The document discusses the key functions of the liver, including synthesizing most plasma proteins like albumin, producing coagulation factors, converting toxic ammonia to urea, and excreting cholesterol and bile acids into bile. It also notes that the liver protein with the shortest half-life is factor VII at 4-6 hours, while albumin has a longer half-life of 20 days. Tests like prothrombin time, serum bilirubin, and albumin levels can help evaluate liver function.

1. EVALUATION OF LIVER
FUNCTION
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3. FUNCTIONS OF THE
LIVER
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
Synthesize most plasma protein



More than 90% of all protein
100% of albumin synthesis occur in the liver
Major exceptions

Immunoglobulins - B lymphocytes

von Willebrand's factor - Endothelial cells and
megakaryocytes
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4. C OAGULATION
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
FACTORS
All the coagulation factors except von
Willebrand factor are synthesized in the liver
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5. U REA
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
Toxic ammonia is converted to urea
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6. SERUM BILIRUBIN
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
Measure of hepatic excretory function
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7. E XCRETED
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
Cholesterol

Bile acids
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INTO BILE

8. W HICH PROTEIN PRODUCED IN THE
LIVER HAS THE SHORTEST HALF - LIFE ?
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
Factor VII - 4-6 hours

Transthyretin factor - 1-2 days

Transferrin - 6 days
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9. A LBUMIN
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
Half-life - 20 days
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Decreases in its serum levels in liver disease

More slowly than those of proteins with shorter
half-lives.
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10. PROTHROMBIN TIME
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
Measures extrinsic clotting system
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
Factor VII is activated by tissue factor
Expressed as INR (international normalized
ratio.
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11. GLUCOSE
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