Systems pharmacology approaches aim to personalize medicine by taking a more holistic view of how drugs interact within biological systems. This presentation introduced systems pharmacology and discussed how accounting for an individual's metabolome, the collection of small molecule metabolites in their body, could improve drug safety and efficacy predictions. The human metabolome establishes a baseline for how tightly drugs should bind to their targets versus other proteins. Considering a drug's effects in the context of metabolite binding profiles may help address issues like inter-individual variability and translational failures between preclinical models and human trials.