Amebiasis is caused by infection with the intestinal protozoan Entamoeba histolytica. It is transmitted through ingestion of cysts from fecally contaminated food or water. Most infections are asymptomatic, but E. histolytica can cause intestinal disease ranging from dysentery to liver abscesses. Diagnosis involves examining stool samples for cysts or trophozoites. Treatment includes metronidazole plus a luminal amebicide for colitis or extraintestinal infections. Prevention focuses on safe water, sanitation, hygiene, and health education to reduce transmission.
Shigellosis = inflammation of intestines (especially the colon) with accompanying severe abdominal cramps, tenesmus and frequent, low-volume stools containing blood, mucus and fecal leukocytes.
Most medically important family of non–spore-forming gram-negative rods.
Most species are normal flora of the GI tract. Salmonella, Shigella, and Yersinia are not normal GI flora.
Major cause of nosocomial infections
Diseases include UTIs, gastroenteritis, septicemia, food poisoning, wound infections, peritonitis, pneumonia, and meningitis
The family exhibits four serological characteristics:
O (somatic) antigen-A cell wall antigen-LPS (heat stable), Used for serological grouping of Salmonella & Shigella.
K (envelope) antigen-Capsular antigen (heat labile)
H (flagellar) antigen-Flagellar antigen-protein (heat labile), Used to serotype Salmonella.
Vi antigen-Capsular antigen of Salmonella Typhi-polysaccharide (heat labile), Role in preventing phagocytosis, may mask O Ag, removed by heating.
Enterobacteriaceae are facultative anaerobes, ferment glucose. Positive nitrate and catalase, non-hemolytic. Except for Plesiomonas, they are oxidase negative.
Escherichia coli species are components of the
Normal animal and human colonic flora;
Flora of a variety of environmental habitats, including long-term care facilities (LTCFs) and hospitals.
E.coli are the cause of most nosocomial infections.
Shigellosis = inflammation of intestines (especially the colon) with accompanying severe abdominal cramps, tenesmus and frequent, low-volume stools containing blood, mucus and fecal leukocytes.
Most medically important family of non–spore-forming gram-negative rods.
Most species are normal flora of the GI tract. Salmonella, Shigella, and Yersinia are not normal GI flora.
Major cause of nosocomial infections
Diseases include UTIs, gastroenteritis, septicemia, food poisoning, wound infections, peritonitis, pneumonia, and meningitis
The family exhibits four serological characteristics:
O (somatic) antigen-A cell wall antigen-LPS (heat stable), Used for serological grouping of Salmonella & Shigella.
K (envelope) antigen-Capsular antigen (heat labile)
H (flagellar) antigen-Flagellar antigen-protein (heat labile), Used to serotype Salmonella.
Vi antigen-Capsular antigen of Salmonella Typhi-polysaccharide (heat labile), Role in preventing phagocytosis, may mask O Ag, removed by heating.
Enterobacteriaceae are facultative anaerobes, ferment glucose. Positive nitrate and catalase, non-hemolytic. Except for Plesiomonas, they are oxidase negative.
Escherichia coli species are components of the
Normal animal and human colonic flora;
Flora of a variety of environmental habitats, including long-term care facilities (LTCFs) and hospitals.
E.coli are the cause of most nosocomial infections.
• Amoebiasis is an infection of small intestine, which is caused by an protozoan called Entamoeba histolytica. It is simply called – Amoebic dysentery.
Amebiasis is a disease caused by a one-celled parasite called Entamoeba histolytica (ent-a-ME-ba his-to-LI-ti-ka).
Who is at risk for amebiasis?
Although anyone can have this disease, it is most common in people who live in developing countries that have poor sanitary conditions. In the United States, amebiasis is most often foundin immigrants from developing countries. It also is found in people who have traveled to developing countries and in people who live in institutions that have poor sanitary conditions. Men who have sex with men can become infected and can get sick from the infection, but they often do not have symptoms.
by Mostafa Mohammadzadeh fallah (MedStudent Iran)
Typhoid perforation is a serious complication of typhoid fever, a bacterial infection caused by Salmonella typhi. It occurs when the infection causes a hole to form in the wall of the intestine, leading to the leakage of contents from the intestine into the abdominal cavity. This can cause severe infection and inflammation of the abdominal cavity, known as peritonitis.
The symptoms of typhoid perforation may include severe abdominal pain, fever, nausea and vomiting, diarrhea or constipation, and signs of shock such as low blood pressure and rapid heart rate. In some cases, there may also be visible signs of a perforation, such as a palpable abdominal mass or signs of fluid accumulation in the abdomen.
The diagnosis of typhoid perforation is typically made through a combination of physical examination, laboratory tests, and imaging studies such as X-rays or CT scans. Treatment typically involves surgical repair of the perforation and aggressive management of the infection and inflammation. This may include antibiotics, intravenous fluids, and other supportive care measures such as pain management and nutritional support.
It is important to seek prompt medical attention if you suspect you or someone you know may have typhoid fever or typhoid perforation. Early diagnosis and treatment are essential for a successful outcome and to prevent further complications.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
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Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
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Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
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June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
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Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
2. Definition
Amebiasis is infection with the parasitic
intestinal protozoan Entamoeba histolytica
(the “tissue-lysing ameba”)
Most infections are probably asymptomatic
E. histolytica can cause disease ranging from
dysentery to extraintestinal infections,
including liver abscesses.
4. LIFE CYCLE AND TRANSMISSION
E. histolytica exists in two stages
1) Cyst form
2) Trophozoite form
Infection (of which humans are the natural hosts) is acquired by ingestion of cysts
contained in fecally contaminated food or water or, more rarely, through oral-anal
sexual contact
Cysts survive stomach acidity and excyst within the small intestine
form the 20- to 50-μm trophozoite stage
Trophozoites can live within the large-bowel lumen without causing disease or can
invade the intestinal mucosa, causing amebic colitis
In some cases, E. histolytica trophozoites invade through the mucosa and into the
bloodstream, traveling through the portal circulation
reach the liver and causing amebic liver abscesses
trophozoites may be excreted into the stool and killed by air
Trophozoite cysts within the large bowel are excreted in the stool, continuing the
life cycle
8. Epidemiology
Most cases of amebiasis are due to Entameba dispare and
entameba moshkovskii which are non invassive parasites
90% cases of amebiasis due to Entameba Histolytica are
asymptomatic
10% of cases are symptomatic
prevalence of Amebic liver abscess is 7 time is higher in men than
women
The disease is more common in areas with poor sanitation and
crowding
Mexico, India, tropical regions of africa, south and central of
America and Asia are endemic for disease
Incidence of disease in this regions are 544 cases in100000
papulation
Entamoeba histolytica is the fourth leading cause of mortality due
to parasitic disease in humans. (The first being malaria). Amebiasis
is the cause of an estimated 50,000-100,000 deaths each year.
10. Pathogenesis
Amoebic trophozoites invade the colon causing colitis. They may also invade the
portal circulation and travel to the liver, causing liver abscess.
Gastrointestinal Pathology
The spectrum of colitis in amoebiasis ranges from mucosal thickening, to multiple
cyst formation, to diffuse Inflammation / oedema, to necrosis and perforation of
colonic wall
Binding of E. histolytica to epithelial cells via galactosamin-lectin. This molecule
shows homologous to human CD59, conferring resistance to complement . A
change in the epithelial permeability is induced, probably via the inter-cellular
tight junctions.
Cell lysis and apoptosis of mucosa are thought to be mediated by amoebapores,
peptides capable of forming pores in lipid bi-layers.
Trophozoites invade through to the submucosa causing flask shaped cysts
Cysteine proteinases released by trophozoites digest extracellular matrix in liver
and colon, and induce interleukin-1 mediated inflammation. Proteinases also
cleave IgA and IgG antibodies.
Neutrophils and macrophages are drawn to invasion sites. E. histolytica can lyse
neutrophils leading to further tissue damage, and contributing towards the
induction of diarrhoea
Inflammation is a significant cause of tissue damage, however, innate immunity
may be the main combatant against the disease
11. Pathogenesis
Hepatic Pathology
Trophozoites invading the colonic mucosa may enter the hepatic
circulation and reach the liver
Well circumscribed abscesses are formed in the liver containing liquefied
cells surrounded by inflammatory cells and trophozoites
Adjacent parenchyma is usually unaffected
15. Asymptomatic carriers (non invasive form)
- 90% without symptoms
- does not damage lumen
Invasive forms:
Amoebic colitis
- flask shaped ulcers superficial or deep
- abd pain, diarrhoea, blood, fever
- tenesmus, peri-anal ulcers
Fulminant colitis - <0.5%
- severely ill with high fever
- intestinal bleeding
- perforation
- paralytic ileus
16. Amoeboma
- 1% of cases
- inflammatory thickening of intestinal wall
- palpable mass with trophozoites
Symptoms of amoebic colitis
Symptoms Percentage
1. Diarrhea 100
2. Dysentery 99
3. Abdominal pain 85
4. Fever 68
5. Dehydration 5
6. Length of symptoms 2 to 4 weeks
17. Symptom Bacillary dysentery Amoebic dysentery
Onset Acute Gradual
General
Condition
Poor Normal
Fever High grade Little fever (adult)
Tenesmus Severe Moderate
Dehydration Frequent Little dehydration
(adult)
Faeces No trophozoites Trophozoites present
Culture Positive Negative
18. Extra-intestinal
Amoebic liver abcess
- via portal system
- 5% of invasive disease
- 10 times more common in men
Pleuropulmonary
- direct spread from liver abcess (10%)
- haematogenous spread
Brain
- abrupt onset & rapid progression
- death in 12-72 hrs
21. Complications
• Amoeboma.
(localized granulomatous mass misdiagnosed
with carcinoma)
• Hemorrhage.
• Perforation of ulcer.
(secondary peritonitis --- rare but fatal)
• Stricture of colon.
(secondary to fibrosis)
• Appendicitis.
• Peritonitis
• Pleural Effusion
22. AMEBIASIS
Diagnosis
Fresh stool or colon mucus shows cysts or
trophozoites
Often 3 or more stool exams required
Serologic tests important to distinguish amebiasis
from ulcerative colitis
Sigmoidoscopy useful to inspect ulcers and obtain
stool or mucus for culture & stain
Abd. CT needed if liver abscess suspected
Abdominal Ultrasound
25. Treatment of Specific Forms of Amebiasis
Asymptomatic Intestinal Infection
Asymptomatic carriers are treated with a luminal amebicide.
Standard luminal amebicides are:
Diloxanide furoate, Iodoquinol, and Paromomycin.
Therapy with a luminal amebicide is also required in the
treatment of all other forms of amebiasis.
Amebic Colitis
Metronidazole plus a luminal amebicide is the treatment of
choice for amebic colitis and dysentery.
Tetracyclines and erythromycin are alternative drugs for
moderate colitis but are not effective against
extraintestinal disease.
Dehydroemetine or emetine can also be used, but are best
avoided because of toxicity.
26. Metronidazole & Tinidazole
Metronidazole is the drug of choice in the treatment
of extraluminal amebiasis.
It kills trophozoites but not cysts of E histolytica and
effectively eradicates intestinal and extraintestinal
tissue infections.
Tinidazole, have similar activity and better toxicity
profile than metronidazole.
27. Prevention & Control
Primary prevention
- Safe excreta disposal
- Safe water supply
- Hygiene
- Health education
Secondary
- Early diagnosis
- Treatment
28. Primary prevention
Sanitation Water Food hygiene H edu.
-excreta -protect -protect food -long
-wash hands -sand filter -acetic acid term
-latrines -boiling -detergent
-food handlers
examine
treat
educate