Find more presentations on the web site: www.solaci.org/
FOURIER: estudio de eventos cardiovasculares con evolocumab
30/03/2017 18:30h Casa del Corazón, Madrid
http://evolocumab.secardiologia.es
#evolocumab
Se abordarán los siguientes temas:
Presentación de resultados del estudio FOURIER
Interpretación de los datos en el contexto actual
Traslación clínica y aplicabilidad de los resultados
Coloquio y preguntas del público
Coupling is a term commonly used in mechanical engineering.
Coupling between two systems depends on how efficient
is the energy transfer from one to another, without much
losses in overcoming resistance. In cardiovascular system, it
pertains to energy transfer from ventricle to systemic arterial
circulation, for maintenance of organ perfusion, commonly
called as ventricular arterial (VA) coupling (ventricular-arterial
coupling).Best coupled systems, theoretically, have 100%
energy transfer, without any loss, i.e., coupling ratio 1. But,
in practice, VA coupling in adults in resting state varies from
0.6 to 1.2.
Extracorporeal membrane oxygenation assisted cardiopulmonary resuscitation (ECPR) is an effective therapy to improve outcomes for children who experience cardiopulmonary arrest. Survival after ECLS varies between 60% and 75%. For ECPR survival is lower, with 40% to 50% of children surviving ECPR. After ECPR good neurological outcomes are seen in 40% to 60% of children. This contrasts with adult patients where neurological outcomes after ECPR are poor. Given these findings the American Heart Association has included ECPR in their 2015 guidelines for children who experience an in hospital cardiac arrest (IHCA).
Various coronary physiological measurements can be made in the cardiac catheterization laboratory using sensor-tipped guidewires; they include the measurement of poststenotic absolute coronary flow reserve, the relative coronary flow reserve, and the pressure-derived fractional flow reserve of the myocardium. Ambiguity regarding abnormal microcirculation has been reduced or eliminated with measurements of relative coronary flow reserve and fractional flow reserve. The role of microvascular flow impairment can be separately determined with coronary flow velocity reserve measurements. In addition to lesion assessment before and after intervention, emerging applications of coronary physiology include the determination of physiological responses to new pharmacological agents, such as glycoprotein IIb/IIIa blockers, in patients with acute myocardial infarction. Measurements of coronary physiology in the catheterization laboratory provide objective data that complement angiography for clinical decision-making
Diagnosis, management, workup in a case of Takayasu's arteritis. Definition, synonyms, history, epidimiology, pathophysiology, etiology of Takayasu's arteritis.
A case of missed diagnosis. Presentation can be in form of heart failure. Differentials can be of Constrictive pericarditis. Restrictive cardiomyopathy/Endomyocardial fibrosis, DCM. This presentation contains clinical presentation, differentials, hemodynamics of cath study, echocardiogrpahy in a case of CP
This is a comprehensive description of coronay lesion assessment from routinely used angiography to advanced imaging modalities like IVUS/OCT including their functional significance by FFR
Presentation given at Arab Health congress on Jan. 29th 2013, with information about (dual source) Cardiac CT of the coronary arteries with technical & practical information and some clinical use cases
A detailed description of ct coronary angiography and calcium scoring with various aspects regarding the preparation, procedure, limitations and a short review regarding post CABG imaging.
Dyslipidemia and CVS by Mohit Soni and Chandan KumarOlgaGoryacheva4
My students Mohit Soni and Chandan Kumar had presented this topic in our 22nd Student Scientific Society Conference in the department of Propaedeutic of Internal Diseases No.2
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmacy.
AMIA Joint Summits 2017: Building Research Data Mart from UCSF OMOP Database ...CTSI at UCSF
Poster presented at AMIA 2017 Joint Summits on Translational and Clinical Informatics.
In this research data delivery project, we explored a less traveled path of building a clinical “data mart” for a registry study on kidney transplant patients based on our institutional OMOP database.
Data Reproducibility in Preclinical Discovery, Is It a Real Problem? 09/17/15CTSI at UCSF
On Sep 17th Catalyst brought a panel of academic and industry thought leaders for a lively discussion on the issue of data reproducibility in academic research. Moderated by Cathy Tralau-Stewart, head of the Therapeutics track of the Catalyst Awards, the panel explored causes and potential solutions for a problem that has been receiving national attention in both scientific and popular media.
Panelists included Keith Yamamoto, Vice Chancellor for Research at UCSF; Larry Tabak, Principle Deputy Director, NIH; John Ioannidis, Professor of Health Research Policy at Stanford School of Medicine; Elizabeth Iorns, Co-Founder, Science Exchange; Parker B. Antin, Board of Directors President, FASEB; Amanda Halford, MBA, VP of Research, Sigma-Aldrich.
http://ctsi.ucsf.edu/news/about-ctsi/data-reproducibility-preclinical-research-and-discovery
Building Your Professional Network with LinkedInCTSI at UCSF
Presentation by Erik Wieland, Applications Manager at UCSF IT, as part of the "UCSF Profiles & LinkedIn Bootcamp for Researchers, Faculty, Staff" on 2/9/2015.
How to Harness the Power of Google Analytics, Email Marketing & Vanity to Inc...CTSI at UCSF
40 minute presentation by Nooshin Latour (@nooshin) & Anirvan Chatterjee (@anirvan) at the UC Computing Services Conference (UCCSC 2014). Evolution of UCSF Profiles research networking system, early promotion at launch, growth/SEO, and engagement with targeted personalized data emails. Full description here: https://uccsc.ucsf.edu/node/101
VIVO 2014: Google Analytics, Email Marketing & Vanity to Increase User Engage...CTSI at UCSF
Poster presented at VIVO 2014 conference: Utilized UCSF Profiles web analytics data to deliver a customized “UCSF Profiles Annual Report” to individual researchers at UCSF, which listed their total annual unique pageviews, broken down by major relevant categories (e.g. pageviews from the UCSF campus, NIH, pharmaceutical companies, foundations, and other universities). Result: Increase in user engagement and edite Profiles pages. UCSF-CTSI Team: Nooshin Latour, MA, Sr. Communications & Marketing Manager and Anirvan Chatterjee, Director of Data Strategy
UCSF Informatics Day 2014 - Keith R. Yamamoto, "Precision Medicine"CTSI at UCSF
Keith R. Yamamoto, PhD — Opening Remarks – Precision Medicine
Vice Chancellor for Research
Executive Vice Dean of the School of Medicine
Professor of Cellular and Molecular Pharmacology
UCSF
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
22. VIEW Your Heart Trial: A proposed NHLBI-endorsed clinical trial
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27. From the Website of The Society for Heart Attack Prevention and Eradication (SHAPE): The Society for Heart Attack Prevention and Eradication was formed to redefine preventive heart health. We are the only non-profit organization that is dedicated to ending the threat of heart attack. To accomplish our immediate objectives we are focused on promoting the SHAPE Guideline, a screening protocol that builds on the old paradigm in cardiology, risk factor detection and treatment.
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29. “ There should be no double standard. Biomedical researchers have performed large-scale randomized trials on a variety of screening tests, and screening tests for coronary artery disease should be subject to the same level of rigor. It is not at all clear that the risk stratification paradigm is the best way to reduce substantially the burden of clinically active coronary artery disease in our population. “
30. “ Our next step is to have the humility to admit that we do not know which approach or combination of approaches is best, but that, in the public interest, we will join forces to design and implement the definitive large-scale randomized trials that our patients and the public should rightly demand.”
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32. Criteria for evaluation of novel markers of cardiovascular risk Hlatky MA, Greenland P, et al. Circulation 2009;119: 2408-16. More than 50 years from Phase 1 to Phase 5!