Nanoteknoloji bir çok alanda olduğu gibi sağlıkta da önemli gelişmelere sebep olmuştur. Hastalık tedavisinde önemli bir yere sahip olan ilaçların, sağladığı yararın yanında getirdiği zararları önlemesinde ve hastalıklarının tedavi edilmesinde nanoteknoloji umut vadetmektedir. Yapay DNA, nanorobotlar, kanser teşhisi ve tedavisi, nanoilaçlar, respirositler ve nanopankreas gibi önemli çalışmaların yapılması, bu sürecin devam ederek gelişeceğini göstermektedir.
This document discusses how nanotechnology can be used to treat cancer in a more targeted way. It begins by introducing nanotechnology and how it operates at the molecular scale. It then describes how cancer cells divide rapidly to form tumors. The traditional cancer treatments of chemotherapy and radiation are described as harmful because they also destroy healthy cells. The document proposes that nanodevices could be programmed to only destroy cancer cells, allowing patients to recover more quickly. It details how nanoparticles could be injected into the body to identify and target cancer cells for imaging and destruction through heating them with radiofrequency signals controlled externally. In conclusion, nanotechnology may enable more accurate, effective and safer cancer treatment by working at the molecular level.
Nanoteknolojiyi insanlar mağara devrinden beri kullanmaktaydı. Devamlı ateş ve dolayısıyla külleriyle ilgilenen insanlar, günümüze kadar gelen mağara resimlerinde nanokarbon küllerden boyalar kullanmışlardı. Romalılar ürettikleri kupalarda, kiliselerin vitray resimlerinde nanoteknoloji kullanılmıştı. Bu sunumda günümzde de tıpta, askeri amaçlarla, elektronikten, çevresel uygulamalara kadar nanoteknolojinin kullanımı hakkında bilgileri verilmektedir. Normalde tüm slatlarda animasyonlar söz konusudur ancak maalesef siz burada slaytları animasyonsuz göreceksiniz. Bu sunumun animasyolu halini ücretsiz olarak Prof.İbrahim Uslu'dan temin edebilirsiniz. Ülkemin bilimsel gelişimine küçük bir katkı olarak da düşünülebilir. Nanobilim, Nanoteknoloji Ve Nanotıp Derneği Başkanı Prof.Dr. İbrahim USLU
Nanotechnology has applications in medicine known as nanomedicine. It can be used to develop highly sensitive biosensors to track cells and movement of drugs, identify diseases through molecular imaging, and provide better disease analysis. Nanoparticles can also be used to enhance drug delivery, though early methods in the 1960s-1970s carried safety risks as the nanoparticles could accidentally alter cells and trigger death. Newer methods aim to safely transport drugs into the body using nanoparticles such as liposomes and dendrimers.
Nanoteknoloji bir çok alanda olduğu gibi sağlıkta da önemli gelişmelere sebep olmuştur. Hastalık tedavisinde önemli bir yere sahip olan ilaçların, sağladığı yararın yanında getirdiği zararları önlemesinde ve hastalıklarının tedavi edilmesinde nanoteknoloji umut vadetmektedir. Yapay DNA, nanorobotlar, kanser teşhisi ve tedavisi, nanoilaçlar, respirositler ve nanopankreas gibi önemli çalışmaların yapılması, bu sürecin devam ederek gelişeceğini göstermektedir.
This document discusses how nanotechnology can be used to treat cancer in a more targeted way. It begins by introducing nanotechnology and how it operates at the molecular scale. It then describes how cancer cells divide rapidly to form tumors. The traditional cancer treatments of chemotherapy and radiation are described as harmful because they also destroy healthy cells. The document proposes that nanodevices could be programmed to only destroy cancer cells, allowing patients to recover more quickly. It details how nanoparticles could be injected into the body to identify and target cancer cells for imaging and destruction through heating them with radiofrequency signals controlled externally. In conclusion, nanotechnology may enable more accurate, effective and safer cancer treatment by working at the molecular level.
Nanoteknolojiyi insanlar mağara devrinden beri kullanmaktaydı. Devamlı ateş ve dolayısıyla külleriyle ilgilenen insanlar, günümüze kadar gelen mağara resimlerinde nanokarbon küllerden boyalar kullanmışlardı. Romalılar ürettikleri kupalarda, kiliselerin vitray resimlerinde nanoteknoloji kullanılmıştı. Bu sunumda günümzde de tıpta, askeri amaçlarla, elektronikten, çevresel uygulamalara kadar nanoteknolojinin kullanımı hakkında bilgileri verilmektedir. Normalde tüm slatlarda animasyonlar söz konusudur ancak maalesef siz burada slaytları animasyonsuz göreceksiniz. Bu sunumun animasyolu halini ücretsiz olarak Prof.İbrahim Uslu'dan temin edebilirsiniz. Ülkemin bilimsel gelişimine küçük bir katkı olarak da düşünülebilir. Nanobilim, Nanoteknoloji Ve Nanotıp Derneği Başkanı Prof.Dr. İbrahim USLU
Nanotechnology has applications in medicine known as nanomedicine. It can be used to develop highly sensitive biosensors to track cells and movement of drugs, identify diseases through molecular imaging, and provide better disease analysis. Nanoparticles can also be used to enhance drug delivery, though early methods in the 1960s-1970s carried safety risks as the nanoparticles could accidentally alter cells and trigger death. Newer methods aim to safely transport drugs into the body using nanoparticles such as liposomes and dendrimers.
Bionanotechnology is an area that applies nanotechnology to biology and medicine. It uses biological materials to create nanoscale devices less than 100 nanometers in size to better understand life processes. Some examples include using nanoparticles like liposomes, dendrimers, carbon nanotubes, quantum dots and gold nanoparticles for applications in drug delivery, imaging, biosensing and gene therapy by taking advantage of their small sizes and unique properties. Bionanotechnology is a rapidly developing field that offers opportunities for new medical technologies at the nanoscale level.
This document discusses nano-medicine and provides an overview of its history, applications, and future potential. It begins with definitions of nano-medicine and a brief history starting from 1959 when Richard Feyman first proposed the idea of studying matter at the nano scale. The document then covers the advantages of nano-scale materials, various diagnostic and therapeutic applications in areas like cancer treatment, vaccines, and tissue engineering. It also discusses challenges like nano-toxicology and concludes that nano-medicine has revolutionized medicine through diverse nanomaterials and applications in drug delivery, imaging, and more.
Application of nanoparticals in drug delivery systemMalay Jivani
This document discusses nanoparticles and their applications in pharmaceuticals, with a focus on using gold nanoparticles (AuNPs) for cancer treatment. It defines nanoparticles and describes some common preparation methods. It then discusses several potential medical applications of nanoparticles, including using them as delivery systems for drugs, genes, and targeting cancer cells. Specifically for AuNPs, it covers their synthesis, properties, and how their surfaces can be functionalized. It describes how AuNPs may be useful for photothermal therapy, radiotherapy, and inhibiting angiogenesis for cancer treatment.
Nanotechnology involves manipulating matter at the nanoscale of 1 to 100 nanometers. It was first conceptualized by physicist Richard Feynman in 1959 and began developing in the 1980s with the invention of the scanning tunneling microscope. Nanomedicine uses nanotechnology to build devices like nanobots and nanosponges that can target diseases at the cellular level. Researchers have developed polymer nanosponges coated in red blood cells that safely remove bacterial toxins from the body. Nanomedicine holds promise for more targeted drug delivery, gene therapy, and future nanomachines for medical applications like direct disease treatment and cellular repairs.
Applications of nanobiotechnology in medicineRameshPandi4
Nanomedicine uses nanotechnology to detect and treat diseases at the molecular level. Applications include using nanoparticles for targeted drug delivery to cancer sites, using nanobots to identify and destroy cancer cells, using photodynamic therapy to destroy tumors by activating nanoparticles with light, and developing nanorobots to remove plaque from arteries or break up kidney stones. Future applications may involve cell-sized robots to detect diseases by floating through the bloodstream or developing respirocytes as artificial red blood cells to deliver oxygen throughout the body.
This document discusses nanotechnology in medicine. It provides an introduction to nanotechnology and its history. It describes how nanotechnology is being used for targeted drug delivery, nasal vaccinations, carbon nanotubes, and potential future nano robots. Some applications of nanotechnology discussed are in diagnosis and treatment of diseases, nano biopharmaceutics, and overcoming challenges like crossing the blood brain barrier. Both advantages like better targeting and diagnostics and disadvantages like potential side effects are covered. Future challenges for nanomedicine are also outlined.
Nanomedicine is an emerging field that uses nanotechnology for medical applications such as diagnosis, treatment, and disease prevention. It involves engineering materials and devices at the nanoscale of 1 to 100 nanometers to exploit their unique properties. This allows for innovations like controlled drug delivery, molecular imaging, and biosensing. Some key technologies involved include nanoparticles, quantum dots, carbon nanotubes, dendrimers, and liposomes. Potential applications range from molecular imaging and cancer theranostics to drug delivery, gene therapy, and tissue engineering. Nanomedicine offers opportunities for earlier disease diagnosis and more effective, safer, and personalized treatment approaches.
- Biomagnification refers to the increasing concentration of chemicals or toxins in organisms at higher levels of the food chain. Nanoparticles used in nanofungicides can potentially biomagnify due to their persistence, ability to accumulate in organisms, and low degradation rates.
- Nanoparticles can enter plants directly through soil, water and air or systemically through the use of nano-based agricultural chemicals. Once inside plants, nanoparticles can cause toxicity, hormone imbalances, and accumulation in plant cells and tissues.
- For safe use of nanotechnology in agriculture, more studies on nanoparticle impacts are needed. Biodegradable nanoparticles should be developed and thorough safety testing of nano-products conducted to prevent biom
A nanocarrier is nano material being used as a transport module for another substance, such as a drug. Commonly used nanocarriers include micelles, polymers, carbon-based materials, liposomes and other substances.Nanocarriers are currently used in drug delivery and their unique characteristics demonstrate potential use in chemotherapy. Nanocarriers include polymer conjugates, polymeric nanoparticles, lipid-based carriers, dendrimers, carbon nanotubes, and gold Nanoparticles.Lipid-based carriers include both liposomes and micelles.
Examples of gold nanoparticles are gold nanoshells and nanocages.Different types of nonmaterial being used in nano carriers allows for hydrophobic and hydrophilic drugs to be delivered throughout the body.
potential problem with nanocarriers is unwanted toxicity from the type of nonmaterial being used. Inorganic nonmaterial can also be toxic to the human body if it accumulates in certain cell organelles new research is being conducted to invent more effective, safer nanocarriers.
Nano pharmaceuticals offer the ability to detect diseases at much earlier stages and the diagnostic applications could build upon conventional procedures using nano particles.
Nano pharmaceuticals represent an emerging field where the sizes of the drug particle or a therapeutic delivery system work at the nanoscale.
Nano pharmaceuticals have enormous potential in addressing this failure of traditional therapeutics which offers site-specific targeting of active agents.
Magnetic nanoparticles, bound to a suitable antibody, are used to label specific molecules, structures or microorganisms.
Gold nanoparticles tagged with short segments of DNA can be used for detection of genetic sequence in a sample.
Multicolor optical coding for biological assays has been achieved by embedding different-sized quantum dots into polymeric microbeads.
Nan pore technology for analysis of nucleic acids converts strings of nucleotides directly into electronic signatures.C-dots (Cornell dots) are the smallest silica-based nanoparticles with the size <10 nm.
There are three main reasons for the popularity of herbal medicine
1. There is a growing concern over the reliance and safety of drugs.
2. Modern medicine is failing to effectively treat many of the most common health condition.
3. Many natural measures are being shown to produce better results than drugs or surgery without the side effects
Nanobiotechnology involves the manipulation of matter at the nanoscale (1-100 nanometers) for applications in biology. Key developments include the atomic force microscope in 1980, which enabled imaging at the atomic level. Nanoparticles such as quantum dots have been used for in vivo cell imaging due to their strong fluorescent signals. Nanodevices have the potential to improve cancer detection and diagnosis by entering cells to determine which are cancerous. They may also preserve patient samples and make tests faster. Challenges include assessing the toxicity and biocompatibility of nanomaterials. Overall, nanobiotechnology could lead to new biomaterials and analytical tools with applications in medicine such as targeted drug delivery and disease diagnosis and treatment.
Nanotechnology involves engineering at the nanoscale (1-100 nanometers) and can be used in various fields including medicine. It has several applications for cancer treatment such as using nanoparticles, nanotubes, quantum dots, dendrimers, liposomes, nanoshells, silica nanoparticles, and nanorobots to more precisely deliver drugs to cancer cells, detect genetic mutations associated with cancer, and potentially diagnose and treat cancer. Nanoparticles in particular show promise for overcoming limitations of conventional cancer treatments like poor solubility, lack of targeting, and side effects by selectively targeting cancer cells and increasing drug localization.
Nanotechnology and potential in Cancer therapy and treatmentladen12
this presentation focuses on new nanotechnology and it possible use in detection and therapy with cancer. it was prepared by final year biochemistry student at NCU.
NANO TECHNOLOGY IN DRUG DELIVERY SYSTEMsathish sak
This document discusses how nanoparticles can be used for targeted drug delivery in cancer and inflammation. Nanoparticles less than 100nm in size can be engineered from biodegradable materials to efficiently carry drugs and be taken up by targeted cells. They allow for higher doses of drugs to be delivered directly to diseased cells over prolonged periods of time, reducing side effects. Examples discussed include using nanoparticles to target cancer cells, tumor angiogenesis, infected macrophages, and inflammatory molecules. The future potential of nanotechnology for improved targeted drug delivery is promising.
Nanomedicines show promise for improving cancer treatment. Nanoparticles can be engineered to target cancer cells specifically and deliver toxic payloads or heat. Gold nanoparticles activated by laser light can hyperthermically destroy tumor cells from the inside. Challenges remain in developing nanoparticles that are safe and can effectively reach tumors. If these challenges can be addressed, nanomedicine may enable more precise cancer detection and treatments with fewer side effects than conventional therapies.
This document discusses nanotechnology and its applications in medicine. It begins with the origins and definitions of nanotechnology. Some key approaches to nanofabrication include top-down and bottom-up methods. Nanocarriers such as liposomes, dendrimers, micelles, and nanoparticles can be used for targeted drug delivery. Nanotechnology has applications in regenerative medicine, disease diagnosis using nanomolecular diagnostics, and in-vitro diagnostics including nano biosensors and nanoarrays. Overall, nanomedicine holds promise for earlier disease detection and more targeted treatment approaches.
Nanotechnology involves controlling and manipulating matter at the atomic and molecular scale from 1-100 nm. It allows the production of materials and devices with special properties not seen in bulk materials. Nanoparticles can be synthesized through various methods and engineered into different structures. Nanomedicine applies nanotechnology for health and medicine, enabling early disease detection and more targeted treatment through nano-sized materials and biosensors. In cancer treatment, nanoparticles can be engineered to target and deliver chemotherapeutics directly to tumor cells to minimize side effects.
Silve nanoparticles are of great interest for use as antimicrobial agents. Smaller Silver Nanoparticles have greater antibacterial activity hence they are new generation of antimicrobials
nano-particles synthesis presented by M, TayyebMuhammad Tayyeb
The document discusses the biosynthesis and effects of nanoparticles. It defines nanoparticles as particles between 1-100 nm in size that have a surrounding interfacial layer affecting their properties. The document outlines the history of nanoparticles and nanotechnology. It describes common physical, chemical, and biological synthesis methods for nanoparticles and compares their advantages and disadvantages. The document discusses factors influencing the antimicrobial activity of nanoparticles and their target sites in bacteria. It also covers factors affecting the production of well-characterized nanoparticles.
Bionanotechnology is an area that applies nanotechnology to biology and medicine. It uses biological materials to create nanoscale devices less than 100 nanometers in size to better understand life processes. Some examples include using nanoparticles like liposomes, dendrimers, carbon nanotubes, quantum dots and gold nanoparticles for applications in drug delivery, imaging, biosensing and gene therapy by taking advantage of their small sizes and unique properties. Bionanotechnology is a rapidly developing field that offers opportunities for new medical technologies at the nanoscale level.
This document discusses nano-medicine and provides an overview of its history, applications, and future potential. It begins with definitions of nano-medicine and a brief history starting from 1959 when Richard Feyman first proposed the idea of studying matter at the nano scale. The document then covers the advantages of nano-scale materials, various diagnostic and therapeutic applications in areas like cancer treatment, vaccines, and tissue engineering. It also discusses challenges like nano-toxicology and concludes that nano-medicine has revolutionized medicine through diverse nanomaterials and applications in drug delivery, imaging, and more.
Application of nanoparticals in drug delivery systemMalay Jivani
This document discusses nanoparticles and their applications in pharmaceuticals, with a focus on using gold nanoparticles (AuNPs) for cancer treatment. It defines nanoparticles and describes some common preparation methods. It then discusses several potential medical applications of nanoparticles, including using them as delivery systems for drugs, genes, and targeting cancer cells. Specifically for AuNPs, it covers their synthesis, properties, and how their surfaces can be functionalized. It describes how AuNPs may be useful for photothermal therapy, radiotherapy, and inhibiting angiogenesis for cancer treatment.
Nanotechnology involves manipulating matter at the nanoscale of 1 to 100 nanometers. It was first conceptualized by physicist Richard Feynman in 1959 and began developing in the 1980s with the invention of the scanning tunneling microscope. Nanomedicine uses nanotechnology to build devices like nanobots and nanosponges that can target diseases at the cellular level. Researchers have developed polymer nanosponges coated in red blood cells that safely remove bacterial toxins from the body. Nanomedicine holds promise for more targeted drug delivery, gene therapy, and future nanomachines for medical applications like direct disease treatment and cellular repairs.
Applications of nanobiotechnology in medicineRameshPandi4
Nanomedicine uses nanotechnology to detect and treat diseases at the molecular level. Applications include using nanoparticles for targeted drug delivery to cancer sites, using nanobots to identify and destroy cancer cells, using photodynamic therapy to destroy tumors by activating nanoparticles with light, and developing nanorobots to remove plaque from arteries or break up kidney stones. Future applications may involve cell-sized robots to detect diseases by floating through the bloodstream or developing respirocytes as artificial red blood cells to deliver oxygen throughout the body.
This document discusses nanotechnology in medicine. It provides an introduction to nanotechnology and its history. It describes how nanotechnology is being used for targeted drug delivery, nasal vaccinations, carbon nanotubes, and potential future nano robots. Some applications of nanotechnology discussed are in diagnosis and treatment of diseases, nano biopharmaceutics, and overcoming challenges like crossing the blood brain barrier. Both advantages like better targeting and diagnostics and disadvantages like potential side effects are covered. Future challenges for nanomedicine are also outlined.
Nanomedicine is an emerging field that uses nanotechnology for medical applications such as diagnosis, treatment, and disease prevention. It involves engineering materials and devices at the nanoscale of 1 to 100 nanometers to exploit their unique properties. This allows for innovations like controlled drug delivery, molecular imaging, and biosensing. Some key technologies involved include nanoparticles, quantum dots, carbon nanotubes, dendrimers, and liposomes. Potential applications range from molecular imaging and cancer theranostics to drug delivery, gene therapy, and tissue engineering. Nanomedicine offers opportunities for earlier disease diagnosis and more effective, safer, and personalized treatment approaches.
- Biomagnification refers to the increasing concentration of chemicals or toxins in organisms at higher levels of the food chain. Nanoparticles used in nanofungicides can potentially biomagnify due to their persistence, ability to accumulate in organisms, and low degradation rates.
- Nanoparticles can enter plants directly through soil, water and air or systemically through the use of nano-based agricultural chemicals. Once inside plants, nanoparticles can cause toxicity, hormone imbalances, and accumulation in plant cells and tissues.
- For safe use of nanotechnology in agriculture, more studies on nanoparticle impacts are needed. Biodegradable nanoparticles should be developed and thorough safety testing of nano-products conducted to prevent biom
A nanocarrier is nano material being used as a transport module for another substance, such as a drug. Commonly used nanocarriers include micelles, polymers, carbon-based materials, liposomes and other substances.Nanocarriers are currently used in drug delivery and their unique characteristics demonstrate potential use in chemotherapy. Nanocarriers include polymer conjugates, polymeric nanoparticles, lipid-based carriers, dendrimers, carbon nanotubes, and gold Nanoparticles.Lipid-based carriers include both liposomes and micelles.
Examples of gold nanoparticles are gold nanoshells and nanocages.Different types of nonmaterial being used in nano carriers allows for hydrophobic and hydrophilic drugs to be delivered throughout the body.
potential problem with nanocarriers is unwanted toxicity from the type of nonmaterial being used. Inorganic nonmaterial can also be toxic to the human body if it accumulates in certain cell organelles new research is being conducted to invent more effective, safer nanocarriers.
Nano pharmaceuticals offer the ability to detect diseases at much earlier stages and the diagnostic applications could build upon conventional procedures using nano particles.
Nano pharmaceuticals represent an emerging field where the sizes of the drug particle or a therapeutic delivery system work at the nanoscale.
Nano pharmaceuticals have enormous potential in addressing this failure of traditional therapeutics which offers site-specific targeting of active agents.
Magnetic nanoparticles, bound to a suitable antibody, are used to label specific molecules, structures or microorganisms.
Gold nanoparticles tagged with short segments of DNA can be used for detection of genetic sequence in a sample.
Multicolor optical coding for biological assays has been achieved by embedding different-sized quantum dots into polymeric microbeads.
Nan pore technology for analysis of nucleic acids converts strings of nucleotides directly into electronic signatures.C-dots (Cornell dots) are the smallest silica-based nanoparticles with the size <10 nm.
There are three main reasons for the popularity of herbal medicine
1. There is a growing concern over the reliance and safety of drugs.
2. Modern medicine is failing to effectively treat many of the most common health condition.
3. Many natural measures are being shown to produce better results than drugs or surgery without the side effects
Nanobiotechnology involves the manipulation of matter at the nanoscale (1-100 nanometers) for applications in biology. Key developments include the atomic force microscope in 1980, which enabled imaging at the atomic level. Nanoparticles such as quantum dots have been used for in vivo cell imaging due to their strong fluorescent signals. Nanodevices have the potential to improve cancer detection and diagnosis by entering cells to determine which are cancerous. They may also preserve patient samples and make tests faster. Challenges include assessing the toxicity and biocompatibility of nanomaterials. Overall, nanobiotechnology could lead to new biomaterials and analytical tools with applications in medicine such as targeted drug delivery and disease diagnosis and treatment.
Nanotechnology involves engineering at the nanoscale (1-100 nanometers) and can be used in various fields including medicine. It has several applications for cancer treatment such as using nanoparticles, nanotubes, quantum dots, dendrimers, liposomes, nanoshells, silica nanoparticles, and nanorobots to more precisely deliver drugs to cancer cells, detect genetic mutations associated with cancer, and potentially diagnose and treat cancer. Nanoparticles in particular show promise for overcoming limitations of conventional cancer treatments like poor solubility, lack of targeting, and side effects by selectively targeting cancer cells and increasing drug localization.
Nanotechnology and potential in Cancer therapy and treatmentladen12
this presentation focuses on new nanotechnology and it possible use in detection and therapy with cancer. it was prepared by final year biochemistry student at NCU.
NANO TECHNOLOGY IN DRUG DELIVERY SYSTEMsathish sak
This document discusses how nanoparticles can be used for targeted drug delivery in cancer and inflammation. Nanoparticles less than 100nm in size can be engineered from biodegradable materials to efficiently carry drugs and be taken up by targeted cells. They allow for higher doses of drugs to be delivered directly to diseased cells over prolonged periods of time, reducing side effects. Examples discussed include using nanoparticles to target cancer cells, tumor angiogenesis, infected macrophages, and inflammatory molecules. The future potential of nanotechnology for improved targeted drug delivery is promising.
Nanomedicines show promise for improving cancer treatment. Nanoparticles can be engineered to target cancer cells specifically and deliver toxic payloads or heat. Gold nanoparticles activated by laser light can hyperthermically destroy tumor cells from the inside. Challenges remain in developing nanoparticles that are safe and can effectively reach tumors. If these challenges can be addressed, nanomedicine may enable more precise cancer detection and treatments with fewer side effects than conventional therapies.
This document discusses nanotechnology and its applications in medicine. It begins with the origins and definitions of nanotechnology. Some key approaches to nanofabrication include top-down and bottom-up methods. Nanocarriers such as liposomes, dendrimers, micelles, and nanoparticles can be used for targeted drug delivery. Nanotechnology has applications in regenerative medicine, disease diagnosis using nanomolecular diagnostics, and in-vitro diagnostics including nano biosensors and nanoarrays. Overall, nanomedicine holds promise for earlier disease detection and more targeted treatment approaches.
Nanotechnology involves controlling and manipulating matter at the atomic and molecular scale from 1-100 nm. It allows the production of materials and devices with special properties not seen in bulk materials. Nanoparticles can be synthesized through various methods and engineered into different structures. Nanomedicine applies nanotechnology for health and medicine, enabling early disease detection and more targeted treatment through nano-sized materials and biosensors. In cancer treatment, nanoparticles can be engineered to target and deliver chemotherapeutics directly to tumor cells to minimize side effects.
Silve nanoparticles are of great interest for use as antimicrobial agents. Smaller Silver Nanoparticles have greater antibacterial activity hence they are new generation of antimicrobials
nano-particles synthesis presented by M, TayyebMuhammad Tayyeb
The document discusses the biosynthesis and effects of nanoparticles. It defines nanoparticles as particles between 1-100 nm in size that have a surrounding interfacial layer affecting their properties. The document outlines the history of nanoparticles and nanotechnology. It describes common physical, chemical, and biological synthesis methods for nanoparticles and compares their advantages and disadvantages. The document discusses factors influencing the antimicrobial activity of nanoparticles and their target sites in bacteria. It also covers factors affecting the production of well-characterized nanoparticles.
Nanopartiküller ve immun sistem; etkileri ve güvenilirlikleriSema Arısoy
Son yıllarda etkin maddelerin yan etkilerini azaltmak ve hedeflendirme sağlamak için nanopartiküler ilaç sistemleri geliştirilmiştir. Ancak bu sistemler insan vücudunda her zaman istenen etkiyi sağlayamamaktadır. Bunun nedenlerinden biride immun sistemdir.
Grafen Çağı, incelik, esneklik ve şeffaflığın tüm elektronik eşyalara sıçradığı, ve yaşamımızın her anını saran bir katmanı nasıl yarattığını merak ediyorsanız raporu inceleyebilirsiniz.
"Bu sunum Gazi Üniversitesi Nanoteknoloji ve Uygulamaları dersinde öğrencim Rabia ŞANKAZAN tarafından hazırlanmıştır. Doğa da nano teknoloji, Geko nasıl tutunur, Kelebeğin kanatlarıve nano boyutlar, Nano ayaklar, Titiz lotus çiçeği ve kendi kendini temizleyebilme özelliği, Kum balığı çölde nasıl yaşar ve nasıl denizde yüzer gibi kumun içinde yüzer ve o güneş altında ve kum içinde dahi pırıl pırıl parlar; tüm bunların açıklamasını bu sunumda bulabilirsiniz. Prof.Dr. İbrahim USLU"
Son yıllarda nanoteknoloji birçok boyutta hayatımızda kendine yer edinmiş durumda. 7 milyar olan Dünya nüfusunun 2050 yılına kadar artış hızıyla beraber 9 milyara çıkacağı düşünülecek olduğunda gıda talebindeki ihtiyaç miktarı da artacaktır. Bunun içinde tarımsal üretimdeki bazı yöntem ve tekniklerin verimliliğinin artırılmasına ihtiyaç duyulacaktır. Nanoteknoloji tarımsal üretim yöntemlerinin geliştirilmesinde bize büyük vaadler sunmaktadır.
4. Her yıl 12 milyon kişiye kanser tanısı konuluyor
Ve
7.6 milyon kişi kanserden yaşamını yitiriyor
5. Her 2 erkekten biri yaşam boyu kanser riski taşırken bu
rakam kadınlarda 3te 1 oranındadır
6. Peki kanser nedir
?
Hücrelerde DNA'nın hasarı sonucu hücrelerinin kontrolsüz
veya anormal bir şekilde büyümesi ve çoğalmasıdır.
7. Kanser tedavisindeki en büyük kısıtlamalardan biri,
ilaçların kanser hücrelerine etki ederken diğer sağlıklı
hücrelere zarar vermesidir.
8. Sadece kanser hücrelerine etki edecek olan tedaviler
üzerinde yapılan çalışmalar son yıllarda olumlu sonuçlar
vermiştir
9. Nanoteknoloji kullanılarak geliştirilen özel taşıyıcı
sistemler sayesinde, sağlıklı hücrelere etki etmeyen ancak
kanserli hücreyi öldüren tedaviler uygulamak artık
mümkün olabilmektedir..
Tümör hücrelerinin geliştiği bölgenin hedef alındığı
“güdümlü” ilaç dağılım sistemleri ile çok daha düşük ilaç
dozlarıyla yüksek tedavi başarısı elde edilir.
Washington Üniversitesi’nden Dr. Younan Wia yaptığı çalışma,bilim dergisi Nature Materials’in kasım sayısı
10. 1990'lı yıllarda başlattıkları araştırmaları sonunda tıbbi
ilaçların istenen her türlü organ ya da hücreye direkt
gönderilmesini sağlayan "nanoelmas ilaç taşıma
yöntemini" geliştirdi
Ortadoğu'nun en büyük nanoteknoloji ar-ge ve üretim tesisinin sahibi NNT
11. Kanser tedavisinde, kanda kolaylıkla dolaşan ve vücudun
her tarafına ulaşan 10-100 nm
büyüklüğünde parçacıklar kullanılır. Kapsül benzeri bu
parçacıkların içine istenilen ilaç
yerleştirilebilir.
12. bor elementini nanoteknolojik yöntemlerle saç telinin yüz
binde biri seviyesine küçülterek, ilaçların vücutta hiçbir
engellemeyle karşılaşmadan hedef organda etkili
olmasının yolunu açıyor.
13. Dünyada ilk ve tek olarak NNT Nanoteknoloji Bor Ürünleri
A.Ş bor ve nanoteknoloji temelli saç telinin yüz binde biri
boyutunda "MCDP" isimli nano partiküllerini
geliştirerek, tıpta önemli bir aşamaya imza attı.
15. "MCDP alternatif tıbbi ilaç olarak kullanıldığı
taktirde, sahip olduğu anormal yüksek emme
kapasitesi, yüzeyindeki serbest elektron fazlalığı ilaç
yüklenebilirliğini arttırmakta ve her bir kristalin
yüzeyindeki yüksek miktarda oksijen içeren fonksiyonel
gruplar, kimyasal İNERT parçacıkları ve yüzey
hidrofilisitesi ve güçlü absorbent özellikleriyle anti kanser
ilaçlarını yüksek miktarda emme ve taşıma özelliğine
sahiptir."
16. 200 nm altındaki nano partiküllerin vücuttaki savunma
mekanizmasının koruyucuları konumundaki hücre
duvarları ve antikorların algılama ölçeğinin altında
olduğundan, hiçbir engellemeyle karşılaşmadan beyin
dahil en ince ve hassas noktalara kolaylıkla
ulaşabileceğini belirtti
17. MCDP nanokristal elmaslar
Toksik özellik taşımıyor
Vücutta enformasyon ve iltihaplanmaya neden olmuyor
Kan dolaşımı ve hücre içinde molekül kütle oluşumunu
tamamen engelliyor
bağışıklık sistemlerinde kansere ve benzeri hastalıklara
yakalanmanın önünü kesecek çözümler sağlıyor.
18. laboratuvar ve klinik çalışmalar sonunda 109 bitkinin
moleküllerini (özü) kombine edilerek ve nanoteknoloji ile
güçlendirilen tamamen doğal ve hiçbir yan etkisi olmayan
bir ürünü de geliştirdiklerini bildirdi.
19. MEDİKAL OLTA
Kanser hastalarında ana tümörden kopan kanserli hücreler
kan ile birlikte bütün vücuda dağılıp buldukları uygun
yerlerde yeni tümörler oluşturuyorlar. Bu durum hastalığı
ölümcül yapan nedenlerin başında geliyor. Saç telinin
ellide biri inceliğinde olan nano-olta ana tümörden kopan
kanserli hücreleri yakalıyor. Yakalanan kanserli hücrelerin
incelenerek hastalığın gidişatı hakkında sürekli bilgi
sahibi olmak mümkün.
20. Termoliz terimi, ısı anlamına gelen –thermo ile bozulmak
manasındaki –lysis kelimelerinden türemiştir.
Termoliz, bir bileşeni bünyesindeki bileşenlere ısıyı
kullanarak ayıran bir kimyasal prosestir. Fototermoliz
sırasında ışık enerjisi, gereken ısıyı üretmek için kullanılır
21. Nano-fototermoliz ise, kısa ışık salınımları ile kısa sürede
patlayacak sıcaklığı depolayabilen nano-taneciklerin
kullanıldığı bir prosestir. Isısal patlama geçiren bu nano-
taneciklere “nano-bombalar” da denebilir.
Tedavide ışığın dalgaboyu, atış salınımı süresi ,tanecik
şekil ve boyutları özenle tasarlanmalıdır.
22. ALTINLA KANSER TEDAVİSİ
Nanaokapsül-Altın nanokabuk
İlaç molekülleri,altın nano-kapsüllerin içine yerleştirilir.
Kapsüllerin yüzeyindeki nanometrik çaptaki delikler akıllı
polimerlerle kaplanır. İçi ilaç dolu nano-kapsüller hedef
kanser hücresine gönderildikten sonra, kızılötesi ışınlar
kullanarak ısıtılır. Böylece polimerlerle kapatılan delikler
açılarak kapsül içindeki ilaç ortama salınır.
23. Ayrıca;
Işığın salınmasıyla beraber içinizde yeni yeni gelişmeye
başlayan tümörün net şekli, konumu ve boyutları bir
bilgisayar ekranında görüntülenir.
24. Tümör pişirme;
Proteinler tarafından tümör hücresine bağlanan
küre, tümörün dokusundan kolaylıkla geçen yakın infrare
ışık ışınlarına maruz bırakıldığında, kabuk ısınır ve
yakınlardaki dokuya zarar vermeden tümörü
„pişirir‟.Buna tümör pişirme yöntemi denir.
profesörü olan Naomi Halas
26. 1- Altın kaplı bir nano-kabuk, bir beyaz kan hücresinden 10
bin kat kadar küçüktür. Doktorlar, kanseri teşhis ve tedavi
etmek için, hastanın kanına bu kabukların binlercesini
gönderir. Vücut içine dağılan kabuklar, yüzeylerine
bağlanan antikorlar yardımıyla buldukları tümör
hücrelerine yapışırlar.
27. 2- Her bir tümörün üzeri yaklaşık 20 nano-kabukla
kaplandıktan sonra, dokuya zarar vermeden geçen yıkan
infrare ışık kabukların parlamasını sağlar. Bir sonraki
adımdaysa, doktorlar yalnızca bağlanan tümörleri ısıtacak
daha yüksek dozda ışık gönderirler
28. 3- Kabuğun dışındaki altın kabuk üzerinde bulunan serbest
elektronlar yoğun ışığın enerjisini toplar, her bir nano-
kabuğu ısıtır ve tümörü pişirir yani yakar. Tüm bunlar tek
bir seansta gerçekleşir.
29. NEDEN ALTIN?
Çoğu kanser hücresi, hücre membranlarının dış yüzüne
genişçe yayılmış bulunan “Epidermal Gelişme Faktörlü
Reseptör (EGFR)” olarak bilinen bir proteine sahiptir.
Buna karşın, sağlıklı hücreler tipik olarak bu proteini
üretemezler. Araştırmacılar, söz konusu bu EGFR
proteinine karşı antikorlara “anti-EGFR” olarak
adlandırılan altın nano-taneciklerin bağlanması ile kanser
hücrelerine karşı bir silah geliştirmişlerdir.
30. Altın nano-tanecikler, kanser hücrelerine saplanır ve onları
parlak hale getirirler (Dr. Ivan El-Sayed, Georgia Tech).
Bu altın nano-tanecikler; güçlü absorplayıcı olmaları, ışık
kararlılığına sahip, zehirleyici etkisi olmayan, antikorlara
ya da proteinlere kolay bağlanabilme özelliğinde ve
ayarlanabilir optik özelliklere sahip olmaları sebebiyle
fototermoliz için en umut verici araçlardır.
31. Kanser hücrelerini öldürmek için çeşitli metotlar
önerilmektedir. Araştırmaların geniş bir bölümünü
kapsayan ve üzerinde en çok durulan metot ise, sıvı
ortamda bulunan aşırı ısıtılmış altın nano-taneciklerin
çevresini kaplayan kabarcık oluşturma ile ilgilidir. Hücre
membranına tutunmuş altın nano-kümeler, normal
hücreler için güvenli olan bir lazer kuvvetinde kötü huylu
kanser hücrelerini yok edecek olan kabarcık oluşumu
veriminde müthiş bir artışa sebep olabilir.
32. NANOİLAÇ
Klinik olarak kullanılan “lipozomal doksorubisin”
nanoilaçlara örnek gösterilebilir. Kadınlarda yumurtalık
kanserinde sıklıkla kullanılan bu ilacın özellikle kalp
hücreleri üzerinde olumsuz etkileri vardır.
Özel bir su geçirmez koruyucu kılıf içine yerleştirilen
doksorubisinin ise kalbe olumsuz etkileri
çok daha azdır.
33. Son yıllarda geliştirilen ve “IT-101” olarak adlandırılan bir
nanoparçacık kanser tedavisinde kullanılmaya başlandı.
*IT-101‟in çapı 30 nm‟dir.
*Kamptotesin adlı ilacı taşıyan bu nanoparçacık
bozulmaya uğramadan kan dolaşımında 40 saat kalabilir.
*Kamptotesin vücuda tek başına verildiğindeyse kanda
sadece birkaç dakika kalabilir;
* Kamptotesin kanser hücreleriyle temas edecek ve onları
öldürecek kadar zaman kazanır.
34. *IT-101 kanserli dokuyla temas ettiğinde kamptotesin
yavaşça dışarı çıkar
*ilaç dışarı çıktıktan sonra görevini tamamlamış olan
nanokapsül küçük parçacıklara ayrılır.
* Bu parçacıklar hasara yol açmadan idrar yoluyla vücuttan
atılır.
*Yapılan klinik çalışmalarda, kamptotesin taşıyan IT-
101‟in, kanser ilaçlarının klasik yan etkileri olan
bulantıya, kusmaya, saç dökülmesine ve ishale yol
açmadığı gösterilmiştir.
35. BİYOMALZEMELER İLE TAKLİTÇİ BEDENSEL
SÜREÇLER
*Kanser hücreleri zararlı yönlerde gelişirler çünkü onlar
sağlıklı hücrelerde olduğu gibi aynı tarz sinyalleri
algılamazlar.
*Kan damarları ile olan etkileşmesine göre bir tümör
yeniden oluşturulabilir. Eğer tümöre olan kan akışı
başarıyla kesilebilirse, o aç kalır ve ölür.
*Ayrıca bu çalışma tümörlü doku kan sirkülasyonu
yolununun ve kanser hücrelerinin nasıl yayıldığının
anlaşılmasında yardımcı olabilir.
36. Bergen araştırma grubunun çalışmaları nano seviyede
sentetik biyomalzemeler ile her biri diğer hücrelerle
bağlantılı olan hücreyi doğal süreçlerle kopyalama
yönündedir.
Profesör Lorens
37. İdeal bir implant nasıl olmalıdır?
İmplant(canlı dokulara cansız maddelerin
yerleştirilmesi), insan vücudunun doğal dokularının
taklidini gerektirir ve hücrelere çabuk çoğalıp
farklılaşmaları için sinyal göndermelidir. Nanoölçek
topolojisi, bunun nasıl meydana geleceğinin kontrolü için
çok önemlidir.
38. Vücudun değişik dokuları içinde onların çevresinde
karşılaştıkları hücrelerin tekrar ürettiği sinyaller yoluyla
hücrelerin nasıl farklılaşacakları ve çoğalacakları kontrol
edilebilir
