This document from the Pennington Biomedical Research Center provides information on omega-3 fatty acids. It defines omega-3 fatty acids and describes their types - ALA, EPA, and DHA. Sources of each type are outlined. The roles of DHA in visual development and EPA/DHA in cardiovascular health are summarized. Studies on omega-3's relationships to coronary heart disease, stroke, cancer, diabetes, inflammatory diseases and disorders like depression are highlighted at a high level.
Omega 3,6 & 9 Fatty AcidsOmega-3 and omega-6 fatty acids are PUFAs and omega-9 fatty acids are usually MUFAs. The omega numbers simply reference how many carbons away from the methyl end of the fatty acid chain that the first carbon-carbon double bond appears. If the double bond is three carbons away, it's called an omega-3 fatty acid.,
Omega−3 fatty acids, also called Omega-3
oils, ω−3 fatty acids or n−3 fatty acids,
are polyunsaturated fatty acids (PUFAs)
characterized by the presence of a double
bond three atoms away from the terminal
methyl group in their chemical structure.
They are widely distributed in nature, being
important constituents of animal lipid
metabolism, and they play an important
role in the human diet and in human
physiology.
https://www.slideshare.net/DauRamChandravanshi1
Omega 3,6 & 9 Fatty AcidsOmega-3 and omega-6 fatty acids are PUFAs and omega-9 fatty acids are usually MUFAs. The omega numbers simply reference how many carbons away from the methyl end of the fatty acid chain that the first carbon-carbon double bond appears. If the double bond is three carbons away, it's called an omega-3 fatty acid.,
Omega−3 fatty acids, also called Omega-3
oils, ω−3 fatty acids or n−3 fatty acids,
are polyunsaturated fatty acids (PUFAs)
characterized by the presence of a double
bond three atoms away from the terminal
methyl group in their chemical structure.
They are widely distributed in nature, being
important constituents of animal lipid
metabolism, and they play an important
role in the human diet and in human
physiology.
https://www.slideshare.net/DauRamChandravanshi1
OMEGA 3 FATTY ACIDS AND ALZHEIMER'S DISEASEBabie Maibam
Prevention of age-related cognitive decline - a public health challenge.Nutrition, a major lifelong environmental factor, offers promising perspectives.
Omega -3 & omega -6 acids and their health effects.Zahir Khan
Omega-3 fatty acids are essential fatty acids, a class of nutrients needed for our body to function normally.
These are the fats of life which help our cells to function properly.
Omega-3 cannot be produced be our body and should be supplied through the diet
Omega 3 fatty acids are the most important and least understood nutrition among people. Here we try to show you a glimpse of what it is.....Read more on our blog....
Omega -3 & Omega -6 Fatty acids and their Health EffectsZahir Khan
Omega-3 fatty acids are essential fatty acids, a class of nutrients needed for our body to function normally.
These are the fats of life which help our cells to function properly.
Omega-3 cannot be produced be our body and should be supplied through the diet
There are 3 very important types of Omega 3 acids
1.Alpha-linolenic acid (ALA)
2.Eicosapentaenoic acid (EPA)
3.Docosahexaenoic acid (DHA)
which have amazing health benefits
Omega 3 plays a major role in a number of functions in our body. Here are they:-
Relaxation and contraction of muscles
Blood clotting
Digestion
Fertility
Cell division
Growth
Movement of calcium and other substances in and out of cells.
Omega-3 fatty acids are essential fatty acids, a class of nutrients needed for our body to function normally.
These are the fats of life which help our cells to function properly.
Omega-3 cannot be produced be our body and should be supplied through the diet.
There are 2 very important types of Omega 3 acids , namely EPA and DHA, which have amazing health benefits.
KALOFLAX 90 Softgel : A Herbal Anti Oxidant & a good source of Omega 3, 6 & 9
See: http://nirogam.com/product_detail/16/Kaloflax-90-Softgels
For more information, please see the link below : http://herbscancure.com/blog/omg-facts-about-omega-3/
One of the most lethal epidemics today in the USA is Chronic inflammation OR silent Inflammation and OMEGA 6 and OMEGA 3 IMBALANCE is the leading cause of this chronic inflammation, which in turn affects your brain, heart and immune system, causing a range of inflammatory diseases such as cancer, heart diseases, arthritis, Alzheimer’s, diabetes, etc.
Zinzino Balance Oil Kit includes NEW and Simplified Omega 6:3 balance HOME TEST allowing anyone take the test at home without going to laboratory and get clear color-coded Omega 6:3 ratio results online.
Balance Oil is not just a fish oil, since it has Cold Pressed Extra Virgin olive oil from Spain acting as an antioxidant for maximum absorption and your exact daily dose is based on your weight.
Learn all the facts now http://inspirezbalance.com/
OMEGA 3 FATTY ACIDS AND ALZHEIMER'S DISEASEBabie Maibam
Prevention of age-related cognitive decline - a public health challenge.Nutrition, a major lifelong environmental factor, offers promising perspectives.
Omega -3 & omega -6 acids and their health effects.Zahir Khan
Omega-3 fatty acids are essential fatty acids, a class of nutrients needed for our body to function normally.
These are the fats of life which help our cells to function properly.
Omega-3 cannot be produced be our body and should be supplied through the diet
Omega 3 fatty acids are the most important and least understood nutrition among people. Here we try to show you a glimpse of what it is.....Read more on our blog....
Omega -3 & Omega -6 Fatty acids and their Health EffectsZahir Khan
Omega-3 fatty acids are essential fatty acids, a class of nutrients needed for our body to function normally.
These are the fats of life which help our cells to function properly.
Omega-3 cannot be produced be our body and should be supplied through the diet
There are 3 very important types of Omega 3 acids
1.Alpha-linolenic acid (ALA)
2.Eicosapentaenoic acid (EPA)
3.Docosahexaenoic acid (DHA)
which have amazing health benefits
Omega 3 plays a major role in a number of functions in our body. Here are they:-
Relaxation and contraction of muscles
Blood clotting
Digestion
Fertility
Cell division
Growth
Movement of calcium and other substances in and out of cells.
Omega-3 fatty acids are essential fatty acids, a class of nutrients needed for our body to function normally.
These are the fats of life which help our cells to function properly.
Omega-3 cannot be produced be our body and should be supplied through the diet.
There are 2 very important types of Omega 3 acids , namely EPA and DHA, which have amazing health benefits.
KALOFLAX 90 Softgel : A Herbal Anti Oxidant & a good source of Omega 3, 6 & 9
See: http://nirogam.com/product_detail/16/Kaloflax-90-Softgels
For more information, please see the link below : http://herbscancure.com/blog/omg-facts-about-omega-3/
One of the most lethal epidemics today in the USA is Chronic inflammation OR silent Inflammation and OMEGA 6 and OMEGA 3 IMBALANCE is the leading cause of this chronic inflammation, which in turn affects your brain, heart and immune system, causing a range of inflammatory diseases such as cancer, heart diseases, arthritis, Alzheimer’s, diabetes, etc.
Zinzino Balance Oil Kit includes NEW and Simplified Omega 6:3 balance HOME TEST allowing anyone take the test at home without going to laboratory and get clear color-coded Omega 6:3 ratio results online.
Balance Oil is not just a fish oil, since it has Cold Pressed Extra Virgin olive oil from Spain acting as an antioxidant for maximum absorption and your exact daily dose is based on your weight.
Learn all the facts now http://inspirezbalance.com/
This webinar is designed to teach practitioners about how to use and recommend the Igennus cardiovascular health treatment protocol for maximum results in your clients. We will cover the evidence for the use of the nutrients within the protocol and provide the recommended dosing regime for a range of cardiovascular health concerns.
During this webinar Dr Bailey reviews the latest evidence for the clinical application of omega-3 fats found in fish oil with a focus on choosing the best source, form, bioavailability and strength for your client’s condition management.
Veganism is on the rise due to growing concerns about the environment and perceived health benefits. However, certain nutrients such as EPA & DHA are difficult to obtain from plant-based diets. Until recently, the only supplemental source of long-chain omega-3s was fish oil. Igennus has recently launched a vegan omega-3 product which combines algae-sourced EPA & DHA with the additional benefit of astaxanthin, a powerful antioxidant.
In this hour-long webinar, Dr Danielle Crida discusses:
- The importance of omega-3s and the omega 6:3 ratio
- Vegan options for omega-3 supplementation
- Our new Vegan Omega-3 & Astaxanthin product
- How to assess omega-3 requirements and measure response to supplementation
- Ensuring optimal nutrition on a plant-based diet: common nutrient deficiencies and how to address them
Learn about the Mediterranean diet, including its role in preventing cardiovascular disease. Find out how the Mediterranean diet can help protect and improve your health and increase your odds for a long life.
Hosted by with Sophie Tully BSc MSc, 10th October
This presentation addresses the role of cholesterol in CVD and the latest evidence into nutritional strategies to manage and treat high cholesterol and support healthy CVD function. Sophie covers the aetiology of CVD and why cholesterol has long been considered an important marker of CVD health and the emergence of newly identified CVD risk factors which may offer a more effective diagnostic tool. Finally she discusses new opinions on nutritional approaches to keep cholesterol levels healthy and prevent CVD events.
Inadequate long-chain omega-3 fatty acid status has a substantial impact on our health. Human RCT, observational, in vitro and in vivo animal studies all demonstrate that omega-3 fats from fish improve inflammatory regulation and its associated conditions. Yet, due to inconsistency in findings, the validity of omega-3 fatty acids as ‘treatments’ has been brought into question in the reporting of studies. To date, few studies have monitored the correlation between omega-3 dose, subsequent cellular enrichment of these fatty acids and clinical outcomes.
In this webinar, Dr Bailey presents the latest evidence for the importance of a biomarker-based, personalised approach to omega-3 treatment – one that significantly improves consistency in clinical outcomes and offers an antidote to the ‘one-size fits all’ approach that is responsible for significant individual variations in response in many published studies.
During this webinar Sophie Tully BSc MSc DipPT will discuss why nutrition research often fails to produce positive results and the methodological flaws that contribute to poor research outcomes.
Sophie will provide a detailed explanation of what we can learn from the recent wave of negative nutrition research and how to carefully consider and determine the right supplement regime for your clients’ health concerns. Covering the most important factors to consider when choosing the nutrients, dose and timescale of a nutritional intervention Sophie will provide you with a practical clinical toolkit that can be applied to all of your protocols to ensure client success.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Hemodialysis: Chapter 3, Dialysis Water Unit - Dr.Gawad
Omega3fattyacids1 121225062726-phpapp02
1. Pennington Biomedical Research Center
Division of Education
Heli J. Roy, PhD
Shanna Lundy, BS
Phillip Brantley, PhD, Director
2. Information:
Omega-3 Fatty Acids
• Omega-3 FA’s are polyunsaturated, meaning they contain more
than one double bond
• They are called omega-3 because the first double bond
counting from the methyl end of the fatty acid is located at the
third carbon atom
PBRC 2005
4. Alpha-linolenic acid (ALA)
• Scientific abbreviation is 18:3n-3
• The first part (18:3) suggests that ALA is an 18-carbon fatty
acid with 3 double bonds
• The second part (n-3) tells you that ALA is an omega-3 fatty
acid
• It is required for health, but cannot be synthesized in humans
• Must be obtained from the diet
PBRC 2005
5. Alpha-linolenic Acid
• Humans can synthesize other omega-3 fatty acids from ALA:
• Eicosapentaenoic acid (EPA): 20:5n-3
• Docosahexaenoic acid (DHA): 22:6n-3
• These two are usually referred to as marine-derived
omega-3 fatty acids because they are abundant in
certain species of fish
• Whereas, ALA is considered a plant-derived omega-3 fatty acid
PBRC 2005
9. Docosahexaenoic acid (DHA)
• Found in very high concentrations in the cell
membranes of the retina
• It conserves and recycles DHA even when
omega-3 fatty acid intake is low
• Studies in animals indicate that DHA is required for
the normal development and function of the retina
PBRC 2005
10. Disease Prevention:
Impaired Visual and Neural Development
• Because the last trimester of pregnancy is a critical period for the
accumulation of DHA in the brain and retina, preterm infants are
particularly vulnerable to adverse effects of insufficient DHA on visual
and neural development
• Although preterm infants can synthesize DHA from ALA, they can’t
synthesize enough to prevent declines in plasma and cellular DHA
levels without additional dietary intake
• Preterm infants fed formulas with DHA added had significantly
improved measures of visual function compared to preterm infants fed
DHA-free formulas in 5 out of 5 randomized controlled trials
PBRC 2005
11. Fish Consumption
And Coronary Heart Disease
• One study followed 1,822 men for 30 years and found that
mortality from CHD was 38% lower in men who consumed an
average of at least 35 g (1.2 ounces) of fish daily than in men
who did not eat fish, while mortality from myocardial infarction
(MI) was 67% lower
PBRC 2005
12. ALA Consumption
And Coronary Heart Disease
• In a prospective study of 43,757 male health professionals followed
for 6 years, a relatively small increase in ALA intake (1% of total
energy) was associated with a 59% decrease in the risk of acute MI
• Women who consumed oil and vinegar salad dressings 5-6 times
weekly had a risk of fatal CHD that was 54% lower than those who
rarely consumed it even after adjusting the analysis for vegetable
intake
• Although the evidence is limited, it is indicated that increased ALA
intakes may decrease the risk for CHD, especially in populations with
relatively low levels of fish consumption
PBRC 2005
13. CHD Treatment
• Results of randomized controlled trials in individuals with
documented coronary heart disease suggest a beneficial effect
of dietary and supplemental omega-3 fatty acids
• Therefore, the American Heart Association has recommended
that individuals with documented CHD consume 1 g/d of EPA
and DHA combined
PBRC 2005
14. Fish Consumption
And Sudden Cardiac Death
• Several studies have found inverse relationships between
fish consumption and sudden cardiac death
• In a prospective study, omega-3 fatty acid intakes equivalent to two
fatty fish meals per week were associated with a 50% decrease in the
risk of primary cardiac arrest
• Plasma levels of EPA and DHA were found to be inversely related to
the risk of sudden death, supporting the idea that omega-3 fatty acids
are at least partially responsible for the beneficial effect of fish
consumption and sudden cardiac death
PBRC 2005
15. Fish Consumption
And Stroke
• A stroke is a result of impaired blood flow to a region of the
brain, which may be due to obstruction of a blood vessel by a blood
clot (thrombotic or ischemic stroke) or the rupture of a blood vessel
(hemorrhagic stroke)
• Even though the effects of increased omega-3 fatty acid intake and
the incidence of stroke have not been studied as thoroughly as the
relationship with CHD, what is available suggests that increased fish
intake may decrease the risk of thrombotic or ischemic stroke but not
hemorrhagic
PBRC 2005
16. Cancer
• Marine-derived fatty acids have been found to inhibit proliferation and
promote apoptosis in breast, prostate, and colon cancer cell lines
cultured outside the body
• Studies in animal models of cancer also indicate that increased intake
of EPA and DHA decreases the occurrence and progression of
mammary, prostate, and intestinal tumors
• However, in humans few have demonstrated significant inverse
relationships between fish or omega-3 fatty acid intake and the risk for
breast, prostate, or colorectal cancers
PBRC 2005
17. Diabetes Mellitus
• Cardiovascular diseases are the leading causes of death in
individuals with diabetes
• Hypertriglyceridemia (fasting serum TG of 200 mg/dl or higher) is a
common lipid abnormality in individuals with Type 2 diabetes
• A number of randomized controlled trials have found that fish oil
supplementation significantly lowers serum triglyceride levels in
diabetic individuals
PBRC 2005
18. Diabetes Mellitus
• But, few control trials have examined the effect of fish
oil supplementation on cardiovascular disease outcomes
in diabetics
• One prospective study, following 5103 women diagnosed with type 2
DM but free of cardiovascular disease at the start of the study, found
decreased risks
• Those with higher fish intakes were associated with significantly
decreased risks of CHD over the 16 years that the study
lasted for, suggesting that increasing EPA and DHA levels may be
beneficial to diabetic individuals, especially those with elevated serum
triglycerides
PBRC 2005
19. Inflammatory Diseases
Rheumatoid arthritis
• Rheumatoid arthritis is the most common
systemic inflammatory rheumatic (joint) disease
• Studies have been conducted to determine the effects of
omega-3 fatty acids on rheumatoid arthritis
• Clinical benefits were observed at a minimum dose of 3 g/day
of EPA + DHA, and were not apparent until at least 12 weeks of
supplementation
PBRC 2005
20. Inflammatory Diseases
Rheumatoid arthritis
• Some investigators report that patients taking omega-3 fatty
acid supplementation were able to lower their doses of
nonsteroidal anti-inflammatory drugs (NSAIDS), but not all
findings on this issue were consistent
PBRC 2005
21. Inflammatory Bowel Disease
Ulcerative colitis and Crohn’s Disease
• Clinical trial results were less consistent with inflammatory
bowel diseases than in patients with rheumatoid arthritis
• A significantly higher proportion of Crohn’s disease patients
supplemented with 2.7 g/day of EPA + DHA remained in
remission over a one-year period than those given placebo
Ileocecal region
PBRC 2005
22. Inflammatory Bowel Disease
Ulcerative colitis and Crohn’s Disease
• In 3 randomized controlled trials of EPA + DHA
supplementation in Ulcerative colitis patients, significant
improvements were reported in at least one outcome
measure, including decreased corticosteroid use, decreased
production of inflammatory mediators, and improvements in
disease activity scores, histology scores, and weight gain Crohn’s
disease
PBRC 2005
Ulcerative Colitis
23. Asthma
• Although there is some evidence that omega-3 fatty acid
supplementation can decrease the production of inflammatory
mediators in asthmatic patients, evidence that omega-3 fatty
acid supplementation decreases the clinical severity of asthma
in controlled trials has been inconsistent
PBRC 2005
24. Immunoglobulin A
nephropathy
• A kidney disorder that results from the deposition of the
immune system protein IgA in the glomeruli (filtering region) of
the kidney
• The cause is unclear, but progressive renal failure may
eventually develop in 15-40% of patients
• Since glomerular IgA deposition results in increased production
of inflammatory mediators, it is thought that omega-3 fatty acid
supplementation could potentially modulate the inflammatory
response and preserve renal function
PBRC 2005
25. Immunoglobulin A
nephropathy
• Several studies have been conducted showing no real significant
benefits, and continuing declines in renal functioning in some
• However, the probability of a minor beneficial effect was high enough
(75%) to provide support for a large placebo-controlled trial of at least
two years duration
• Currently, researchers are conducting this study, comparing fish oil to
alternate day prednisone treatment and a placebo in children and
young adults
PBRC 2005
26. Major Depression
And Bipolar Disorder
• Several small studies have found omega-3 fatty acid levels to be
lower in the plasma and fat of individuals suffering from depression
compared to controls
• In one study conducted, for 30 individuals, with bipolar
disorder, consuming large amounts of EPA (6.2 g/d) and DHA (3.4
g/d), they had a significantly longer period of remission than those on
an olive oil placebo over a 4 month period
• Patients who took the EPA + DHA supplement also
experienced less depression than those who took
the placebo
PBRC 2005
27. Major Depression
And Bipolar Disorder
• Although these very limited pilot studies produce somewhat
optimistic results, larger and long-term randomized trial are
needed to determine the efficacy of marine-derived omega-3
fatty acid supplementation on major depression
PBRC 2005
28. Schizophrenia
• Schizophrenia is a chronic disabling brain disorder that affects
approximately 1% of the population
• A pilot study in 45 schizophrenic patients found
that the addition of 2 g/day of EPA to standard
antipsychotic therapy was superior to the addition of
a 2 g/day to DHA or a placebo in decreasing residual symptoms
• Although limited evidence does suggest that EPA supplementation
may be a useful adjunct to antipsychotic therapy in schizophrenic
patients, larger long-term studies addressing clinically relevant
outcomes are needed
PBRC 2005
29. References
• Ascherio A, et al. BMJ. 1996;313(7049):84-90.
• Daviglus ML, Stamler J, Orencia AJ, et al. N Engl J Med. 1997;336(15):1046-1053
• Siscovick DS et al. JAMA. 1995;274(17):1363
• Albert CM et al. N Engl J Med. 2002;346(15):1113.
• Rose DP, Connolly JM. Pharmacol Ther. 1999;83(3):217-244.
• Bartsch H, Nair J, Owen RW. Carcinogenesis. 1999;20(12):2209-2218.
• Terry PD, Rohan TE, Wolk. Am J Clin Nutr. 2003;77(3):532-543
• Montori VM, Farmer A, Wollan PC, Dinneen SF. Diabetes Care. 2000;23(9):1407-1415.
• Hu FB, Cho E, Rexrode KM, Albert CM, Manson JE. Circulation. 2003;107(14):1852-1857.
• Kremer JM. Am J Clin Nutr. 2000;71(1 Suppl):349S-351S.
• Kjeldsen-Kragh J, Lund JA, Riise T, et al. J Rheumatol. 1992;19(10):1531-1536.
• Lau CS, Morley KD, Belch JJ. Br J Rheumatol. 1993;32(11):982-989.
PBRC 2005
30. References
• Aslan A, Triadafilopoulos G. Am J Gastroenterol. 1992;87(4):432-437.
• Hawthorne AB, Daneshmend TK, Hawkey CJ, et al. Gut. 1992;33(7):922-928.
• Stenson WF, Cort D, Rodgers J, et al. Ann Intern Med. 1992;116(8):609-614.
• Donadio JV, Grande JP. N Engl J Med. 2002;347(10):738-748.
• Wyatt RJ, Hogg RJ. Pediatr Nephrol. 2001;16(2):156-167
• Stoll AL, Severus WE, Freeman MP, et al. Arch Gen Psychiatry. 1999;56(5):407-412.
• Peet M, Brind J, Ramchand CN, Shah S, Vankar GK. Schizophr Res. 2001;49(3):243-
251.
• Joy CB, Mumby-Croft R, Joy LA. Cochrane Database Syst Rev. 2000(2):CD001257
• http://lpi.oregonstate.edu/infocenter/othernuts/omega3fa/index.html
• http://www.google.com/imghp?hl=en&tab=wi&q=
PBRC 2005