This document discusses pain management techniques for labor and delivery. It begins by outlining the pain pathways involved in each stage of labor. It then discusses the effects of pain and stress on the mother and fetus. Various analgesic techniques are discussed, including systemic opioids, nitrous oxide, local anesthetics, and regional techniques like epidural and combined spinal-epidural blocks. Risks, benefits, and considerations for both maternal and fetal safety are provided for each technique. The document concludes by emphasizing individualizing the analgesic approach based on the patient's goals and labor stage while optimizing outcomes and safety.
Advances in the field of labour analgesia have tread a long journey from the days of ether and chloroform in 1847 to the present day practice of comprehensive programme of labour pain management using evidence-based medicine. Newer advances include introduction of newer techniques like combined spinal epidurals, low-dose epidurals facilitating ambulation, pharmacological advances like introduction of remifentanil for patient-controlled intravenous analgesia, introduction of newer local anaesthetics and adjuvants like ropivacaine, levobupivacaine, sufentanil, clonidine and neostigmine, use of inhalational agents like sevoflourane for patient-controlled inhalational analgesia using special vaporizers, all have revolutionized the practice of pain management in labouring parturients.
Advances in the field of labour analgesia have tread a long journey from the days of ether and chloroform in 1847 to the present day practice of comprehensive programme of labour pain management using evidence-based medicine. Newer advances include introduction of newer techniques like combined spinal epidurals, low-dose epidurals facilitating ambulation, pharmacological advances like introduction of remifentanil for patient-controlled intravenous analgesia, introduction of newer local anaesthetics and adjuvants like ropivacaine, levobupivacaine, sufentanil, clonidine and neostigmine, use of inhalational agents like sevoflourane for patient-controlled inhalational analgesia using special vaporizers, all have revolutionized the practice of pain management in labouring parturients.
Methods to manage labour pain.
Analgesics and anaesthetic techniques used in labour..
Newer modalities in labour pain reduction.
Coping with labour pain
β –agonists use is decreasing worldwide due to safer alternative: Atosiban.
Atosiban: as effective as nifedipine with fewer cardiovascular side effects.
Mc Gill pain scale, history , pathophysiology of labour pain , ideal labour analgesia, non pharmacological methods , birth philosophies , pharmacological methods ,systemic and inhalational agents , regional analgesia
This topic includes Introduction for analgesia and anesthesia used in obstetrics, maternal risk factors for anesthesia, anatomical and physiological considerations, analgesia during labour and delivery, sedatives and analgesia, opioid analgesics, combination of narcotics and antiemetics, inhalation methods, commonly used local anesthesia in obstetrics, spinal anesthesia, infiltration anesthesia, patient controlled anesthesia, psychoprophylaxis, general anesthesia for cesarean section, complication of general anesthesia and its management.
Methods to manage labour pain.
Analgesics and anaesthetic techniques used in labour..
Newer modalities in labour pain reduction.
Coping with labour pain
β –agonists use is decreasing worldwide due to safer alternative: Atosiban.
Atosiban: as effective as nifedipine with fewer cardiovascular side effects.
Mc Gill pain scale, history , pathophysiology of labour pain , ideal labour analgesia, non pharmacological methods , birth philosophies , pharmacological methods ,systemic and inhalational agents , regional analgesia
This topic includes Introduction for analgesia and anesthesia used in obstetrics, maternal risk factors for anesthesia, anatomical and physiological considerations, analgesia during labour and delivery, sedatives and analgesia, opioid analgesics, combination of narcotics and antiemetics, inhalation methods, commonly used local anesthesia in obstetrics, spinal anesthesia, infiltration anesthesia, patient controlled anesthesia, psychoprophylaxis, general anesthesia for cesarean section, complication of general anesthesia and its management.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. THE LABOUR IS REPORTED TO BE ONE OF
THE MOST PAINFUL EXPERIENCES IN A
WOMAN’S LIFE.
3. Pain Pathways-
First stage of labour- uterine contraction + cervical
dilatation.
Afferent- visceral afferent from uterus (symathetic)
T 10, 11, 12, L 1 posterior segments.
Second stage- distension of pelvic floor, vagina and
perineum by descending head
Afferent- sensory fibres of S 2, 3, 4 (pudendal nerve)
4.
5. EFFECTS OF PAIN AND STRESS
release of adrenocorticotropic
hormone, cortisol, catecholamines, and b-endorphins.
b-adrenergic agents have uterine relaxant effects and
higher epinephrine levels are associated with anxiety
and prolonged labour.
animal studies indicate that both epinephrine and
nor-epinephrine can decrease uterine blood flow in
the absence of maternal heart rate and blood pressure
changes, contributing to occult fetal asphyxia.
6. Maternal psychological stress (induced by bright lights
or toe clamp) can detrimentally affect uterine blood
flow and fetal acid-base status (animal studies)
Postpartum women suffer objective deficits in
cognitive and memory function when compared with
nonpregnant women.
7. Analgesia for Labor and Delivery
Always controversial!
“Birth is a natural process”
Women should suffer!!
Concerns for mother’s safety
Concerns for baby
Concerns for effects on labor
9. ANALGESIA FOR LABOUR
Psychoprophylaxis-
nonpharmacologic method
Relaxation, concentration on
breathing, acupuncture, gentle massage, and partner
participation.
may be used alone, or in conjunction with parenteral
or regional techniques.
efficacy of these techniques is largely unproven
because of a lack of randomized clinical trials.
there are no serious safety concerns with any of these
techniques.
10. Acupuncture
Acupuncture alleviates labour pain and reduces use of
both epidural analgesia and parenteral opioids.
Arranging to have a qualified provider available at the
time of delivery may be challenging.
11. Under Water Delivery
No advantage in labour outcome or in reducing the
need for analgesia.
The request for epidural analgesia was delayed by
about 30 minutes.
Lack of trials demonstrating safety and the rare but
reported unusual complications such as fetal infection
or asphyxia.
12. Others-
Intracutaneous sterile water injections- similar gating
mechanism as acupuncture.
transcutaneous electrical nerve stimulation during
labour- made the pain less disturbing, doesn’t decrease
it.
13. Placental Transfer of Drugs:
Maternal, Drug, Placental and Fetal Factors
Lipid solubility
Molecular size
Total dose of drug
Concentration gradient
Maternal metabolism and excretion
Degree of ionization
pKa of drug, maternal and fetal pH
Protein binding - mother and fetus
Uterine blood flow
14. Sedatives
Do not possess analgesic qualities.
Used early in labour to relieve anxiety or to aid in
sleep.
Cross the placenta freely.
Barbiturates, Phenothiazines, and Benzodiazepines.
Barbiturate and benzodiazepines are not used
routinely in obstetrics.
16. Systemic Opioid Analgesia
Morphine-like pharmacological activity.
Natural- morphine and codeine
Semisynthetic- hydromorphone and heroine
Synthetic- meperidine and fentanyl
Provide sedation and a sense of euphoria.
Analgesic effect in labour is limited.
Primary mechanism of action is sedation.
17. Advantages-
Easy administration.
Inexpensive.
Avoids complications of regional block.
Does not require skilled personnel.
Few serious maternal complications.
18. Disadvantages-
All drugs easily cross placenta.
Pain relief inadequate in most cases
Maternal sedation
Nausea, vomiting, gastric stasis
Fetal heart rate effects:
Loss of beat-to-beat variability
Sinusoidal rhythm
Dose-related maternal / neonatal depression
Newborn neurobehavioral depression
20. Tramadol
Centrally acting opioid analgesic used in treating severe
pain.
Route- IV or IM
Dose- 50 mg
Emetic.
Should be given with antiemetic.
Maximum respiratory depression and low apgar score
occur in newborns that are delivered within-
3 hours after an IM administration
2 hours after an IV administration.
21. Meperidine
Meperidine 100 mg is roughly equi-analgesic to
morphine 10 mg.
Side effects- tachycardia, nausea and vomiting, and a
delay in gastric emptying.
Normeperidine - active metabolite of
meperidine, potentiating meperidine's depressant
effects in the newborn. Concentrations increase
slowly, therefore, exerts its effect on the newborn
during the second hour after administration.
Multiple doses of meperidine = greater accumulation
of both meperidine and normeperidine in fetal tissues.
22. Fentanyl
Fast-onset, short-acting synthetic opioid.
Requires frequent redosing or the use of a patient-
controlled intravenous infusion pump.
Fewer neonatal effects and less maternal sedation and
nausea.
Other opioids are
nalbuphine, pentazocine, buprenorphine and
butorphanol
23. Inhalational analgesia
Easy to administer (no needles)
Nitrous oxide is administered in subanaesthetic
concentrations. (N2O 30-50%)
Analgesia without loss of consciousness.
Crosses the placenta but is eliminated efficiently, no
untoward neonatal effects.
No effects on uterine contractions.
Most effective for short term (1-2 hrs) pain relief
Most beneficial in late first stage of labour.
24. Local and regional techniques
Local infiltration
Pudendal block
Paracervical block
Paravertebral (lumbar sympathetic block)
Epidural - lumbar (caudal)
Spinal
Combined spinal-epidural (CSE)
25. Perineal Infiltration
Direct infiltration of 1% lignocaine is used for perineal
and lower vaginal lacerations.
Advance the needle and inject and aspirate to avoid
intravascular injection.
Dose of lignocaine is 3-4 mg/kg plain solution, and 7-8
mg/kg with added epinephrine.
1% solution = 10 mg/ml
For 6O kg woman total dose should not exceed 200 mg
or 20 ml.
After local infiltration one should wait 3 minutes
before proceeding.
26. Paracervical block
5 to 6 ml of a dilute solution of local anesthetic
without epinephrine (e.g., 1 percent lidocaine or 1 or 2
percent 2-chloroprocaine) is injected into the mucosa
of the cervix at the 3- and 9-o'clock positions
fetal bradycardia that follows in 2 to 70 percent of
applications
fetal acidosis and death have been reported
Paracervical block should be used cautiously at all
times and should not be used at all in mothers with
fetuses in either acute or chronic distress.
27. mechanism of postparacervical block bradycardia-
local anesthetic injected close to the uterine artery
passed to the fetus
uterine artery vasoconstriction secondary to a direct
effect of the local anesthetic on the uterine artery
local anesthetic injected directly into the uterine
musculature increases uterine tone
28. Pudendal nerve block
minor regional block, effective and very safe.
Using a 20-gauge needle, inject 5 to 10 ml of local
anesthetic just below the ischial spine.
Because the hemorrhoidal nerve may be aberrant in 50
percent of patients, some prefer to inject a portion of
the local anesthetic somewhat posterior to the spine.
Although a transperineal approach to the ischial spine
is possible, most prefer the transvaginal approach.
One-percent lidocaine or 2-percent 2-chloroprocaine
can be used
29. satisfactory for all spontaneous vaginal deliveries and
episiotomies, and for some outlet or low operative
vaginal deliveries.
The potential for local anesthetic toxicity is higher
with pudendal block compared with perineal
infiltration because of large vessels proximal to the
injection site. Aspiration before injection is
particularly important.
30. Regional Analgesia for Labor
Epidural (LA or opioids)
Spinal (LA ± opioids)
CSE- combined spinal epidural (opioids ± LA)
31. Fetal / Neonatal Effects of Regional
Analgesia in Labor
Uterine perfusion maintained.
Profound hypotension & possible fetal compromise.
LA toxicity - extremely rare.
FHR changes:
baseline variability
periodic decelerations (due to maternal
catecholamine)
Neurobehavioral effects absent with current agents.
32. Epidural Analgesia
Epidural block is the most effective and least
depressant (pharmacologic option) allowing for an
alert, participating mother.
(guidelines American College of Obs & gynae)
Primary indication is the patient's desire for pain
relief.
Medical indications during labor- selected forms of
cardiovascular and respiratory disease, and prevention
or treatment of autonomic hyperreflexia in parturients
with a high spinal cord lesion.
33. Epidural analgesia prevents increases in both cortisol
and 11-hydroxycorticosteroid levels during labor, but
systemically administered opioids do not.
Epidural analgesia also attenuates elevations of
epinephrine, norepinephrine, and endorphin levels.
35. Types-
Lumbar- routinely done
Caudal- not favoured
36. Lumbar-
Low concentrations of local anesthetic are injected at
L2-L5.
Affecting the small easily blocked sympathetic nerves
that mediate early labour pain.
Sparing the sensation of pressure and motor function
of the perineum and lower extremities.
Dose can be adjusted according to patient’s response.
37. Choice of epidural local anaesthetic
Lignocaine- rapid onset, dense motor block, risk of
cumulative toxicity with repeated doses.
Bupivacaine- good sensory block with minimal motor
effect.
No adverse effect on labour with 0.0625%
concentration
Highly protein bound, fetal blood concentrations are
lower than with other local anaesthetics.
38. Epidural Opioids in Labour
Inadequate analgesics used alone
Synergistic with local anesthetics
Speedy onset of analgesia
Improves quality of analgesia
Permits use of very dilute LA solutions
Help relieve persistent perineal pain and unblocked
segments
39. Fentanyl and Sufentanil
Rapid onset, few side effects
Sufentanil slightly more effective
No significant fetal drug accumulation
No serious adverse neonatal effects with either
40. Side effects of epidural-
hypotension
local anesthetic toxicity
allergic reaction
high or total spinal anesthesia
neurologic injury
spinal headache.
Fetal bradycardia
41. The effect of epidural analgesia on labour
progression, fetal position, and risk of cesarean
delivery is controversial.
Randomized studies support the conclusion that
epidural analgesia results in a modest prolongation of
both the first and second stages of labour.
Significant increase in the use of oxytocin for labour
augmentation.
42. Increased rate of instrumental delivery.
Several well-designed randomized studies suggest
that, in settings with baseline low rates of caesarean
delivery, epidural analgesia does not increase the risk
of caesarean delivery.
43. Epidural analgesia during labor is associated with an
increase in maternal temperature.
Dependent on the duration of exposure.
Possible mechanisms- noninfectious inflammatory
activation, changes in thermoregulation, and acquired
intrapartum infection.
44. Combined spinal epidural
Opioids ± LA
Rapid onset of intense analgesia.
Ideal in late or rapidly progressing labour.
Very low failure rate.
Less need for supplemental boluses.
Minimal motor block (“walking epidural”)
Walking epidural- Use of opioid only to allow
parturients to ambulate during labour because there is
little or no interference with motor function.
45. Early intrathecal opioids followed by continuous
epidural infusion in active labour may be a good
option for women desiring regional analgesia, offering
superior pain control until active labour has been
achieved.
46. One randomized study found that use of intrathecal
opioids increased speed of cervical dilatation and
decreased length of labour when compared with
conventional epidural.
The use of intrathecal opioids improved pain control in
early labor without increasing the risk of caesarean
delivery.
avoids maternal sedation , decreases nausea and vomiting.
comparisons of intrathecal opioid analgesia versus epidural
or parenteral opioids in labour found the use of intrathecal
opioids significantly increases the risk of fetal bradycardia .
47. Fetal heart rate should be monitored during and after
the administration of either epidural or intrathecal
medications to allow for timely intrauterine
resuscitation.
No increase in emergency caesarean delivery.
48. Conclusions
Individualize technique to patient’s goals and stage of
labour.
Optimize management for spontaneous delivery.
Provide safe, cost-effective analgesia.