Ureases (EC 3.5.1.5), functionally, belong to the superfamily of amidohydrolases and phosphodiesterase. Nickel containing metalloenzyme. Ureases are found in numerous bacteria, fungi, algae, plants, and some invertebrates, as well as in soils, as a soil enzyme. Not synthesized by animals. James B. Sumner in 1926, Noble Prize in Chemistry in 1946. Urease catalyzes the hydrolysis of urea to from ammonia and Carbon dioxide