The document discusses newer aspects of iron supplementation. It summarizes that iron amino acid chelate, or ferrous bis glycinate, has advantages over other forms of iron supplementation, including being non-buffered in the stomach, non-precipitated in the intestine, not antagonized by phytates, and having superior and dependable bioavailability due to its unique chelate design, which potentially allows for smaller doses with fewer side effects. The document examines what is known, unknown, and needs to be known about different forms of iron supplementation and their absorption parameters.
Ferrous Bisglycinate is chelated iron form, in which iron is chelated with two amino acids.
Small, stable molecule with no ionic charge
Does not react with other nutrients
Bioavailable (easily absorbed)
Safe
Less gastric upset
treating anemia is a big challenge.oral iron therapy do not adequately treat IDA. IV ferric carboxy maltose (FCM)effectively treats IDA by circumventing the problem compliance of oral iron therapy.
Calcium and Vitamin D Supplementation in PregnancySujoy Dasgupta
lectured delivered by Dr Sujoy Dasgupta in the CME on "High Risk Pregnancy" organized by the BOGS (Bengal Obettric snd Gynaecological Society) and Wanburry Pharma
Ferrous Bisglycinate is chelated iron form, in which iron is chelated with two amino acids.
Small, stable molecule with no ionic charge
Does not react with other nutrients
Bioavailable (easily absorbed)
Safe
Less gastric upset
treating anemia is a big challenge.oral iron therapy do not adequately treat IDA. IV ferric carboxy maltose (FCM)effectively treats IDA by circumventing the problem compliance of oral iron therapy.
Calcium and Vitamin D Supplementation in PregnancySujoy Dasgupta
lectured delivered by Dr Sujoy Dasgupta in the CME on "High Risk Pregnancy" organized by the BOGS (Bengal Obettric snd Gynaecological Society) and Wanburry Pharma
the lecture will explain the benefits of using omega 3 in pediatric neurology cases including the use for normal brain functions development in normal babies, premature babies, GDD , cases with cortical visual defect , ADHD, Autism , and anxiety
omega 3 might be of benefits for children with epilepsy , migraine and stroke
Role of Calcium in pregnancy DR. SHARDA JAIN Dr. Jyoti Agarwal Dr. Rashmi Jai...Lifecare Centre
ROLE OF CALCIUM IN PREGNANCY
FOCUS :
Daily requirement of calcium according to age
Calcium metabolism in pregnancy
Calcium requirement in pregnancy
Maternal benefits
Fetal benefits
Reduction in blood lead levels
Nutrition to improve calcium
Guidelines about dietary calcium intake / supplements in pregnancy
Anemia in pregnancy &role of parenteral iron therapysusanta12
Iron deficiency anemia is most common anemia during pregnancy whic needs careful evaluation and treatment by Dr Susanta Kumar Behera,Department of Obstetrics & Gynecology, MKCG Medical College, Brahmapur,ODISHA,INDIA
Folic acid and vitamin B9, is one of the B vitamins.The recommended daily intake level of folate is 400 micrograms from foods or dietary supplements.Folic acid is used to treat anemia caused by folic acid deficiency.It is also used as a supplement by women during pregnancy to prevent neural tube defects (NTDs) in the baby.
The most common causes of anemia are poor nutrition, iron deficiencies, micronutrients deficiencies including folic acid, vitamin A and vitamin B12, diseases like malaria, hookworm infestation and schistosomiasis.
Vitamin D regulates estrogen biosynthesis through VDR’s
Direct regulation of the expression of the aromatase gene
Maintaining extracellular calcium homoeostasis
Vitamin D increases progesterone secretion by
Granulosa cell leutinisation – HOXA10 expression
Increased 3 β- HSD mRNA levels
Vitamin D increases placental sex steriod production
Regulates human chorionic expression
Secretion from human syncitiotrophoblasts (promoter- CYP19 )
intravenous iron sucrose is a ray of hope for treating iron defeciency anemia which is still a major problem in india. It circumvents the problem of compliance and its large safety encourages its routine use in antenatal care and is highly suitable for treating postpartum anemia...
the lecture will explain the benefits of using omega 3 in pediatric neurology cases including the use for normal brain functions development in normal babies, premature babies, GDD , cases with cortical visual defect , ADHD, Autism , and anxiety
omega 3 might be of benefits for children with epilepsy , migraine and stroke
Role of Calcium in pregnancy DR. SHARDA JAIN Dr. Jyoti Agarwal Dr. Rashmi Jai...Lifecare Centre
ROLE OF CALCIUM IN PREGNANCY
FOCUS :
Daily requirement of calcium according to age
Calcium metabolism in pregnancy
Calcium requirement in pregnancy
Maternal benefits
Fetal benefits
Reduction in blood lead levels
Nutrition to improve calcium
Guidelines about dietary calcium intake / supplements in pregnancy
Anemia in pregnancy &role of parenteral iron therapysusanta12
Iron deficiency anemia is most common anemia during pregnancy whic needs careful evaluation and treatment by Dr Susanta Kumar Behera,Department of Obstetrics & Gynecology, MKCG Medical College, Brahmapur,ODISHA,INDIA
Folic acid and vitamin B9, is one of the B vitamins.The recommended daily intake level of folate is 400 micrograms from foods or dietary supplements.Folic acid is used to treat anemia caused by folic acid deficiency.It is also used as a supplement by women during pregnancy to prevent neural tube defects (NTDs) in the baby.
The most common causes of anemia are poor nutrition, iron deficiencies, micronutrients deficiencies including folic acid, vitamin A and vitamin B12, diseases like malaria, hookworm infestation and schistosomiasis.
Vitamin D regulates estrogen biosynthesis through VDR’s
Direct regulation of the expression of the aromatase gene
Maintaining extracellular calcium homoeostasis
Vitamin D increases progesterone secretion by
Granulosa cell leutinisation – HOXA10 expression
Increased 3 β- HSD mRNA levels
Vitamin D increases placental sex steriod production
Regulates human chorionic expression
Secretion from human syncitiotrophoblasts (promoter- CYP19 )
intravenous iron sucrose is a ray of hope for treating iron defeciency anemia which is still a major problem in india. It circumvents the problem of compliance and its large safety encourages its routine use in antenatal care and is highly suitable for treating postpartum anemia...
Mais alguns estudos publicados sobre suplementação com ferro heme.
O ferro heme não é afetado por outros alimentos ou bebidas ingeridos simultaneamente.
Os largamente utilizados inibidores da bomba de prótons, tais como Losec, por exemplo, impedem a absorção de ferro não-heme e causam, em muitos casos, a depleção de ferro.
O ferro heme não se desintegra antes de ser absorvido, se comporta como uma estrutura inteira e não compete com o ferro não-heme na absorção.
Significa que o ferro heme não vai interagir com o ferro não-heme na absorção ou eficácia.
O ferro heme é absorvido como uma estrutura inteira, sem se desintegrar e sem liberar os íons de ferro livre reativos causadores dos efeitos colaterais gastrointestinais tão comuns.
Produtos de ferro heme têm potencial para complementar a terapia da anemia. Isto significaria uma economia substancial para a comunidade e uma muito melhor qualidade de vida para os pacientes.
O ferro heme funciona bem com crianças e é absorvido num grau maior do que o ferro não-heme.
Official Compounds of Iron by Subodh Pharma LearningSubodh Kamble
Class: Diploma in Pharmacy
Subject: Pharmaceutical Chemistry 1st
Topic: Official Compounds of Iron
Includes the Importance of Iron, Iron Deficiency Anemia, Iron Poisoning and its treatment, Incompatibilities of Iron Compounds
Some more published studies on heme iron supplementation. A collection of scientific published studies to draw conclusions on the properties of this unique form of iron supplementation.
What you need to know about heme iron as food supplementation and how this came about.
Iron is an important part of the red blood cells that carry oxygen to all the cells of the body. Our bodies contain 4-5 grammes of iron. It may be difficult to get enough of this important nutrient unless meat courses are part of the diet.
This is what our customers need to know. Simple answers to important questions. Heme iron unquestionably offers the best way to supplement and prevent iron depletion.
Heme iron is not affected by other simultaneously ingested food or drink.
Proton-pump inhibitors such as Losec e.g stops the uptake of non-heme iron leading to iron depletion in
many cases.
Heme iron enters as a whole structure without disintegrating before uptake and does not compete with non-heme iron for uptake.
There are few, if any, side-effects and good efficacy for heme iron when used with fertile females.
Heme Iron works well with children and is absorbed to a greater degree than syntethic iron. It will also not inhibit zinc absorption.
Heme iron will not interact with non-heme iron for uptake or efficacy.
What do we know?
Some more published studies of heme iron supplementation
Heme iron is not affected by other simultaneously ingested food or drink.
Proton-pump inhibitors such as Losec e.g stops the uptake of non-heme iron leading to iron depletion in
many cases.
Heme iron enters as a whole structure without disintegrating before uptake and does not compete with non-heme iron for uptake.
There are few, if any, side-effects and good efficacy for heme iron when used with fertile females.
Heme Iron works well with children and is absorbed to a greater degree than syntethic iron. It will also not inhibit zinc absorption.
Heme iron will not interact with non-heme iron for uptake or efficacy.
The uptake of heme iron is very high, up to 40 %
O ferro heme não é afetado por outro alimento ou bebida simultaneamente ingerido.
Os inibidores da bomba de prótons, como Losec por exemplo, interrompem a absorção do ferro não-heme levando à depleção de ferro em muitos casos.
O ferro heme é absorvido como uma unidade, sem se desintegrar antes da absorção e não compete com o ferro não-heme para a absorção.
Poucos efeitos colaterais e boa eficácia para o ferro heme quando usado por mulheres férteis.
Ferro heme funciona bem com crianças e é absorvido em maior grau do que o ferro sintético. Também não irá inibir a absorção de zinco.
O ferro heme não vai interagir com ferro não-heme para absorção e eficácia.
A absorção do ferro heme é muito elevada,
Small Linear/ Cyclic Bioactive/Synthetic peptides for the treatment of Iron Deficiency Anaemia. Softwares used were licenced versions. Method is specific for laboratory scale only, for fine crystals, Glycine / Alanine are better starting materials.
Essentials of Automations: Optimizing FME Workflows with ParametersSafe Software
Are you looking to streamline your workflows and boost your projects’ efficiency? Do you find yourself searching for ways to add flexibility and control over your FME workflows? If so, you’re in the right place.
Join us for an insightful dive into the world of FME parameters, a critical element in optimizing workflow efficiency. This webinar marks the beginning of our three-part “Essentials of Automation” series. This first webinar is designed to equip you with the knowledge and skills to utilize parameters effectively: enhancing the flexibility, maintainability, and user control of your FME projects.
Here’s what you’ll gain:
- Essentials of FME Parameters: Understand the pivotal role of parameters, including Reader/Writer, Transformer, User, and FME Flow categories. Discover how they are the key to unlocking automation and optimization within your workflows.
- Practical Applications in FME Form: Delve into key user parameter types including choice, connections, and file URLs. Allow users to control how a workflow runs, making your workflows more reusable. Learn to import values and deliver the best user experience for your workflows while enhancing accuracy.
- Optimization Strategies in FME Flow: Explore the creation and strategic deployment of parameters in FME Flow, including the use of deployment and geometry parameters, to maximize workflow efficiency.
- Pro Tips for Success: Gain insights on parameterizing connections and leveraging new features like Conditional Visibility for clarity and simplicity.
We’ll wrap up with a glimpse into future webinars, followed by a Q&A session to address your specific questions surrounding this topic.
Don’t miss this opportunity to elevate your FME expertise and drive your projects to new heights of efficiency.
Elevating Tactical DDD Patterns Through Object CalisthenicsDorra BARTAGUIZ
After immersing yourself in the blue book and its red counterpart, attending DDD-focused conferences, and applying tactical patterns, you're left with a crucial question: How do I ensure my design is effective? Tactical patterns within Domain-Driven Design (DDD) serve as guiding principles for creating clear and manageable domain models. However, achieving success with these patterns requires additional guidance. Interestingly, we've observed that a set of constraints initially designed for training purposes remarkably aligns with effective pattern implementation, offering a more ‘mechanical’ approach. Let's explore together how Object Calisthenics can elevate the design of your tactical DDD patterns, offering concrete help for those venturing into DDD for the first time!
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
Connector Corner: Automate dynamic content and events by pushing a buttonDianaGray10
Here is something new! In our next Connector Corner webinar, we will demonstrate how you can use a single workflow to:
Create a campaign using Mailchimp with merge tags/fields
Send an interactive Slack channel message (using buttons)
Have the message received by managers and peers along with a test email for review
But there’s more:
In a second workflow supporting the same use case, you’ll see:
Your campaign sent to target colleagues for approval
If the “Approve” button is clicked, a Jira/Zendesk ticket is created for the marketing design team
But—if the “Reject” button is pushed, colleagues will be alerted via Slack message
Join us to learn more about this new, human-in-the-loop capability, brought to you by Integration Service connectors.
And...
Speakers:
Akshay Agnihotri, Product Manager
Charlie Greenberg, Host
Software Delivery At the Speed of AI: Inflectra Invests In AI-Powered QualityInflectra
In this insightful webinar, Inflectra explores how artificial intelligence (AI) is transforming software development and testing. Discover how AI-powered tools are revolutionizing every stage of the software development lifecycle (SDLC), from design and prototyping to testing, deployment, and monitoring.
Learn about:
• The Future of Testing: How AI is shifting testing towards verification, analysis, and higher-level skills, while reducing repetitive tasks.
• Test Automation: How AI-powered test case generation, optimization, and self-healing tests are making testing more efficient and effective.
• Visual Testing: Explore the emerging capabilities of AI in visual testing and how it's set to revolutionize UI verification.
• Inflectra's AI Solutions: See demonstrations of Inflectra's cutting-edge AI tools like the ChatGPT plugin and Azure Open AI platform, designed to streamline your testing process.
Whether you're a developer, tester, or QA professional, this webinar will give you valuable insights into how AI is shaping the future of software delivery.
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...Ramesh Iyer
In today's fast-changing business world, Companies that adapt and embrace new ideas often need help to keep up with the competition. However, fostering a culture of innovation takes much work. It takes vision, leadership and willingness to take risks in the right proportion. Sachin Dev Duggal, co-founder of Builder.ai, has perfected the art of this balance, creating a company culture where creativity and growth are nurtured at each stage.
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024Albert Hoitingh
In this session I delve into the encryption technology used in Microsoft 365 and Microsoft Purview. Including the concepts of Customer Key and Double Key Encryption.
Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024Tobias Schneck
As AI technology is pushing into IT I was wondering myself, as an “infrastructure container kubernetes guy”, how get this fancy AI technology get managed from an infrastructure operational view? Is it possible to apply our lovely cloud native principals as well? What benefit’s both technologies could bring to each other?
Let me take this questions and provide you a short journey through existing deployment models and use cases for AI software. On practical examples, we discuss what cloud/on-premise strategy we may need for applying it to our own infrastructure to get it to work from an enterprise perspective. I want to give an overview about infrastructure requirements and technologies, what could be beneficial or limiting your AI use cases in an enterprise environment. An interactive Demo will give you some insides, what approaches I got already working for real.
8. What me may not know! How do the iron salts compare, with each claiming to be better!
9.
10. Iron formulation adoption curve Unrealistic Over-enthusiasm Initial optimism Backlash antipathy Realistic adoption New concept
11. Iron absorption parameters 6.Bioavailability 5. Elemental iron 7. Phytate inhibition 2. Form administered 4. Dose 3. Status of patient's iron stores 1. Stability in gastric acids
12. Iron absorption parameters Elemental iron: Amount of iron in a supplement that is available for absorption. Bioavailability: Fraction of the elemental iron that reaches the systemic circulation Phytate inhibition reducing the absorption of iron by 15-fold
Speaker Notes For purposes of this presentation, we will use the definitions on this and the following 3 slides Many of these definitions have been established by organizations involved in developing nutritional guidelines for groups and populations Some of them were agreed upon by the Council for purposes of the roundtable discussion—these are marked with a double asterisk We will use these definitions to maintain a common language as we discuss prenatal nutrition I won’t comment on all of them, but will focus on those that may not be as familiar as others An adequate intake, or AI, value is established for a nutrient when there is insufficient scientific data available to establish an RDA An AI level generally meets or exceeds the amount of a nutrient needed to maintain an adequate nutritional state in the majority of members of a specific age and gender group Dietary reference intakes , or DRIs , are a comprehensive set of nutrient reference values for healthy populations that can be used to plan and assess appropriate diets DRIs reflect the current state of scientific knowledge regarding nutrient requirements and include RDAs, AIs , and tolerable upper intake levels
Speaker Notes For purposes of this presentation, we will use the definitions on this and the following 3 slides Many of these definitions have been established by organizations involved in developing nutritional guidelines for groups and populations Some of them were agreed upon by the Council for purposes of the roundtable discussion—these are marked with a double asterisk We will use these definitions to maintain a common language as we discuss prenatal nutrition I won’t comment on all of them, but will focus on those that may not be as familiar as others An adequate intake, or AI, value is established for a nutrient when there is insufficient scientific data available to establish an RDA An AI level generally meets or exceeds the amount of a nutrient needed to maintain an adequate nutritional state in the majority of members of a specific age and gender group Dietary reference intakes , or DRIs , are a comprehensive set of nutrient reference values for healthy populations that can be used to plan and assess appropriate diets DRIs reflect the current state of scientific knowledge regarding nutrient requirements and include RDAs, AIs , and tolerable upper intake levels
