Local anaesthesia is a loss of sensation in a circumscribed area without loss of consciousness. The document discusses the history of local anaesthesia from ancient times to modern developments. It also covers the desirable properties, mechanisms of action, classifications, pharmacology and clinical aspects of local anaesthetics. The summary provides a high-level overview of the key topics covered in the document relating to the definition, history, properties and mechanisms of local anaesthetics.
brief description on posterior superior alveolar nerve block.
its uses in dentistry, technique and action. locating PSA nerve is easy and this is the most used nerve block in dentistry.
brief description on posterior superior alveolar nerve block.
its uses in dentistry, technique and action. locating PSA nerve is easy and this is the most used nerve block in dentistry.
One of the most painful but easy-to-treat dental emergencies is a dry socket.
• Dry socket symptoms are experienced after a tooth extraction.
• This condition requires follow-up care by the doctor who performed the surgery, an oral surgeon or a dentist who is familiar with how to treat it.
For more information, contact :-
Dr Sachdeva's Dental Aesthetic And Implant Institute,
I 101, Ashok Vihar Phase 1, Delhi- 110052
Contact us at
• Phone : +919818894041,01142464041
• Our Websites:
• www.sachdevadentalcare.com
• www.dentalclinicindelhi.com
• www.dentalimplantindia.co.in
• www.dentalcoursesdelhi.com
• www.facialaestheticsdelhi.com
#drysocket #management #thirdmolarextraction #extractioncomplications
Odontogenic keratocyst (OKC) is the cyst arising from the cell rests of dental lamina. It can occur anywhere in the jaw, but commonly seen in the posterior part of the mandible. Radiographically, most OKCs are unilocular when presented at the periapex and can be mistaken for radicular or lateral periodontal cyst.
One of the most painful but easy-to-treat dental emergencies is a dry socket.
• Dry socket symptoms are experienced after a tooth extraction.
• This condition requires follow-up care by the doctor who performed the surgery, an oral surgeon or a dentist who is familiar with how to treat it.
For more information, contact :-
Dr Sachdeva's Dental Aesthetic And Implant Institute,
I 101, Ashok Vihar Phase 1, Delhi- 110052
Contact us at
• Phone : +919818894041,01142464041
• Our Websites:
• www.sachdevadentalcare.com
• www.dentalclinicindelhi.com
• www.dentalimplantindia.co.in
• www.dentalcoursesdelhi.com
• www.facialaestheticsdelhi.com
#drysocket #management #thirdmolarextraction #extractioncomplications
Odontogenic keratocyst (OKC) is the cyst arising from the cell rests of dental lamina. It can occur anywhere in the jaw, but commonly seen in the posterior part of the mandible. Radiographically, most OKCs are unilocular when presented at the periapex and can be mistaken for radicular or lateral periodontal cyst.
ESP block - future direction and remaining questionsAmit Pawa
This Talk was delivered by Dr Pawa on 5th June 2021 as part of the ISURA 2021 hybrid conference held in Toronto.
The Future Direction of this block and remaining questions to be answered are covered here
It remains the responsibility of all clinicians using LA
to understand their potential
for severe systemic toxicity and to be prepared to respond immediately to these events when they occur.
Dr. Sapna Vadera is a Mumbai based Facial Cosmetic & Cranio-Maxillofacial Surgeon. Her passion is clearly reflected in the kind of work she is doing. She is not only a dedicated Surgeon but is a Researcher, Trainer and International Speaker as well. Dr. Sapna has more than 30 International publications to her credit, in peer reviewed journals of International repute. At this young age, she has co-authored a book chapter in a book by Springer publication. She was the Youngest Key-Note Speaker at the 44th AOMSI National Conference held in Bangalore, 2019. She is also a reviewer for multiple journals with Elsevier. She has been awarded by various organizations such as the Award for Excellance in Cosmetology by IDA Molaris, Chennai in 2022, Excellence in Facial Cosmetics by Indian Health Professional Awards in 2019, and the Youth Icon of the Year 2019 by IADS.
A blend of Modern techniques and expertise of an artist, Dr. Sapna Vadera’s teaching methods are unique. She creates an extravagant and fruitful learning environment for the trainees, who travel from all over India as well as Internationally, to attend training programs with her.
With years of experience in Facial Cosmetics and Hair Rejuvenation, the courses conducted by Dr. Sapna Vadera are tailor-made to cover the entire aspect of Facial Cosmetics, Anti-aging and Hair restoration in a comprehensive way. Her students receive the best quality training not only in various aesthetic therapies, treatments, diagnostic procedures, aftercare methodologies, and clinic management, but also about the intricacies of financial planning in running a successful aesthetic practice.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Telegram: bmksupplier
signal: +85264872720
threema: TUD4A6YC
You can contact me on Telegram or Threema
Communicate promptly and reply
Free of customs clearance, Double Clearance 100% pass delivery to USA, Canada, Spain, Germany, Netherland, Poland, Italy, Sweden, UK, Czech Republic, Australia, Mexico, Russia, Ukraine, Kazakhstan.Door to door service
Hot Selling Organic intermediates
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Local Anesthesia in Oral and Maxillofacial Surgery
1. LOCAL ANAESTHESIA
Dept Of Oral And Maxillofacial Surgery
VSPM’S Dental College, Nagpur
Presented by: Guided by:
Dr. Sapna K Vadera Dr. S.R.Shenoi
(P.G. Student) (Prof, Guide and H.O.D)
2. CONTENT
Introduction
History
Definition
Desirable properties
Mode of impulse transmission
Mechanism of action of L.A
Factors affecting L.A action
Classification
Pharmacology
3. Composition of L.A
Systemic effects of L>A
Topical Local anesthetics
Containdications of L.A
Vasocontrictors
Clinical aspects
Complications
Future Directions
Summary
CONTENT
4. INTRODUCTION
The efforts of human kind to find the means to control pain presents as
one of the greatest challenges in medicine. Pain is the phenomenon
wisely instituted by nature as a warning sign of a condition that may be
detrimental to our bodies.
Pain-free operating is of obvious benefit to the patient, it also helps the
operator as treatment can be performed in a calm, unhurried manner.
Joseph A et al,pharmacology of Local Anesthetics used in oral surgery ,Anesthesia:Oral and Maxillofacial clinics of North America;
Volume 25, Issue 3, Pages 453-466 (August 2013)
5. Local anaesthesia is the mainstay of pain control for outpatient oral surgical
procedures.
The ability to provide safe, effective local anaesthesia is the cornerstone of
clinical oral surgical practice. Its use and effectiveness depends on patient
considerations, the extent and duration of the procedure, the choice of drug and
technique, and the skill and experience of the practitioner.
INTRODUCTION
Joseph A et al,pharmacology of Local Anesthetics used in oral surgery ,Anesthesia:Oral and Maxillofacial clinics of North America;
Volume 25, Issue 3, Pages 453-466 (August 2013)
6. Alcohol is the oldest known sedative. It was used in the ancient
Mesopotamia thousands of years ago.
3400 B.c-The ‘Euphoric’ effect of Opium was discovered by
Summerians.
Joseph Priestly(1733-1804)- discovered various gases like- nitrous
oxide, ammonia, oxygen.
HISTORY
Fonseca J Raymond,Chapter 3; Local aneasthetics,Vol 1: Anesthesia and pain control, Dentoalveolar Surgery, Practice Managment,
Implant Surgery, oral and maxillofacial Surgery,pg- 35-55,vol 1,2nd edition,2009, Saunders, Elsevier
7. 1801-Humphry Davy
- Anesthetic properties of nitrous oxide.
-Coined the term ‘laughing gas’.
Dec 10,1844- Sir Horace Well attended lecture on ‘Chemical
Phenomenon’ by Gardner.(nitrous oxide)
HISTORY
Fonseca J Raymond,Chapter 3; Local aneasthetics,Vol 1: Anesthesia and pain control, Dentoalveolar Surgery, Practice Managment,
Implant Surgery, oral and maxillofacial Surgery,pg- 35-55,vol 1,2nd edition,2009, Saunders, Elsevier
8. Dec 11,1844, Nitrous oxide was
administered to Dr. Horace Well,
rendering him unconcious & able
to have wisdom tooth extracted
without awareness of pain.
HISTORY
T. Y. Euliano,J. S. Gravenstein, Essential Anesthesia -From Science to Practice:United States of America by Cambridge University
Press, New York;2004: Introduction A very short history of anesthesia;p.1-4
9. 16th oct, 1846, ether was
administered by Sir William Morton
for the removal of mandibular
tumor.
Experiment was published in Boston
daily journal. And led to the
discovery of Surgical anesthesia.
HISTORY
10. 1850’s Cocaine isolated, hypodermic needle developed
1853 Chloroform used as anesthetic by Dr.John Snow
Chloroform being used as anesthesia
HISTORY
T. Y. Euliano,J. S. Gravenstein, Essential Anesthesia -From Science to Practice:United States of America by Cambridge University
Press, New York;2004: Introduction A very short history of anesthesia;p.1-4
11. 1884 Carl Koller introduces cocaine into
medical practice
1884 Halsted injected cocaine directly into
mandibular nerve and brachial plexus
Carl Koller
(1857 -1944)
William
Halsted
HISTORY
T. Y. Euliano,J. S. Gravenstein, Essential Anesthesia -From Science to Practice:United States of America by Cambridge University
Press, New York;2004: Introduction A very short history of anesthesia;p.1-4
12. 1905 Procaine synthesized by Einhorn
1948 First amide L.A (Lidocaine) synthesized by Lofgren
1960 Mepivacaine
1983 Bupivacaine
2000 Articaine
HISTORY
Joseph A et al,pharmacology of Local Anesthetics used in oral surgery ,Anesthesia:Oral and Maxillofacial clinics of
North America; Volume 25, Issue 3, Pages 453-466 (August 2013)
13. DEFINITION
Loss of pain sensation over a specific area of the
anatomy without loss of consciousness but also to the
interruption of all other sensations ,including
temperature, pressure, and motor function.
Bennett Richard C.,Monheim’s Local Anesthesia and Pain Control in Dental Practice 7th edition page
no.2,CBS publishers and distributers
14. DEFINITION
Local anesthesia is defined as a loss of sensation in a
circumscribed area of the body caused by a
depression of excitation in nerve endings or an
inhibition of the conduction process in peripheral
nerves.
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An
imprint of Elsevier.
15. DESIRABLE
PROPERTIES
Non irritating.
No permanent alteration of nerve structure.
Low systemic toxicity.
Must be effective ( injected or applied locally)
Short onset of anaesthesia.
Long duration of action.
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An
imprint of Elsevier.
16. Potency sufficient to give complete anesthesia.
Free from producing allergic reactions.
Stable in solution and readily undergo biotranformation in
the body.
Sterile and capable of being sterlized.
DESIRABLE
PROPERTIES
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An
imprint of Elsevier.
17. MODE OF IMPULSE
CONDUCTION
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
23. ACETYLCHOLINE THEORY
MECHANISM OF ACTION OF
LOCAL ANESTHESIA
http://cnx.org/resources/09ab17c9199ed6fb925c5fae201df4bcfac9b846/Figure_35_02_01.jpg
24. CALCIUM DISPLACEMENT
THEORY
MECHANISM OF ACTION OF
LOCAL ANESTHESIA
https://wikispaces.psu.edu/download/thumbnails/42338579/image2.jpg?version=1&modificationDate=1248755004
000&api=v2
25. MECHANISM OF ACTION OF
LOCAL ANESTHESIA
SURFACE CHARGE THEORY
http://cnx.org/resources/09ab17c9199ed6fb925c5fae201df4bcfac9b846/Figure_35_02_01.jpg
26. MECHANISM OF ACTION OF
LOCAL ANESTHESIA
MEMBRANE EXPANSION THEORY
http://cnx.org/resources/09ab17c9199ed6fb925c5fae201df4bcfac9b846/Figure_35_02_01.jpg
27. MECHANISM OF ACTION OF
LOCAL ANESTHESIA
MEMBRANE EXPANSION THEORY
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
28. MECHANISM OF ACTION OF
LOCAL ANESTHESIA
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
SPECIFIC RECEPTOR THEORY
29. RNH+
==== RN+ H+
low pH RNH+
> RN+
+ H+
high pH RNH+
< RN + H+
Henderson Hasselbalch equation
Log base/acid = pH - pKa
DISSOCIATION OF
LOCAL ANESTHETICS
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
30. Mechanism of action of L.A molecule.
Anesthetic pKa of 7.9; tissue pH of 7.4
Effect of decreased pH on action of L.A
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
CLINICAL IMPLICATIONS
31. Factor Action affected Description
pKa Onset Lower pKa = more rapid onset of action, more uncharged molecules present to diffuse
through nerve sheath.
Lipid solubility Anesthetic potency Increased lipid solubility = increased potency
Protein binding Duration Increased protein binding allows anesthetic cations to be more firmly attached to protein
located at receptor sites, thus duration of action is increased
Non-nervous
tissue
diffusibility
Onset Increased diffusibility = decreased time of onset
Vasodilator
activity
Anesthetic potency
and duration
Greater vasodilator activity = increased blood flow to region = rapid removal of anesthetic
molecules from injection site, thus decreased anesthetic potency and decreased duration
FACTORS AFFECTING LOCAL
ANESTHETIC ACTION
32. CLASSIFICATION
A) BASED ON DURATION OF ACTION:
1) Ultra Short acting anesthetics (less than 30 mins)
2) Short acting anesthetics(45 to 75 mins)
3) Medium acting anesthetics (90-150 mins)
4) Long acting anesthetics (180 mins or longer)
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
33. B)SURFACE ANESTHETICS:
1)Soluble agents- E.g. Cocaine,
Lidocaine,
Tetracaine
2)Insoluble agents- E.g. Benzocaine,
Oxethazine
CLASSIFICATION
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
34. C) BASED ON BIOLOGICAL SITE
1) CLASS A- Agents acting at receptor site on external
surface of nerve membrane.
E.g. Biotoxins
2) CLASS B- Agents acting at receptor sites on internal
surface of nerve membrane.
E.g. lidocaine
CLASSIFICATION
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
36. 3) CLASS C- Agents acting by a receptor
independent, physicochemical agents.
E.g. Benzocaine.
4) CLASS D- Agents acting by combination of
receptor and receptor independent
mechanisms.
E.g. Articaine , Prilocaine.
CLASSIFICATION
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
37. Based on the chemistry
Esters Amides Quinilones
e.g. Articaine e.g. centbucridine
Lidocaine
Bupivacaine
Mepivacaine ,prilocaine
Benzoic Paraaminobenzoic
e.g. Butacaine e.g. Procaine
Cocaine Cloroprocaine
Benzocaine Propoxycaine
Tetracaine
Piperocaine
38. PHARMACOLOGY
UPTAKE
• Degree of vasoactivity
• Vasodialating properties.
• Procaine is a potent vasodialator.
• Cocaine - only L.A having vasoconstriction action
• Vasodilatation - the rate of absorption of L.A. into
the blood - duration and depth of anesthesia.
Joseph A et al,pharmacology of Local Anesthetics used in oral surgery ,Anesthesia:Oral and Maxillofacial clinics of North America;
Volume 25, Issue 3, Pages 453-466 (August 2013)
39. ORAL ROUTE
• Except cocaine , L.A are absorbed poorly , if at all from the G.I.
tract
• 72% OF drug undergoes significant hepatic first pass effect.
TOPICAL ROUTE
• Applied to intact skin- No anesthetic action.
• Damaged or sunburn skin- anesthetic effect
• EMLA-can be used on intact skin
PHARMACOLOGY
Joseph A et al,pharmacology of Local Anesthetics used in oral surgery ,Anesthesia:Oral and Maxillofacial clinics of North America;
Volume 25, Issue 3, Pages 453-466 (August 2013)
40. INJECTION
• Rate of uptake after s.c., i.m., or i.v., is related to the
vascularity at the site of injection and vasoactivity of
the drug.
• I.V administration of L.A., is used for the management
of ventricular dsyrhythmias
PHARMACOLOGY
ROUTE TIME TO PEAK LEVEL
(MIN)
INTRAVENOUS 1
TOPICAL 5
INTRAMUSCULAR 5-10
SUBCUTANEOUS 30 - 90
Joseph A et al,pharmacology of Local Anesthetics used in oral surgery ,Anesthesia:Oral and Maxillofacial clinics of North America;
Volume 25, Issue 3, Pages 453-466 (August 2013)
41. DISTRIBUTION
Plasma conc. Of local anasthetics have significant
effect on potential toxicity of the drug.
PHARMACOLOGY
Blood level of anaesthetics depends on-
• 1.Rate at which drug is absorbed into CVS.
• 2. Rate of distribution of drug from vascular
compartment to tissues.
• 3.Elimination of drug through metabolic or excretory
pathway.
Joseph A et al,pharmacology of Local Anesthetics used in oral surgery ,Anesthesia:Oral and Maxillofacial clinics of North America;
Volume 25, Issue 3, Pages 453-466 (August 2013)
42. Esters - Hydrolyzed in plasma by enzyme Pseudocholinesterase
Procaine hydrolyzed by pseudo cholinesterase's
Para amino benzoic acid Diethylamine
Excreted unchanged urine further transformed-urine
• Atypical Pseudocholinesterase
PHARMACOLOGY
Joseph A et al,pharmacology of Local Anesthetics used in oral surgery ,Anesthesia:Oral and Maxillofacial clinics of North America;
Volume 25, Issue 3, Pages 453-466 (August 2013)
43. Amide
Mostly gets metabolised in Liver
Relative contraindication for patient with liver
dysfuction.
PHARMACOLOGY
Joseph A et al,pharmacology of Local Anesthetics used in oral surgery ,Anesthesia:Oral and Maxillofacial clinics of North America;
Volume 25, Issue 3, Pages 453-466 (August 2013)
44. EXCRETION
KIDNEYS
Esters readily undergo biotransformation-small conc.
in urine as parent compound compared to amide.
Renal impairment- Relative contraindication
PHARMACOLOGY
Joseph A et al,pharmacology of Local Anesthetics used in oral surgery ,Anesthesia:Oral and Maxillofacial clinics of North America;
Volume 25, Issue 3, Pages 453-466 (August 2013)
45. COMPOSITION
Local anesthetic drug –eg lignocaine . 21.3 mg/ml
Vasopressor drug - eg adrenaline.1:80,000, 1:20,0000
Reducing agent - eg Sodium meta bi sulfide. 0.4-0.5mg
Preservative – eg Methyl paraben.0.1%
For isotonicity – Normal Saline . 6mg
Diluting agent – Distal water
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
46. SYSTEMIC EFFECTS
CNS
• Easily crosses blood brain barrier.
• Causes CNS depression at low doses.
Blood level Effect
• 0.5-4μg/ml - Anticonvulsant action, direct depression
Increase in seizure threshold.
• 4.5-7μg/ml - Preseizure signs and symptoms caused by
depression of inhibitory neuron
• > 7.5μg/mi - Tonic clonic seizure.
entire blokage of inhibitory neuron.
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
47. CVS
• Causes myocardial depression.
• Produces peripheral vasodialation and hypotension.
• Maximum dose-
4.4 mg/kg body weight (plain)
7 mg/kg body weight (with adrenaline)
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
SYSTEMIC EFFECTS
48. RESPIRATORY SYSTEM
Dual effect.
Low doses- direct relaxant action on bronchial smooth
muscles.
High doses- Respiratory arrest as a result of CNS
depression
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
SYSTEMIC EFFECTS
49. 49
NotesMain unwanted effectsPlasma
half-life
Tissue
penetration
DurationOnsetDrug
Rarely used, only as spray for
upper respiratory tract
Cardiovascular and CNS
effects due to block of
amine uptake
~1hGoodMediumMediumCocaine
No longer usedCNS: restlessness,
shivering, anxiety,
occasionally convulsions
followed by respiratory
depression
CVS: bradycardia and
decreased cardiac output,
vasodilatation, which can
cause cardiovascular
collapse
<1hPoorShortMediumProcaine
(2-4%)
Widely used for local
anaesthesia .Also used i.V.
For treating ventricular
arrhythmias mepivacaine is
similar
Less tendency to cause
CNS effects
~2hGoodMediumRapidLignocaine
(lidocaine)
(2%)
Widely used because of long
duration of action.
Ropivacaine is similar, with
less cardiotoxicity
As lingocaine, but greater
cardiotoxicity
~2hModerateLongSlowBupivacaine
(0.5%)
Widely used, not for obstetric
analgesia because of risk of
neonatal
methaemoglobinaemia
No vasodilator activity, can
cause
methaemoglobinaemia
~2hModerateMediumMediumPrilocaine
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
50. TOPICAL
ANAESTHESIA
Insoluble in water- soluble in vehicle such as alcohol,
polyethylene glycol, propylene glycol, or carboxymethyl
cellulose – can be used for surface application
Advantage
1. By incorporating the anesthetic into a viscous liquid, a gel, or
an ointment, they remain in contact with the area for a longer
period, thereby increasing the duration of action.
2. poorly absorbed into the circulation,
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
51. BENZOCAINE
• Poor solubility in water
• Poor absorption into CVS
• Remains longer at the site of application
• Prolonged use – localized allergic
reaction
• Availability as: Aerosol, Gel, Gel patch,
Ointment , Solution
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
TOPICAL
ANAESTHESIA
52. EMLA
• Cream (Lidocaine 2.5% +Prilocaine 2.5%)
• Emulsion in which oil phase is eutectic mix of
lidocaine and prilocaine in a ratio of 1:1 by wt
• Supplied as 5g or 30 gm tube or as an EMLA
disc.
• Can be used to provide surface anesthesia o
intact skin.
• Contraindicated-pts with congenital idiopathic
methhemogloulinemia.
TOPICAL
ANAESTHESIA
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
53. LIGNOCAINE
• Lidocaine base- poorly soluble in
water-5%, used on ulcerated,abraded
and lacerated wound.
• Lidocaine hydrochloride- water soluble
-2%.
• Aerosol spray, gel, ointment, patch,
solution.
• Topical form-20mg/ml
TOPICAL
ANAESTHESIA
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
54. CONTRINDICATIONS
ABSOLUTE
• Local anaesthetic allergy
• Bisulfite allergy
RELATIVE
• Atypical plasma cholinesterase
• Methemoglobinemia
• Significant cardiovascular, liver or renal disease.
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
55. VASOCONSTRICTOR
Need for vasoconstrictor
• ↑ absorption of L.A into CVS → removal from injection site
• Rapid diffusion of L.A from inj site → ↓ duration of action &
depth of anesthesia.
• Higher plasma level of L.A → ↑ risk of toxicity
• ↑ bleeding at inj site.
Fonseca J Raymond,Chapter 3; Local aneasthetics,Vol 1: Anesthesia and pain control, Dentoalveolar Surgery, Practice Managment,
Implant Surgery, oral and maxillofacial Surgery,pg- 35-55,vol 1,2nd edition,2009, Saunders, Elsevier
56. Addition of vasoconstrictor
• Constriction of blood vessels → ↓ tissue perfusion
• Slow absorption into CVS → low anesthetic blood level → ↓
risk of toxicity.
• Higher volume of L.A around nerve → ↑ duration of action
• ↓ bleeding at inj site
VASOCONSTRICTOR
Fonseca J Raymond,Chapter 3; Local aneasthetics,Vol 1: Anesthesia and pain control, Dentoalveolar Surgery, Practice Managment,
Implant Surgery, oral and maxillofacial Surgery,pg- 35-55,vol 1,2nd edition,2009, Saunders, Elsevier
57. Adrenergic system- α and β receptors.
β - β1 and β2
α – α1 and α2
β1 - Heart
β2 - Vascular beds of skeletal muscle and pulmonary
vasculature.
α1 - peripheral vasculature.
α2 - CNS
SYSTEMIC EFFECTS
Fonseca J Raymond,Chapter 3; Local aneasthetics,Vol 1: Anesthesia and pain control, Dentoalveolar Surgery, Practice Managment,
Implant Surgery, oral and maxillofacial Surgery,pg- 35-55,vol 1,2nd edition,2009, Saunders, Elsevier
59. CLINICAL ASPECTS
Max dose of lidocaine without adrenaline is = 300mg
Max dose of LA with adrenaline = 500mg
Max safe dose of adrenaline =0.2mg/visit
2% Lignocaine= 2g in 100 ml
2000mg in 100 ml
20 mg in 1ml - 1 mg= 1/20
500mg=1/20500= 25ml can be given safely for a normal pt
Adrenaline present in our vials is in conc. of 1:200,000
1ml=1/200,000=0.005mg
0.005mg-1ml
As MRD-0.2mg , so for normal pt- 0.2 mg=1/0.0050.2= 40ml of LA can be
administered safely
61. [A] LOCAL COMPLICATIONS:-
Needle breakage
Pain on injection
Burning on injection
Parasthesia or persistent anesthesia
Trismus
Hematoma
Infection
Sloughing of tissues
Soft tissue injury
Facial nerve paralysis
Post anesthetic intra-oral lesions
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
62. B. Systemic
Drug allergy
Toxicity
Cvs and respiratory complications
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
63. 1.Needle breakage
Use of larger needles for nerve blocks.
Use longer needles when sufficient
depth injections are to be given.
As hub is the weakest part, avoid
inserting a needle into the tissues to its
hub.
Do not redirect the needle, instead
withdraw almost completely and then
redirect it.
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
64. 2. PAIN ON INJECTION
Proper technique.
Usage of topical anesthesia.
Slowly injecting local anesthetic.
Correct temperature of L.A.
Management:
No Management generally required only reassurance is
given to the patient.
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
65. 3. BURNING ON INJECTION:
pH of solution.
Rapid injection of L.A. to adherent tissues like palate.
Contamination of local anesthetic solution.
Warmed solution.
Prevention:
Slowing of injection should help.
Ideal rate : 1 ML per minute.
Max. rate : 1.8 ML per minute.
Storage of solution at room temperature.
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
66. 4. TRISMUS
Cause:
Most common : Trauma to muscles or blood vessels in infratemporal
fossa.
Usually, injury to medial pterygoid muscles, also superior constrictor
of pharyna and masseter muscles can cause trismus.
L.A. into which alcohol or cold sterilizing solutions have diffused, may
produce irritation and cause this problems.
• The injection of L.A. either intramuscularly or supramuscularly lead to rapidly
progressive necrosis of exposed muscle fibres.
• Haemorrhage.
• Low grade infection.
• Multiple needle penetration at the same site.
• Excessive volumes of solution deposited in a restricted area produces
distention causing trismus.
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
67. Prevention:
Use of sharp, sterile, disposable needles.
Proper care for and handle dental L.A. cartridges.
Use aseptic technique.
Practice atraumatic insertion and injection technique.
Use minimum effective volumes of solution.
Avoid repeat injections and multiple insertion in the same
area.
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
68. Management:
Heat Therapy
Warm saline rinse
Analgesics:
Muscle relaxant
Physiotherapy consisting of opening and closing the mouth as well
as lateral exursion of mandible
Complete recovery : About six weeks(range: 4-20 weeks)
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
69. 1. Toxicity
Too large dose of local anesthetic drug
Unusually rapid absorption of the drug
Accidental intravenous injection
High concentration of drug
Unusually slow biotransformation
Slow elimination
Injection of solution In highly vascular area without the
addition of vasoconstrictor
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
70. Early symptoms
On cerebral cortex
a. Talkativeness
b. Restlessness
c. Apprehension
d. disorientation
e. Tremors of hands and feet
On Medulla
a. Lethargy
b. Sleepiness
c. Drowsiness
d. Muscular weakness
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
71. Late symptoms
On cerebral cortex
a. Increased blood pressure
b. Increased pulse rate
c. Increased respiratory rate
d. Generalized seizure
On medulla
a. Decrease blood pressure
b. Decrease pulse rate
c. Decease heart rate
d. Respiration depression
e. Unconsciousness
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
72. Cortical depression
a. Unresponsiveness
b. Unconsciousness
c. Stupor
d. coma
Medullary depression
a. Depression of cardiovascular function
b. Respiratory depression
c. hypoxia
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
73. Prevention
Pre analgesic evaluation of the patient
Use the weakest possible concentration of drug
Use vasoconstrictor whenever possible
Use of least possible volume
Aspirate before injection
Slow injection
Monitor the patient carefully after injection
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
74. In slow onset (5min after administration)
-Position (supine with feet elevated slightly)
-Assess and maintain airway
-Assess breathing
-Assess circulation
-Definitive care
1. Reassure the patient
2. Oxygen administration to prevent acidosis
3. Monitor and record vital signs
4. Diazepam administered slowly intravenously (5mg/min)
Treatment
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
75. In severe overdose reaction (rapid onset)
-Position (supine with feet elevated slightly)
-Assess and maintain airway
-Assess breathing
-Assess circulation
-Definitive care in the presence of tonic clonic seizure
1.Protect patient’s arms ,legs and head.Loosen tight clothing.
2.Administer oxygen
3. Administer anticonvulsant –IV Diazepam at rate 5mg/min
or midazolam 1mg/min.
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
76. Postseizure (postictal) phase
-Position (supine with feet elevated slightly)
-Assess and maintain airway
-Assess breathing
-Assess circulation
-Definitive care
1.Administer IV fluids
2.Allow the patient to rest until recovery
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
77. Drug Allergy may be defined as a specific type of
hypersensitivity to drug or chemical compound
brought about by an alteration in the body’s reaction
to an antigenic substance.
2. Allergy
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
78. Type Mechanism Principle
Antibody
Or cell
Time of
reaction
Clinical
examples
I Anaphylaxis (Immediate,
Homocytochromic , antigenic
induced , antibody mediated)
IgE Sec to min -Anaphylaxis
-Atopic bronchial asthma
-Allergic rhinitis
-Urticaria
-Angioedema
-Hay fever
II Cytotoxic(antimembrane) IgG
IgM
- -Transfusion reaction
-Autoimmune hemolysis
-Hemolytic anemia
-Certain drug reaction
III Immune complex(Serum sickness
like)
IgG 6-8 hrs -Membranous
glomerulonephritis
-Serum sickness
-Acute Viral hepatitis
Classification of allergic diseases
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
79. Type mechanism Principle
antibody
Time of
reaction
Clinical examples
IV Cell mediated (delayed) or
Tuberculin type response
- 48 hrs -Allergic contact dermatitis
-Infectious
granulomas(tuberculosis
,mycoses)
-Tissue graft rejection
-Chronic hepatitis
Classification of allergic diseases
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
80. 1. Early phase –Skin reactions
a. Pt complains of feeling sick
b. Intense itching
c. Flushing(erythema)
d. Urticaria over the face and upper chest
e. Angioedema
2. GI disturbances related to smooth muscle spasm
a. Severe abdominal cramps
b. Nausea and vomiting
c. Diarrhea
Typical Reaction Progression of Generalized
Anaphylaxis
81. 3. Respiratory Symptoms
a. Respiratory distress
b. Dyspnea
c. Wheezing
d. Flushing
e. Cyanosis
f. Perspiration
g. Tachycardia
h. Possible laryngeal edema
4. Cardiovascular system
a. Pallor
b. Lightheadedness
c. Tachycardia
d. Hypotension
e. Cardiac dysrhythmias
f. Unconsciousness
g. Cardiac arrest
Typical Reaction Progression of Generalized
Anaphylaxis
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
82. Recognize problem
( itching, hives, edema,flushed skin)
Discontinue dental treatment
Activate office emergency team
P –Position patient comfortably
A-B-C-Assess and perform basic life support as needed
Activate emergency medical service if recovery not immediate
D- Provide definitive management as needed
In more generalized slow onset skin reaction
Observe patient Administer oral Administer IM or IV +oral
histamine blocker histamine blocker every 4-6 hrly
50 mg diphenhydramine or 10mg
Chlorpheniramine
Medical consultation prior to future dental care
Management of delayed onset ,allergic skin reaction
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
83. Recognize problem
( itching, hives, edema,flushed skin ,conjunctivitis ,Rhinitis)
Discontinue dental treatment
Activate office emergency team
P –Position patient comfortably
A-B-C-Assess and perform basic life support as needed
Activate emergency medical service if recovery not immediate
D- Provide definitive management as needed
management of more rapid onset allergic reaction is predicted on presence or absence of signs of
respiratory or cardiovascular involvement
(Monitor vital signs)
(no CVS or respiratory involvement) (CVS or respiratory involvement)
Administer Oral or IM
Histamin blocker (50 mg diphenhydramine or P-reposition patient
10 mg chlorpheniramine
Allow recovery and discharge patient
Management of rapid onset ,allergic skin reaction
84. CVS involvement No CVS involvement
Hypotension
Supine position with legs elevated Comfortable
Administer Oxygen
Administer 0.3 ml epinephrine IM every 5-20 min .as needed to a total of 3
doses.
Summon medical assistance
Administer histamine blocker 50 mg diphenhydramine (IM)
Permit recovery and discharge of patient
Malamed F Stanley,pg-1,Chapter I, Neurophysiology, Handbook of local anesthesia,Sixth edition,2013, An imprint of Elsevier.
86. BUFFERED LOCAL
ANESTHESIA
Fonseca J Raymond,Chapter 3; Local aneasthetics,Vol 1: Anesthesia and pain control, Dentoalveolar Surgery, Practice Managment,
Implant Surgery, oral and maxillofacial Surgery,pg- 35-55,vol 1,2nd edition,2009, Saunders, Elsevier
87. MICROPARTICULATE
FORMULATIONS
Fonseca J Raymond,Chapter 3; Local aneasthetics,Vol 1: Anesthesia and pain control, Dentoalveolar Surgery, Practice Managment,
Implant Surgery, oral and maxillofacial Surgery,pg- 35-55,vol 1,2nd edition,2009, Saunders, Elsevier
88. REVERSAL OF LOCAL
ANESTHESIA
Formulation of phentolamine mesylate (OraVerse)
a-adrenergic antagonist
1.7 ml cartridges containing 0.4 mg phentolamine
mesylate.
Joseph A et al,pharmacology of Local Anesthetics used in oral surgery ,Anesthesia:Oral and Maxillofacial clinics of North America;
Volume 25, Issue 3, Pages 453-466 (August 2013)
89. ELECTRONIC DENTAL
ANESTHESIA
Joseph A et al,pharmacology of Local Anesthetics used in oral surgery ,Anesthesia:Oral and Maxillofacial clinics of North America;
Volume 25, Issue 3, Pages 453-466 (August 2013)
90. Fonseca J Raymond,Chapter 3; Local aneasthetics,Vol 1: Anesthesia and pain control, Dentoalveolar Surgery, Practice Managment,
Implant Surgery, oral and maxillofacial Surgery,pg- 35-55,vol 1,2nd edition,2009, Saunders, Elsevier
ELECTRONIC DENTAL
ANESTHESIA
93. SUMMARY
Local anesthesia remains the foundation of pain control in dentistry
especially when combined with moderate-deep sedation for invasive
and painful procedures in the contemporary oral and maxillofacial
surgical model.
Dentistry has never had the choice of local anesthetic drugs and
techniques that can be tailored to individual patients and procedures
as are available today
94. Local anesthetics remain the safest and most effective drugs in
medicine and dentistry to relieve introperative and
postoperative pain.
It is only with a through understanding of pharmacology and
anatomy that clinicians have the basic clinical foundation to
enhance the care of patients.
SUMMARY
1. SPECIFICITY THEORY:(DESCARTES 1664, MULER 1840)
Pain occurs due to the stimulation of the specific pain receptors
(nociceptors) with the transmission of pain stimuli to the brain directly by the nerves
PAIN IS PURELY AN AFFERENT SENSORY EXPERIENCE
2.PATTERN THEORY: (GOLDSCHEIDER IN 1894)
Proposed that stimulus intensity and central summation are the critical determinants of pain. Particular patterns of nerve impulses that evoke pain are produced by the summation of the sensory input within the dorsal horn of the spinal column.
Pain occurs when total output of the cells exceeds a critical level
GATE CONTROL THEORY: Melzack and Wall 1965
Postulates :
1. Information about presence of injury is transmitted to the central nervous system by small peripheral nerves
2. Cells in spinal cord or nucleus of fifth cranial nerve which are exited by these injury signals, are also facilitated/inhibited by other large peripheral nerves that also carry information about pain, pressure.
3. Descending control system originating in brain modulate the excitability of the cells that transmit information about injury.
Proposed the substantia gelatinosa as a modulating gate where non-noxious stimuli can modify pain.
Large diameter fiber input has the ability to modulate the synaptic transmission of small diameter fibers within the dorsal horn
Large for pressure vibration and temperature
Small- noxious or painful sensation
According to the theory, lamina II inhibitory interneurons can be activated directly or indirectly (via excitatory interneurons) by stimulation of non-noxious large sensory afferents from the skin that would then block the projection neuron and therefore block the pain.
Thus rubbing a painful area relieves the pain.
Pain control is the foundation of successful dental patient management. Good injection technique is essential for consistent anesthesia . Dental professionals must use the medications available to them with caution and confidence. The patient’s psychological state must be evaluated before the administration of any anesthesia . A relaxed ,confident patient will respond better to local anesthesia . An anxious or phobic dental patient may require some type of intervention strategy to relieve the stress before administering anesthesia.Other considerations such as the health of the tissues and deviation from normal anatomy must be assessed as well.
Excellent pain control is an essential part of surgical practice. Local anaesthesia is the mainstay of pain control for outpatient oral surgery procedures.
The provision of many dental treatments depends upon achieving excellent local anaesthesia. Pain-free operating is of obvious benefit to the patient, it also helps the operator as treatment can be performed in a calm, unhurried fashion.
The efforts of human kind to find the means to control pain presents as one of the greatest challenges in medicine. Pain is the phenomenon wisely instituted by nature as a warning sign of a condition that may be detrimental to our bodies. Pain-free operating is of obvious benefit to the patient, it also helps the operator as treatment can be performed in a calm, unhurried manner.
Local anaesthesia is the mainstay of pain control for outpatient oral surgical procedures.
The ability to provide safe, effective local anesthesia is the cornerstone of clinical oral surgical practice. Its use and effectiveness depends on patient considerations, the extent and duration of the procedure, the choice of drug and technique, and the skill and experience of the practitioner.
The use of anesthesia has been well mentioned since the pre history tyms.
Oct 16th 1846, Sir william morton was inspired by the idea of horace well and administered ether, allowing surgeon Jhon Collin to painlessly remove a mandibular tumor from Edward Gilbert Abbott at massachusetts general hosptal
1885- corning advocated the use of torniquet to retard the absorption of drug and prlong its effect
1903- heinrich broun addition of epinephrine to act as chemical torniquet to prlong duration
Cocain analog...procain
Procain remain in use in dentistry till 1948
It should not be irritating to the tissues to which it is applied
It should not cause any permanent alteration of nerve structure
It should have low systemic toxicity.
It must be effective regardless of whether it is injected into the tissues or applied locally to mucous membranes.
The time of onset of anesthesia should be as short as possible.
The duration of action must be long enough to permit completion of the procedure yet not so long as to require an extended recovery.
It should have potency sufficient to give complete anesthesia without the use of harmful concentrated solutions.
It should be relatively free from producing allergic reactions.
It should be stable in solution and readily undergo biotransformation in the body.
sterile and capable of being sterlized
The duration of action must be long enough to permit completion of the procedure yet not so long as to require an extended recovery.
It should have potency sufficient to give complete anesthesia without the use of harmful concentrated solutions.
It should be relatively free from producing allergic reactions.
It should be stable in solution and readily undergo biotransformation in the body.
sterile and capable of being sterlized
The electrochemical state of the neuron at rest
Every neuron has a separation of electrical charge across its cell membrane.
maintained because the lipid bilayer acts as a barrier to the diffusion of ions
Some ions permitted to cross more easily than other
Neuronal membranes contain ion channelProtein tubes that span the membrane
Nongated- stay open all the time
Gated - Open on the occasion of an action potential, causing a change in the permeability of the membrane (Voltage- gated & Ligand- gated)
Na+ and Cl- are more concentrated outside the cell
K+ and organic anions (organic acids, bicarbonates and proteins) are more concentrated inside. The overall effect of this ionic distribution is the resting potential
Electrical potential difference, ranges from about -60 to -70 mV.
Chloride ions, concentrated outside the cell tend to move inward down their concentration gradient through nongated chloride channels
But the relative excess of negative charge inside the membrane tend to push chloride ions back out of the cell
SAME WITH POTASSIUM
Na is not at equilibrium , it is more concentrated outside than inside and therefore tends to flow into the cell down its concentration gradient
Na is driven into the cell by the electrical potential difference across the membrane.
But what about sodium?
Electrostatic and Chemical forces act together on Na ions to drive them into the cell
But as there are not a significant no: of open Na channel ,even though the net force is large the flux is minimal .
An increase in the membrane conductance to Na ions Cause influx of Na and depolarization.
Drug molecules bind to specific receptors present on the external or internal axoplasmic surface of sodium channels & by acting directly on them, decrease or eliminate permeability to Na2+ leading to interruption of nerve conduction.
Local anesthetics are available as salts (usually hydrochlorides) for clinical use.
The salts, both water soluble and stable, is dissolved in either sterile water or saline.
In this solution it exists simultaneously as unchanged molecule (RN), also called base and positively charged molecules (RNH+) called cations.
RNH+ ==== RN+ H+
The relative concentration of each ionic form in the solution varies in the pH of the solution or surrounding tissue.
In the presence of high concentration of hydrogen ion (low pH) the equilibrium shifts to left and most of the anesthetic solution exists in cationic form.RNH+ > RN+ + H+
As hydrogen ion concentration decreases (higher pH) the equilibrium shifts towards the free base form.
RNH+ < RN + H+
The relative proportion of ionic form also depends on pKa or DISSOCIATION CONSTANT, of the specific local anesthetic.
The pKa is a measure of molecules affinity for H+ ions.
When the pH of the solution has the same value as pKa of the local anesthetic, exactly half the drug will exists in the RNH+ form and exactly half in RN form.
The percentage of drug existing in either form can be determined by Henderson Hasselbalch equation
Log base/acid = pH - pKa
Most commercially prepared solutions of local anesthetics without a vasoconstrictor have a pH between 5.5 and 7. when these solutions are deposited into tissue the vast buffering capacity of the tissue fluids rapidly returns the pH at the injection site to a normal 7.4.
Local anesthetic solutions containing vasopressor (epinephrine) are acidified to retard oxidation of vasoconstrictor, there by prolonging the period of the drug effectiveness.
Sodium bisulfite is commonly used in concentration between 0.05% and 0.1%.
A 2% solution on lidocaine, with a pH of 6.8 is acidified to 4.2 by addition of sodium bisulfite.
Even in this situation the large buffering capacity of the tissue tends to maintain a normal tissue pH, how ever it does require a longer time.
Intact skin forms impermeable barrier to diffusion of local anesthetic. Recently formulated EMLA (eutectic mixture of local anesthetic) enable local anesthetic to penetrate intact skin.
Tropical anesthetics can be employed effectively where ever skin is no longer intact.
The buffering capacity of the mucous membrane is quite poor, thus tropical application of local anesthesia with a pH between 5.5 and 6.5 lowers the regional pH to below normal, and less anesthetic base is formed. Increasing the pH of drug provides more RN form.
To make the tropical anesthetic more effective a more concentrated form of drug is used 5% or 10% lidocaine.
LA agents are available as acid salts of weak bases
The LA weak base (BNHOH) must be combined with a strong acid (HCI) in order to make acid salt (BNHCL) that is soluble in solution
BNHOHWEAK BASE +HCLSTRONG ACID = BNHCL + HOH
For this solution to act as an LA it must dissociate into a freebase (BH)
The relative proportion of each form present in the solution depends on the pH of the solution or the surrounding tissues.
ed concentration of hydrogen ion =ed ph
RNH+ > RN+H+
ed hydrogen ion conc =ed ph
RNH+ > RN+H+
Two factors involved :
Diffusion of the agent through the nerve sheath.= lipid soluble, free base form (RN) is responsible for diffusion
Binding at the receptor site in the cell membrane
Clinical implication
L.A with low pKa has high no: of Lipophilic free be to diffuse , but anaesthetic action inadequate as at intracellular pH 0f 7.4, only very small base molecule dissociate to cationic form .
L.A with a high pKa, has very few molecules available in RN form at tissue pH of 7.4. The onset of action thus slow .
L.A solutions containing vasoconstrictors , contain sodium bisulfite as an antioxidant , to prevent oxidation of L.A solution
Due to this pH of solution is reduced .
When this solution injected , it takes time for L.A to act as compared to its plain counterpart , because it takes time for the tissue buffering capacity to maintain normal pH
(example:procaine = 1, etidocaine = 140)
Etidocaine produces conduction blockade at very low concentrations whereas procaine poorly suppresses nerve conduction, event at higher concentrations
1) Ultra Short acting anesthetics (less than 30 mins)-
* 2-Chloroprocaine without a vasoconstrictor
* 2% Lidocaine without vasoconstrictor
2) Short acting anesthetics(45 to 75 mins)-
* 2% Lidocaine with 1:1,00,000 epinephrine
*4% Prilocaine when used for nerve block
3) Medium acting anesthetics (90-150 mins)-
*4% Prilocaine with 1:2,00,000 epinephrine
*2% Lidocaine and 2% Mepivacaine with vasoconstrictor
4) Long acting anesthetics (180 mins or longer)-
*0.5% Bupivacaine with 1:2,00,000 epinephrine
*0.5% or 1.5% etidocaine with 1:2,00,000 epinephrine
Tetreadoxin, saxidoxin
Ester-linked L.A= readily hydrolyzed in aqueous solution.
Amide-linked L.A= relatively resistant to hydrolysis.
Anesthetic amine or base = poorly soluble in water and unstable on exposure to air. =has little or no clinical value = local anesthetics that are used for injection are dispensed as salts, most commonly the hydrochloride salt dissolved in either sterile water or saline .
UPTAKE
Most local anesthetics , vasodilating properties
Procaine= most vasodilating- used in case of accidental intrarterial injection
Cocaine = only L.A =vasoconstriction
Vasodilatation = the rate of absorption of L.A. into the blood= duration and depth of anesthesia.
ORAL ROUTE
Except cocaine , L.A are absorbed poorly , if at all from the G.I. tract
Also they undergoes significant hepatic first pass effect
TOPICAL ROUTE
Applied to intact skin = No anesthetic action
EMLA= can be used on intact skin
INJECTION
Rate of uptake after s.c., i.m., or i.v., is related to the vascularity of the site of injection.
I.V administration of L.A., is used for the management of ventricular
Dsyrhythmias
Distributed throughout all the tissues.. Highly perfused organs have higher conc..heart, brain thn muscle
Skeletal muscle gets more due to more mass
Later two serves to decrease the blood level
Rate of hydrolysis has impact on toxicity…more hydrolised less toxic
Allergy is not related to parent compound procaine …bute PABA..
1 in 2800 people have atypical pseudocholineesterase…cester la can cause toxicity..heridetory..
Reducing agent- sodium…preservative of adrenaline..in contact with o2..gets reduced and further decreases ph
Increases h,r, automaticity, conduction, contraction.
B2- vasodialation ans relaxation of trachea
A1- severe vasoconstriction. Thr fore la with adrenaline ar periphery is not adviced.
A2- decreased sympathetic outflow of blood frm brain.
Levonordefrin- sympathomimetic use as nasal decongestant α-methylnorepinephrine Corbadrine
Phenylephrine is a selective α1-adrenergic receptor agonist of the phenethylamine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure
This complication has become extremely rare, since the advent or introduction of disposable needles.
Causes:
Sudden unexpected movement by the patient as the needles penetrate muscles or contacts periostuem.
Convulsion in patient with history of epilepsy.
In paediatric age group, due to non compliance with the patient.
Due to gagle reflex of the patient, the patient may bite giving rise to needle breakage.
Using a thin needle (e.g. 30 gauge needle).
Too much deep injection into tissues with less part of needles visible may lead to breakage at the hub.
Frequency:
Smaller needles (30 gauge) has more frequency of breakage than larger ones (25 gauge)
PROLONGED regional blockade may have useful applications for both acute and chronic pain management. Currently available local anesthetics rarely last beyond 12 h, unless catheter infusions are used. [1] Previous work in our laboratories has shown the feasibility of prolonged regional blockade using surgically implantable pellets consisting of polymer-local anesthetics matrixes. These comprised either dibucaine or bupivacaine in polyanhydride polymer pellets[2,3] or either bupivacaine or tetracaine in polylactic-co-glycolic acid polymer microspheres. [4] In these studies, sensory and motor blockade lasted for periods of 1–10 days, depending on the type of preparation and dose used.
It is available in 1.7 ml cartridges containing 0.4 mg phentolamine mesylate.
Intra pdl injection
Costly, time taking, requires space