This document discusses different types of low vision devices used to help people with low vision. It describes optical devices like telescopes, magnifying spectacles, and magnifiers that use lenses to improve vision. It also discusses non-optical devices like illumination aids, reading stands, and software that help without using lenses. A variety of telescopes, magnifiers, and other low vision devices are presented along with their uses, advantages, and disadvantages. The document provides an overview of the options available to enhance vision for those with low vision.
Low Vision Near Systems-Microscopes,Magnifiers & Electronic systemsHarsh Jain
Different Optical devices used in Low vision patients.
Its very important to take proper assessment and calculations for giving Optical devices like Microscopes,Magnifier etc.
The references are given.
Low Vision Near Systems-Microscopes,Magnifiers & Electronic systemsHarsh Jain
Different Optical devices used in Low vision patients.
Its very important to take proper assessment and calculations for giving Optical devices like Microscopes,Magnifier etc.
The references are given.
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Fitting an Astigmatic Patient is really a challenging.Though fitting a Toric Cornea is another challenge in CL Dispensing practice.This Slide will give you a basic considerations in RGP Toric lens.
Contact lens for congenital aphakia and other eye conditions for infants and toddlers. The slide presentation encompasses indications for CL fitting in paediatric, contact lens options, fitting techniques, challenges and contact lens as myopia control.
Fitting an Astigmatic Patient is really a challenging.Though fitting a Toric Cornea is another challenge in CL Dispensing practice.This Slide will give you a basic considerations in RGP Toric lens.
Magnification is a method of increasing the size of the image
so that enough of the retina is stimulated to send an impulse
through the optic nerve allowing an object to be perceived .
Optometry instruments is a presentation to describe instrument in a beautiful way. use this tool to improve your knowledge. stay blessed. Regards Muhammad Akbar Rashid Qadri.
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Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
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Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
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solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
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30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
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models for evolution of the dark matter halo mass function.
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Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Body fluids_tonicity_dehydration_hypovolemia_hypervolemia.pptx
Low vision Aids
1. Low Vision Devices
Different types of telescopes
Magnifiers and other devices in low vision
Presented By:- Guided By:-
Mohammad Aamir Miss Sravani Reddy Mam
B.Optometry 5th sem Faculty- SLAS ITM
School of Life & Allied Science University Raipur
ITM University Raipur,
Chhattisgarh
2. Low vision:- A condition caused by eye disease, in which visual acuity is 20/70
or poorer in the better-seeing eye and cannot be corrected or improved with regular
eyeglasses.
3. Low vision device:- A device to help to improve visual ability of a person
with low vision. Low vision devices may be optical or non-optical. Optical devices
such as a magnifying glass involve the use of lenses to improve vision whereas non-
optical devices such as large print help bring images closer to the eyes.
4. Types of low vision devices
Optical:-
1- Distance
2- Near
Magnifiers
Electronic devices
Non Optical
5. Low vision optical devices for distance
Telescopes:-
Work on the principle of angular magnification
Telescopes with magnification from 2x to 10x are prescribed
They can be prescribed for distance, intermediate and near tasks
Field of view decreases with magnification
Types:-
Hand held monocular
Clip on design
Bioptic design: mounted on a pair of eye glasses
7. Principal:-
Telescopes consist of two lenses ( in practice two optical system) mounted such
the focal point of the objective coincides with the focal point of the ocular.
Objective lens is converging lens
Galilean telescope
The eye piece is a negative lens and the
objective is a positive lens
Resultant image is a virtual and erect
Loss of light reduces brightness of the image
Field quality is poor
Keplerian telescope
Both eye piece and objective are positive leens
Resultant image is real and inverted. Prisms are
incorporated to erect the image
Loss of light is more in this system
Field quality is relatively good
8. Magnification of a telescope is given by the formula M=fₒ/fₑ
Telescopes can be used to focus near objects by
- changing the distance between objective and ocular lens
- increasing the power of the objective lens
9. Advantages:-
Only possible device to enhance distant vision
Disadvantages:-
Restriction of the field of view
Appearance and apprehension
Expensive and costly
Depth perception is distorted
10. Low vision optical devices for near
Magnifying Spectacles
High plus reading glasses to magnify the images
Given as an add to the best distance refraction
Reading distance is calculated by 100 divided by add
Magnification is 1/4th the power of lens
Used for near work
Amount of add needed depends on the accommodation and the reading distance
11. Advantages:-
Hands are free
Field of view larger when compared to telescope
Greater reading speed
Can be given in both monocular and binocular forms
More portable
Cosmetically acceptable
Disadvantages:-
Higher the power, closer the reading distance
Close reading distance causes fatigue and unacceptable posture
Patients with eccentric fixation are unable to fix through these glasses
12. Low vision optical devices for near
Magnifiers
Useful for near work
Designed to be held close to the reading material to enlarge the image
The eye lens distance should be minimum to achieve larger magnification
Two types;
Hand magnifier
Stand magnifiers
Hand Magnifiers Stand Magnifiers
13. Hand Magnifiers
Available from +4.0 to +68.0 D
Available in three designs:-
• Aspheric – reduces thickness and peripheral distortion
• Aplantic - flat and wide distortion free field and good clarity
• Biaspheric – eliminating aberrations from both surfaces
Most patients accept up to 6x magnification
14. Advantages:-
The eye to lens distance can be varied
Patient can maintain normal reading distance
Work well with patients with eccentric viewing
Some have light source which further enhance vision
Easily available, over the counter
Disadvantages:-
It occupies both hands
Patients with tremors, arthritis etc have difficulty holding the magnifier
Maintaining focus is a problem especially for elderly
Field of vision is limited
15. Stand Magnifiers
The magnifiers are stand mounted
The patient needs to place the stand magnifier on the reading material and move
across the page to read
Has a fixed focus
Advantages:-
They are a choice for patients with tremors, arthritis and constricted visual
fields
Disadvantages:-
Field of vision is reduced
Too close reading posture is uncomfortable for the patient
Blocks good lighting unless self illuminated
16.
17. Low vision optical devices for near
Closed circuit television system
Closed circuit television system (CCTV) consists of a monitor, a camera and a
platform to place the reading text
It has control for brightness, contrast and change of polarity
Magnification varies from 3X to 60X
18. Non Optical Devices
Illumination
Positioning:-
Light source should be to the side of better eye
Moving light closer will yield higher illumination
Higher levels of illumination is needed in patients with:-
Lost cone function (macular degeneration)
Glaucoma retinopathy
Retinitis pigmentosa, Chorioretinitis
Reduced illumination:-
Albinism
Aniridia
20. Non Optical Devices
Writing Guide
Black cards with rectangular cut outs horizontally along the card
The patient can feel the empty cut out spaces and write
22. Non Optical Devices
Typo scope / Reading guide
Masking device with a line cut out from an opaque, non reflecting black plastic
or thick paper
Reduces glare and controls contrast
23. Non Optical Devices
Notex
It is a rectangular piece of cardboard with steps on top right corner which helps
in identifying the currency of the note
1st cut indicates Rs. 100, 2nd cut indicates Rs. 50, and so on.
24. Non Optical Devices
Relative size devices
Larger object subtends a larger visual angle at the eye and is thus easier to
resolve
Large print material
Large type playing cards, computer keyboards
Enlarged clocks, telephones, calendars
25. Non Optical Devices
Computer software
Jaws screen reading software
Connect out loud internet and email software
Magic 8.0 screen magnification software and speech
26. Non Optical Devices
Glare reducing devices
Glare is described as unwanted light
It is disabling in patients with cataracts, corneal opacities, albinism, retinitis
pigmentosa
Devices to prevent glare:
Sunglasses
Caps
Umbrella
Polaroid glasses
NoIR filters
Corning photochromic filters
(CPF glasses)
27. Non Optical Devices
CPF Glasses
Attenuate 100% of UVB wavelengths.
Block 99% of UVA wavelengths.
Block 99% of UVA wavelengths. in the eye, causing discomfort and hazy
illusion.
Attenuate 98% of high-energy blue light, with exception of CPF 450, which is
96% of high-energy blue light.
The number of the CPF glasses correspond to wavelength in nanometers above
which light is transmitted
28. Non Optical Devices
Color and contrast enhancement
Maximize contrast by using a light color against black or dark color
Choose colors in the room or working area which have high contrast
29. Non Optical Devices
Pinhole Glasses
Multiple holes of approximately 1mm size are made in the glasses
The distance between the holes should be at least 3-3.5 mm or
approximately the size of the pupil
Used in patients with corneal opacities or conditions with irregular
reflexes
Not used in patients with central field defects as it reduces
illumination and visual acuity
30. Non Optical Devices
Mobility Assisting Devices
Patients with low vision suffer a major problem of mobility
Long canes
Strong portable lights