During this webinar Sophie Tully BSc MSc DipPT will discuss why nutrition research often fails to produce positive results and the methodological flaws that contribute to poor research outcomes.
Sophie will provide a detailed explanation of what we can learn from the recent wave of negative nutrition research and how to carefully consider and determine the right supplement regime for your clients’ health concerns. Covering the most important factors to consider when choosing the nutrients, dose and timescale of a nutritional intervention Sophie will provide you with a practical clinical toolkit that can be applied to all of your protocols to ensure client success.
Advanced nutrition for the brain series: stress, the HPA-axis and neuroinflammation. Targeted nutritional interventions for successful treatment of mental health conditions.
Inflammation is a major contributing factor to chronic modern illness and is driven, in part, by chronic stress and HPA-axis over stimulation. Mental health conditions, in particular clinical depression, are increasingly linked with neuroinflammation. As such, anti-inflammatory interventions are known to result in significant clinical benefits.
During this webinar Dr Bailey will discuss the biological mechanisms linking stress, chronic inflammation and mood disorders, together with a review of the current evidence for a targeted, anti-inflammatory nutrition approach to treatment. Nina will also clarify why some of the recent trials have failed to report benefits and how to optimise your anti-inflammatory interventions to treat clients with anxiety, depression, schizophrenia and PTSD.
In this informative webinar, with expert nutritionist Dr Nina Bailey, you will learn about how we can optimise our diet to help manage many of the symptoms associated with CFS/ME, namely lack of energy, extreme fatigue and ‘brain fog’:
Foods the brain and body needs to function optimally: what we should be eating
Foods that starve the brain and body of nutrients and energy: what foods we really need to avoid
Supplements: the best nutrients for providing energy and treating symptoms associated with CFS/ME, backed up by science
By making some relatively simple dietary changes that may, in some cases, include the use of dietary supplements, it is possible to see significant improvement in symptoms.
Following the launch of the Igennus MindCare range, Sophie kicks off our in-depth advanced nutrition for the brain education series by taking a look at the current research into various different brain boosting nutrients and explaining why we chose the specific formulations and doses used in MindCare. Covering everything from boosting mood to performing mentally complex tasks under pressure, Sophie provides the latest scoop on what really works and how we can use brain boosting nutrients as a spring-board for client success.
Fibromyalgia syndrome is a common chronic pain condition that affects at least 2% of the adult population. Chronic widespread pain is the defining feature of FM, but patients may also exhibit a range of other symptoms, including sleep disturbance, fatigue, irritable bowel syndrome, headaches and mood disorders. While the aetiology of the condition is not completely understood, it is believed that a number of factors (rather than one in isolation) are most likely to lead to its development. Thus, the onset of fibromyalgia syndrome can be influenced by hormonal and/or chemical imbalances, chronic stress and/or a traumatic event, genetic predisposition and even pre-existing illness.
In this hour-long webinar, Dr Nina Bailey covers:
• An overview of the aetiology of fibromyalgia
• The signs and symptoms of fibromyalgia
• Factors that can contribute to or exacerbate fibromyalgia syndrome
• Managing symptoms via dietary manipulation and lifestyle change
• Supporting nutrients/supplements for those with fibromyalgia syndrome
The role of diet in managing immune dysfunction and inflammatory processes that contribute to ADHD and related neurodevelopmental disorders
ADHD is a neurodevelopmental disorder characterised by lack of attention, impulsiveness, and hyperactivity. Its cause is considered to be multifactorial, involving a combination of genetics, perinatal factors (e.g., low birth weight, prematurity, prenatal exposure to toxins such as alcohol and/or smoke), as well as environmental and socioeconomic factors.
The immune system is a key player in gut–brain interactions, with extensive alterations in immune function known to contribute to the pathophysiology of neurodevelopmental disorders, including dysregulated inflammation, elevated levels of pro-inflammatory cytokines and altered immune cell function. In this webinar Dr Nina Bailey will describe the role of immune dysfunction and inflammatory processes linked to the pathophysiology of neurodevelopmental disorders and will provide an overview of the nutritional interventions that can help to successfully manage symptoms.
Advanced nutrition for the brain series: stress, the HPA-axis and neuroinflammation. Targeted nutritional interventions for successful treatment of mental health conditions.
Inflammation is a major contributing factor to chronic modern illness and is driven, in part, by chronic stress and HPA-axis over stimulation. Mental health conditions, in particular clinical depression, are increasingly linked with neuroinflammation. As such, anti-inflammatory interventions are known to result in significant clinical benefits.
During this webinar Dr Bailey will discuss the biological mechanisms linking stress, chronic inflammation and mood disorders, together with a review of the current evidence for a targeted, anti-inflammatory nutrition approach to treatment. Nina will also clarify why some of the recent trials have failed to report benefits and how to optimise your anti-inflammatory interventions to treat clients with anxiety, depression, schizophrenia and PTSD.
In this informative webinar, with expert nutritionist Dr Nina Bailey, you will learn about how we can optimise our diet to help manage many of the symptoms associated with CFS/ME, namely lack of energy, extreme fatigue and ‘brain fog’:
Foods the brain and body needs to function optimally: what we should be eating
Foods that starve the brain and body of nutrients and energy: what foods we really need to avoid
Supplements: the best nutrients for providing energy and treating symptoms associated with CFS/ME, backed up by science
By making some relatively simple dietary changes that may, in some cases, include the use of dietary supplements, it is possible to see significant improvement in symptoms.
Following the launch of the Igennus MindCare range, Sophie kicks off our in-depth advanced nutrition for the brain education series by taking a look at the current research into various different brain boosting nutrients and explaining why we chose the specific formulations and doses used in MindCare. Covering everything from boosting mood to performing mentally complex tasks under pressure, Sophie provides the latest scoop on what really works and how we can use brain boosting nutrients as a spring-board for client success.
Fibromyalgia syndrome is a common chronic pain condition that affects at least 2% of the adult population. Chronic widespread pain is the defining feature of FM, but patients may also exhibit a range of other symptoms, including sleep disturbance, fatigue, irritable bowel syndrome, headaches and mood disorders. While the aetiology of the condition is not completely understood, it is believed that a number of factors (rather than one in isolation) are most likely to lead to its development. Thus, the onset of fibromyalgia syndrome can be influenced by hormonal and/or chemical imbalances, chronic stress and/or a traumatic event, genetic predisposition and even pre-existing illness.
In this hour-long webinar, Dr Nina Bailey covers:
• An overview of the aetiology of fibromyalgia
• The signs and symptoms of fibromyalgia
• Factors that can contribute to or exacerbate fibromyalgia syndrome
• Managing symptoms via dietary manipulation and lifestyle change
• Supporting nutrients/supplements for those with fibromyalgia syndrome
The role of diet in managing immune dysfunction and inflammatory processes that contribute to ADHD and related neurodevelopmental disorders
ADHD is a neurodevelopmental disorder characterised by lack of attention, impulsiveness, and hyperactivity. Its cause is considered to be multifactorial, involving a combination of genetics, perinatal factors (e.g., low birth weight, prematurity, prenatal exposure to toxins such as alcohol and/or smoke), as well as environmental and socioeconomic factors.
The immune system is a key player in gut–brain interactions, with extensive alterations in immune function known to contribute to the pathophysiology of neurodevelopmental disorders, including dysregulated inflammation, elevated levels of pro-inflammatory cytokines and altered immune cell function. In this webinar Dr Nina Bailey will describe the role of immune dysfunction and inflammatory processes linked to the pathophysiology of neurodevelopmental disorders and will provide an overview of the nutritional interventions that can help to successfully manage symptoms.
Nutrition is a key factor in the onset and progression of cognitive decline, yet despite a growing pool of research, little evidence exists to support the efficacy of single nutrients in this complex area. The most promising evidence comes from specific dietary patterns and nutrients in the prevention and slowed progression of neurodegenerative disease. During this webinar, Dr Bailey will focus on the synergistic role of key nutrients involved in the mechanisms that drive cognitive decline and support healthy brain aging. Topics include:
- Risk factors for cognitive decline
- Biological mechanisms underpinning cognitive decline
Dietary patterns that offer protection and support against cognitive decline
- The role of specific nutrients in protecting brain health and function
- Nutritional recommendations for healthy brain ageing
Around 250,000 people in the UK are currently thought to be affected by CFS/ME. The high level of disability that is often associated with this debilitating condition can be both physically and mentally challenging for patients and appears to stem from a combination of symptoms such as fatigue, pain, sleep disturbance, cognitive impairment, depression and, in many cases, symptoms mirroring those of irritable bowel syndrome.
With no current cure and no validated, universally accepted, ‘one-size-fits-all’ approach to the treatment, many clients are seeking natural alternatives to conventional approaches.
Taking a personalised and functional medicine approach, Dr Nina Bailey reviews the latest science on ME/CFS and the underlying mechanisms that can be targeted with nutritional interventions and explains how to ensure your therapeutic approach is right for your clients.
Covered in the webinar:
1. CFS/ME background /causes/symptoms
2. Update on the mechanisms associated with CFS/ME:
- Immune disturbances
- Oxidative stress and inflammation
- The kynurenine pathway and neurotransmitter dysregulation
- Mitochondrial dysfunction and related mechanisms
* Methylation
* Detoxification
* Glycolysis
* Citric acid cycle/Krebs
* Oxidative phosphorylation
3. An overview of current treatment options
4. Nutritional intervention – an evidence-based approach
5. Nutritional supplementation
The Footprint Forum in association with Partners In Purchasing tackled the role of food in staff performance and wellbeing. And while the idea of mood food is far from mainstream, more and more big businesses are looking at the concept
AHS13 Grayson Wheatley - What is Optimal Health? Complexity Science, Chaos Th...Ancestral Health Society
An ancestral lifestyle relies on alignment of nutrition, physical activity and sleep for achieving optimal health and well-being. New research in complexity science - a rapidly evolving body of work that studies dynamic networking systems - has cast doubt on the effectiveness of how we measure expected outcomes in health and medicine. Complex systems may better explain human health by focusing not on single data elements as “cause-and-effect” but on the interactions among complex biological systems. The implications of complexity science and chaos theory on leading an ancestral lifestyle and achieving optimal health will be discussed.
How Can Hormone Therapy Help To Fix Chronic Fatigue?Vinay Choubey
Hormone therapy typically refers to bioidentical hormone replacement therapy, or BHRT, which is a series of continual treatments that are used to balance the level of hormones in your body. BHRT is usually a treatment that is given to patients who are experiencing age-related changes in physical and psychological health, including experiencing long-lasting fatigue and the symptoms associated with reduced energy.
During this webinar Dr Bailey reviews the latest evidence for the clinical application of omega-3 fats found in fish oil with a focus on choosing the best source, form, bioavailability and strength for your client’s condition management.
Nutrition is a key factor in the onset and progression of cognitive decline, yet despite a growing pool of research, little evidence exists to support the efficacy of single nutrients in this complex area. The most promising evidence comes from specific dietary patterns and nutrients in the prevention and slowed progression of neurodegenerative disease. During this webinar, Dr Bailey will focus on the synergistic role of key nutrients involved in the mechanisms that drive cognitive decline and support healthy brain aging. Topics include:
- Risk factors for cognitive decline
- Biological mechanisms underpinning cognitive decline
Dietary patterns that offer protection and support against cognitive decline
- The role of specific nutrients in protecting brain health and function
- Nutritional recommendations for healthy brain ageing
Around 250,000 people in the UK are currently thought to be affected by CFS/ME. The high level of disability that is often associated with this debilitating condition can be both physically and mentally challenging for patients and appears to stem from a combination of symptoms such as fatigue, pain, sleep disturbance, cognitive impairment, depression and, in many cases, symptoms mirroring those of irritable bowel syndrome.
With no current cure and no validated, universally accepted, ‘one-size-fits-all’ approach to the treatment, many clients are seeking natural alternatives to conventional approaches.
Taking a personalised and functional medicine approach, Dr Nina Bailey reviews the latest science on ME/CFS and the underlying mechanisms that can be targeted with nutritional interventions and explains how to ensure your therapeutic approach is right for your clients.
Covered in the webinar:
1. CFS/ME background /causes/symptoms
2. Update on the mechanisms associated with CFS/ME:
- Immune disturbances
- Oxidative stress and inflammation
- The kynurenine pathway and neurotransmitter dysregulation
- Mitochondrial dysfunction and related mechanisms
* Methylation
* Detoxification
* Glycolysis
* Citric acid cycle/Krebs
* Oxidative phosphorylation
3. An overview of current treatment options
4. Nutritional intervention – an evidence-based approach
5. Nutritional supplementation
The Footprint Forum in association with Partners In Purchasing tackled the role of food in staff performance and wellbeing. And while the idea of mood food is far from mainstream, more and more big businesses are looking at the concept
AHS13 Grayson Wheatley - What is Optimal Health? Complexity Science, Chaos Th...Ancestral Health Society
An ancestral lifestyle relies on alignment of nutrition, physical activity and sleep for achieving optimal health and well-being. New research in complexity science - a rapidly evolving body of work that studies dynamic networking systems - has cast doubt on the effectiveness of how we measure expected outcomes in health and medicine. Complex systems may better explain human health by focusing not on single data elements as “cause-and-effect” but on the interactions among complex biological systems. The implications of complexity science and chaos theory on leading an ancestral lifestyle and achieving optimal health will be discussed.
How Can Hormone Therapy Help To Fix Chronic Fatigue?Vinay Choubey
Hormone therapy typically refers to bioidentical hormone replacement therapy, or BHRT, which is a series of continual treatments that are used to balance the level of hormones in your body. BHRT is usually a treatment that is given to patients who are experiencing age-related changes in physical and psychological health, including experiencing long-lasting fatigue and the symptoms associated with reduced energy.
During this webinar Dr Bailey reviews the latest evidence for the clinical application of omega-3 fats found in fish oil with a focus on choosing the best source, form, bioavailability and strength for your client’s condition management.
Omega−3 fatty acids, also called Omega-3
oils, ω−3 fatty acids or n−3 fatty acids,
are polyunsaturated fatty acids (PUFAs)
characterized by the presence of a double
bond three atoms away from the terminal
methyl group in their chemical structure.
They are widely distributed in nature, being
important constituents of animal lipid
metabolism, and they play an important
role in the human diet and in human
physiology.
https://www.slideshare.net/DauRamChandravanshi1
Nutrition science seems to change on an almost daily basis and much of what was previously considered mainstream or consensus science is being challenged and changed as the new wave of more personalised intervention trials start to clarify many of the reasons behind why nutrition study results can be so conflicting.
No research area, it seems, is more subject to conflicting and confusing results than that of omega-3s which is why, here at Igennus, we do our best to stay on top of ALL the omega-3 research so we can not only help you unpick the fact from fiction (and answer all your questions about every single product on the market!), but also ensure our formulations and education reflect the most cutting edge and clinically proven ingredient research.
Dr Bailey’s ever-growing brain contains a veritable treasure chest of omega-3 knowledge and as we know you are big fans of the work she does, this webinar is dedicated to Dr Bailey’s brain and sharing with you all the latest updates, innovations and applied therapeutic research that she has been reading about over the last year. We aim to help you separate fish oil fact from fiction by answering as many of your omega-3 and fatty acid therapeutic-related questions as possible. Covering everything from which and how much omega-3 to take for certain conditions, how and when taking omega-3 can affect the benefit and amount absorbed, why very high doses can be dangerous, the truth behind what companies and headlines are telling you about omega-3s, to any other areas you want us to cover! We will do our best to cover the most common and important questions and concerns we hear about from you via phone or email and when out and about training in stores and at events every day. As always, we will also clarify some of the reasons behind the frustratingly confusing conflicts in the research and media and what exciting things are coming out of the omega-3 world.
Inadequate long-chain omega-3 fatty acid status has a substantial impact on our health. Human RCT, observational, in vitro and in vivo animal studies all demonstrate that omega-3 fats from fish improve inflammatory regulation and its associated conditions. Yet, due to inconsistency in findings, the validity of omega-3 fatty acids as ‘treatments’ has been brought into question in the reporting of studies. To date, few studies have monitored the correlation between omega-3 dose, subsequent cellular enrichment of these fatty acids and clinical outcomes.
In this webinar, Dr Bailey presents the latest evidence for the importance of a biomarker-based, personalised approach to omega-3 treatment – one that significantly improves consistency in clinical outcomes and offers an antidote to the ‘one-size fits all’ approach that is responsible for significant individual variations in response in many published studies.
This webinar is designed to teach practitioners about how to use and recommend the Igennus cardiovascular health treatment protocol for maximum results in your clients. We will cover the evidence for the use of the nutrients within the protocol and provide the recommended dosing regime for a range of cardiovascular health concerns.
Newly established clinical biomarkers including the AA to EPA ratio highlight the extent to which inflammation underlies chronic illnesses. Dr Bailey presents compelling evidence for an EPA-based fatty acid approach to resolving inflammation that, when applied together with Igennus’ new Opti-O-3 blood spot fatty acid biomarker test, provides an effective nutrition management strategy for health practitioners treating a variety of conditions. Learn how this straightforward blood spot method can add value to your clinical approach by identifying your clients’ individual omega-3 requirements needed to manage biomarkers that correlate with long-term health and reduced disease risk.
With a growing number of conditions being grouped under the ‘umbrella’ of autoimmune disease, supporting clients who are, increasingly, presenting with various, and often multiple, autoimmune conditions, can appear complex at first glance.
In this webinar, Dr Danielle Crida outlines a clinical protocol that can support most autoimmune conditions, and takes a deep dive into the role of the immune system and key inflammatory processes at play.
Many clients take bone health for granted until they’re presented with a diagnosis of osteoporosis, often following a fracture. Whether your client is nutrient deficient, concerned about bone health, or diagnosed with a metabolic bone disease, adding the right nutrients to a protocol is paramount.
In her latest webinar, Dr Danielle Crida discusses:
- The importance of bone health
- Consequences of low bone mineral density
- The most important nutrients for bone health and their synergistic roles
- Exercise and lifestyle choices for bone strength
- Supplement and dosing recommendations, introducing our new Ca/Mg/D3/K2/Boron product
Did you know that food storage and preparation can hugely affect its nutritional value? For example, the antioxidant capacity of blueberries actually increases with freezing, and letting crushed garlic rest for 10 minutes before cooking allows for the development of compounds with amazing health benefits.
Learn the tricks of the trade for getting the most out of your food in this short webinar with nutritionist Dr Danielle Crida.
Confused about what to eat for better health? Dr Danielle Crida, trained medical doctor and nutritionist, will guide you through the basic ingredients of a nutritious and delicious diet. This short webinar will discuss how to build the foundations of your meals with macronutrients, and provide tips on how to ensure you are meeting your requirements for vitamins and minerals. We know getting started is the hard part, so we’ll provide a free editable shopping list and tips for a kitchen clearout to set you up for success.
Magnesium plays a role in over 300 biochemical reactions, therefore affecting almost every system of the body when levels are insufficient. In her latest webinar, Dr Danielle Crida focuses on the important role magnesium plays in all stages of a woman’s life, supporting:
- Menstrual cramps
- A healthy pregnancy and postpartum
- Menopausal symptoms, such as hot flushes and mood changes
- Women-predominant conditions, e.g. osteoporosis and thyroid conditions
Veganism is on the rise due to growing concerns about the environment and perceived health benefits. However, certain nutrients such as EPA & DHA are difficult to obtain from plant-based diets. Until recently, the only supplemental source of long-chain omega-3s was fish oil. Igennus has recently launched a vegan omega-3 product which combines algae-sourced EPA & DHA with the additional benefit of astaxanthin, a powerful antioxidant.
In this hour-long webinar, Dr Danielle Crida discusses:
- The importance of omega-3s and the omega 6:3 ratio
- Vegan options for omega-3 supplementation
- Our new Vegan Omega-3 & Astaxanthin product
- How to assess omega-3 requirements and measure response to supplementation
- Ensuring optimal nutrition on a plant-based diet: common nutrient deficiencies and how to address them
While Lyme disease is considered to be relatively uncommon in the UK, it is likely that many cases are simply undiagnosed, many of which turn up in our clinics frustrated by conventional approaches to managing their symptoms. Being able to identify clients with suspected Lyme disease is vital, as many cases that present with early or initial symptoms of fever, headache or other neurological symptoms as a consequence of a tick-borne bacterial infection, simply do not relate these symptoms to having been bitten. As such, this highlights the importance of the need to take comprehensive and detailed client history notes, certainly when a client is reporting symptoms that have not responded to conventional interventions.
With appropriate antibiotic treatment, most patients with early-stage Lyme disease recover rapidly and completely. Signs and symptoms of Lyme disease, however, vary by disease stage, and because many individuals who present with symptoms fail to recall a history of a tick bite or to report the classic bulls-eye rash, they often miss out on what is a relatively narrow window of opportunity to prevent the condition from progressing.
As Lyme disease is a multi-system illness, if left untreated, it can progress to affect the skin, joints, immune system, nervous system, or other vital organs, with many of the symptoms becoming indistinguishable from other multi-system conditions such as fibromyalgia or chronic fatigue syndrome.
In this hour-long webinar, Dr Nina Bailey discusses strategies for practitioners to help identify and manage symptoms of Lyme disease.
As healthcare practitioners, we are well aware of the endless benefits of vitamin C in supporting immune health, antioxidant support, energy production, collagen formation, nervous system function and iron absorption. Faced with a huge array of vitamin C products, however, how can we be confident we’re recommending the best supplement to our clients?
During R&D for our latest addition to the Igennus Healthcare Nutrition synergistic range of supplements, we were impressed by both the high absorption of Ester-C and the unprecedented uptake and retention in immune cells. Ester-C boasts an impressive 10x higher bioavailability in leukocytes, whilst its pH neutral composition means it’s also gentle on the stomach.
In this webinar, Dr Danielle Crida discusses:
- A recap of vitamin C basics
- The research that led to the production of Ester-C
- The case for Ester-C: success in clinical use above standard vitamin C supplements
- Practical applications and dosing
As natural healthcare practitioners, we all understand the pivotal and complex role that magnesium plays. Required for over 300 biochemical reactions and metabolic functions including cellular signalling, function & energy production, it is no surprise magnesium is one of the most used supplements in a clinician’s toolbox.
Magnesium supplementation is, however, not as straightforward as we are led to believe. With considerations such as carrier, dose and bioavailability to consider, are we really doing clients (and magnesium) justice with a standard ‘go-to’ product?
In this educational webinar, Dr Nina Bailey not only discusses magnesium in clinical practice but, importantly, also uncovers the perils and pitfalls of the magnesium supplement ‘scene’, in the quest to provide clinical excellence, and the important supplemental factors that must be considered to optimise magnesium status and provide clinical efficacy.
Dr Bailey discusses:
1. A brief overview of the clinical implications of magnesium deficiency
2. Magnesium in practice:
-Supporting digestive complaints and overcoming
malabsorption
-The importance of magnesium for structural support
-Supporting energy levels and insulin sensitivity
3. How to ensure clinically effective dosing and supplementation
The imbalance between free radical production and endogenous antioxidant defence may result in cellular oxidative stress, causing oxidative damage to various cellular components, such as DNA, proteins and membrane lipids. The human system employs the use of endogenous enzymatic and non-enzymatic antioxidant defence systems against the onslaught of free radicals and oxidative stress.
Unsurprisingly, oxidative damage has been implicated in and is believed to be a key factor causing various pathological conditions, such as cardiovascular disease, neurodegenerative disease, diabetes and cancer. Free radicals can be quenched through a number of mechanisms. Antioxidants directly scavenge free radicals (e.g., via hydrogen atom transfer or electron transfer), prevent free radical formation by chelating metal ions and by interrupting the radical chain reactions of lipid peroxidation, thus retarding its progression. Enzymatic antioxidants include superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. Non-enzymatic antioxidants include vitamins A, C, and E, glutathione, alpha-lipoic acid, carotenoids, and coenzyme Q10. Other antioxidants include polyphenols, minerals (copper, zinc, manganese, and selenium), and cofactors (B-vitamins). Together, antioxidants work synergistically with each other using different mechanisms against different free radicals and stages of oxidative stress.
The benefits associated with antioxidants are numerous and diverse but it can be a minefield when choosing the appropriate antioxidant support for clients. In this hour-long webinar, Dr Nina Bailey discusses the direct and indirect benefits and actions of key antioxidants including (but not limited to) astaxanthin, alpha lipoic acid, polyphenols and co-enzyme Q10, with a focus on:
-Antioxidant sources and benefits
-Mechanisms and actions
-When to combine antioxidants for synergistic effects
-Overcoming bioavailability issues
-Targeted intervention, which antioxidant(s) and why
Astaxanthin, the naturally occurring carotenoid responsible for the pink-red pigmentation of wild salmon and crustaceans such as shrimp and lobsters, is a potent and effective antioxidant that boasts an ability to combat oxidative stress 6000x greater than that of vitamin C, 800x coenzyme Q10, 550x vitamin E and 75x alpha lipoic acid. Naturally, we are very excited to introduce AstaPure astaxanthin to our Pure Essentials range, launching in March!
Most commonly associated with preventing age-related diseases, astaxanthin’s unique chemical structure that spans the cell membrane gives rise to an exciting and diverse array of health benefits. New research is coming out daily suggesting astaxanthin is a highly effective tool in combating age-related diseases and cardiovascular disease, as well as boosting the immune system, liver and brain function.
Join Dr Nina Bailey for this ‘Introductory’ ingredient training webinar and discover:
Astaxanthin’s most exciting mechanisms of action
How its unique structure makes it so potent
An overview of some of the most compelling research into astaxanthin’s health benefits
When to use astaxanthin in clinical practice & dosing guidelines
Histamine intolerance (which can easily be mistaken for an IgE reaction) results from the imbalance of accumulated histamine and the capacity for histamine degradation. Symptoms of histamine intolerance are diverse in nature because histamine exerts its numerous biological reactions via 4 receptors, located on target cells in various tissues, with the severity of symptoms dependent on circulating histamine levels. The signs and symptoms of histamine intolerance can often be misinterpreted or simply go undetected in many individuals.
In this hour-long webinar, Dr Nina Bailey covers:
· The biological roles of histamine and how/why histamine intolerance arises
· The signs and symptoms of histamine intolerance
· High histamine foods/histamine liberators
· Factors that can contribute to or exacerbate histamine intolerance
· How to optimise your diet to reduce histamine reactions
· Supporting nutrients/supplements for those with histamine intolerance
Polycystic ovary syndrome (PCOS) is a common hormonal disorder, thought to affect between 4%–8% of women of reproductive age. Due to a lack of awareness, and the dramatic variation in the signs and symptoms between individuals, a large number of women may have PCOS without being at all aware of it. Unless help is sought for common symptoms (including oily skin and recurring acne; irregular, infrequent or absent periods; excess facial and body hair growth; head hair loss or thinning; weight gain) a formal diagnosis may never be made and issues can persist unmanaged until menopause. PCOS is most commonly diagnosed in women hoping to become pregnant, but who experience fertility issues as a result of irregular ovulation or miscarriage. In this webinar, Dr Nina Bailey PhD outlines the key mechanisms in the pathophysiology of PCOS, the signs and symptoms that should trigger further investigation, and the key nutritional strategies that can be adopted to help women manage the condition.
During this webinar, Sophie covers the double-edged sword of inflammation and oxidative stress as driving factors in chronic modern illness and why addressing these factors with nutritional intervention does not always produce the desired effects; it may even, in some cases, be harmful. Taking a personalised and functional medicine approach, Sophie reviews the underlying mechanisms that can be targeted with nutritional interventions and explains how to ensure your therapeutic approach is right for your clients.
Igennus are excited to announce the launch of our new product, Longvida® Curcumin. During this webinar, Dr Bailey reviews the research behind the therapeutic use of curcumin and why Longvida is the world’s most advanced formulation of the nutrient.
Curcumin is a polyphenol compound obtained from the rhizome of Curcuma longa, also known as turmeric. This Indian spice has a long history of use in Ayurvedic medicine as a treatment for inflammatory conditions. Curcumin is well documented for its antioxidant, anti-inflammatory and anti-cancer activities. Although it has been shown to be safe at high doses (12g/d), it is poorly absorbed, undergoes rapid intestinal and hepatic metabolism and is rapidly eliminated from the body. As such, standard curcumin demonstrates poor bioavailability, even at high doses, limiting its therapeutic potential.
After much research and discussion (it’s a big and complicated topic!) between the Igennus nutrition scientists, the decision as to which type of curcumin we would use for our Synergistic Nutrients range was actually a very straightforward one. Longvida Curcumin utilises a novel delivery system (SLCP), which protects curcumin from the harsh environment of the stomach and promotes its rapid absorption into the bloodstream and target tissues, even at low doses – resulting in an incredible 285x superior bioavaibility compared with standard curcumin, 65x higher peak plasma levels and 7x longer-lasting action. Longvida is the only formulation proven to deliver high levels of free form, unconjugated curcumin, into the bloodstream. Free form curcumin is the form required for therapeutic benefits, and the only form proven to cross the blood brain barrier.
This webinar covers:
- What curcumin is, what it does and how?
- Why free form curcumin is essential for therapeutic effects
- The research and current evidence for Longvida Curcumin’s unique health benefits
- How Longvida overcomes significant bioavailability issues associated with curcumin use
- To who, why and when you should recommend curcumin
…and more.
Catherine Jeans has been working with children’s nutrition for the past six years, specialising in family health, including babies, toddlers and teens. Working with children presents various challenges as a nutritional practitioner – not only getting the child to jump on board with the changes, but as important, making sure the parents are able to motivate their child and make the time to help them prepare the right food.
In this webinar, Catherine will go through:
– Logistical challenges – managing parents and their expectations, at what point to include children in consultations and how to talk to children about weight loss, digestive health and sugar.
-The realities of changing a child’s diet – what can you realistically achieve and how to motivate children to change.
– Case studies from babies to teens – Catherine will go through various case studies from her practice, including allergies, food intolerances, Coeliac disease, weight management and sugar addicts.
This webinar will give you an interesting insight into the practicalities of working with women and couples as they go through their fertility journey, from pre-conception, through to pregnancy and post-natal recovery. Catherine presents this online lecture through the use of key case studies, highlighting:
• The importance of supporting the adrenals for female fertility, and how this may impact on progesterone levels
• Key functional tests which may help you understand what may be preventing conception and successful pregnancy outcomes
• How to work with women going through assisted conception
• How to become a “fertility detective” and support couples with unexplained fertility issues
• Using a 3 month window between trying to conceive again – key supplements for optimal results
• Managing common problems found in pregnancy - iron deficiency anaemia to hyperemesis gravidarum
• How nutritional therapists can support women before birth and the early post-natal recovery – what really needs to go in the hospital bag!
• Preventing post-natal burn out - many women, especially after their second pregnancy, experience post-natal burn out after roughly 6 to 9 months after birth. Why is this and how we can we support women through this?
During this webinar, Dr Bailey will provide an update on current research into the systems and pathways that contribute to inflammatory illness onset and progression and provides you with practical solutions to support your clients with chronic inflammatory health conditions. Covering the latest applied nutrition science, she will review what we know today about the role of omega-3s, digestive health, NFK-B in inflammation and the therapeutic potential of EPA & DHA, curcumin, CoQ10, quercetin, specific probiotic strains and more.
Fatty acids carry out many functions that are necessary for maintaining optimal health, and the fatty acid status of a client provides valuable information that relates to both risk and progression of a range of diseases. Determining fatty acid status assists the practitioner in identifying those individuals who would benefit from omega-3 supplementation. The Igennus Opti-O-3 biomarker test is a safe, cost effective and minimally invasive dried blood spot (DBS) method that can be carried out by the client at home. In addition, the Opti-O-3 offers a personalised approach to condition management by focusing on optimising validated biomarkers of disease risk through identification of the client’s unique fatty acid requirements.
In this refresher webinar, Dr Bailey will discuss:
- Fatty acid testing: who, why and when?
- Why choose the Igennus Opti-O-3: a comparison of laboratories
- How to interpret results, including:
- New fatty acid reference ranges
- Overview of fatty acid functions
- Intervention considerations
- Personalised intervention
Nutritional immunology is a fascinating but highly complex and conflicted subject area. With almost every nutrient we consume having the ability to affect our immune response in one way or another and the activation of the immune system dramatically increasing nutrient requirements, understanding the genetic, cellular and metabolic mechanisms that interact, control and conflict with the immune system and how to manipulate them to our advantage, is fundamental to optimal health.
We are thrilled to announce that we have linked up with Professor Phillip Calder, a world renowned and highly cited expert in nutritional immunology, with over 500 publications to his name. Professor Calder will be joining us as our guest speaker for our January Webinar to help us kick off what promises to be our most exciting year of clinical nutrition education yet.
In this detailed Q&A session Professor Calder will shed light on a whole host of fascinating topics from the latest research into nutrition immunology, his projects involving nutrigenomics, probiotics and omega-3s, the real science behind effective clinical omega-3 interventions, his thoughts on the best forms of lipid supplementation, and doing some serious nutrition science myth busting.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
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This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Cardiac conduction defects can occur due to various causes.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
2. Today’s talk objectives:
• To gain a deep understanding of why nutrition
research often fails to produce expected results
• To understand how to critically review nutrition
research to determine which nutrients really work –
with a focus on brain health
• Understand how failures in research methods help us
to be better clinicians
• Learn how to use this information to ensure success
with your clinical protocols
4. Alarming headlines, but
DO FISH OILS REALLY FAIL?
“Do fish oils REALLY keep the brain
young? Study finds 'no evidence' that
omega-3 supplements slow mental
decline”
“Is your omega-3 fish oil
supplement any good - or a load
of old codswallop?”
“Omega-3 supplements do little to
protect you from heart diseases,
says new study”
“The benefits of omega-3
seem fishy”
“Experts cast doubt
on omega-3”
“Insufficient evidence to support
omega-3 as a treatment for depression”
– Cochrane review
“Fish oils are no benefit
for diabetes”
5. Inconsistencies arising from dietary intervention studies give mixed results and create confusing
messages (Von Schacky 2015; Harris 2015)
Poor heterogeneity in study designs, background diets, endpoint definitions, and baseline fish or
omega−3 fatty acid intakes cloud meta-analysis outcomes
Patients recruited regardless of their baseline levels and treated with fixed doses
Recent RCTs (virtually all of which have been conducted in European or North American cohorts
[low dietary fish intakes]) use relatively low doses (376–850 mg EPA & DHA) which at least partly
explains their failure
CVD secondary-prevention populations - include many individuals who are already taking multiple
heart medications such as statins, aspirin, and ACE inhibitors, which may obscure the effect of
omega-3 fatty acids
The inter-individual variability in response to a fixed dose of EPA + DHA has been found to be large,
i.e. to vary up to a factor of 13
Not all ‘fish oils’ are the same - addressing quality/concentration and purity
Study design to incorporate use of biomarkers?
6. Omega-3 dosing – ‘one size fits all?’
Effects of a single dose of EPA & DHA (3.4 g) taken with
breakfast on the Omega-3 index (n =20)
(Harris et al., 2013)
40 individuals with a baseline omega-3 index <5%
(black bar) and post treatment (white bar) after a 6-
week intervention with omega-3 EPA & DHA (0·5 g/d)
• The mean omega-3 index increased from 4·37% to
6·80% and inter-individual variability in response was
high (varied by a factor of up to 13 inter-individually)
(Kohler et al. 2010)
7. We are all biochemically unique – our needs for, production of and
response to omega-3 differs considerably:
Many factors influence how we utilise omega-3 in supplement form, i.e.
o Omega-3 baseline levels
o Body weight, age, gender, etc
Supplement digestibility/bioavailability [rTG, EE, phospholipids]
Understanding the dose-response effects of EPA and DHA and ‘condition related’
requirements
o EPA vs DHA – no longer viable to address them simply as ‘omega-3’
Tissue concentrations of these omega-3 fatty acids may be critical to achieving biological
effects
Increasing omega-3 intake is not the same as increasing omega-3 levels!
8. The EPA/DHA dilemma
Although EPA and DHA are both long-chain polyunsaturated fatty acids (PUFAs), the
molecules are often reported to produce biochemical and physiological responses that are
qualitatively and quantitatively different from each other
The kinetics of EPA and DHA differ between different cell types
The marked differences between the effects of EPA and DHA indicate that it is an over-
simplification to generalise the effects of omega-3 PUFA on cell function
It is the EPA in excess of DHA that is the active component in fish oil [treating depression]
Verlengia et al., 2004; Martins 2009; Sublette et al., 2011; Russell & Burgin-Maunder 2012
9. EPA and DHA utilisation differences
High DHA intake reduces delta-6-desaturase activity
Studies often report no increase in DHA levels with pure EPA
supplementation – DHA saturation?
In some cases [depression/neurodevelopmental disorders] high
DHA supplementation has been shown to worsen health outcomes
12 week intervention with 1.8 g omega-3 (1.2g EPA + 0.6g
DHA) in young healthy males aged 18-25
During the washout period, EPA and DHA levels decreased
back to baseline levels, with EPA levels rapidly returned to
baseline levels within 2 weeks of stopping fish oil
supplementation, while serum DHA returned to baseline
levels only by the end of the washout period
Suggests high EPA requirements
Roke & Mutch 2014
Time (weeks)
10. The unique benefits of pure EPA
EPA (unlike DHA) reduces the pro-inflammatory activity of AA in a number of ways
EPA is an inhibitor of the enzyme delta-5-desaturase that produces AA
EPA directly displaces AA from cell membranes
EPA competes with AA for the enzyme PLA2 necessary to release AA from the membrane
phospholipids
EPA competes with COX and LOX enzymes to prevent the conversion of AA to its
eicosanoids
As such, studies show that EPA plus DHA oils are less effective at reducing inflammation
than pure EPA oils
12. Strength/concentration of the active ingredient
within the total oil volume
Bioavailability of the omega-3 form used
Accurate ‘dosing’ – as [mg/kg/day] determined
according to the baseline omega-3 index
For an intervention to be successful you need to raise omega-3 levels and reduce the
inflammatory capacity of omega-6 AA
A combination of factors determine omega-3 intervention success:
TG EE rTG PL
13. The power of rTG omega-3
Dyerberg et al., 2010 graph shows the % increase in serum EPA+DHA content following 2 weeks of EPA
and DHA supplementation Av. 3.3g per day.
rTG oil delivered biggest increase in serum lipid content in the lowest volume of oil and
lowest total dose of EPA+DHA (all others delivered 200mg EPA + DHA or more)
14. Importance of oil concentration
Higher concentrations increase cellular omega-3 levels more than the same
dose provided at a lower concentration
Brunton and Collins 2007
15. Importance of dose plus concentration
Higher dose high concentrations from rTG fish oil increase cellular omega-3
levels up to 5x more than krill oil and 3x more than standard fish oil
Laidlaw et al.,
2014
Comparison of
manufacturer-
recommended
dose of rTG, EE
concentrated
fish oils with Krill
oil (PL) and
salmon oil (TG)
16. Subjects (n = 35) were randomly assigned to consume one of four products, in random order,
for a 28-day period, followed by a 4-week washout period
Subsequent testing of the remaining three products, followed by 4-week washout periods,
continued until each subject had consumed each of the products
Laidlaw et al., 2014
A randomised clinical trial to determine the efficacy of manufacturers’ recommended doses of
omega-3 fatty acids from different sources in facilitating cardiovascular disease risk reduction
20. Omega-3 increases blood flow to the brain supplying oxygen and fuel, essential for
neurotransmitter production and function, memory, learning, cognition, and brain and
neurone cell structure
Benefits restricted to those with sub-optimal omega-3
intake – surprised?!
21.
22. DHA is for memory and
learning if intake is low
EPA in excess of DHA for
cognitive performance, in
particular attention
Total omega-
3 needed to
be >400mg
‘DHA only’
often resulted
in detrimental
effects to
cognition
Many benefits of DHA
associated with increased
blood flow
>1month intervention needed
for benefits to be seen
23.
24. Amino Acids. 2000;19(3-4):635-42.
A taurine and caffeine-containing drink stimulates cognitive performance and well-being.
Seidl R1, Peyrl A, Nicham R, Hauser E.
The findings clearly indicate that the mixture of three key ingredients of Red Bull Energy
Drink used in the study (caffeine, taurine, glucuronolactone) have positive effects upon
human mental performance and mood.
Psychopharmacology (Berl). 2001 Nov;158(3):322-8.
An evaluation of a caffeinated taurine drink on mood, memory and information processing
in healthy volunteers without caffeine abstinence.
Warburton DM1, Bersellini E, Sweeney E.
RESULTS:
In both studies, the caffeinated, taurine-containing beverage produced improved attention
and verbal reasoning, in comparison with a sugar-free and the sugar-containing drinks. The
improvement with the verum drink was manifested in terms of both the mean number
correct and the reaction times. Another important finding was the reduction in the variability
of attentional performance between participants.
25. • L-Theanine + taurine calm and focus the mind via GABA and
dopamine activation
• Caffeine stimulates the brain, increasing energy, alertness and
information processing speed
• L-Theanine + caffeine enhance focus and reduce distractibility
27. Omega-3
• EPA and DHA are essential for mood-regulating
neurotransmitter production and function
• EPA reduces inflammation, which directly attacks and
degrades serotonin, leading to low mood and depression
37. EPA and DHA utilisation differences
Roke & Mutch 2014
Time (weeks)
• Half the DHA dose = same enrichment and longer lasting elevation
within the cells of the brain compared with EPA
• Conditions requiring EPA MUST dose with excess EPA at least 3:1
38. Vitamin D
• acts as a mood stabiliser
• low levels increase risk of anxiety and depression
• Studies show mixed results (in some case worsening) in
managing depression
39. Should vitamin D supplements be recommended to
prevent chronic diseases? BMJ 2015;
350 doi: http://dx.doi.org/10.1136/bmj.h321
Bottom line:
Do not recommend vitamin D supplements to prevent chronic disease
because clear evidence of benefit does not currently exist and adverse
effects cannot be excluded
40. ‘all studies without flaws demonstrated a statistically significant
improvement in depression with Vitamin D supplements…… the
effect size was comparable to that of anti-depressant medication.’
NB: Only effective in those who are deficient AND dose given must
result in a changed serum Vit D level
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011048/
43. BUT almost all studies of omega-3 use to boost
cognitive function have shown little or no
benefits – why?
• Study population
• Dose given
• EPA or DHA
• Cognitive tests chosen
• Duration of intervention time
• Is it already too late?
44. B vitamins
• B1,2,3 and 5
– support mitochondria of the brain and CNS
– aid detoxification pathways
– reduce inflammation
• B6, B12 and folate in their most active and bioavailable forms
– homocysteine recycling
– elevated levels = significant risk factor for age-related cognitive decline
48. Brain studies are extremely difficult to conduct
Why??
What's the optimal
length of time for
this intervention
Which nutrients should
be used? Single, isolated
nutrients or blends….
What dose do we
give?
What's the right
population for this study
and intervention?
What else might be affecting
the participants’ brains?
49. Part 3 : translating this into
successful personalised nutrition
and clinical practice
50. There are still numerous gaping holes in
research which, for now, prevent firm
conclusions being made.
So - what can we learn from the negative
studies and what we can do in clinic to
ensure therapeutic success?
51. 1: Choosing the right dose for EACH participant
It is increasingly apparent that the right dose for the right person is vital in
ensuring study success.
Before the study even begins we must know each individual participant’s baseline
level of the nutrient being investigated and, where possible, dose according to
pre-determined and validated dosing guidelines.
Translated into a practical clinical setting, testing (genotype and phenotype)
is key to understand biochemical individuality and whether or not your client
actually needs, and will indeed benefit from, a specific nutrient intervention.
Using established dosing guidelines where available - such as that calculated using
the omega-3 index biomarker and body weight – can at least help us to achieve
health-protective levels of a nutrient in our clients, from which we can try to
establish the therapeutic dose.
52. 2: What plasma or cellular levels need to be reached in order to have a
clinical effect in this specific area of health?
Whilst there is still no known ‘ideal’ plasma level of each and every nutrient for each and
every condition, the severity of deficiency tells us whether the nutrient in question is
likely to contribute to clinical results and how high we should commence the dose.
Remember - the lower the baseline levels (and the bigger/heavier they are), the more a
person will need to take in order to raise their plasma levels to that associated with
health benefits.
Those with the lowest baseline levels are likely to have the highest level of dysfunction.
Raising their levels closer to ‘ideal’ should help them to notice a tangible benefit to their
health. People with closer-to-adequate plasma levels may still benefit but the scale of
improvement is likely to be smaller and may therefore go unnoticed.
Using current levels and dosing between known therapeutic doses and upper tolerable
limits will help to get quicker positive results.
53. 3: How does the body prioritise which clinical benefit it needs most?
If the client or study participant has more than one condition with high
requirements of this particular nutrient how do we determine how the body
will prioritise distribution?
If you have 3 major organ systems all requiring additional support and you give a
relatively modest dose of a nutrient which is known to contribute to all of these
systems, then perhaps most, or all, of that nutrient gets shuttled to the organ with
the greatest need.
How do we dose correctly if more than one system is crying out for the
nutrient?
We need to look at the body as a whole when designing single nutrient studies for
single clinical benefits to determine if an endogenous competition might be the
reason for our negative outcome!
54. 4: One nutrient alone does not always have the power to significantly
benefit one area of health
This is really key and is the reason humans have evolved to eat food, not
nutrients.
Our organs and systems are extremely complex and it is impossible to isolate
just one nutrient as being ‘most’ important for function.
It is likely that looking at the overall benefits of a combination of nutrients is
much more useful than looking at each nutrient’s impact alone.
The positive research for specific diets, for example the MIND diet in supporting
healthy cognitive ageing and the DASH diet for heart and metabolic health, is
much better established than most isolated nutrients.
55. 5: Choose the right participants for this study and choose what
specific outcome suits them best?
If you want to be sure your client, or participant, will respond it is clear you
need to
a) choose a nutrient that they actually need
b) use a population who require the targeted benefit.
There’s no point in targeting someone with depression knowing it has
inflammatory roots and choosing to give them glucosamine to treat non-
existent joint pain and then expecting their joint pain to improve!
In the AERDS2 study it is clear, for a number of reasons, that both omega-3 and the population
chosen were not ideal for the desired outcomes to be tested. The participants were not
malnourished, poorly educated or financially disadvantaged - all factors known to correlate with
fish consumption and increased risk of brain function decline.
56. 6 and 7: When and for how long is optimal for this intervention?
Understanding what factor, and at which point in the life cycle, has the ability
to impact on long-term health outcomes is vital in determining the likelihood
of positive outcomes from clinical studies.
If the ‘damage’ has already been done, an intervention may only prevent
worsening of symptoms, rather than result in benefits and…
If the intervention is not given for the optimal length of time it may never
reach significance.
The order and length of interventions we choose to use in our day-to-day
clinics will determine if, and to what extent, a client will respond.
58. 1. Which symptoms
and systems are of
most concern to you
AND your client?
2. What
strategies
can you
implement?
3. What
impact could
this have?
5. So where
do I start?
4. Does this
change the
benefit
gained or
perceived?
60. Is the intervention you
choose right for the
client?
Is the nutrient right at this
time in their treatment
plan?
What else might be
affecting whether
or not this nutrient
could be effective?
What other
demands might
there be in the
body for this
nutrient?
What are their current
levels of this nutrient?
What other nutrients are needed
to make sure this nutrient can
work in the desired area?
?
Start here:
62. • Choose an optimal starting dose
• Limit changes to other factors that could affect positive
outcomes or reduce the likelihood of noticing a benefit
• Make sure the client can be and is committed to compliance
• Don’t overwhelm the system with single nutrient
interventions; optimise the baseline diet and lifestyle and
target systems, not symptoms, initially
• Introduce new nutrients slowly, review regularly, and
routinely stop intake to make sure the nutrients chosen are
individually beneficial and contributing significantly at that
point in the protocol
• Plot it out!
64. Planning how the whole process of support might look,
including:
what to give and when, relative to the specific organ system and
outcome of greatest concern, from the outset of treatment,
together with recognising the importance of compliance to
certain interventions beyond just a few months,
as well as not being afraid to revisit treatment options at
different times in a treatment plan
is essential to creating a successful support plan.
65. Pharmepa® RESTORE & MAINTAIN™
The fastest, most effective, clinical omega-3
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66. ‘RESTORE’
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Therapeutic role of Pharmepa®
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Inflammatory regulation
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Heart, brain and eye health
Reduce risk of chronic illness and help
protect against inflammatory disease
68. References
Bays HE, Ballantyne CM, Braeckman RA, Stirtan WG, Soni PN: Icosapent ethyl, a pure ethyl ester of eicosapentaenoic acid: effects on circulating markers of inflammation from the
MARINE and ANCHOR studies. American journal of cardiovascular drugs : drugs, devices, and other interventions 2013, 13:37-46.
Hull MA, Sandell AC, Montgomery AA, Logan RF, Clifford GM, Rees CJ, Loadman PM, Whitham D: A randomized controlled trial of eicosapentaenoic acid and/or aspirin for colorectal
adenoma prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme (The seAFOod Polyp Prevention Trial): study protocol for a randomized
controlled trial. Trials 2013, 14:237.
Flock MR, Skulas-Ray AC, Harris WS, Etherton TD, Fleming JA, Kris-Etherton PM: Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a
dose-response randomized controlled trial. Journal of the American Heart Association 2013, 2:e000513.
Harris WS: The omega-3 index: clinical utility for therapeutic intervention. Current cardiology reports 2010, 12:503-508.
Harris WS: Pushing the limits with omega-3 fatty acids. Trends in cardiovascular medicine 2015.
Harris WS, Von Schacky C: The Omega-3 Index: a new risk factor for death from coronary heart disease? Preventive medicine 2004, 39:212-220.
Harris WS, Varvel SA, Pottala JV, Warnick GR, McConnell JP: Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications
for clinical utility. Journal of clinical lipidology 2013, 7:433-440.
Kohler A, Bittner D, Low A, von Schacky C: Effects of a convenience drink fortified with n-3 fatty acids on the n-3 index. The British journal of nutrition 2010, 104:729-736.
Martins JG: EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-
analysis of randomized controlled trials. Journal of the American College of Nutrition 2009, 28:525-542.
Puri BK, Leavitt BR, Hayden MR, Ross CA, Rosenblatt A, Greenamyre JT, Hersch S, Vaddadi KS, Sword A, Horrobin DF, et al: Ethyl-EPA in Huntington disease: a double-blind,
randomized, placebo-controlled trial. Neurology 2005, 65:286-292.
Puri BK, Bydder GM, Counsell SJ, Corridan BJ, Richardson AJ, Hajnal JV, Appel C, McKee HM, Vaddadi KS, Horrobin DF: MRI and neuropsychological improvement in Huntington
disease following ethyl-EPA treatment. Neuroreport 2002, 13:123-126.
Russell FD, Burgin-Maunder CS: Distinguishing health benefits of eicosapentaenoic and docosahexaenoic acids. Marine drugs 2012, 10:2535-2559.
Sublette ME, Ellis SP, Geant AL, Mann JJ: Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. The Journal of clinical psychiatry 2011, 72:1577-
1584.
Surette ME: The science behind dietary omega-3 fatty acids. CMAJ : Canadian Medical Association journal = journal de l'Association medicale Canadienne 2008, 178:177-180.
Verlengia R, Gorjao R, Kanunfre CC, Bordin S, de Lima TM, Martins EF, Newsholme P, Curi R: Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji
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Editor's Notes
Clearly, in CVD trials - participants with a high Omega-3 Index at baseline [and presumably throughout the study] few, if any, CVD events are to be expected, whereas they are more likely in individuals with a low Omega-3 Index
100,000 years ago
A large intervention trial based on the Omega-3 Index with clinical endpoints remains [needs] to be performed
EPA
DHA
Total omega-3
Concentrated fish oil (rTG)
650
450
1100
Concentrated fish oil (EE)
756
228
984
Salmon oil (TG)
180
220
400
Krill oil (PL)
150
90
240
So I want to use brain health nutrition research to further highlight research flaws and to start to highlight what we need to be looking for in studies to find the ‘real’ answers
Let’s take a look at some of the recent ‘negative’ studies and try and figure out why?!
Potent fine-tuning of focus, concentration and memory
Improved cognitive performance for demanding tasks
Combination of nutrients actually usually more helpful to asses – when we look at one nutrient and one outcome the often any benefit is lost as you need to address a number of pathways to calm the mind, reduce distractibility enhance process and fine tune attention in order for significant benefits to be observed.
This was the forest plot from that latest Cochrane review looking at the role of Omega-3 in depression – BUT why do this and lump EPA and DHA together when two previous reviews had been conducted to show that splitting treatment down into EPA vs DHA resulted in very different outcomes.
The kynurenine (KYN)/tryptophan ratio, serotonin and depression
The kynurenine (KYN) pathway, which is initiated by indoleamine 2,3-dioxygenase (IDO), is a main tryptophan metabolic pathway and shares tryptophan with the serotonin (5-HT) pathway
Activation of tryptophan 2,3-dioxygenase (TDO), present in liver and brain, is up regulated by cortisol whilst cytokines activate IDO and kynurenine monooxygenase (KMO) (Oxenkrug 2010)
Not only are serotonin levels reduced as a result of the diversion of tryptophan but elevated quinolinic acid production has neurotoxic effects via agonist actions on N-methyl-D-aspartate receptors (NMDA) triggering neuronal apoptosis, thus further contributing to depressive symptoms (Heyes et al., 1992)
Elevated quinolinic acid accumulation in certain areas of the brain tissue has been reported in depressed patients (Steiner et al., 2011)
The kynurenine (KYN)/tryptophan ratio, serotonin and depression
The kynurenine (KYN) pathway, which is initiated by indoleamine 2,3-dioxygenase (IDO), is a main tryptophan metabolic pathway and shares tryptophan with the serotonin (5-HT) pathway
Activation of tryptophan 2,3-dioxygenase (TDO), present in liver and brain, is up regulated by cortisol whilst cytokines activate IDO and kynurenine monooxygenase (KMO) (Oxenkrug 2010)
Not only are serotonin levels reduced as a result of the diversion of tryptophan but elevated quinolinic acid production has neurotoxic effects via agonist actions on N-methyl-D-aspartate receptors (NMDA) triggering neuronal apoptosis, thus further contributing to depressive symptoms (Heyes et al., 1992)
Elevated quinolinic acid accumulation in certain areas of the brain tissue has been reported in depressed patients (Steiner et al., 2011)
The kynurenine (KYN)/tryptophan ratio, serotonin and depression
The kynurenine (KYN) pathway, which is initiated by indoleamine 2,3-dioxygenase (IDO), is a main tryptophan metabolic pathway and shares tryptophan with the serotonin (5-HT) pathway
Activation of tryptophan 2,3-dioxygenase (TDO), present in liver and brain, is up regulated by cortisol whilst cytokines activate IDO and kynurenine monooxygenase (KMO) (Oxenkrug 2010)
Not only are serotonin levels reduced as a result of the diversion of tryptophan but elevated quinolinic acid production has neurotoxic effects via agonist actions on N-methyl-D-aspartate receptors (NMDA) triggering neuronal apoptosis, thus further contributing to depressive symptoms (Heyes et al., 1992)
Elevated quinolinic acid accumulation in certain areas of the brain tissue has been reported in depressed patients (Steiner et al., 2011)
The kynurenine (KYN)/tryptophan ratio, serotonin and depression
The kynurenine (KYN) pathway, which is initiated by indoleamine 2,3-dioxygenase (IDO), is a main tryptophan metabolic pathway and shares tryptophan with the serotonin (5-HT) pathway
Activation of tryptophan 2,3-dioxygenase (TDO), present in liver and brain, is up regulated by cortisol whilst cytokines activate IDO and kynurenine monooxygenase (KMO) (Oxenkrug 2010)
Not only are serotonin levels reduced as a result of the diversion of tryptophan but elevated quinolinic acid production has neurotoxic effects via agonist actions on N-methyl-D-aspartate receptors (NMDA) triggering neuronal apoptosis, thus further contributing to depressive symptoms (Heyes et al., 1992)
Elevated quinolinic acid accumulation in certain areas of the brain tissue has been reported in depressed patients (Steiner et al., 2011)
The kynurenine (KYN)/tryptophan ratio, serotonin and depression
The kynurenine (KYN) pathway, which is initiated by indoleamine 2,3-dioxygenase (IDO), is a main tryptophan metabolic pathway and shares tryptophan with the serotonin (5-HT) pathway
Activation of tryptophan 2,3-dioxygenase (TDO), present in liver and brain, is up regulated by cortisol whilst cytokines activate IDO and kynurenine monooxygenase (KMO) (Oxenkrug 2010)
Not only are serotonin levels reduced as a result of the diversion of tryptophan but elevated quinolinic acid production has neurotoxic effects via agonist actions on N-methyl-D-aspartate receptors (NMDA) triggering neuronal apoptosis, thus further contributing to depressive symptoms (Heyes et al., 1992)
Elevated quinolinic acid accumulation in certain areas of the brain tissue has been reported in depressed patients (Steiner et al., 2011)
The kynurenine (KYN)/tryptophan ratio, serotonin and depression
The kynurenine (KYN) pathway, which is initiated by indoleamine 2,3-dioxygenase (IDO), is a main tryptophan metabolic pathway and shares tryptophan with the serotonin (5-HT) pathway
Activation of tryptophan 2,3-dioxygenase (TDO), present in liver and brain, is up regulated by cortisol whilst cytokines activate IDO and kynurenine monooxygenase (KMO) (Oxenkrug 2010)
Not only are serotonin levels reduced as a result of the diversion of tryptophan but elevated quinolinic acid production has neurotoxic effects via agonist actions on N-methyl-D-aspartate receptors (NMDA) triggering neuronal apoptosis, thus further contributing to depressive symptoms (Heyes et al., 1992)
Elevated quinolinic acid accumulation in certain areas of the brain tissue has been reported in depressed patients (Steiner et al., 2011)
Supplements alone are not magic bullets – they are not and so should not be treated like a drug in research and outcome expectations. Perhaps for the same reasons that so many drugs are failing. Disease is multifaceted targeting 1 pathway with one ‘chemical’ is usually either not enough or leads to down stream effects that could be detrimental!
We must not be put off by negative research outcomes and reports. We are in a funny place with nutrition at the moment where we are still discovering what it is we don’t know rather than what does not work. The more negative research that comes out the more we must scrutinise what is missing in order to better design future interventions that factor in everything needed for changes to be seen. Realistically it is likely that we will never see a day where all factors that impact outcome can be controlled for as ethically and logistically it is just too hard to achieve.
We are currently stuck between a rock and a hard place with evidence based medicine to quote my favorited physician Dr Gregory House! “absence of evidence is not evidence of absence” meaning we still don’t 100% know what is going on in the human body and how best to tackle these issues with nutrition and simply because supposed ‘robust’ gold standard RTC trials ‘prove’ there are no benefits does not mean their aren’t. We have to weight up mechanisms, synergy, diet PLUS lifestyle and safety of an intervention to come up with the best plan of action and hope along the lines we stumble upon something wonderful that could just make the difference.