This document provides a summary of haematinics - agents used to treat various types of anaemia. It discusses iron, vitamin B12 and folic acid deficiencies which can cause anaemia. It then focuses on iron deficiency anaemia, its causes, symptoms as hypochromic microcytic anaemia. Treatment includes oral iron preparations like ferrous gluconate and ferrous sulfate. The distribution, requirements and sources of dietary iron are outlined. Finally, the structure and function of haemoglobin as the oxygen carrying pigment in red blood cells is described.
Official Compounds of Iron by Subodh Pharma LearningSubodh Kamble
Class: Diploma in Pharmacy
Subject: Pharmaceutical Chemistry 1st
Topic: Official Compounds of Iron
Includes the Importance of Iron, Iron Deficiency Anemia, Iron Poisoning and its treatment, Incompatibilities of Iron Compounds
Official Compounds of Iron by Subodh Pharma LearningSubodh Kamble
Class: Diploma in Pharmacy
Subject: Pharmaceutical Chemistry 1st
Topic: Official Compounds of Iron
Includes the Importance of Iron, Iron Deficiency Anemia, Iron Poisoning and its treatment, Incompatibilities of Iron Compounds
Iron poisoning (physical appearance, sources- dietary and environmental, uses- industrial and biological, usual fatal dose, toxicokinetics, mode of action, clinical features, diagnosis, treatment, autopsy features
Hematinics and Erythropoietin- Pharmacology of Hematinicsnetraangadi2
Pharmacology of Hematinics - pharmacology of Iron preparations including both oral and parenteral preparations
Treatment of iron deficiency anemia and vit B 12 deficiency Anemia
Differential diagnosis of IDA and Thalasemia or acute chronic diseases, ELISA, Total iron, TIBC, Serum Transferrin, Peripheral Smear, Complete blood count.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Iron poisoning (physical appearance, sources- dietary and environmental, uses- industrial and biological, usual fatal dose, toxicokinetics, mode of action, clinical features, diagnosis, treatment, autopsy features
Hematinics and Erythropoietin- Pharmacology of Hematinicsnetraangadi2
Pharmacology of Hematinics - pharmacology of Iron preparations including both oral and parenteral preparations
Treatment of iron deficiency anemia and vit B 12 deficiency Anemia
Differential diagnosis of IDA and Thalasemia or acute chronic diseases, ELISA, Total iron, TIBC, Serum Transferrin, Peripheral Smear, Complete blood count.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Hemodialysis: Chapter 3, Dialysis Water Unit - Dr.Gawad
UNIT-IV_Haematinics.pdf
1. See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/321938743
PHARMACEUTICAL INORGANIC CHEMISTRY: Haematinics
Presentation · December 2017
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2. PHARMACEUTICAL INORGANIC CHEMISTRY (BP104T) UNIT – IV: Haematinics
Dr. Sumanta Mondal_ Lecture Notes_B.Pharm-I Sem._GITAM UNIVERSITY
E-mail: logonchemistry@gmail.com
1
HAEMATINICS are the agents used for formation of blood to treat various types of anaemia’s. These include:
Iron, Vitamin B12 and Folic Acid.
ANAEMIA
- Decreased capacity of RBCs to carry oxygen to tissues.
- Anaemia occurs when the balance between production and destruction of RBCs is disturbed by:
(a) Blood loss (acute or chronic)
(b) Impaired red cell formation due to:
Deficiency of essential factors, i.e. iron, vitamin B12, folic acid.
Bone marrow depression (hypoplastic anaemia), erythropoietin deficiency.
(c) Increased destruction of RBCs (haemolytic anaemia)
- Iron deficiency occurs due to:
1. Malnutrition
2. Loss
3. Congenital atransferrinemia (inability to release iron from transferrin)
- Types of Anaemia:
1. Microcytic hypochromic–mainly due to iron deficiency.
2. Macrocytic/megaloblastic –mainly due to deficiency of vitamin B12 and folic acid
3. Haemolytic Anaemia
4. Pernicious Anaemia –decreased intrinsic factor
HAEMATOPOIESIS
- The production of circulating erythrocytes, leukocytes and platelets from undifferentiated stem cells, is called
haematopoiesis.
It requires:
1. Iron –for Hb formation
2. Vitamin B12
3. Folic acid
4. Hematopoietic growth factors
5. Proteins that regulate the proliferation and differentiation of hematopoietic cells.
DISTRIBUTION OF IRON IN BODY
- Iron is an essential body constituent. Total body iron in an adult is 2.5-5 g (average 3.5 g). It is more in men (50
mg/ kg) than in women (38 mg/kg).
- It is distributed into:
Haemoglobin (Hb) : 66%
Iron stores as ferritin and haemosiderin : 25%
Myoglobin (in muscles) : 3%
Parenchymal iron (in enzymes, etc.) : 6%
- Haemoglobin is a protoporphyrin; each molecule having 4 iron containing haeme residues. It has 0.33% iron; thus
loss of 100 ml of blood (containing 15 g Hb) means loss of 50 mg elemental iron. To raise the Hb level of blood
by 1 g/ dl about 200 mg of iron is needed. Iron is stored only in ferric form, in combination with a large protein
apoferritin.
DAILY REQUIREMENT OF IRON
- To make good average daily loss, iron requirements are:
Adult male : 0.5--1 mg (13µg/kg)
Adult female (menstruating) :1-2 mg (21µg/kg)
Infants : 60µg/kg
Children : 25µg/kg
Pregnancy : 3-5µg/kg
3. PHARMACEUTICAL INORGANIC CHEMISTRY (BP104T) UNIT – IV: Haematinics
Dr. Sumanta Mondal_ Lecture Notes_B.Pharm-I Sem._GITAM UNIVERSITY
E-mail: logonchemistry@gmail.com
2
DIETARY SOURCES OF IRON
Rich : Liver, egg yolk, oyster, dry beans, dry fruits, wheat germ, yeast.
Medium : Meat, chicken, fish, spinach, banana, apple.
Poor : Milk and its products, root vegetables.
FACTORS FACILITATING IRON ABSORPTION
Acid: Acid enhances dissolution and reduction of ferric iron.
Reducing Substances: Ascorbic acid reduces ferric iron and forms absorbable complexes
Meat: Meat also facilitates iron absorption by increasing HCl secretion
Pregnancy/ Menstruation: Due to increased iron requirement
FACTORS IMPEDING IRON ABSORPTION
Phosphates: Phosphates are present in egg yolk.
Phytates: Phytates occur in wheat and maize
Alkalies: Alkalies form non-absorbable complexes as well and oppose the reduction
Tetracyclines: Tetracyclines impede absorption.
ELIMINATION OF IRON
No mechanism is present for elimination of iron from body except exfoliation of intestinal cells. Trace amounts
of iron are lost in faeces, urine, bile and sweat.
Less than 1 mg/day of iron is lost.
IRON DEFICIENCY ANAEMIA
Iron deficiency anaemia manifests as hypochromic, microcytic anaemia, in which:
(i) Erythrocyte mean cells volume is low (ii) Mean cell Hb concentration is low
Causes
A. People with increased iron requirements
i. Infants
ii. Children during rapid growth
iii. Pregnant and lactating women
iv. Patients of chronic kidney disease (due to increased loss during haemodialysis)
B. Inadequate iron absorption seen in
i. Gastrectomy [A gastrectomy is a medical procedure where all or part of the stomach is surgically removed].
ii. Generalized malabsorption
iii. Females, menstrual bleeding or during postmenopausal
iv. Males and most common site is GIT.
C. Adults, due to blood loss
TREATMENT OF IRON DEFICIENCY
Oral preparations can be used. Oral preparation is present in the form of salts like: Ferrous gluconate, Ferrous
sulphate, Ferrous fumarate.
Parenteral Therapy: Iron dextran, Sodium ferric gluconate complex, Iron sucrose.
Adverse effect of oral iron preparation: Individuals differ in susceptibility like epigastric pain, heartburn,
nausea, vomiting, staining of teeth, metallic taste, bloting, colic and Constipation is more common (believed to
be due to astringent action of iron).
FORMULA FOR CALCULATING TOTAL DOSE OF IRON IN GRAMS
- Dose of iron in grams = 0.25 x (normal Hb – Patients Hb)
- Iron requirement (mg) = 4.4 x body weight (kg) x Hb deficit (g/ dl)
[Hb = -Haemoglobin]
Bloat is any abnormal gas swelling, or increase in diameter of the abdominal area. As a symptom, the patient feels a full and tight
abdomen, which may cause abdominal pain and is sometimes accompanied by increased stomach growling, or more seriously, the
total lack of it.
4. PHARMACEUTICAL INORGANIC CHEMISTRY (BP104T) UNIT – IV: Haematinics
Dr. Sumanta Mondal_ Lecture Notes_B.Pharm-I Sem._GITAM UNIVERSITY
E-mail: logonchemistry@gmail.com
3
Iron(II)sulphate or Ferrous sulfate
Molecular formula FeSO4• xH2O
Molar mass FeSO4•7H2O 278.02 g/mol
Synonym Green vitriol, Iron vitriol, Copperas
Properties
Appearance :
White crystals (anhydrous); White yellow crystals (monohydrate);
Blue green crystals (heptahydrate)
Crystal structure : Orthorhombic (anhydrous); Monoclinic (heptahydrate);
Odor : Odorless
Taste : Astringents and metallic taste
Density : 3.65 g/cm3
(anhydrous); 3 g/cm3
(monohydrate); 1.895 g/cm3
(heptahydrate)
Melting point : 6800
C (anhydrous); 3000
C (monohydrate); 60–640
C (heptahydrate)
Solubility in water :
Monohydrate: 44.69 g/100 mL (770
C);
Heptahydrate: 15.65 g/100 mL (00
C); 20.5 g/100 mL (100
C); 29.51 g/100 mL (250
C);
39.89 g/100 mL (40.10
C); 51.35 g/100 mL (540
C)[
Refractive index : 1.591 (monohydrate); 1.471 (heptahydrate)
Preparation
- In the finishing of steel prior to plating or coating, the steel sheet or rod is passed through pickling baths of
sulfuric acid. This treatment produces large quantities of iron(II) sulfate as a byproduct.
Fe + H2SO4 → FeSO4 + H2
- Ferrous sulfate is also prepared commercially by oxidation of pyrite
2 FeS2 + 7 O2 + 2 H2O → 2 FeSO4 + 2 H2SO4
Reaction
- On heating, iron (II) sulfate first loses its water of crystallization and the original green crystals are converted
into a brown colored anhydrous solid. When further heated, the anhydrous material releases sulfur dioxide and
white fumes of sulfur trioxide, leaving a reddish-brown iron (III) oxide [Ferric oxide] at about 6800
C.
2 FeSO4 → Fe2O3 + SO2 + SO3
- Iron (II) sulfate is a reducing agent. For example, it reduces nitric acid to nitrogen monoxide and chlorine to
chloride.
6 FeSO4 + 3 H2SO4 + 2 HNO3 → 3 Fe2(SO4)3 + 4 H2O + 2 NO
6 FeSO4 + 3 Cl2 → 2 Fe2(SO4)3 + 2 FeCl3
- Upon exposure to air, it oxidizes to form a corrosive brown-yellow coating of "basic ferric sulfate", which is an
adduct of iron(III) oxide and iron(III) sulfate:
12 FeSO4 + 3 O2 → 4 Fe2(SO4)3 + 2 Fe2O3
5. PHARMACEUTICAL INORGANIC CHEMISTRY (BP104T) UNIT – IV: Haematinics
Dr. Sumanta Mondal_ Lecture Notes_B.Pharm-I Sem._GITAM UNIVERSITY
E-mail: logonchemistry@gmail.com
4
Assay
- Assay based on oxidation-reduction titration methods.
- Weight accurate about 0.5 gm of ferrous sulfate, dissolved in a mixture of 25 m of dilute sulfuric acid and 25 ml of
freshly boiled and cooled water, and titrate with 0.02M Potassium permanganate.
- Each ml 0.02M Potassium permanganate is equivalent to 27.802 mg of FeSO4•7H2O (ferrous sulfate heptahydrate)
- Each ml 0.02M Potassium permanganate is equivalent to 27.802 mg of FeSO4 (Anhydrous ferrous sulfate)
Uses
- Ferrous sulfate is a haematinic agents, it is used to treat and prevent iron deficiency anaemia.
- Ferrous sulfate was used in the manufacture of inks, most notably iron gall ink
- Woodworkers use ferrous sulfate solutions to color maple wood a silvery hue.
- In horticulture it is used for treating iron chlorosis.
- Ferrous sulfate is sometimes added to the cooling water flowing through the brass tubes of turbine condensers to
form a corrosion resistant protective coating.
- It is used in gold refining.
- Green vitriol is also a useful reagent in the identification of mushrooms.
Dose: 60 mg to 600 mg
Ferrous sulfate side effects
- Constipation
- Upset stomach
- Black or dark‐colored stools or
- Temporary staining of the teeth
Drug-Drug interaction with ferrous sulfate
- Chloramphenicol
- Cimetidine
- Levodopa
- Methyldopa
- Penicillamine
Storage: Store in amber color bottle or light resistant container.
Note By:
o Hypochromic anemia is a generic term for any type of anemia in which the red blood cells (erythrocytes) are
paler than normal. (Hypo- refers to less, and chromic means color.) A normal red blood cell will have an area of
pallor in the center of it; it is biconcave disk shaped. In hypochromic cells, this area of central pallor is increased.
This decrease in redness is due to a disproportionate reduction of red cell hemoglobin.
o PALLOR means an unhealthy pale appearance.
6. PHARMACEUTICAL INORGANIC CHEMISTRY (BP104T) UNIT – IV: Haematinics
Dr. Sumanta Mondal_ Lecture Notes_B.Pharm-I Sem._GITAM UNIVERSITY
E-mail: logonchemistry@gmail.com
5
Ferrous gluconate
Properties
Appearance : A greenish-yellow to grey powder or granules
Odor : Slight caramel odor
Taste : Caramel test
Melting point : 1880
C
Solubility :
Freely but slowly soluble in water giving a greenish-brown solution, more readily
soluble in hot water, practically insoluble in alcohol, but soluble in glycerin.
Preparation:
- Gluconic acid is first prepared by oxidation of glucose by dilute nitric acid, and then barium carbonate is
added to get barium gluconate. This is treated with ferrous sulfate which gives ferrous gluconate.
Uses
- Ferrous gluconate is effectively used in the treatment of hypochromic anemia.
- Ferrous gluconate is also used as a food additive when processing black olives.
Possible side effects of ferrous gluconate
- Common Side Effects: Constipation; darkened or green stools; diarrhea; loss of appetite; nausea; stomach
cramps, pain, or upset; vomiting.
- Severe Side Effects: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest;
swelling of the mouth, face, lips, or tongue); black, tarry stools; blood or streaks of blood in the stool; fever;
severe or persistent nausea, stomach pain, or vomiting; vomit that looks like blood or coffee grounds.
Dose:
Men: 8 mg/day; Women: 18 mg/day; Pregnant women: 27 mg/day; Lactating women: 9 mg/day
Molecular formula C12H22FeO14• xH2O
Molar mass FeSO4•7H2O 446.1 (anhydrous)
Synonym Ferrosi gluconas
7. PHARMACEUTICAL INORGANIC CHEMISTRY (BP104T) UNIT – IV: Haematinics
Dr. Sumanta Mondal_ Lecture Notes_B.Pharm-I Sem._GITAM UNIVERSITY
E-mail: logonchemistry@gmail.com
6
Structure and functions of haemoglobin
- Haemoglobin is an oxygen carrying pigment, which is present in red blood cells.
- It has two parts (i) Heme which is a prosthetic group (ii) Globin protein.
- Heme containing proteins present in aerobic animals and concerned with the transport of oxygen.
- Heme part is same in all the animals; the difference is in the globin chains, which have different amino acids in
different animals.
Structure of haemoglobin:
- Heme has one central iron, which is attached to four pyrrole rings. The iron is the forum of ferric ion. the pyrrole ring
are connected by methylene bridges.
- Globulins are the protein parts and consist of four chains.
- In human there are two alpha chains and other two may be beta, delta, gamma or epsilon depending on the type of
haemoglobin.
Function of haemoglobin:
- As oxygen and carbon dioxide carrier.
- The red color of blood is due to haemoglobin.
- Buffering action.
- Haemoglobin plays an important role in the modulation of erythrocyte metabolism.
- Transportation
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