This document summarizes amebiasis, caused by the intestinal protozoan Entamoeba histolytica. The parasite is typically acquired by ingesting cysts from fecally contaminated food, water or surfaces. In the intestines, trophozoites emerge which can invade the intestinal lining in some cases, causing a spectrum of symptoms from dysentery to liver abscesses. Amebiasis is common in developing areas with poor sanitation, though travelers and immigrants are also at risk. Diagnosis involves examining stool samples microscopically and using serology tests. Treatment involves antimicrobial drugs to eliminate the parasite from the intestines and treat extra-intestinal infections.
Amebiasis is a disease caused by a one-celled parasite called Entamoeba histolytica (ent-a-ME-ba his-to-LI-ti-ka).
Who is at risk for amebiasis?
Although anyone can have this disease, it is most common in people who live in developing countries that have poor sanitary conditions. In the United States, amebiasis is most often foundin immigrants from developing countries. It also is found in people who have traveled to developing countries and in people who live in institutions that have poor sanitary conditions. Men who have sex with men can become infected and can get sick from the infection, but they often do not have symptoms.
by Mostafa Mohammadzadeh fallah (MedStudent Iran)
Amebiasis is a disease caused by a one-celled parasite called Entamoeba histolytica (ent-a-ME-ba his-to-LI-ti-ka).
Who is at risk for amebiasis?
Although anyone can have this disease, it is most common in people who live in developing countries that have poor sanitary conditions. In the United States, amebiasis is most often foundin immigrants from developing countries. It also is found in people who have traveled to developing countries and in people who live in institutions that have poor sanitary conditions. Men who have sex with men can become infected and can get sick from the infection, but they often do not have symptoms.
by Mostafa Mohammadzadeh fallah (MedStudent Iran)
Typhoid perforation is a serious complication of typhoid fever, a bacterial infection caused by Salmonella typhi. It occurs when the infection causes a hole to form in the wall of the intestine, leading to the leakage of contents from the intestine into the abdominal cavity. This can cause severe infection and inflammation of the abdominal cavity, known as peritonitis.
The symptoms of typhoid perforation may include severe abdominal pain, fever, nausea and vomiting, diarrhea or constipation, and signs of shock such as low blood pressure and rapid heart rate. In some cases, there may also be visible signs of a perforation, such as a palpable abdominal mass or signs of fluid accumulation in the abdomen.
The diagnosis of typhoid perforation is typically made through a combination of physical examination, laboratory tests, and imaging studies such as X-rays or CT scans. Treatment typically involves surgical repair of the perforation and aggressive management of the infection and inflammation. This may include antibiotics, intravenous fluids, and other supportive care measures such as pain management and nutritional support.
It is important to seek prompt medical attention if you suspect you or someone you know may have typhoid fever or typhoid perforation. Early diagnosis and treatment are essential for a successful outcome and to prevent further complications.
A concise revision on the pathology and current management of liver hepatic cysts and abscesses. Being a copy of seminar presentation I for the HepatoPancreaticoBiliary Unit of the Division of General Surgery, Ahmadu Belllo University Teaching Hospital, Zaria.
Amoebiasis is an intestinal infection caused by the parasite Entamoeba histolytica. While it can affect individuals of all ages, including pediatric populations, it is more common in areas with poor sanitation and hygiene practices.
In pediatrics, amoebiasis can present with a range of symptoms, which can vary from mild to severe. Some children may be asymptomatic carriers, meaning they carry the parasite without showing any signs of illness. However, when symptoms do occur, they typically include diarrhea, abdominal pain, bloating, and sometimes blood or mucus in the stool. In severe cases, the infection can lead to dysentery, with frequent, watery, and bloody stools, along with fever and dehydration.
Amoebiasis is transmitted through the ingestion of food or water contaminated with fecal matter containing the parasite. This can occur through improper handwashing, consumption of contaminated food or water, or contact with contaminated surfaces. The parasite can also spread from person to person in areas with poor sanitation.
Diagnosing amoebiasis in pediatric patients involves laboratory testing of stool samples to identify the presence of Entamoeba histolytica. Treatment typically involves medications to eliminate the parasite, such as metronidazole or tinidazole. In some cases, additional medications may be prescribed to alleviate symptoms and manage complications.
Prevention of amoebiasis in pediatrics focuses on practicing good hygiene and ensuring the consumption of clean and safe food and water. Measures include regular handwashing, especially before eating or handling food, drinking purified or boiled water, avoiding raw or undercooked foods, and maintaining hygienic conditions in food preparation and storage.
Early recognition and appropriate treatment of amoebiasis in pediatrics are important to alleviate symptoms, prevent complications, and minimize the risk of transmission to others. Parents and caregivers should seek medical attention if they suspect their child has amoebiasis or if the child develops persistent diarrhea or other concerning symptoms.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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2. Amoebiasis
Amebiasis is a disease which is caused by the intestinal
protozoan Entamoeba histolytica.
- About 90 % of diseases are asymptomatic, and
the remaining 10 % produce a spectrum of clinical syndromes
ranging from dysentery to abscesses of the liver or other
organs.
3. LIFE CYCLE AND TRANSMISSION
• E. histolytica is acquired by ingestion of
viable cysts from fecally contaminated
water, food or hands.
• Less common means of transmission
include contaminated water, oral and
anal sexual practices, and in rare
instances direct rectal inoculation through
colonic irrigation devices
4. • Motile trophozoites are released
from cysts in the small intestine
and, in most patients, remain as
harmless commensals in the
large bowel.
• After encystation, infectious cysts
are shed in the stool and can
survive for several weeks in a
moist environment.
• In some patients, the trophozoites
invade either the bowel mucosa,
causing symptomatic colitis, or
the bloodstream, causing distant
abscesses of the liver, lungs, or
brain
5. EPIDEMIOLOGY
• About 10 % of the world's population is infected
with E. histolytica;
• Amebiasis is the third most common cause of
death from parasitic disease (after
schistosomiasis and malaria).
• Areas of highest incidence (due to inadequate
sanitation and crowding) include most
developing countries in the tropics, particularly
Mexico, India, and nations of Central and South
America, tropical Asia, and Africa.
• The main groups at risk in developed countries
are travelers, recent immigrants, homosexual
men, and inmates of institutions.
6. PATHOGENESIS AND PATHOLOGY
• Both trophozoites and cysts are found in the
intestinal lumen, but only trophozoites invade
tissue.
• The trophozoite is 20 to 60 um in diameter and
contains vacuoles and a nucleus with a
characteristic central karyosome.
• In animals, depletion of intestinal mucus, diffuse
inflammation, and disruption of the epithelial
barrier occur before trophozoites actually come
into contact with the colonic mucosa.
• Trophozoites attach to colonic mucus and
epithelial cells by a galactose-inhibitable lectin.
7. PATHOGENESIS AND
PATHOLOGY
• The earliest intestinal lesions are
microulcerations of the mucosa of
the cecum, sigmoid colon, or
rectum that release
erythrocytes, inflammatory
cells, and epithelial cells.
• Proctoscopy reveals small ulcers
with heaped up margins and
normal intervening mucosa.
• Submucosal extension of
ulcerations under viable-
appearing surface mucosa
causes the classic "flask-shaped"
ulcer containing trophozoites at
the margins of dead and viable
tissues.
8. ETIOLOGY
Entamoeba histolytica –
forma magna, f. minuta, f.
cystica
CLINICAL SYNDROME
Intestinal Amebiasis
• The most common type of
amebic infection is
asymptomatic cyst passage.
Even in highly endemic areas,
most patients harbor
nonpathogenic strains.
9. Incubation period – some days to 3-4
months
Acute amoebiasis
• Symptomatic amebic colitis develops 2 to 6
weeks after the ingestion of infectious cysts.
• Lower abdominal pain and mild diarrhea
develop gradually and are followed by malaise,
weight loss, and diffuse lower abdominal or
back pain.
• Cecal involvement may mimic acute
appendicitis.
• Patients with full-blown dysentery may pass 10
to 12 stools per day.
• The stools contain little fecal material and
consist mainly of blood and mucus.
• In contrast to those with bacterial diarrhea,
fewer than 40 % of patients with amebic
dysentery are febrile.
• Virtually all patients have heme-positive stools.
10. • In contrast to those with bacterial
diarrhea, fewer than 40 % of patients with
amebic dysentery are febrile.
• Virtually all patients have heme-positive
stools.
• More fulminant intestinal infection, with
severe abdominal pain, high fever, and
profuse diarrhea, is rare and occurs
predominantly in children.
• Patients may develop toxic megacolon, in
which there is severe bowel dilation with
intramural air.
11. • Amebomas are inflammatory mass
lesions that develop owing to chronic
intestinal forms of amebiasis.
• An occasional patient presents only with
an asymptomatic or tender abdominal
mass caused by an ameboma, which is
easily confused with cancer on barium
studies. A positive serologic test or
biopsy can prevent unnecessary surgery
in this setting.
• The syndrome of postamebic
colitis persistent diarrhea following
documented cure of amebic colitis is
controversial; no evidence of recurrent
amebic infection can be found, and re-
treatment usually has no effect.
12. Amebic Liver Abscess
• Extraintestinal infection by E.
histolytica most often involves the
liver. Pleuropulmonary
involvement, which is reported in
20 to 30 % of patients, is the most
frequent complication of amebic
liver abscess.
• Liver
scans, ultrasonography, computed
tomography and magnetic
resonance imaging are all useful
for detection of the round or oval
hypoechoic cyst.
13. • the typical patient with amebic colitis
has less prominent fever than in
these conditions and heme-positive
stools with few neutrophils,
• correct diagnosis requires bacterial
cultures, microscopic examination of
stools, and amebic serologic testing.
14. TREATMENT
Tissue amebicides
• Metronidazole ( Trichomonacid, Flagyl, Klion, Efloran)
tb. 0,25 gr, 30 mg/kg, 3/day, 8-10 days;
• Tinidazole (Fasigyn)
tb. 0,150, 0,5 gr, 2,o gr , 2/day, 3-5 days;
• Dehydroemetin
tb. 0,01 gr, amp. 2 ml.(0,06 gr), dose 1-1,5 mg/kg/day,
per os - 2 tb. 3 /day, i.m. - 1-1,5 mg/kg max. 90
mg/day, 3/day, 5-10 days.
• Amoebic abscesses
Dehydroemetin – Arthrochin или Chloroquin 1 gr/day,
4 х 1, 2 days and 2х1 tb 25 days,
In children - 10 mg/kg/day, 2-3 weeks, till 300
mg/day, Tetracyclin tb. 0,25 gr, 2,о gr , 4 times per
day, 10 days.
• Patients with cysts - Metronidazole, Diloxinide tb.0,5 gr
3 x1, 10 days, Dijodoquin
15. PREVENTION
• Amebic infection is spread by ingestion of food
or water contaminated with cysts.
• Since an asymptomatic carrier may excrete up
to 15 million cysts per day, prevention of
infection requires adequate sanitation and
eradication of cyst carriage.
• In high-risk areas, infection can be minimized by
the avoidance of unpeeled fruits and vegetables
and the use of bottled water.
• Because cysts are resistant to readily attainable
levels of chlorine, disinfection by iodination
(tetraglycine hydroperiodide) is recommended.
• There is no effective prophylaxis.
• Dispanserisation – 5 years with control
examinatins
16. Lambliosis
GIARDIASIS
Giardia lamblia is a cosmopolitan protozoal
parasite that inhabits the small intestines of
humans and other mammals.
Giardiasis is one of the most common parasitic
diseases worldwide and causes both endemic
and epidemic intestinal disease and diarrhea.
17. Life Cycle
• Infection
follows the
ingestion of
the
environmenta
lly hardy
cysts, which
excyst in the
small
intestine,
releasing
trophozoites
that multiply
by binary
fission