Cannabinoids obtained from Cannabis sativa have potential anticancer properties. Major cannabinoids include THCA, CBDA, and CBGA. Studies show cannabinoids can induce cancer cell death, inhibit cell proliferation and tumor angiogenesis, and prevent metastasis. They also alleviate side effects of chemotherapy like nausea and pain. However, more research is needed to optimize cannabinoid therapies and their combination with chemotherapy.