This document discusses early signs of spina bifida that can be detected on ultrasound as early as the first trimester. It identifies two key signs - the "lemon sign" and "banana sign" - that present differently depending on the trimester. The lemon sign represents abnormal frontal bone development and can be seen as a decreased fronto-maxillary facial angle in the first trimester or scalloping of the frontal bones in the second trimester. The banana sign represents cerebellar herniation and can be seen as proximity of the midbrain to the occiput or anteriorly curved cerebellar hemispheres in the first and second trimesters respectively. These signs allow for early diagnosis of spina