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Zolpidem tartrate 5 mg tablets smpc taj pharmaceuticalsTaj Pharma
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Linezolid Tablets USP 600mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Linezolid Dosage & Rx Info | Linezolid Uses, Side Effects Linezolid: Indications, Side Effects, Warnings, Linezolid -Drug Information –Taj Pharma, Linezolid dose Taj pharmaceuticals Linezolid interactions, Taj Pharmaceutical Linezolid contraindications, Linezolid price, Linezolid Taj Pharma Linezolid SmPC-Taj Pharma Stay connected to all updated on Linezolid Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
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Ciprofloxacin Tablets USP 250mg/500mg/750mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Ciprofloxacin Dosage & Rx Info | Ciprofloxacin Uses, Side Effects Ciprofloxacin : Indications, Side Effects, Warnings, Ciprofloxacin -Drug Information –Taj Pharma, Ciprofloxacin dose Taj pharmaceuticals Ciprofloxacin interactions, Taj Pharmaceutical Ciprofloxacin contraindications, Ciprofloxacin price, Ciprofloxacin Taj Pharma Ciprofloxacin SmPC-Taj Pharma Stay connected to all updated on Ciprofloxacin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?
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Trazodone Hydrochloride
Tablets IP 25mg, 50mg, 100mg
(Sesyrin) Taj Pharma
1.NAME OF THE MEDICINAL PRODUCT
Trazodone Hydrochloride Tablets IP 25mg
(Sesyrin) Taj Pharma
Trazodone Hydrochloride Tablets IP 50mg
(Sesyrin) Taj Pharma
Trazodone Hydrochloride Tablets IP 100mg
(Sesyrin) Taj Pharma
2. QUALITATIVE AND QUANTITATIVE
COMPOSITION
a) Each uncoated tablet contains:
Trazodone Hydrochloride 25mg
Excipients q.s.
Colour: Ponceau 4R
b) Each uncoated tablet contains:
Trazodone Hydrochloride 50mg
Excipients q.s.
Colour: Tartrazine
c) Each uncoated tablet contains:
Trazodone Hydrochloride 100mg
Excipients q.s.
Colour: Brilliant Blue FCF
For the full list of excipients, see section 6.1.
3. PHARMACEUTICAL FORM
Tablet
4. CLINICAL PARTICULARS
4.1 Therapeutic indications
Trazodone relieves symptoms of all types of
depression including depressive illness
accompanied by anxiety.
4.2 Posology and method of administration
Posology
Depression
Adult
Initially 150 mg/day in divided doses after food
or as a single dose on retiring.
This may be increased up to 300 mg/day in a
single or divided dose. The major portion of a
divided dose should be taken when retiring. The
dose may be further increased to 600 mg/day in
divided doses in hospitalised patients.
Elderly
For very elderly patients or frail patients, the
recommended initial starting dose is reduced to
100 mg/day in divided doses or as a single night
time dose (see section 4.4). This may be
incrementally increased, under supervision,
according to efficacy and tolerance. In general,
single doses above 100 mg should be avoided in
these patients. It is unlikely that 300 mg/day will
be exceeded.
Paediatric population
Trazodone is not recommended for use in
children below the age of 18 years due to a lack
of data on safety.
Depression accompanied by Anxiety
As for depression
Anxiety
75 mg increasing to 300 mg/day as necessary.
A decrease of the side-effects (increase of the
resorption and decrease of the peak plasma
concentration) can be reached by taking
trazodone hydrochloride after a meal.
Current psychiatric opinion is that withdrawal of
the medication should be gradual.
Patients with hepatic impairment
Trazodone undergoes extensive hepatic
metabolism, see section 5.2, and has also been
associated with hepatotoxicity, see sections 4.4
and 4.8. Therefore caution should be exercised
when prescribing for patients with hepatic
impairment, particularly in cases of severe
hepatic impairment. Periodic monitoring of liver
function may be considered.
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Patients with renal impairment
No dosage adjustment is usually necessary, but
caution should be exercised when prescribing for
patients with severe renal impairment (see also
sections 4.4 and 5.2).
Method of administration
For oral administration.
4.3 Contraindications
Hypersensitivity to the active substance or to any
of the excipients listed in section 6.1.
Alcohol intoxication and intoxication with
hypnotics.
Acute myocardial infarction.
4.4 Special warnings and precautions for use
Paediatric population
Trazodone should not be used in children and
adolescents under 18. Suicidal behaviour
(suicidal attempt and suicidal planning) and
hostility (essentially aggressiveness, opposing
behaviour and anger) have been observed in a
clinical study on children and adolescents treated
with antidepressant more frequently than with
placebo. Moreover, long-term safety data on
children and adolescents regarding growth,
maturation and cognitive and behavioural
development are not available.
Suicide/suicidal thoughts or clinical worsening
Depression is associated with an increased risk
of suicidal thoughts, self-harm and suicide
(suicide-related events). This risk persists until
significant remission occurs. As improvement
may not occur during the first few weeks or more
of treatment, patients should be closely
monitored until such improvement occurs. It is
general clinical experience that the risk of
suicide may increase in the early stages of
recovery.
Other psychiatric conditions for which trazodone
is prescribed can also be associated with an
increased risk of suicide related events. In
addition, these conditions may be co-morbid
with major depressive disorder. The same
precautions observed when treating patients with
major depressive disorder should therefore be
observed when treating patients with other
psychiatric disorders.
Patients with a history of suicide-related events,
or those exhibiting a significant degree of
suicidal ideation prior to commencement of
treatment are known to be at greater risk of
suicidal thoughts or suicide attempts, and should
receive careful monitoring during treatment. A
meta-analysis of placebo-controlled clinical trials
of antidepressant drugs in psychiatric disorders
showed an increased risk of suicidal behaviour
with antidepressants compared to placebo in
patients less than 25 years old.
Close supervision of patients and in particular
those at high risk should accompany drug
therapy especially in early treatment and
following dose changes. Patients (and caregivers
of patients) should be alerted about the need to
monitor for any clinical worsening, suicidal
behaviour or thoughts and unusual changes in
behaviour and to seek medical advice
immediately if these symptoms present.
To minimise the potential risk of suicide
attempts, particularly at therapy initiation, only
restricted quantities of trazodone should be
prescribed at each occasion.
It is recommended that careful dosing and
regular monitoring is adopted in patients with the
following conditions:
• Epilepsy, specifically abrupt increases or
decreases of dosage should be avoided
• Patients with hepatic or renal impairment,
particularly if severe
• Patients with cardiac disease, such as angina
pectoris, conduction disorders or AV blocks of
different degree, recent myocardial infarction
• Hyperthyroidism
• Micturition disorders, such as prostate
hypertrophy, although problems would not be
anticipated as the anticholinergic effect of
trazodone is only minor
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• Acute narrow angle glaucoma, raised intra-
ocular pressure, although major changes would
not be anticipated due to the minor
anticholinergic effect of trazodone
Should jaundice occur in a patient, trazodone
therapy must be withdrawn.
Severe hepatic disorders with potential fatal
outcome have been reported with trazodone use
(see section 4.8). Patients should be instructed to
report immediately signs such as asthenia,
anorexia, nausea, vomiting, abdominal pain or
icterus to a physician. Investigations including
clinical examination and biological assessment
of liver function should be undertaken
immediately, and withdrawal of trazodone
therapy be considered.
Administration of antidepressants in patients
with schizophrenia or other psychotic disorders
may result in a possible worsening of psychotic
symptoms. Paranoid thoughts may be intensified.
During therapy with trazodone a depressive
phase can change from a manic-depressive
psychosis into a manic phase. In that case
trazodone must be stopped.
Interactions in terms of serotonin
syndrome/malignant neuroleptic syndrome have
been described in case of concomitant use of
other serotonergically acting substances like
other antidepressants (e.g. tricyclic
antidepressants, SSRI's, SNRI's and MAO-
inhibitors) and neuroleptics. Malignant
neuroleptic syndromes with fatal outcome have
been reported in cases of coadministration with
neuroleptics, for which this syndrome is a known
possible adverse drug reaction. See sections 4.5
and 4.8 for further information.
Since agranulocytosis may clinically reveal itself
with influenza-like symptoms, sore throat and
fever, in these cases it is recommended to check
haematology.
Hypotension, including orthostatic hypotension
and syncope, has been reported to occur in
patients receiving trazodone. Concomitant
administration of antihypertensive therapy with
trazodone may require a reduction in the dose of
the antihypertensive drug.
Elderly patients may more often experience
orthostatic hypotension, somnolence, and other
anticholinergic effects of trazodone. Careful
consideration should be given to the potential for
additive effects with concomitant medication use
such as with other psychotropics or
antihypertensives or in the presence of risk
factors such as comorbid disease, which may
exacerbate these reactions. It is recommended
that the patient/carer is informed of the potential
for these reactions and monitored closely for
such effects following initiation of therapy, prior
to and following upward dose titration.
Following therapy with trazodone, particularly
for a prolonged period, an incremental dosage
reduction to withdrawal is recommended, to
minimise the occurrence of withdrawal
symptoms, characterised by nausea, headache
and malaise.
There is no evidence that trazodone
hydrochloride possesses any addictive properties.
As with other antidepressant drugs, cases of QT
interval prolongation have been reported with
trazodone very rarely. Caution is advised when
prescribing trazodone with medicinal products
known to prolong QT interval. Trazodone should
be used with caution in patients with known
cardiovascular disease including those associated
with prolongation of the QT interval.
Potent CYP3A4 inhibitors may lead to increases
in trazodone serum levels. See section 4.5 for
further information.
As with other drugs with alpha-adrenolytic
activity, trazodone has very rarely been
associated with priapism. This may be treated
with an intracavernosum injection of an alpha-
adrenergic agent such as adrenaline or
metaraminol. However there are reports of
trazodone-induced priapism which have required
surgical intervention or led to permanent sexual
dysfunction. Patients developing this suspected
adverse reaction should cease trazodone
immediately.
As this medicinal product contains lactose,
patients with rare hereditary problems of
galactose intolerance, the Lapp lactase deficiency
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or glucose-galactose malabsorption should not
take this medicine.
4.5 Interaction with other medicinal products
and other forms of interaction
General: The sedative effects of antipsychotics,
hypnotics, sedatives, anxiolytics and
antihistaminic drugs may be intensified; dosage
reduction is recommended in such instances.
The metabolism of antidepressants is accelerated
due to hepatic effects by oral contraceptives,
phenytoin, carbamazepine and barbiturates. The
metabolism of antidepressants is inhibited by
cimetidine and some other antipsychotics.
CYP3A4 inhibitors: Drug metabolism studies in
vitro are indicative that there is a potential for
drug interactions when trazodone is given with
potent CYP3A4 inhibitors such as erythromycin,
ketoconazole, itraconazole, ritonavir, indinavir
and nefazodone. It is likely that potent CYP3A4
inhibitors may lead to substantial increases in
trazodone plasma concentrations with the
potential for adverse effects. Exposure to
ritonavir during initiation or resumption of
treatment in patients receiving trazodone will
increase the potential for excessive sedation,
cardiovascular, and gastrointestinal effects. It has
been confirmed in in-vivo-studies in healthy
volunteers, that a ritonavir dose of 200 mg BID
increased the plasma levels of trazodone by
greater than two-fold, leading to nausea, syncope
and hypotension. If trazodone is used with a
potent CYP3A4 inhibitor, a lower dose of
trazodone should be considered. However, co-
administration of trazodone and potent CYP3A4
inhibitors should be avoided where possible.
Carbamazepine reduced plasma concentrations
of trazodone when coadministered. Concomitant
use of carbamazepine 400 mg daily led to a
decrease of plasma concentrations of trazodone
and its active metabolite m-
chlorophenylpiperazine of 76% and 60%,
respectively. Patients should be closely
monitored to see if there is a need for an
increased dose of trazodone when taken with
carbamazepine.
Trazodone may enhance the effects of muscle
relaxants and volatile anaesthetics, and caution
should be exercised in such instances. Similar
considerations apply to combined administration
with sedative and anti-depressants drugs,
including alcohol. Trazodone intensifies the
sedative effects of alcohol. Alcohol should be
avoided during trazodone therapy.
Trazodone has been well tolerated in depressed
schizophrenic patients receiving standard
phenothiazine therapy and also in depressed
parkinsonian patients receiving therapy with
levodopa. Antidepressants can accelerate the
metabolism of levodopa.
Tricyclic antidepressants: concurrent
administration should be avoided due to the risk
of interaction. Serotonin syndrome and
cardiovascular side effects are possible and
should be forewarned.
Fluoxetine: rare cases have been reported of
elevated trazodone plasma levels and adverse
effects when trazodone had been combined with
fluoxetine, a CYP1A2/2D6 inhibitor. The
mechanism underlying a pharmacokinetic
interaction is not fully understood. A
pharmacodynamic interaction (serotonin
syndrome) could not be excluded.
Monoamine oxidase inhibitors: Possible
interactions with monoamine oxidase inhibitors
have occasionally been reported. Although some
clinicians do give both concurrently, use of
trazodone concomitantly with MAOI's, or within
two weeks from discontinuation of these
substances is not recommended. The
administration of MAOI's within one week since
discontinuation of trazodone treatment is not
recommended either.
Phenothiazines: Severe orthostatic hypotension
has been observed in cases of concomitant use
with phenothiazines, like e.g. chlorpromazine,
fluphenazine, levomepromazine and
perphenazine.
Other: Concomitant use of Trazodone with drugs
known to prolong the QT interval may increase
the risk of ventricular arrhythmias, including
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torsade de pointes. Caution should be used when
these drugs are coadministered with trazodone.
Since trazodone is only a weak inhibitor of
noradrenaline re-uptake and does not modify the
blood pressure response to tyramine, interference
with the hypotensive action of guanethidine-like
compounds is unlikely. However, studies in
laboratory animals suggest that trazodone may
inhibit most of the acute actions of clonidine. In
the case of other types of antihypertensive drug,
although no clinical interactions have been
reported, the possibility of potentiation should be
considered.
Undesirable effects may be more frequent when
trazodone is administered together with
preparations containing Hypericum perforatum
(St. Johns wort).
There have been reports of changes in
prothrombin time in patients concomitantly
receiving trazodone and warfarin.
Concurrent use of trazodone may result in
elevated serum levels of digoxin or phenytoin.
Monitoring the serum levels should be
considered in these patients.
4.6 Fertility, pregnancy and lactation
Pregnancy
Data on a limited number (< 200) of exposed
pregnancies indicate no adverse effects of
trazodone on pregnancy or on the health of the
foetus/newborn child. To date, no other relevant
epidemiological data are available. The safety of
trazodone in human pregnancy has not been
established. Animal studies do not indicate direct
or indirect harmful effects with respect to
pregnancy, embryonal/foetal development,
parturition or postnatal development at
therapeutic doses (see section 5.3). On basic
principles, therefore, its use during the first
trimester should be avoided.
Caution should be exercised when prescribing to
pregnant women. When trazodone is used until
delivery, newborns should be monitored for the
occurrence of withdrawal symptoms.
Breast-feeding
Limited data indicate that excretion of trazodone
in human breast milk is low, but levels of the
active metabolite are not known. Due to the
paucity of data, a decision on whether to
continue/discontinue breast-feeding or to
continue/discontinue therapy with trazodone
should be made taking into account the benefit of
trazodone therapy to the woman.
4.7 Effects on ability to drive and use
machines
Trazodone has minor or moderate influence on
the ability to drive and use machines. As with all
other drugs acting on the central nervous system,
patients should be cautioned against the risks of
driving or operating machinery until they are
sure they are not affected by drowsiness,
sedation, dizziness, confusional states or blurred
vision.
4.8 Undesirable effects
Cases of suicidal ideation and suicidal
behaviours have been reported during trazodone
therapy or early after treatment discontinuation
(see section 4.4).
Trazodone has had no effect on arterial blood
pCO2 or pO2 levels in patients with severe
respiratory insufficiency due to chronic bronchial
or pulmonary disease.
The following symptoms, some of which are
commonly reported in cases of untreated
depression, have also been recorded in patients
receiving trazodone therapy.
MedDRA
System Organ
Class
Frequency not known
(cannot be estimated from
the available data)
Blood and
lymphatic
system
disorders
Blood dyscrasias (including
agranulocytosis,
thrombocytopenia,
eosinophilia, leucopenia and
anaemia)
Immune system
disorders
Allergic reactions
Endocrine
disorders
Syndrome of Inappropriate
Antidiuretic Hormone
Secretion
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Metabolism and
nutrition
disorders
Hyponatraemia1
, weight loss,
anorexia, increased appetite
Psychiatric
disorders
Suicidal ideation or suicidal
behaviours2
, confusional state,
insomnia, disorientation,
mania, anxiety, nervousness,
agitation (very occasionally
exacerbating to delirium),
delusion, aggressive reaction,
hallucinations, nightmares,
libido decreased, withdrawal
syndrome
Nervous system
disorders
Serotonin syndrome,
convulsion, neuroleptic
malignant syndrome, dizziness,
vertigo, headache, drowsiness3
,
restlessness, decreased
alertness, tremor, blurred
vision, memory disturbance,
myoclonus, expressive aphasia,
paraesthesia, dystonia, taste
altered
Cardiac
disorders
Cardiac
arrhythmias4
(including
Torsade de Pointes,
palpitations, premature
ventricular contractions,
ventricular couplets,
ventricular tachycardia),
bradycardia, tachycardia, ECG
abnormalities (QT
prolongation)2
Vascular
disorders
Orthostatic hypotension,
hypertension, syncope
Respiratory,
thoracic and
mediastinal
disorders
Nasal congestion, dyspnoea
Gastrointestinal
disorders
Nausea, vomiting, dry mouth,
constipation, diarrhoea,
dyspepsia, stomach pain,
gastroenteritis, increased
salivation, paralytic ileus
Hepatobiliary
disorders
Hepatic function abnormalities
(including jaundice and
hepatocellular damage)5
,
cholestasis intrahepatic, severe
hepatic disorders such as
hepatitis/fulminant hepatitis
and hepatic failure with
potentially fatal outcome
Skin and
subcutaneous
tissue disorders
Skin rash, pruritus,
hyperhidrosis
Musculoskeletal
and connective
tissue disorders
Pain in limb, back pain,
myalgia, arthralgia
Renal and
urinary
disorders
Micturition disorders
Reproductive
system and
breast disorders
Priapism6
General
disorders and
administration
site conditions
Weakness, oedema, influenza-
like symptoms, fatigue, chest
pain, fever
Investigations Elevated liver enzymes
1
Fluid and electrolyte status should be
monitored in symptomatic patients.
2
See also section 4.4
3 Trazodone is a sedative antidepressant and
drowsiness, sometimes experienced during the
first days of treatment, usually disappears on
continued therapy.
4
Studies in animals have shown that trazodone is
less cardiotoxic than the tricyclic antidepressants,
and clinical studies suggest that the drug may be
less likely to cause cardiac arrhythmias in man.
Clinical studies in patients with pre-existing
cardiac disease indicate that trazodone may be
arrhythmogenic in some patients in that
population.
5
Adverse effects on hepatic function, sometimes
severe, have been rarely reported. Should such
effects occur, trazodone should be immediately
discontinued.
6
See also section 4.4
Reporting of suspected adverse reactions
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Reporting suspected adverse reactions after
authorisation of the medicinal product is
important. It allows continued monitoring of the
benefit/risk balance of the medicinal product.
4.9 Overdose
Symptoms
The most frequently reported reactions to
overdose have included drowsiness, dizziness,
nausea and vomiting. In more serious cases
coma, tachycardia, hypotension, hyponatraemia,
convulsions and respiratory failure have been
reported. Cardiac features may include
bradycardia, QT prolongation and torsade de
pointes. Symptoms may appear within 24 hours
or more after overdose.
Overdoses of trazodone in combination with
other antidepressants may cause serotonin
syndrome.
Management
There is no specific antidote to trazodone.
Activated charcoal should be considered in
adults who have ingested more than 1 g
trazodone, or in children who have ingested more
than 150 mg trazodone within 1 hour of
presentation. Alternatively, in adults, gastric
lavage may be considered within 1 hour of
ingestion of a potentially life-threatening
overdose.
Observe for at least 6 hours after ingestion (or 12
hours if a sustained release preparation has been
taken). Monitor BP, pulse and Glasgow Coma
Scale (GCS). Monitor oxygen saturation if GCS
is reduced. Cardiac monitoring is appropriate in
symptomatic patients.
Single brief convulsions do not require
treatment. Control frequent or prolonged
convulsions with intravenous diazepam (0.1-0.3
mg/kg body weight) or lorazepam (4 mg in an
adult and 0.05 mg/kg in a child). If these
measures do not control the fits an intravenous
infusion of phenytoin may be useful. Give
oxygen and correct acid base and metabolic
disturbances as required.
Treatment should be symptomatic and supportive
in the case of hypotension and excessive
sedation. If severe hypotension persists consider
use of inotropes, e.g. dopamine or dobutamine.
5. PHARMACOLOGICAL PROPERTIES
5.1 Pharmacodynamic properties
Pharmacotherapeutic group: other antidepressants
Trazodone is a potent antidepressant, it also has
anxiety reducing activity. Trazodone is
triazolopyridine derivative chemically unrelated
to known tricyclic, tetracyclic and other
antidepressant agents. It has negligible effect on
noradrenaline re-uptake mechanisms. Whilst the
mode of action of trazodone is not known
precisely, it antidepressant activity may concern
noradrenergic potentiation by mechanisms other
than uptake blockade. A central antiserotonin
effect may account for the drug's anxiety
reducing properties.
5.2 Pharmacokinetic properties
Trazodone is rapidly absorbed from the
gastrointestinal tract and extensively
metabolised. Paths of metabolism of trazodone
include n-oxidation and hydroxylation. The
metabolite m-chlorophenylpiperazine is active.
Trazodone is excreted in the urine almost
entirely in the form of its metabolites, either in
free or in conjugated form. The elimination of
trazodone is biphasic, with a terminal elimination
half-life of 5 to 13 hours. Trazodone is excreted
in breast milk.
There was an approximate two-fold increase in
terminal phase half-life and significantly higher
plasma concentrations of trazodone in 10
subjects aged 65–74 years compared with 12
subjects aged 23–39 years following a 100 mg
dose of trazodone. It was suggested that there is
an age-related reduction in hepatic metabolism of
trazodone.
In vitro studies in human liver microsomes show
that trazodone is metabolised by cytochrome
P4503A4 (CYP3A4) to form m-
chlorophenylpiperazine. Whilst significant, the
role of this pathway in the total clearance of
trazodone in vivo has not been fully determined.
5.3 Preclinical safety data
8. Trazodone Hydrochlo ride Table ts IP 25mg; 50mg; 100mg (Sesyrin ) Taj Pharma Taj Pharma : Uses, Side Effects, Interacti ons, Pictures, Warnings, T razodone Hydrochlo ride Table ts IP 25mg; 50mg ; 100mg (Sesyrin ) Taj Pharma Dosage & Rx Info | T razodone Hydrochloride Table ts IP 25mg; 50 mg; 100mg (Sesyrin) Taj Pha rma Uses, Side Effects, Trazodone Hydrochloride Ta blets IP 25mg; 50 mg; 100mg (Sesyrin) Taj Pha rma Indicati ons, Side Effects, Warnings, Trazod one Hydrochlo ride Table ts IP 25mg; 50mg; 100mg (Sesyrin ) Taj Pharma - Drug Inf orma tion – Taj Pha rma, T razodone Hydrochlo ride Table ts IP 25m g; 50mg; 100mg (Sesyri n) Taj Pharma dose Taj pha rmaceuticals Trazodon e Hydrochlorid e Tablets IP 25mg; 50mg; 100 mg (Sesyrin) Taj Pha rma in teractio ns, Taj Pharmaceu tical Trazodone Hydrochloride Ta blets IP 25mg; 50 mg; 100 mg (Sesyrin) Taj Pha rma con traindicati ons, Trazodone Hydrochloride Ta blets IP 25mg; 50 mg; 100mg (Sesyrin)
Taj Pharma p rice, Trazodone Hydrochloride Ta blets IP 25mg; 5 0mg; 100 mg (Sesyrin) Taj Pha rma Taj Pha rma T razodone Hydrochlo ride Table ts IP 25mg; 50mg ; 100mg (Sesyrin ) Taj Pharma SMPC - Taj Pharma Stay connecte d to all up dated o n Trazodone Hyd rochloride Ta blets IP 25mg; 5 0mg; 100 mg (Sesyrin) Taj Pha rma Taj Pha rmaceu ticals Taj pharmaceuticals Hyderabad. Su mmary o f Pro duct Cha racteristics, SmPC.
There are no preclinical data relevant to the
prescriber, which is not presented in other areas
of the summary of medicinal product
characteristics.
6. PHARMACEUTICAL PARTICULARS
6.1 List of excipients
Microcrystalline Cellulose, Maize Starch,
Lactose Monohydrate, Crospovidone, Povidone
K30, Magnesium Stearate
Opadry Contents
Titanium Dioxide, Lactose Monohydrate,
Hydroxypropylmethylcellulose (HPMC) 2910
15cp, Polyethylene Glycol,
Hydroxypropylmethylcellulose (HPMC) 2910
3cp, Hydroxypropylmethylcellulose (HPMC)
2910 50cp, Iron Oxide Red, Indigo Carmine
aluminium Lake FD & C Blue No. 2., Iron Oxide
Yellow.
6.2 Incompatibilities
Not known.
6.3 Shelf life
2 years.
6.4 Special precautions for storage
No special precautions for storage.
6.5 Nature and contents of container
Polyvinyldene chloride coated polyvinylchloride
(60gsm), aluminium foil blisters.
Polypropylene tablet containers with
polyethylene caps (with optional polyethylene
ullage filler).
High density polyethylene (HDPE) bottle with
polyethylene snap closure.
Blister pack sizes (may or may not be in calendar
packs):- 20, 28, 30, 56, 84, 90, 100, 112, 120,
168 and 180.
HDPE and Polypropylene pack sizes: - 5, 7, 10,
15, 20, 21, 25, 28, 30, 50, 56, 60, 84, 90, 100,
112, 120, 168, 180, 200, 250 and 500.
Not all pack sizes may be marketed.
6.6 Special precautions for disposal and other
handling
No special requirements for disposal.
7. Manufactured in India By:
TAJ PHARMACEUTICALS LIMITED
At Plot No.: 220, Mahagujarat Industrial Estate,
At & Post: Moraiya, Tal – Sanand, Dist.
Ahmedabad, Gujarat, INDIA.