Sodium cromoglycate was discovered in 1965 as a treatment for asthma and allergic reactions. It acts as a mast cell stabilizer, inhibiting the release of chemical mediators from sensitized mast cells and preventing asthmatic attacks. Sodium cromoglycate is used as an inhaler, nasal spray, or eye drops to treat conditions like bronchial asthma, allergic rhinitis, and allergic conjunctivitis. Common side effects include skin rashes, bronchospasm, and throat irritation. It is poorly absorbed orally but absorption increases when used as an aerosol inhaler.

3. INTRODUCTION:
Sodium Cromoglycate also known as Sodium
Cromoglicate. a synthetic non-steroidal anti-
inflammatory drug, inhaled to prevent asthmatic
attacks and allergic reactions.
Sodium cromoglycate is traditionally described as a
mast cell stabilizer, and is commonly marketed as
the sodium salt, sodium cromoglycate or cromolyn
sodium

4. Sodium cromoglycate (SCG) was discovered
in1965 by the late Dr. Roger Altounyan (who was
himself a lifelong asthma sufferer)
developed by Fisons Pharmaceuticals for use as
an inhaled drug in asthma, primarily of allergic
origin. The drug was selected after over 200
compounds had been tested by Altounyan

5. Sodium cromoglycate acts by inhibiting the release of
chemical mediators from sensitized mast cells. It is used in
the prophylactic treatment of both allergic and exercise-
induced asthma, but does not affect an established
asthmatic attack.
Cromolyn sodium probably interferes with the antigen-
stimulated calcium transport across the mast cell
membrane, thereby inhibiting mast cell release of
histamine, leukotrienes, and other substances that cause
hypersensitivity reactions.

6. BRONCHIAL ASTHMA
ALLERGIC RHINITIS
ALLERGIC CONGUCTIVITUS

7. AS AN INHALER: (Fintal inhaler)
PREPARATION: 1mg metered dose inhaler.
DOSE: 2 puffs (Q.I.D)
AS A NASAL SPRAY : (Fintal nasal spray)
PREPARATION: 2% aqueous solution
DOSE: 2 squeezes in each nostrils (Q.I.D)
AS EYE DROPS: (Fintal eye drops)
PREPARATION: 2% aqueous solution
DOSE: 1 drop in each eye (Q.I.D)

8. Skin rashes
Bronchospasm
Throat irritation
dizziness
Flare up of skin
Arthralgia
Sometime urticaria

9. ABSORPTION: poorly absorbed orally i.e. 0.5% but in
the form of aerosol its absorption rate increased up
to 1.5%
ELIMINATION: most of absorbed drug is excreted
unchanged by liver & kidneys within a few days &
none appears to undergo metabolic degradation.