reporting of adr post marketing studies pre marketing studies detection of adr types of adr adverse drug reaction general introduction importance application toxicokinetic programmed screening blind screening single screening screening types screening method in-vitro model in-vivo model patsm animal models reproduction resipirtaory factors affecting excretion major minor routes routes of drug excretion drug excretion adme drug development pharmacokinetic human keratocytes acetylcholine apoptosis marta sloniecka research paper pathways of secondary messengers secondary messengers nitric oxide calcium ip3-dag prolactin growth hormone (somatotropin)
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