1) Labour analgesia aims to relieve maternal pain during childbirth while preserving the progress of labour and safety of both mother and baby.
2) Regional techniques like epidural analgesia are commonly used as they provide effective pain relief and allow movement.
3) Epidural analgesia involves injecting local anaesthetics near the spinal cord in the epidural space, providing pain relief. Combined spinal-epidural is also used.
4) General anaesthesia is rarely used and has risks like aspiration so regional techniques are preferred when possible for labour analgesia.
This topic includes Introduction for analgesia and anesthesia used in obstetrics, maternal risk factors for anesthesia, anatomical and physiological considerations, analgesia during labour and delivery, sedatives and analgesia, opioid analgesics, combination of narcotics and antiemetics, inhalation methods, commonly used local anesthesia in obstetrics, spinal anesthesia, infiltration anesthesia, patient controlled anesthesia, psychoprophylaxis, general anesthesia for cesarean section, complication of general anesthesia and its management.
Advances in the field of labour analgesia have tread a long journey from the days of ether and chloroform in 1847 to the present day practice of comprehensive programme of labour pain management using evidence-based medicine. Newer advances include introduction of newer techniques like combined spinal epidurals, low-dose epidurals facilitating ambulation, pharmacological advances like introduction of remifentanil for patient-controlled intravenous analgesia, introduction of newer local anaesthetics and adjuvants like ropivacaine, levobupivacaine, sufentanil, clonidine and neostigmine, use of inhalational agents like sevoflourane for patient-controlled inhalational analgesia using special vaporizers, all have revolutionized the practice of pain management in labouring parturients.
This topic includes Introduction for analgesia and anesthesia used in obstetrics, maternal risk factors for anesthesia, anatomical and physiological considerations, analgesia during labour and delivery, sedatives and analgesia, opioid analgesics, combination of narcotics and antiemetics, inhalation methods, commonly used local anesthesia in obstetrics, spinal anesthesia, infiltration anesthesia, patient controlled anesthesia, psychoprophylaxis, general anesthesia for cesarean section, complication of general anesthesia and its management.
Advances in the field of labour analgesia have tread a long journey from the days of ether and chloroform in 1847 to the present day practice of comprehensive programme of labour pain management using evidence-based medicine. Newer advances include introduction of newer techniques like combined spinal epidurals, low-dose epidurals facilitating ambulation, pharmacological advances like introduction of remifentanil for patient-controlled intravenous analgesia, introduction of newer local anaesthetics and adjuvants like ropivacaine, levobupivacaine, sufentanil, clonidine and neostigmine, use of inhalational agents like sevoflourane for patient-controlled inhalational analgesia using special vaporizers, all have revolutionized the practice of pain management in labouring parturients.
Methods to manage labour pain.
Analgesics and anaesthetic techniques used in labour..
Newer modalities in labour pain reduction.
Coping with labour pain
Mc Gill pain scale, history , pathophysiology of labour pain , ideal labour analgesia, non pharmacological methods , birth philosophies , pharmacological methods ,systemic and inhalational agents , regional analgesia
History, Myths, Indications & Contraindications, and Methods of painless labor as a means of natural way of childbirth with a lot of benefits for mothers & babies.
Methods to manage labour pain.
Analgesics and anaesthetic techniques used in labour..
Newer modalities in labour pain reduction.
Coping with labour pain
Mc Gill pain scale, history , pathophysiology of labour pain , ideal labour analgesia, non pharmacological methods , birth philosophies , pharmacological methods ,systemic and inhalational agents , regional analgesia
History, Myths, Indications & Contraindications, and Methods of painless labor as a means of natural way of childbirth with a lot of benefits for mothers & babies.
Labor Analgesia- A Maternal Blessing.pptxNabidulIslam1
the basic physiology of Labour pain and all the modern techniques of Labour Analgesia compiled in Short Presentation. The main emphasis is one the Epidural Labour Analgesia, its indications, contraindications, techniques, advantages and positive outcomes.
Obstetric analgesia and anesthesia 2021OBGYN Notes
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Lactation management is the science and art of assisting women and infants with breastfeeding, because the mother-infant pair is dynamically interrelated for breastfeeding, it is imperative to consider both individuals when attempting to assess and “manage” breastfeeding.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
2. Labour analgesia
“Delivery of the infant into the
arms of a conscious and pain-
free mother is one of the most
exciting and rewarding
moments in medicine.”
3. DEFINITION
According to the American
Society of Anaesthesiology (ASA)
“in the absence of a medical
contraindication, maternal request
is a sufficient medical indication for
pain relief during labor”
4. Idealgoal of obstetric analgesic
Attenuate maternal anxiety, fatigue and deliver healthy baby
Drugs should not cross placental barrier
Minimal effects on mother, foetus or neonate
Could be administered late in labour
Easy to administer with minimal monitoring: IV, bolus,
intermittent or continuous infusion, PCA
Rapid, Profound, Consistent Analgesia (Stage I & II) & preserve
Uterine contractility
Onset, offset should match time-course of Uterine contractions
Easily reversible if necessary
Facilitate Surgical Anaesthesia avoiding GA
5. cont…
• No motor effect:
Ambulation
Maternal Expulsive Efforts
Progress of Labour
Achieves labour analgesia in 1st stage of labour
Should maintain Uterine blood flow.
6. Normal labour
Series of events that
take place in the genital
organs in an effort to expel
the fetus out of the uterus
through the vagina
7. Criteria of normal labour
Spontaneous in onset
At term
Vertex presentation
Natural termination
8. Onset of labour
Regular painful uterine
Contractions accompanied by
Ruptured membranes
Bloody show
Complete cervical effacement
Painful rhythmic contractions with cervical
dilatation of 3-4 cm
9. Patho-physiology of labour pain
Visceral pain
First stage
T10 - L1
Distension and stretching of LUS
Somatic pain
Second stage
S2-S4
Distension of pelvic and perineal structures and
compression of LS plexus
10. Pain pathway in I stageand II stageof labour
First stage :
Uterine contraction + cervical dilatation
Afferent –visceral afferent from uterus
T10,11,12,L1 Posterior segments
Second stage:
Distension of pelvic floor ,vagina,perineum
by descending head
Afferent –sensory fibers of S2,3,4 (Pudendal
nerve)
11. Effect of pain and stress
Release of adreno-cortisol ,catecholamine’s ,
and beta endorphins
Beta –adnergic agents have uterine relaxant
effects and higher epinephrine level are
associated with anxiety and prolonged
labour
Maternal psychological stress can
determentally affect uterine blood flood and
fetal acid base status.
12. Effect of labour pain onmother and fetus
Labour pain causes-
Marked stimulation of respiration
and circulation in mother.
Activation of sympathetic nervous
system
Mental disturbance- postpartum
depression and post traumatic stress
disorder
13. Techniques of labour analgesia
Complementary or Alternative treatment
Mind–body interventions
Bio electromagnetic
Physical methods : massage, heating pads, warm
bath
Alternative medication : Acupuncture, hypnosis
Conventional Treatments
Systemic analgesia: IV , inhalational
Regional techniques
General anaesthesia
14. Regional anaesthesiatechniques
Most commonly performed regional techniques
for labor are-
Epidural analgesia
Spinal block/analgesic
Combined spinal-epidural blocks.
Less frequently performed-
Paravertebral block
Paracervical block
Pudendal block
15. Perineal infiltration
Direct infiltration of 1% lignocaine is used for
perineal and lower vaginal lacerations.
Advance the needle and inject and aspirate to
avoid intravascular injection.
Dose of lignocaine is 3-4 mg/kg plain solution,
and 7-8 mg/kg with added epinephrine.
1% solution = 10 mg/ml
After local infiltration one should wait 3 minutes
before proceeding.
16. Para cervical nerve block
INDICATIONS:
Relieve the pain of uterine contractions
and the perineal discomfort is removed
by Pudendal nerve block
TECHNIQUES:
Place the patient in dorsal lithotomy
17. cont…
Place speculum to obtain good visualization of the
entire cervix
Place 2 to 3 ml of lidocaine at the 6 or 12 clock position
Grasp the anesthetized portion of the cervix with a
tentaculum or a traumatic vulsellum forceps
Inject 10cc of lidocaine at or just above each utero
sacral ligament 1cm under the mucosa where vagina
reflects off the cervix
Inspect the injections sites for bleeding
Wait 10 minutes before proceeding with the procedure
18. Pudendalnerve block
INDICATIONS:
Pudendal nerve block is mostly used for
forceps and assisted breech delivery. It does
not relive the pain of labour but affords
perineal analgesia and relaxation
TECNIQUES:
It may be either blocked by transvaginal or
transperineal route.
20. cont…
20 ml syringe -1
15cm 17-20 gauge spinal needle
20ml of 1% lignocaine hydrochloride are required
The index and middle finger of one hand are
introduced into the vagina ,finger tips are placed
on the tip of the ischial spine of one side. The
needle is passed along the groove of the fingers and
guided to pierce the vaginal wall on the apex of
ischial spine and thereafter to push a little to pierce
the Sacro- Spinous ligament just above the ischial
spine tip. After aspirating to exclude blood about
10ml of the solution is injected .The similar
procedure is adopted to block the nerve of the
other side by changing the hands.
21. cont…..
COMPLICATIONS:
Lacerations of vaginal mucosa
Prolonged II stage of labour due to loss of bearing
down reflex
Systemic anesthetic complications like
drowsiness ,loss consciousness ,hypotension and
bradycardia
Hematomas
Infections
Needle stick injury
23. Pre requisites for epidural analgesia
Maternal consent
Maternal /fetal status
Progress of labour
Iv cannula
Maternal hydration
Monitor vital status
Continuous fetal monitor
safety
28. Contraindications of epidural analgesia
Sepsis at injection site
Hemorrhagic disease or anti coagulant
therapy
Supine hypotension
Hypovolemic
Neurological disease
Spinal deformity or chronic low back pain
29. Drugs usedin epidural anaesthesia
Lidocaine:
Rapid onset, dense motor block, risk of
cumulative toxicity with repeated doses
Bupivacaine:
Good sensory block with minimal
motor effect
30. Epidural opiods in labour
Inadequate analgesics used alone
Synergistic with local anaesthetics
Speedy onset of analgesia
Improves quality of analgesia
Permits use of very dilute LA solutions
Help relieve persistent perineal pain and unblocked
segments
31. cont…
Fentanyl and Sufentanil
Rapid onset, few side effects
Sufentanil slightly more effective
No significant fetal drug
accumulation
No serious adverse neonatal effects
with either
32. Role of midwife in epidural analgesia
Support for the laboring woman
Continuous monitoring of vital signs and
fetal status
Pain assessment
Continues fetal heart rate monitoring
Continuous epidural infusion monitoring
33. Spinalanaesthesia
INDICATIONS:
To alleviate pain during delivery and III stage
of labour
Forceps or ventose delivery
LSCS
ADVANTAGES OF SPINAL ANAESTHESIA:
Less fetal hypoxia
34. Side effects of spinal analgesia
Hypotension due to blocking of sympathetic
fibers leading to vasodilatation and low
cardiac output
Respiratory depression
Post spinal headache
Transient or permanent paralysis
Urinary retention
39. Benefits of CSE analgesia
CSE provides more effective
analgesia
CSE is faster in onset
CSE has lower failure rate 10%
comparing to 14% in epidural only
40. Disadvantages of CSE
Risk of threading epidural catheter
intrathecally
Excessive high block
Increase the risk of fetal
bradycardia from spinal block
Increase equipment cost
41. Contra indications
Patient refused
Sepsis
Hypovolemic
Coagulapathy
Elevated ICD
Back injury
Chronic back pain
Localized infection in injection site
42. complications
Headache
Back pain
Injury to nerves
Epidural hematomas
Hypotension
Shivering
Bladder distension
Supine hypotension
Leg numbness and weakness
45. Prevention of complications
NPO during labour
H2 blocker should be given night before and
to be repeated one hour before the
administration of GA to raise gastric PH
Intubation with adequate cricoids pressure
Awake extubation should be routine
46. Management
Immediate suctioning of oropharynx and
nasopharynx is done to remove the inhaled
fluid
CPAP is given to maintain the oxygen
saturation of 95%
Pulseoximeter is useful guide
Antibiotics are administered when infection
is evident
47. Role of midwife during postoperative LSCS
Pain killers to prevent pneumothorax or
thrombhophelebitis
Pain assessment
Comfort measures
Early ambulation
Assisting in breast feeding
Stool softeners
High fiber diet
Assessing vital signs and wound healing