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1 
Macromolecules 
copyright cmassengale
2 
Organic Compounds 
• Compounds that contain CARBON 
are called organic. 
• Macromolecules are large organic 
molecules. 
copyright cmassengale
3 
Carbon (C) 
• Carbon has 4 electrons in outer 
shell. 
• Carbon can form covalent bonds 
with as many as 4 other atoms 
(elements). 
• Usually with C, H, O or N. 
• Example: CH4(methane) 
copyright cmassengale
4 
Macromolecules 
• Large organic molecules. 
• Also called POLYMERS. 
• Made up of smaller “building blocks” 
called MONOMERS. 
• Examples: 
1. Carbohydrates 
2. Lipids 
3. Proteins 
4. Nucleic acids (DNA and RNA) copyright cmassengale
5 
Question: 
How Are 
Macromolecules 
Formed? 
copyright cmassengale
6 
Answer: Dehydration Synthesis 
• Also called “condensation reaction” 
• Forms polymers by combining 
monomers by “removing water”. 
HO H HO H 
H2O 
HO H 
copyright cmassengale
7 
Question: 
How are 
Macromolecules 
separated or 
digested? 
copyright cmassengale
8 
Answer: Hydrolysis 
• Separates monomers by “adding 
water” 
HO H 
H2O 
HO H HO H 
copyright cmassengale
9 
Carbohydrates 
copyright cmassengale
10 
Carbohydrates 
• Small sugar molecules to large 
sugar molecules. 
• Examples: 
A. monosaccharide 
B. disaccharide 
C. polysaccharide 
copyright cmassengale
11 
Carbohydrates 
Monosaccharide: one sugar unit 
Examples: glucose (C6H12O6) 
deoxyribose 
ribose 
Fructose 
Galactose 
glucose 
copyright cmassengale
12 
Carbohydrates 
Disaccharide: two sugar unit 
Examples: 
– Sucrose (glucose+fructose) 
– Lactose (glucose+galactose) 
– Maltose (glucose+glucose) 
glucose glucose 
copyright cmassengale
13 
Carbohydrates 
Polysaccharide: many sugar units 
Examples: starch (bread, potatoes) 
glycogen (beef muscle) 
cellulose (lettuce, corn) 
glucose glucose 
glucose glucose 
glucose glucose 
cellulose 
glucose glucose 
copyright cmassengale
14 
Lipids 
copyright cmassengale
15 
Lipids 
• General term for compounds which are 
not soluble in water. 
• Lipids are soluble in hydrophobic 
solvents. 
• Remember: “stores the most energy” 
• Examples: 1. Fats 
2. Phospholipids 
3. Oils 
4. Waxes 
5. Steroid hormones 
6. co pTyrigrhti cgmalsysecngaelerides
16 
Lipids 
Six functions of lipids: 
1. Long term energy storage 
2. Protection against heat loss 
(insulation) 
3. Protection against physical shock 
4. Protection against water loss 
5. Chemical messengers (hormones) 
6. Major component of membranes 
(phospholipids) 
copyright cmassengale
17 
Lipids 
Triglycerides: 
composed of 1 glycerol and 3 
fatty acids. 
H 
H-C----O 
H-C----O 
H-C----O 
H 
glycerol 
O 
C-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH3 
O 
C-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH3 
fatty acids 
O 
C-CH2-CH2-CH2-CH 
copyright cmassengale
18 
Fatty Acids 
There are two kinds of fatty acids you may see 
these on food labels: 
1. Saturated fatty acids: no double bonds 
(bad) 
O 
C-CH2-CH2-CH2-saturated CH2-CH2-CH2-CH2-CH2-CH2-CH3 
2. Unsaturated fatty acids: double bonds 
(good) 
O 
C-CH2-CH2-CH2unsaturated -CH 
copyright cmassengale
19 
Proteins 
copyright cmassengale
20 
Proteins (Polypeptides) 
• Amino acids (20 different kinds of aa) 
bonded together by peptide bonds 
(polypeptides). 
• Six functions of proteins: 
1. Storage: albumin (egg white) 
2. Transport: hemoglobin 
3. Regulatory: hormones 
4. Movement: muscles 
5. Structural: membranes, hair, nails 
6. Enzymes: cellular reactions 
copyright cmassengale
21 
Proteins (Polypeptides) 
Four levels of protein structure: 
A.Primary Structure 
B. Secondary Structure 
C. Tertiary Structure 
D.Quaternary Structure 
copyright cmassengale
22 
Primary Structure 
Amino acids bonded together 
by peptide bonds (straight 
chains) 
Amino Acids (aa) 
aa1 aa2 aa3 aa4 aa5 aa6 
Peptide Bonds 
copyright cmassengale
23 
Secondary Structure 
• 3-dimensional folding arrangement of a 
primary structure into coils and pleats 
held together by hydrogen bonds. 
• Two examples: 
Alpha Helix 
Beta Pleated Sheet 
Hydrogen Bonds 
copyright cmassengale
24 
Tertiary Structure 
• Secondary structures bent and folded 
into a more complex 3-D arrangement 
of linked polypeptides 
• Bonds: H-bonds, ionic, disulfide 
bridges (S-S) 
• Call a “subunit”. 
Alpha Helix 
Beta Pleated Sheet 
copyright cmassengale
25 
Quaternary Structure 
• Composed of 2 or more 
“subunits” 
• Globular in shape 
• Form in Aqueous environments 
• Example: enzymes (hemoglobin) 
subunits 
copyright cmassengale
26 
Nucleic 
Acids 
copyright cmassengale
27 
Nucleic acids 
• Two types: 
a. Deoxyribonucleic acid (DNA-double 
helix) 
b. Ribonucleic acid (RNA-single 
strand) 
• Nucleic acids are composed of long 
chains of nucleotides linked by 
dehydration synthesis. 
copyright cmassengale
28 
Nucleic acids 
• Nucleotides include: 
phosphate group 
pentose sugar (5-carbon) 
nitrogenous bases: 
adenine (A) 
thymine (T) DNA only 
uracil (U) RNA only 
cytosine (C) 
guanine (G) 
copyright cmassengale
29 
Nucleotide 
Phosphate 
Group 
O 
O=P-O 
O 
N 
Nitrogenous base 
(A, G, C, or T) 
CH2 
O 
C1 C4 
C3 C2 
5 
Sugar 
(deoxyribose) 
copyright cmassengale
30 
DNA - double helix 
P 
P 
P 
O 
O 
O 
1 
2 
3 
3 
5 
4 
5 
3 
5 
P 
P 
P 
O 
5 
2 3 
O 
O 
1 
4 
5 
5 
3 
3 
G C 
T A 
copyright cmassengale
copyright cmassengale 31

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Macromolecules1

  • 2. 2 Organic Compounds • Compounds that contain CARBON are called organic. • Macromolecules are large organic molecules. copyright cmassengale
  • 3. 3 Carbon (C) • Carbon has 4 electrons in outer shell. • Carbon can form covalent bonds with as many as 4 other atoms (elements). • Usually with C, H, O or N. • Example: CH4(methane) copyright cmassengale
  • 4. 4 Macromolecules • Large organic molecules. • Also called POLYMERS. • Made up of smaller “building blocks” called MONOMERS. • Examples: 1. Carbohydrates 2. Lipids 3. Proteins 4. Nucleic acids (DNA and RNA) copyright cmassengale
  • 5. 5 Question: How Are Macromolecules Formed? copyright cmassengale
  • 6. 6 Answer: Dehydration Synthesis • Also called “condensation reaction” • Forms polymers by combining monomers by “removing water”. HO H HO H H2O HO H copyright cmassengale
  • 7. 7 Question: How are Macromolecules separated or digested? copyright cmassengale
  • 8. 8 Answer: Hydrolysis • Separates monomers by “adding water” HO H H2O HO H HO H copyright cmassengale
  • 10. 10 Carbohydrates • Small sugar molecules to large sugar molecules. • Examples: A. monosaccharide B. disaccharide C. polysaccharide copyright cmassengale
  • 11. 11 Carbohydrates Monosaccharide: one sugar unit Examples: glucose (C6H12O6) deoxyribose ribose Fructose Galactose glucose copyright cmassengale
  • 12. 12 Carbohydrates Disaccharide: two sugar unit Examples: – Sucrose (glucose+fructose) – Lactose (glucose+galactose) – Maltose (glucose+glucose) glucose glucose copyright cmassengale
  • 13. 13 Carbohydrates Polysaccharide: many sugar units Examples: starch (bread, potatoes) glycogen (beef muscle) cellulose (lettuce, corn) glucose glucose glucose glucose glucose glucose cellulose glucose glucose copyright cmassengale
  • 14. 14 Lipids copyright cmassengale
  • 15. 15 Lipids • General term for compounds which are not soluble in water. • Lipids are soluble in hydrophobic solvents. • Remember: “stores the most energy” • Examples: 1. Fats 2. Phospholipids 3. Oils 4. Waxes 5. Steroid hormones 6. co pTyrigrhti cgmalsysecngaelerides
  • 16. 16 Lipids Six functions of lipids: 1. Long term energy storage 2. Protection against heat loss (insulation) 3. Protection against physical shock 4. Protection against water loss 5. Chemical messengers (hormones) 6. Major component of membranes (phospholipids) copyright cmassengale
  • 17. 17 Lipids Triglycerides: composed of 1 glycerol and 3 fatty acids. H H-C----O H-C----O H-C----O H glycerol O C-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH3 O C-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH3 fatty acids O C-CH2-CH2-CH2-CH copyright cmassengale
  • 18. 18 Fatty Acids There are two kinds of fatty acids you may see these on food labels: 1. Saturated fatty acids: no double bonds (bad) O C-CH2-CH2-CH2-saturated CH2-CH2-CH2-CH2-CH2-CH2-CH3 2. Unsaturated fatty acids: double bonds (good) O C-CH2-CH2-CH2unsaturated -CH copyright cmassengale
  • 19. 19 Proteins copyright cmassengale
  • 20. 20 Proteins (Polypeptides) • Amino acids (20 different kinds of aa) bonded together by peptide bonds (polypeptides). • Six functions of proteins: 1. Storage: albumin (egg white) 2. Transport: hemoglobin 3. Regulatory: hormones 4. Movement: muscles 5. Structural: membranes, hair, nails 6. Enzymes: cellular reactions copyright cmassengale
  • 21. 21 Proteins (Polypeptides) Four levels of protein structure: A.Primary Structure B. Secondary Structure C. Tertiary Structure D.Quaternary Structure copyright cmassengale
  • 22. 22 Primary Structure Amino acids bonded together by peptide bonds (straight chains) Amino Acids (aa) aa1 aa2 aa3 aa4 aa5 aa6 Peptide Bonds copyright cmassengale
  • 23. 23 Secondary Structure • 3-dimensional folding arrangement of a primary structure into coils and pleats held together by hydrogen bonds. • Two examples: Alpha Helix Beta Pleated Sheet Hydrogen Bonds copyright cmassengale
  • 24. 24 Tertiary Structure • Secondary structures bent and folded into a more complex 3-D arrangement of linked polypeptides • Bonds: H-bonds, ionic, disulfide bridges (S-S) • Call a “subunit”. Alpha Helix Beta Pleated Sheet copyright cmassengale
  • 25. 25 Quaternary Structure • Composed of 2 or more “subunits” • Globular in shape • Form in Aqueous environments • Example: enzymes (hemoglobin) subunits copyright cmassengale
  • 26. 26 Nucleic Acids copyright cmassengale
  • 27. 27 Nucleic acids • Two types: a. Deoxyribonucleic acid (DNA-double helix) b. Ribonucleic acid (RNA-single strand) • Nucleic acids are composed of long chains of nucleotides linked by dehydration synthesis. copyright cmassengale
  • 28. 28 Nucleic acids • Nucleotides include: phosphate group pentose sugar (5-carbon) nitrogenous bases: adenine (A) thymine (T) DNA only uracil (U) RNA only cytosine (C) guanine (G) copyright cmassengale
  • 29. 29 Nucleotide Phosphate Group O O=P-O O N Nitrogenous base (A, G, C, or T) CH2 O C1 C4 C3 C2 5 Sugar (deoxyribose) copyright cmassengale
  • 30. 30 DNA - double helix P P P O O O 1 2 3 3 5 4 5 3 5 P P P O 5 2 3 O O 1 4 5 5 3 3 G C T A copyright cmassengale