This document discusses various anatomical challenges that can be encountered when performing radial artery catheterization, including spasm, loops, tortuosity, and variations in arterial anatomy. It provides examples of anatomical variations like radial loops, high junctions, and accessory radial arteries. It also discusses challenges posed by vascular diseases like atherosclerosis and vasospasm, as well as iatrogenic complications. Potential solutions for overcoming challenges are proposed, such as maintaining wire position, using smaller wires and catheters, preventing spasm, and considering alternative access sites if needed.
The Transradial technique is the true minimally invasive "Drive-through" approach to perform percutaneous coronary and peripheral angiograms and interventions.
A woman in her late 40s with a history of hypertension presented to the emergency department after multiple episodes of palpitations with near syncope. While in the
emergency department, she developed monomorphic ventricular tachycardia (VT) with hemodynamic instability and was successfully cardioverted. She continued to have nonsustained monomorphic VT, so intravenous amiodarone and oral metoprolol were initiated. She was admitted for further evaluation. Results of tests of electrolyte levels and coronary angiography were normal. Cardiac magnetic resonance imaging with
gadolinium contrast revealed normal-sized cardiac chambers and normal biventricular
function without delayed enhancement. The presenting electrocardiogram (ECG)
is shown in Figure 1.
Salient features of the book are -
- The book provides a shortcut to understand and remember certain specific formulae and points you require to interpret the 12-lead ECG.
- Treatment protocols (in green boxes) for most of the important conditions are also included.
- View sample ECGs as you read along the topics.
- The content is explained in a very simple language to provide good conceptions, written from a student’s point of view.
- People can gain their belief in the book after going through sample ECGs which would be available at www.themedicalpost.net/ecg
- The book competes with the other books available in the market in simplicity, summaries, treatment protocols, live diagrams and regularly updated sample ECGs on the website.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
1. Anatomical challenges
Spasm, loops, tortuosity
Ian C Gilchrist, MD, FACC, FSCAI
Professor of Medicine
Heart & Vascular Institute
Penn State/Hershey Medical Center
Hershey, PA
Duke Master 2011
3. Challenges in the Vasculature
Anatomic Variability
Vascular Disease
Iatrogenic Complications
http://www.ohcaptain.com/2010/05/insights-from-road.html
Duke Master 2011
5. Challenge #1: Anatomical Variability
Expect variability
1540 patients-96.8% success, high-volume radial operators, United Kingdom
Catheter in accessory radial
Brachial artery
Radial Loop Tortuosity Accessory Radial
(2.3%) (2.0%) (7.0%)
Anatomic variation associated with >3/4 of procedural failures
Lo, Nolan et al, Heart 2009;95:410-415. Duke Master 2011
6. Normal Arm Arterial System
Axillary
Artery
Biceps Brachii
Muscle
Brachial
Artery
Brachioradialis
Muscle
Radial Ulnar
Artery Artery
Adapted from Jelev L, Cardiovasc Intervent Radiol 2008;31:1008
Duke Master 2011
7. Normal Arm Angiogram
Radial Artery
Ulnar Artery Brachial Artery
J Invasive Cardiol. 2010;22:536–540
Duke Master 2011
8. Varied Radial Connections
Unusual courses, no effect on passage
Radial-Axillary
Junction
Radial-Brachial
Junction Superficial Radial
With High Junction
Adapted from Jelev L, Cardiovasc Intervent Radiol 2008;31:1008
Duke Master 2011
10. High Radial Junction with Crossover
No crossover
Crossover:
Potential for difficult
passage &
complications
Adapted from Jelev L, Cardiovasc Intervent Radiol 2008;31:1008
Duke Master 2011
11. Spectrum of Crossover
Tight Fit
Tight Turn
Adapted from Jelev L, Cardiovasc Intervent Radiol 2008;31:1008
Duke Master 2011
21. Solution: Plan for Success
1. Well positioned wrist/relaxed patient
2. Micropuncture needle access
3. Prevent spasm & anticoagulate
4. Use your wire as a friend
5. If in doubt take a picture
6. Maintain central access with your wire
The Radial Is Not a Small Femoral Artery
Duke Master 2011
22. Solution: Failure of Wire to Advance
during initial access
1. Insert sheath to gain partial access
– Confirm arterial access
– Treat spasm
2. Load hydrophilic .035” wire in catheter & try
to advance into central system
3. If successful, advance vascular sheath in
place over cardiac catheter & advance
coronary catheter.
Duke Master 2011
23. Solution: Hydrophilic Wire Fails to
Advance?
1. Look under fluoroscopy at position
2. Obtain limited angiogram to define the
anatomy
3. Twisting wrist may straighten forearm
vessels, while a deep breath may change
more proximal arteries
4. Consider smaller flexible wires, the other
radial artery, the ulnar artery, or even the
femoral
Duke Master 2011
24. Solution: Wire is your friend
• Maintain wire or catheter position as central
as possible (don’t retreat)
• Use a standard .035” angiographic wire to
hold position or help reposition catheters
• Exchange over a long wire or “jet” exchange
over standard length wires
Do Not Retreat from Success
Duke Master 2011
25. Solution: Catheter “Jetting”
1. Start with catheter in ascending aorta
2. Pass .035” wire (not hydrophilic) into catheter
3. Fix wire in place & back catheter to end of wire
4. Attached 10cc syringe with fluid on catheter
5. Forcefully inject while pulling “jetting” catheter off
wire until free from access sheath
6. Confirm wire still in central aortic position
Hoorntje JCA. Cathet Cardiovasc Diagn 18:284, 1989.
Duke Master 2011
26. Returning with Next Catheter
1. Confirm wire is still in ascending aorta
2. Advance flushed catheter over wire until wire
exits catheter’s hub
– Ectopy indicates wire pushed into ventricle
– Fluid should drip from catheter as the wire
displaces flush, if not, wire may have prolapsed
down descending aorta
3. Remove wire and continue procedure
Duke Master 2011
27. Solution: Spasm during procedure
Use more pharmacology
Use smaller French equipment
Minimize mechanical manipulation
Wipe wire, flush catheters, and “jet” with
antispasmodic agents (nitrates, Ca++
blockers)
Warm the arm or room
Duke Master 2011
28. Summary
Variety is part of normal arm vasculature
Makes radial “fun”
Potentially a cause for failure, but…
Challenges can be overcome resulting in success
Expect it, have a plan, you will succeed
Duke Master 2011