This document provides information on the use of the drug Levocetirizine dihydrochloride 5 mg film-coated tablets, manufactured by Taj Pharmaceuticals. It discusses the drug's approved therapeutic indications, posology and dosing recommendations, contraindications, warnings and precautions, known drug interactions, and common adverse effects. The key information includes that Levocetirizine is indicated for allergic rhinitis and chronic idiopathic urticaria. The recommended adult dose is one 5 mg tablet daily. Dosing adjustments are required for patients with renal impairment. No dose adjustment is needed for patients with hepatic impairment alone.
Levosimendan for Injection Taj Pharma SmPCTajPharmaQC
Levosimendan for Injection 12.5mg, 25mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Levosimendan Dosage & Rx Info | Levosimendan Uses, Side Effects Levosimendan: Indications, Side Effects, Warnings, Levosimendan -Drug Information –Taj Pharma, Levosimendan dose Taj pharmaceuticals Levosimendan interactions, Taj Pharmaceutical Levosimendan contraindications, Levosimendan price, Levosimendan Taj Pharma Levosimendan SmPC-Taj Pharma Stay connected to all updated on Levosimendan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Cetirizine hydrochloride 10mg tablets smpc taj pharmaceuticalsTaj Pharma
Cetirizine Hydrochloride Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Cetirizine Hydrochloride Dosage & Rx Info | Cetirizine Hydrochloride Uses, Side Effects -: Indications, Side Effects, Warnings, Cetirizine Hydrochloride - Drug Information - Taj Pharma, Cetirizine Hydrochloride dose Taj pharmaceuticals Cetirizine Hydrochloride interactions, Taj Pharmaceutical Cetirizine Hydrochloride contraindications, Cetirizine Hydrochloride price, Cetirizine Hydrochloride Taj Pharma Cetirizine Hydrochloride 10mg TabletsSMPC- Taj Pharma . Stay connected to all updated on Cetirizine Hydrochloride Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Desloratadine Tablets 5mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Desloratadine Dosage & Rx Info | Desloratadine Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Desloratadine-Drug Information –Taj Pharma, Desloratadine dose Taj pharmaceuticals Desloratadine interactions, Taj Pharmaceutical Desloratadine contraindications, Desloratadine price, Desloratadine Taj Pharma Desloratadine SmPC-Taj Pharma Stay connected to all updated on Desloratadine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Fexofenadine hydrochloride 180 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Fexofenadine hydrochloride Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Fexofenadine hydrochloride Dosage & Rx Info | Fexofenadine hydrochloride Uses, Side Effects -: Indications, Side Effects, Warnings, Fexofenadine hydrochloride - Drug Information - Taj Pharma, Fexofenadine hydrochloride dose Taj pharmaceuticals Fexofenadine hydrochloride interactions, Taj Pharmaceutical Fexofenadine hydrochloride contraindications, Fexofenadine hydrochloride price, Fexofenadine hydrochloride Taj Pharma Fexofenadine hydrochloride 180 mg Film-Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Fexofenadine hydrochloride Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Clarithromycin for Injection Taj Pharma SmPCTajPharmaQC
Clarithromycin for Infusion 500mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Clarithromycin Dosage & Rx Info | Clarithromycin Uses, Side Effects Clarithromycin: Indications, Side Effects, Warnings, Clarithromycin -Drug Information –Taj Pharma, Clarithromycin dose Taj pharmaceuticals Clarithromycin interactions, Taj Pharmaceutical Clarithromycin contraindications, Clarithromycin price, Clarithromycin Taj Pharma Clarithromycin SmPC-Taj Pharma Stay connected to all updated on Clarithromycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Levosimendan for Injection Taj Pharma SmPCTajPharmaQC
Levosimendan for Injection 12.5mg, 25mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Levosimendan Dosage & Rx Info | Levosimendan Uses, Side Effects Levosimendan: Indications, Side Effects, Warnings, Levosimendan -Drug Information –Taj Pharma, Levosimendan dose Taj pharmaceuticals Levosimendan interactions, Taj Pharmaceutical Levosimendan contraindications, Levosimendan price, Levosimendan Taj Pharma Levosimendan SmPC-Taj Pharma Stay connected to all updated on Levosimendan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Cetirizine hydrochloride 10mg tablets smpc taj pharmaceuticalsTaj Pharma
Cetirizine Hydrochloride Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Cetirizine Hydrochloride Dosage & Rx Info | Cetirizine Hydrochloride Uses, Side Effects -: Indications, Side Effects, Warnings, Cetirizine Hydrochloride - Drug Information - Taj Pharma, Cetirizine Hydrochloride dose Taj pharmaceuticals Cetirizine Hydrochloride interactions, Taj Pharmaceutical Cetirizine Hydrochloride contraindications, Cetirizine Hydrochloride price, Cetirizine Hydrochloride Taj Pharma Cetirizine Hydrochloride 10mg TabletsSMPC- Taj Pharma . Stay connected to all updated on Cetirizine Hydrochloride Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Desloratadine Tablets 5mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Desloratadine Dosage & Rx Info | Desloratadine Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Desloratadine-Drug Information –Taj Pharma, Desloratadine dose Taj pharmaceuticals Desloratadine interactions, Taj Pharmaceutical Desloratadine contraindications, Desloratadine price, Desloratadine Taj Pharma Desloratadine SmPC-Taj Pharma Stay connected to all updated on Desloratadine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Fexofenadine hydrochloride 180 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Fexofenadine hydrochloride Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Fexofenadine hydrochloride Dosage & Rx Info | Fexofenadine hydrochloride Uses, Side Effects -: Indications, Side Effects, Warnings, Fexofenadine hydrochloride - Drug Information - Taj Pharma, Fexofenadine hydrochloride dose Taj pharmaceuticals Fexofenadine hydrochloride interactions, Taj Pharmaceutical Fexofenadine hydrochloride contraindications, Fexofenadine hydrochloride price, Fexofenadine hydrochloride Taj Pharma Fexofenadine hydrochloride 180 mg Film-Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Fexofenadine hydrochloride Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Clarithromycin for Injection Taj Pharma SmPCTajPharmaQC
Clarithromycin for Infusion 500mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Clarithromycin Dosage & Rx Info | Clarithromycin Uses, Side Effects Clarithromycin: Indications, Side Effects, Warnings, Clarithromycin -Drug Information –Taj Pharma, Clarithromycin dose Taj pharmaceuticals Clarithromycin interactions, Taj Pharmaceutical Clarithromycin contraindications, Clarithromycin price, Clarithromycin Taj Pharma Clarithromycin SmPC-Taj Pharma Stay connected to all updated on Clarithromycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Generic Finasteride 1mg Tablets for Effective Hair Loss TreatmentThe Swiss Pharmacy
Generic Finasteride 1 mg Tablets are used to treat male pattern hair loss. This medicine increases hair growth while at the same time prevents further hair loss.
Finasteride 1mg specifically lowers the levels of DHT in the scalp, thus helping to reverse the balding process. Finasteride 1 mg tblets do not affect hair on other parts of the body. Men with mild to moderate, but not complete, hair loss can expect to benefit from the use of Finasteride 1mg tablets. Generic Finasteride 1mg tablets are not indicated for use in women.
Finax (Finasteride 1 mg Tablets) are used to prevent male pattern hair loss (androgenetic alopecia) and stimulate hair growth in men. Administration of Finax decreases scalp and serum DHT concentration, a major cause of male pattern hair loss. In this way, Finasteride 1 mg Tablets help to reverse the balding process and prevent further hair loss.
Zoledronic acid Solution for Infusion Taj Pharma SmPCTajPharmaQC
Zoledronic acid 4 mg/100 ml Solution for Infusion Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Zoledronic acid Dosage & Rx Info | Zoledronic acid Uses, Side Effects Zoledronic acid: Indications, Side Effects, Warnings, Zoledronic acid -Drug Information –Taj Pharma, Zoledronic acid dose Taj pharmaceuticals Zoledronic acid interactions, Taj Pharmaceutical Zoledronic acid contraindications, Zoledronic acid price, Zoledronic acid Taj Pharma Zoledronic acid SmPC-Taj Pharma Stay connected to all updated on Zoledronic acid Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Haloperidol 5mg per ml solution for injection smpc taj pharmaceuticalsTaj Pharma
Haloperidol - Drug Information - Taj Pharma, Haloperidol dose Taj pharmaceuticals Haloperidol interactions, Taj Pharmaceutical Haloperidol contraindications, Haloperidol price, Haloperidol Taj Pharma Haloperidol Injection 5mg/ml SMPC- Taj Pharma . Stay connected to all updated on Haloperidol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Pramirol (Pramipexole Dihydrochloride Tablets) is a non-ergot dopamine agonist and is used alone or with other medicines to treat Parkinson's disease. This medication is also used to treat Moderate-to-severe primary Restless Legs Syndrome (RLS) that causes an unusual urge to move the legs.
Fluoxetine 20 mg hard capsules smpc taj pharmaceuticalsTaj Pharma
FLUOXETINE Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, FLUOXETINE Dosage & Rx Info | FLUOXETINE Uses, Side Effects -: Indications, Side Effects, Warnings, FLUOXETINE - Drug Information - Taj Pharma, FLUOXETINE dose Taj pharmaceuticals FLUOXETINE interactions, Taj Pharmaceutical FLUOXETINE contraindications, FLUOXETINE price, FLUOXETINE Taj Pharma Fluoxetine 20mg Hard Capsules SMPC- Taj Pharma . Stay connected to all updated on FLUOXETINE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Fludarabine phosphate 25 mgml concentrate for solution for injection or infus...Taj Pharma
FLUDARABINE PHOSPHATE Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, FLUDARABINE PHOSPHATE Dosage & Rx Info | FLUDARABINE PHOSPHATE Uses, Side Effects -: Indications, Side Effects, Warnings, FLUDARABINE PHOSPHATE - Drug Information - Taj Pharma, FLUDARABINE PHOSPHATE dose Taj pharmaceuticals FLUDARABINE PHOSPHATE interactions, Taj Pharmaceutical FLUDARABINE PHOSPHATE contraindications, FLUDARABINE PHOSPHATE price, FLUDARABINE PHOSPHATE Taj Pharma Cancer, oncologyFludarabine phosphate 25 mg/ml Concentrate for Solution for Injection or Infusion. SMPC- Taj Pharma
Haloperidol 5mg per 5ml oral solution smpc taj pharmaceuticalsTaj Pharma
Haloperidol - Drug Information - Taj Pharma, Haloperidol dose Taj pharmaceuticals Haloperidol interactions, Taj Pharmaceutical Haloperidol contraindications, Haloperidol price, Haloperidol Taj Pharma Haloperidol Oral Solution 5 mg/5 ml SMPC- Taj Pharma . Stay connected to all updated on Haloperidol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Crestor Tablets to treat high cholesterol and related conditionsThe Swiss Pharmacy
Crestor Tablets (Rosuvastatin calcium) is a synthetic lipid-lowering agent used in combination with exercise, diet, and weight-loss to treat high cholesterol and related conditions. It is also indicated for risk reduction of MI, stroke, and arterial revascularization procedures in patients without clinically evident CHD, but with multiple risk factors
This PDF deals with important catchpoints regarding the use of 5-alpha reductase inhibitors, their safety and efficacy stats, and important counselling tips.
Letrozole 2.5 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
LETROZOLE Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, LETROZOLE Dosage & Rx Info | LETROZOLE Uses, Side Effects -: Indications, Side Effects, Warnings, LETROZOLE - Drug Information - Taj Pharma, LETROZOLE dose Taj pharmaceuticals LETROZOLE interactions, Taj Pharmaceutical LETROZOLE contraindications, LETROZOLE price, LETROZOLE Taj Pharma Cancer, oncologyLetrozole 2.5 mg film-coated tablets. SMPC- Taj Pharma . Stay connected to all updated on LETROZOLE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Promethazine 10 mg tablets smpc taj pharmaceuticalsTaj Pharma
Promethazine hydrochloride Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Promethazine hydrochloride Dosage & Rx Info | Promethazine hydrochloride Uses, Side Effects -: Indications, Side Effects, Warnings, Promethazine hydrochloride - Drug Information - Taj Pharma, Promethazine hydrochloride dose Taj pharmaceuticals Promethazine hydrochloride interactions, Taj Pharmaceutical Promethazine hydrochloride contraindications, Promethazine hydrochloride price, Promethazine hydrochloride Taj Pharma Promethazine hydrochloride 10 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Promethazine hydrochloride Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Quetiapine 25mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Quetiapine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Quetiapine Dosage & Rx Info | Quetiapine Uses, Side Effects -: Indications, Side Effects, Warnings, Quetiapine - Drug Information - Taj Pharma, Quetiapine dose Taj pharmaceuticals Quetiapine interactions, Taj Pharmaceutical Quetiapine contraindications, Quetiapine price, Quetiapine Taj Pharma Cancer, oncologyQuetiapine 25mg Film Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Quetiapine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Mirtazapine 30mg tablets smpc taj pharmaceuticalsTaj Pharma
Mirtazapine 30mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Mirtazapine Dosage & Rx Info | Mirtazapine Uses, Side Effects - Mirtazapine: Indications, Side Effects, Warnings, Mirtazapine - Drug Information - Taj Pharma, Mirtazapine dose Taj pharmaceuticals Mirtazapine interactions, Taj Pharmaceutical Mirtazapine contraindications, Mirtazapine price, Mirtazapine Taj Pharma Mirtazapine 30mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Mirtazapine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Linezolid 600 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Linezolid Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Linezolid Dosage & Rx Info | Linezolid Uses, Side Effects -: Indications, Side Effects, Warnings, Linezolid - Drug Information - Taj Pharma, Linezolid dose Taj pharmaceuticals Linezolid interactions, Taj Pharmaceutical Linezolid contraindications, Linezolid price, Linezolid Taj Pharma Linezolid 600 mg Film-Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Linezolid Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Generic Finasteride 1mg Tablets for Effective Hair Loss TreatmentThe Swiss Pharmacy
Generic Finasteride 1 mg Tablets are used to treat male pattern hair loss. This medicine increases hair growth while at the same time prevents further hair loss.
Finasteride 1mg specifically lowers the levels of DHT in the scalp, thus helping to reverse the balding process. Finasteride 1 mg tblets do not affect hair on other parts of the body. Men with mild to moderate, but not complete, hair loss can expect to benefit from the use of Finasteride 1mg tablets. Generic Finasteride 1mg tablets are not indicated for use in women.
Finax (Finasteride 1 mg Tablets) are used to prevent male pattern hair loss (androgenetic alopecia) and stimulate hair growth in men. Administration of Finax decreases scalp and serum DHT concentration, a major cause of male pattern hair loss. In this way, Finasteride 1 mg Tablets help to reverse the balding process and prevent further hair loss.
Zoledronic acid Solution for Infusion Taj Pharma SmPCTajPharmaQC
Zoledronic acid 4 mg/100 ml Solution for Infusion Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Zoledronic acid Dosage & Rx Info | Zoledronic acid Uses, Side Effects Zoledronic acid: Indications, Side Effects, Warnings, Zoledronic acid -Drug Information –Taj Pharma, Zoledronic acid dose Taj pharmaceuticals Zoledronic acid interactions, Taj Pharmaceutical Zoledronic acid contraindications, Zoledronic acid price, Zoledronic acid Taj Pharma Zoledronic acid SmPC-Taj Pharma Stay connected to all updated on Zoledronic acid Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Haloperidol 5mg per ml solution for injection smpc taj pharmaceuticalsTaj Pharma
Haloperidol - Drug Information - Taj Pharma, Haloperidol dose Taj pharmaceuticals Haloperidol interactions, Taj Pharmaceutical Haloperidol contraindications, Haloperidol price, Haloperidol Taj Pharma Haloperidol Injection 5mg/ml SMPC- Taj Pharma . Stay connected to all updated on Haloperidol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Pramirol (Pramipexole Dihydrochloride Tablets) is a non-ergot dopamine agonist and is used alone or with other medicines to treat Parkinson's disease. This medication is also used to treat Moderate-to-severe primary Restless Legs Syndrome (RLS) that causes an unusual urge to move the legs.
Fluoxetine 20 mg hard capsules smpc taj pharmaceuticalsTaj Pharma
FLUOXETINE Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, FLUOXETINE Dosage & Rx Info | FLUOXETINE Uses, Side Effects -: Indications, Side Effects, Warnings, FLUOXETINE - Drug Information - Taj Pharma, FLUOXETINE dose Taj pharmaceuticals FLUOXETINE interactions, Taj Pharmaceutical FLUOXETINE contraindications, FLUOXETINE price, FLUOXETINE Taj Pharma Fluoxetine 20mg Hard Capsules SMPC- Taj Pharma . Stay connected to all updated on FLUOXETINE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Fludarabine phosphate 25 mgml concentrate for solution for injection or infus...Taj Pharma
FLUDARABINE PHOSPHATE Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, FLUDARABINE PHOSPHATE Dosage & Rx Info | FLUDARABINE PHOSPHATE Uses, Side Effects -: Indications, Side Effects, Warnings, FLUDARABINE PHOSPHATE - Drug Information - Taj Pharma, FLUDARABINE PHOSPHATE dose Taj pharmaceuticals FLUDARABINE PHOSPHATE interactions, Taj Pharmaceutical FLUDARABINE PHOSPHATE contraindications, FLUDARABINE PHOSPHATE price, FLUDARABINE PHOSPHATE Taj Pharma Cancer, oncologyFludarabine phosphate 25 mg/ml Concentrate for Solution for Injection or Infusion. SMPC- Taj Pharma
Haloperidol 5mg per 5ml oral solution smpc taj pharmaceuticalsTaj Pharma
Haloperidol - Drug Information - Taj Pharma, Haloperidol dose Taj pharmaceuticals Haloperidol interactions, Taj Pharmaceutical Haloperidol contraindications, Haloperidol price, Haloperidol Taj Pharma Haloperidol Oral Solution 5 mg/5 ml SMPC- Taj Pharma . Stay connected to all updated on Haloperidol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Crestor Tablets to treat high cholesterol and related conditionsThe Swiss Pharmacy
Crestor Tablets (Rosuvastatin calcium) is a synthetic lipid-lowering agent used in combination with exercise, diet, and weight-loss to treat high cholesterol and related conditions. It is also indicated for risk reduction of MI, stroke, and arterial revascularization procedures in patients without clinically evident CHD, but with multiple risk factors
This PDF deals with important catchpoints regarding the use of 5-alpha reductase inhibitors, their safety and efficacy stats, and important counselling tips.
Letrozole 2.5 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
LETROZOLE Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, LETROZOLE Dosage & Rx Info | LETROZOLE Uses, Side Effects -: Indications, Side Effects, Warnings, LETROZOLE - Drug Information - Taj Pharma, LETROZOLE dose Taj pharmaceuticals LETROZOLE interactions, Taj Pharmaceutical LETROZOLE contraindications, LETROZOLE price, LETROZOLE Taj Pharma Cancer, oncologyLetrozole 2.5 mg film-coated tablets. SMPC- Taj Pharma . Stay connected to all updated on LETROZOLE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Promethazine 10 mg tablets smpc taj pharmaceuticalsTaj Pharma
Promethazine hydrochloride Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Promethazine hydrochloride Dosage & Rx Info | Promethazine hydrochloride Uses, Side Effects -: Indications, Side Effects, Warnings, Promethazine hydrochloride - Drug Information - Taj Pharma, Promethazine hydrochloride dose Taj pharmaceuticals Promethazine hydrochloride interactions, Taj Pharmaceutical Promethazine hydrochloride contraindications, Promethazine hydrochloride price, Promethazine hydrochloride Taj Pharma Promethazine hydrochloride 10 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Promethazine hydrochloride Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Quetiapine 25mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Quetiapine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Quetiapine Dosage & Rx Info | Quetiapine Uses, Side Effects -: Indications, Side Effects, Warnings, Quetiapine - Drug Information - Taj Pharma, Quetiapine dose Taj pharmaceuticals Quetiapine interactions, Taj Pharmaceutical Quetiapine contraindications, Quetiapine price, Quetiapine Taj Pharma Cancer, oncologyQuetiapine 25mg Film Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Quetiapine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Mirtazapine 30mg tablets smpc taj pharmaceuticalsTaj Pharma
Mirtazapine 30mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Mirtazapine Dosage & Rx Info | Mirtazapine Uses, Side Effects - Mirtazapine: Indications, Side Effects, Warnings, Mirtazapine - Drug Information - Taj Pharma, Mirtazapine dose Taj pharmaceuticals Mirtazapine interactions, Taj Pharmaceutical Mirtazapine contraindications, Mirtazapine price, Mirtazapine Taj Pharma Mirtazapine 30mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Mirtazapine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Linezolid 600 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Linezolid Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Linezolid Dosage & Rx Info | Linezolid Uses, Side Effects -: Indications, Side Effects, Warnings, Linezolid - Drug Information - Taj Pharma, Linezolid dose Taj pharmaceuticals Linezolid interactions, Taj Pharmaceutical Linezolid contraindications, Linezolid price, Linezolid Taj Pharma Linezolid 600 mg Film-Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Linezolid Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Loratadine 10 mg tablets smpc taj pharmaceuticalsTaj Pharma
Loratadine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Loratadine Dosage & Rx Info | Loratadine Uses, Side Effects -: Indications, Side Effects, Warnings, Loratadine - Drug Information - Taj Pharma, Loratadine dose Taj pharmaceuticals Loratadine interactions, Taj Pharmaceutical Loratadine contraindications, Loratadine price, Loratadine Taj Pharma Loratadine 10 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Loratadine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Levofloxacin Injection 5mg/ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Levofloxacin Dosage & Rx Info | Levofloxacin Uses, Side Effects Levofloxacin: Indications, Side Effects, Warnings, Levofloxacin -Drug Information –Taj Pharma, Levofloxacin dose Taj pharmaceuticals Levofloxacin interactions, Taj Pharmaceutical Levofloxacin contraindications, Levofloxacin price, Levofloxacin Taj Pharma Levofloxacin SmPC-Taj Pharma Stay connected to all updated on Levofloxacin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Sertraline 50 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Sertalin Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Sertalin Dosage & Rx Info | Sertalin Uses, Side Effects -: Indications, Side Effects, Warnings, Sertalin - Drug Information - Taj Pharma, Sertalin dose Taj pharmaceuticals Sertalin interactions, Taj Pharmaceutical Sertalin contraindications, Sertalin price, Sertalin Taj Pharma Sertalin 50mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Sertalin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Venlafaxine 75mg tablets smpc taj pharmaceuticalsTaj Pharma
Venlafaxine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Venlafaxine Dosage & Rx Info | Venlafaxine Uses, Side Effects -: Indications, Side Effects, Warnings, Venlafaxine - Drug Information - Taj Pharma, Venlafaxine dose Taj pharmaceuticals Venlafaxine interactions, Taj Pharmaceutical Venlafaxine contraindications, Venlafaxine price, Venlafaxine Taj Pharma Venlafaxine 75mg tablets SMPC- Taj Pharma . Stay connected to all updated on Venlafaxine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Sildenafil 50 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Sildenafil Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Sildenafil Dosage & Rx Info | Sildenafil Uses, Side Effects -: Indications, Side Effects, Warnings, Sildenafil - Drug Information - Taj Pharma, Sildenafil dose Taj pharmaceuticals Sildenafil interactions, Taj Pharmaceutical Sildenafil contraindications, Sildenafil price, Sildenafil Taj Pharma Sildenafil 50 mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on Sildenafil Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Levetiracetam 500 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Levetiracetam Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Levetiracetam Dosage & Rx Info | Levetiracetam Uses, Side Effects -: Indications, Side Effects, Warnings, Levetiracetam - Drug Information - Taj Pharma, Levetiracetam dose Taj pharmaceuticals Levetiracetam interactions, Taj Pharmaceutical Levetiracetam contraindications, Levetiracetam price, Levetiracetam Taj Pharma Levetiracetam 500mg Film Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Levetiracetam Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Hydroxyzine hydrochloride 10mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Hydroxyzine hydrochloride Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Hydroxyzine hydrochloride Dosage & Rx Info | Hydroxyzine hydrochloride Uses, Side Effects -: Indications, Side Effects, Warnings, Hydroxyzine hydrochloride - Drug Information - Taj Pharma, Hydroxyzine hydrochloride dose Taj pharmaceuticals Hydroxyzine hydrochloride interactions, Taj Pharmaceutical Hydroxyzine hydrochloride contraindications, Hydroxyzine hydrochloride price, Hydroxyzine hydrochloride Taj Pharma Hydroxyzine hydrochloride 10mg Film-coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Hydroxyzine hydrochloride Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Exemestane Tablets USP 25mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Exemestane Dosage & Rx Info | Exemestane Uses, Side Effects Exemestane: Indications, Side Effects, Warnings, Exemestane -Drug Information –Taj Pharma, Exemestane dose Taj pharmaceuticals Exemestane interactions, Taj Pharmaceutical Exemestane contraindications, Exemestane price, Exemestane Taj Pharma Exemestane SmPC-Taj Pharma Stay connected to all updated on Exemestane Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Etoposide 50 mg, 100mg capsule, soft smpc taj pharmaceuticalsTaj Pharma
ETOPOSIDE - Drug Information - Taj Pharma, ETOPOSIDE dose Taj pharmaceuticals ETOPOSIDE interactions, Taj Pharmaceutical ETOPOSIDE contraindications, ETOPOSIDE price, ETOPOSIDE Taj Pharma Cancer, oncologyEtoposide 50 mg, 100mg capsule, soft SMPC- Taj Pharma . Stay connected to all updated on ETOPOSIDE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Paroxetine 20 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Paroxetine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Paroxetine Dosage & Rx Info | Paroxetine Uses, Side Effects -: Indications, Side Effects, Warnings, Paroxetine - Drug Information - Taj Pharma, Paroxetine dose Taj pharmaceuticals Paroxetine interactions, Taj Pharmaceutical Paroxetine contraindications, Paroxetine price, Paroxetine Taj Pharma Paroxetine 20 mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on Paroxetine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Paliperidone ER Tablets Taj Pharma SmPCTajPharmaQC
Paliperidone 3mg/6mg/9mg/12mg Extended-release Tablets Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Paliperidone Dosage & Rx Info | Paliperidone Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Paliperidone-Drug Information –Taj Pharma, Paliperidone dose Taj pharmaceuticals Paliperidone interactions, Taj Pharmaceutical Paliperidone contraindications, Paliperidone price, Paliperidone Taj Pharma Paliperidone SmPC-Taj Pharma Stay connected to all updated on Paliperidone Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Gefitinib Tablets 25mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Gefitinib Dosage & Rx Info | Gefitinib Uses, Side Effects Gefitinib: Indications, Side Effects, Warnings, Gefitinib -Drug Information –Taj Pharma, Gefitinib dose Taj pharmaceuticals Gefitinib interactions, Taj Pharmaceutical Gefitinib contraindications, Gefitinib price, Gefitinib Taj Pharma Gefitinib SmPC-Taj Pharma Stay connected to all updated on Gefitinib Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Gefitinib 250 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
GEFITINIB Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, GEFITINIB Dosage & Rx Info | GEFITINIB Uses, Side Effects -: Indications, Side Effects, Warnings, GEFITINIB - Drug Information - Taj Pharma, GEFITINIB dose Taj pharmaceuticals GEFITINIB interactions, Taj Pharmaceutical GEFITINIB contraindications, GEFITINIB price, GEFITINIB Taj Pharma Cancer, oncologyGefitinib 250 mg film-coated tablets. SMPC- Taj Pharma
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Zolpiderm tartrate 5mg and 10mg tablets pil, taj pharmaceuticals.Taj Pharma
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
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Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Levocetirizine dihydrochloride 5 mg film coated tablets smpc- taj pharmaceuticals
1. Levocetirizine dihydrochloride 5 mg film-coated tablets SMPC, Taj Phar maceuticals
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RX
LEVOCETRIZINE
DIHYDROCHLORIDE
FILM COATED
TABLETS
5MG
1.NAME OF THE MEDICINAL PRODUCT
Levocetirizine dihydrochloride 5 mg film-coated
tablets
2. QUALITATIVE AND QUANTITATIVE
COMPOSITION
Each film-coated tablet contains 5 mg
levocetirizine dihydrochloride (equivalent to 4.2
mg of levocetirizine).
Excipient: each film-coated tablet contains 64.0
mg lactose monohydrate.
For a full list of excipients, see section 6.1.
3. PHARMACEUTICAL FORM
Film-coated tablet.
White to off-white, oval, biconvex film-coated
tablets,
4. CLINICAL PARTICULARS
4.1 Therapeutic indications
Levocetirizine is indicated for:
- the relief of nasal and ocular symptoms of
seasonal and perennial allergic rhinitis;
- the relief of symptoms of chronic idiopathic
urticaria.
4.2 Posology and method of administration
The film-coated tablet must be taken orally,
swallowed whole with liquid and may be taken
with or without food.
Adults and adolescents 12 years and above
The daily recommended dose is 5 mg (one film-
coated tablet) once daily.
Children aged 6 to 12 years
The daily recommended dose is 5 mg (one film-
coated tablet) daily.
Levocetirizine is not recommended for use in
children below age 6 due to insufficient data on
safety and efficacy.
Elderly
For the time being, there is no data to suggest
that the dose needs to be reduced in elderly
patients provided that the renal function is
normal.
Patients with moderate to severe renal
impairment: there are no data to document the
efficacy/safety ratio in patients with renal
impairement. Since levocetirizine is mainly
excreted via renal route (see section 5.2), in
cases no alternative treatment can be used, the
dosing intervals must be individualized
according to renal function. Refer to the
following table and adjust the dose as indicated.
To use this dosing table, an estimate of the
patient's creatinine clearance (CLcr) in ml/min is
needed. The CLcr (ml/min) may be estimated
from serum creatinine (mg/dl) determination
using the following formula:
Dosing adjustments for adult patients with
impaired renal function:
In pediatric patients suffering from renal
impairment, the dose will have to be adjusted on
an individual basis taking into account the renal
clearance of the patient, his age and his body
weight.
Group Creatinine
clearance (ml/min)
Dosage and
frequency
Normal ≥ 80 One tablet daily
Mild 50 - 79 One tablet daily
Moderate 30 - 49 One tablet every
two days
Severe 30 One tablet every
three days
End-stage renal
disease -
patients
undergoing
dialysis
10 Contra-indicated
2. Levocetirizine dihydrochloride 5 mg film-coated tablets SMPC, Taj Phar maceuticals
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Patients with hepatic impairment
No dose adjustment is needed in patients with
solely hepatic impairment.
Patients with hepatic impairment and renal
impairment
Dose adjustment is recommended (see Patients
with moderate to severe renal impairment
above).
4.3 Contraindications
Hypersensitivity to levocetirizine, to any of the
excipients, to hydroxyzine or to any piperazine
derivatives.
Patients with severe renal impairment at less
than 10 ml/min creatinine clearance.
Patients with rare hereditary problems of
galactose intolerance, the Lapp lactase
deficiency or glucose- galactose malabsorption
should not take levocetirizine film-coated
tablets.
4.4 Special Warnings and precautions for use
Do not exceed the stated dose.
The use of levocetirizine dihydrochloride is not
recommended in children aged less than 6 years
since the currently available film-coated tablets
do not yet allow dose adaptation.
At therapeutic doses, no clinically significant
interactions have been demonstrated with
alcohol (for a blood alcohol level of 0.5 g/L).
Nevertheless, precaution is recommended if
alcohol is taken concomitantly.
Caution in epileptic patients and patients at risk
of convulsions is recommended.
4.5 Interaction with other medicinal products
and other forms of interaction
Due to the pharmacokinetic, pharmacodynamic
and tolerance profile of levocetirizine, no
interactions are expected with this antihistamine.
Actually, neither pharmacodynamic nor
significant pharmacokinetic interaction was
reported in drug-drug interactions studies
performed, notably with pseudoephedrine or
theophylline (400 mg/day).
The extent of absorption of levocetirizine is not
reduced with food, although the rate of
absorption is decreased.
4.6 Fertility, Pregnancy and lactation
Very rare clinical data on exposed pregnancies
are available. Animal studies do not indicate
direct or indirect harmful effects with respect to
pregnancy, embryonal/fetal development,
parturition or postnatal development. Caution
should be exercised when prescribing to
pregnant or breast feeding women because
levocetirizine passes into breast milk.
4.7 Effects on ability to drive and use
machines
Objective measurements of driving ability, sleep
latency and assembly line performance have not
demonstrated any clinically relevant effects at
the recommended dose of 5 mg.
Patients intending to drive, engaging in
potentially hazardous activities or operating
machinery should not exceed the recommended
dose and should take their response to the
medicinal product into account. In these
sensitive patients, concurrent use with alcohol or
other CNS depressants may cause additional
reductions in alertness and impairment of
performance.
4.8 Undesirable Effects
The frequency of undesirable effects has been
defined as: very common (≥1/10); common
(≥1/100 to <1/10); uncommon (≥1/1,000 to
≤1/100); rare (≥1/10,000 to ≤1/1,000); very rare
(≤1/10,000); not known (cannot be estimated
from the available data).
Commo
n
Uncom
mon
Rare Very rare
Blood and
lymphatic
system
disorders
Thrombocyt
openia
Immune
system
disorders
Hypersens
itivity
Anaphylacti
c shock
Psychiatri
c
disorders
Somnol
ence
Agitatio
n
Aggressio
n
Confusion
Depressio
Tic
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n
Hallucinat
ion
Insomnia
Nervous
system
disorders
Dizzine
ss
Headac
he
Paraest
hesia
Convulsio
ns
Movement
disorders
Dysgeusia
Syncope
Tremor
Dystonia
Dyskinesia
Eye
disorders
Accomodati
on disorder
Blurred
vision
Oculogyrati
on
Cardiac
disorders
Tachycard
ia
Respirator
y, thoracic
and
mediastin
al
disorders
Pharyn
gitis
Rhinitis
*
Gastrointe
stinal
disorders
Abdomi
nal pain
Dry
mouth
Nausea
Diarrho
ea
Hepatobili
ary
disorders
Hepatic
function
abnormal
(increased
transamina
ses,
alklaline
phosphatis
e, γ-GT
and
bilirubin)
Skin and
subcutane
ous tissue
disorders
Pruritus
Rash
Urticaria Angioneurot
ic oedema
Fixed drug
eruption
Renal and
urinary
disorders
Dysuria
Enuresis
General
disorders
and
administra
tion site
conditions
Fatigue Astheni
a
Malaise
Oedema
Investigati
ons
Weight
increased
* in children
4.9 Overdose
Symptoms
Symptoms observed after an overdose of
levocetirizine are mainly associated with CNS
effects or with effects that could suggest an
anticholinergic effect.
Adverse events reported after an intake of at
least 5 times the recommended daily dose are:
confusion, diarrhoea, dizziness, fatigue,
headache, malaise, mydriasis, pruritus,
restlessness, sedation, somnolence, stupor,
tachycardia, tremor and urinary retention.
Management of overdoses
There is no known specific antidote to
levocetirizine.
Should overdose occur, symptomatic or
supportive treatment is recommended. Gastric
lavage should be considered following ingestion
of a short occurrence.
Levocetirizine is not effectively removed by
dialysis.
5. PHARMACOLOGICAL PROPERTIES
5.1 Pharmacodynamic properties
Pharmacotherapeutic group: Antihistamine for
systemic use, piperazine derivatives, ATC Code:
R06A E09
Levocetirizine, the (R) enantiomer of cetirizine,
is a potent and selective antagonist of peripheral
H1-receptors.
Binding studies revealed that levocetirizine has
high affinity for human H1-receptors (Ki = 3.2
nmol/l). Levocetirizine has an affinity 2-fold
higher than that of cetirizine (Ki = 6.3 nmol/l).
Levocetirizine dissociates from H1-receptors
with a half-life of 115 ± 38 min. After single
administration, levocetirizine shows a receptor
occupancy of 90% at 4 hours and 57% at 24
hours.
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Pharmacodynamic studies in healthy volunteers
demonstrate that, at half the dose, levocetirizine
has comparable activity to cetirizine, both in the
skin and in the nose.
The pharmacodynamic activity of levocetirizine
has been studied in randomised, controlled trials:
In a study comparing the effects of levocetirizine
5mg, desloratadine 5mg, and placebo on
histamine-induced wheal and flare,
levocetirizine treatment resulted in significantly
decreased wheal and flare formation which was
highest in the first 12 hours and lasted for 24
hours, (p<0.001) compared with placebo and
desloratadine.
The onset of action of levocetirizine 5 mg in
controlling pollen-induced symptoms has been
observed at 1 hour post drug intake in placebo
controlled trials in the model of the allergen
challenge chamber.
In vitro studies (Boyden chambers and cell
layers techniques) show that levocetirizine
inhibits eotaxin-induced eosinophil
transendothelial migration through both dermal
and lung cells.
Levocetirizine inhibits the histamine-mediated
early phase of the allergic reaction and also
reduces the migration of certain inflammatory
cells and the release of certain mediators
associated with the late allergic response.
The efficacy and safety of levocetirizine has
been demonstrated in several double-blind,
placebo controlled, clinical trials performed in
adult patients suffering from seasonal allergic
rhinitis or perennial allergic rhinitis.
The paediatric safety and efficacy of
levocetirizine tablets has been studied in two
placebo controlled clinical trials including
patients aged 6 to 12 years and suffering from
seasonal and perennial allergic rhinitis,
respectively. In both trials, levocetirizine
significantly improved symptoms and increased
health-related quality of life.
In a placebo-controlled clinical trial including
166 patients suffering from chronic idiopathic
urticaria, 85 patients were treated with placebo
and 81 patients with levocetirizine 5mg once
daily over six weeks. Treatment with
levocetirizine resulted in significant decrease in
pruritus severity over the first week and over the
total treatment period as compared to placebo.
Levocetirizine also resulted in a larger
improvement of health-related quality of life as
assessed by the Dermatology Life Quality Index
as compared to placebo.
Pharmacokinetic / pharmacodynamic
relationship
5 mg levocetirizine provides a similar pattern of
inhibition of histamine-induced wheal and flare
as 10 mg cetirizine. As for cetirizine, the action
on histamine-induced skin reactions was out of
phase with the plasma concentrations.
ECGs did not show relevant effects of
levocetirizine on QT interval.
5.2 Pharmacokinetic properties
The pharmacokinetics of levocetirizine are linear
with dose- and time-independent with low inter-
subject variability. The pharmacokinetic profile
is the same when given as the single enantiomer
or when given as cetirizine. No chiral inversion
occurs during the process of absorption and
elimination.
Absorption
Levocetirizine is rapidly and extensively
absorbed following oral administration. Peak
plasma concentrations are achieved 0.9 h after
dosing. Steady state is achieved after two days.
Peak concentrations are typically 270 ng/ml and
308 ng/ml following a single and a repeated 5
mg o.d. dose, respectively. The extent of
absorption is dose-independent and is not altered
by food, but the peak concentration is reduced
and delayed.
Distribution:
No tissue distribution data are available in
humans, neither concerning the passage of
levocetirizine through the blood-brain-barrier. In
rats and dogs, the highest tissue levels are found
in liver and kidneys, the lowest in the CNS
compartment.
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Levocetirizine is 90% bound to plasma proteins.
The distribution of levocetirizine is restrictive,
as the volume of distribution is 0.4 l/kg.
Biotransformation
The extent of metabolism of levocetirizine in
humans is less than 14% of the dose and
therefore differences resulting from genetic
polymorphism or concomitant intake of enzyme
inhibitors are expected to be negligible.
Metabolic pathways include aromatic oxidation,
N- and O- dealkylation and taurine conjugation.
Dealkylation pathways are primarily mediated
by CYP 3A4 while aromatic oxidation involved
multiple and/or unidentified CYP isoforms.
Levocetirizine had no effect on the activities of
CYP isoenzymes 1A2, 2C9, 2C19, 2D6, 2E1
and 3A4 at concentrations well above peak
concentrations achieved following a 5 mg oral
dose.
Due to its low metabolism and absence of
metabolic inhibition potential, the interaction of
levocetirizine with other substances, or vice-
versa, is unlikely.
Elimination
The plasma half-life in adults is 7.9 ± 1.9 hours.
The mean apparent total body clearance is 0.63
ml/min/kg. The major route of excretion of
levocetirizine and metabolites is via urine,
accounting for a mean of 85.4% of the dose.
Excretion via feces accounts for only 12.9% of
the dose. Levocetirizine is excreted both by
glomerular filtration and active tubular
secretion.
Renal impairment
The apparent body clearance of levocetirizine is
correlated to the creatinine clearance. It is
therefore recommended to adjust the dosing
intervals of levocetirizine, based on creatinine
clearance in patients with moderate and severe
renal impairment. In anuric end stage renal
disease subjects, the total body clearance is
decreased by approximately 80% when
compared to normal subjects.
5.3 Preclinical safety data
Non-clinical data reveal no special hazard for
humans based on conventional studies of safety
pharmacology, repeated dose toxicity,
genotoxicity, carcinogenic potential, toxicity to
reproduction.
6. PHARMACEUTICAL PARTICULARS
6.1 List of excipients
ablet core
Lactose monohydrate
Cellulose microcrystalline
Magnesium stearate (E572)
Film-coating
Hypromellose (E464)
Titanium dioxide (E171)
Macrogol 400
6.2 Incompatibilities
Not applicable.
6.3 Shelf life
3 years.
6.4 Special precautions for storage
Store in the original package in order to protect
from moisture
6.5 Nature and contents of container
PVC/PVDC: Al blisters or oPA/Al/PVC:Al
blisters
Pack sizes:
Blisters containing 7, 10, 14, 15, 20, 21, 28, 30,
40, 50, 56, 60, 70, 90, 100, 112 or 120 tablets
Unit dose blisters containing: 30x1 tablets
Not all pack sizes may be marketed.
6.6 Special precautions for disposal and other
handling
No special requirements.
7. MANUFACTURER:
Manufactured in India by:
TAJ PHARMACEUTICALS LTD.
Mumbai, India
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At: 615, GIDC, Kerala, Bavla, Dist. Ahmedabad
438225, Gujarat, INDIA
This leaflet was last revised in October 2019