The posterior superior alveolar (PSA) nerve block is a widely used technique for anesthetizing the maxillary molars, though it may not sufficiently anesthetize the mesio buccal root of the maxillary first molar in up to 28% of patients. Key considerations include the risk of hematoma and the depth of needle penetration, with an average recommended depth of 16mm using a short needle. Indications for the PSA block include treatment of multiple maxillary molars and instances where supraperiosteal injection is contraindicated.