This document discusses nutritional factors that may play a role in delaying the onset of dementia. It defines dementia and discusses the limited effectiveness of current drug treatments. Preventing or delaying dementia progression through modifiable risk factors is a priority. The document examines lifestyle and genetic risk factors for cognitive decline and dementia. It discusses the roles of homocysteine, cardiovascular health, diabetes, depression, and inflammation. Specific nutrients that may help reduce oxidative damage and dementia risk through various mechanisms are outlined, including alpha lipoic acid, carnosine, coenzyme Q10, B vitamins, and adherence to a Mediterranean-style diet high in omega-3 fatty acids.
Intermittent fasting and metabolic syndromefathi neana
Metabolic syndrome reached an epidemic
No Cure by Insulin, Drugs, Low fat diet
Can be cured by Bariatric surgery, Intermittent fasting, Very low carb diet
In this informative webinar, with expert nutritionist Dr Nina Bailey, you will learn about how we can optimise our diet to help manage depressive symptoms:
- Foods the brain needs to function: what we should be eating
- Foods that starve the brain of nutrients: what foods we really need to avoid
- Food, mood and money: how to eat well on a budget
- Supplements: the best nutrients for depression, backed up by science
By making some relatively simple dietary changes that may, in some cases, include the use of dietary supplements, it is possible to see significant improvement in symptoms.
Osteoporosis is a Skeletal disorder characterized by compromised Bone strength. Bone strength primarily reflects the integration of: 1- Bone Density (Mass) 2- Bone Quality 3- Bone Turnover (Recycling). leading to an increased Fragility and risk of fracture.
Osteoporosis is a serious public health concern due to its prevalence worldwide. Currently over 200 million people worldwide suffer from this disease. Approximately 30% of all postmenopausal women have osteoporosis in the USA & Europe. At least 40% of these women and 15-30% of men will sustain one or more fragility fractures in their remaining lifetime. Ageing of populations worldwide will be responsible for a major increase in the incidence of osteoporosis in postmenopausal women. An initial fracture is a major risk factor for a new fracture. An increased risk of 86% for any fracture in people that have already sustained a fracture. Patients with a history of vertebral fracture have a 2.3-fold increased risk of future hip fracture and a 1.4-fold increase in risk of distal forearm fracture.
Prevention and Treatment of Osteoporosis and Fragility fracture:
A- Therapeutic Life style: 1- Good Nutritious Diet. 2- Exercise. 3- Prevention of falls
B- Drug therapy: 1- Anti resorptive agent. 2- Bone forming agents. 3- Other agents
Intermittent fasting and metabolic syndromefathi neana
Metabolic syndrome reached an epidemic
No Cure by Insulin, Drugs, Low fat diet
Can be cured by Bariatric surgery, Intermittent fasting, Very low carb diet
In this informative webinar, with expert nutritionist Dr Nina Bailey, you will learn about how we can optimise our diet to help manage depressive symptoms:
- Foods the brain needs to function: what we should be eating
- Foods that starve the brain of nutrients: what foods we really need to avoid
- Food, mood and money: how to eat well on a budget
- Supplements: the best nutrients for depression, backed up by science
By making some relatively simple dietary changes that may, in some cases, include the use of dietary supplements, it is possible to see significant improvement in symptoms.
Osteoporosis is a Skeletal disorder characterized by compromised Bone strength. Bone strength primarily reflects the integration of: 1- Bone Density (Mass) 2- Bone Quality 3- Bone Turnover (Recycling). leading to an increased Fragility and risk of fracture.
Osteoporosis is a serious public health concern due to its prevalence worldwide. Currently over 200 million people worldwide suffer from this disease. Approximately 30% of all postmenopausal women have osteoporosis in the USA & Europe. At least 40% of these women and 15-30% of men will sustain one or more fragility fractures in their remaining lifetime. Ageing of populations worldwide will be responsible for a major increase in the incidence of osteoporosis in postmenopausal women. An initial fracture is a major risk factor for a new fracture. An increased risk of 86% for any fracture in people that have already sustained a fracture. Patients with a history of vertebral fracture have a 2.3-fold increased risk of future hip fracture and a 1.4-fold increase in risk of distal forearm fracture.
Prevention and Treatment of Osteoporosis and Fragility fracture:
A- Therapeutic Life style: 1- Good Nutritious Diet. 2- Exercise. 3- Prevention of falls
B- Drug therapy: 1- Anti resorptive agent. 2- Bone forming agents. 3- Other agents
Nutrition is a key factor in the onset and progression of cognitive decline, yet despite a growing pool of research, little evidence exists to support the efficacy of single nutrients in this complex area. The most promising evidence comes from specific dietary patterns and nutrients in the prevention and slowed progression of neurodegenerative disease. During this webinar, Dr Bailey will focus on the synergistic role of key nutrients involved in the mechanisms that drive cognitive decline and support healthy brain aging. Topics include:
- Risk factors for cognitive decline
- Biological mechanisms underpinning cognitive decline
Dietary patterns that offer protection and support against cognitive decline
- The role of specific nutrients in protecting brain health and function
- Nutritional recommendations for healthy brain ageing
Intermittent fasting is an Interventional strategy where in individuals are subjected to varying periods of fasting.
It doesn’t specify which foods you should eat but rather when you should eat them.
Intermittent fasting (IF) is an eating pattern that cycles between periods of fasting and eating.
It’s currently very popular in the health and fitness community.
Recently attracted attention because:
1- Its Evidence-Based Health Benefits
2- Its potential for correcting metabolic Abnormalities
3- Better adherence than other methods
While low to moderate doses are generally safe, caffeine is addictive and users can become dependent on it and find it difficult to quit or even cut back.Caffeine dependence was even named as a new mental disorder this year. Anyone who's ever quit cold turkey knows it can trigger pounding headaches, mental fuzziness and fatigue for a couple of days until the body adjusts.
Slide set that accompanied a public lecture on Nutrients and Bone Health held in London September 2011. The lecture focused on the importance of diet and lifestyle in maintaining healthy bone and preventing osteoporosis. Aspects of diagnosis are reviewed and the use of bone markers to indicate bone turnover are discussed in relation to monitoring the response to treatment.
Nutrition is a key factor in the onset and progression of cognitive decline, yet despite a growing pool of research, little evidence exists to support the efficacy of single nutrients in this complex area. The most promising evidence comes from specific dietary patterns and nutrients in the prevention and slowed progression of neurodegenerative disease. During this webinar, Dr Bailey will focus on the synergistic role of key nutrients involved in the mechanisms that drive cognitive decline and support healthy brain aging. Topics include:
- Risk factors for cognitive decline
- Biological mechanisms underpinning cognitive decline
Dietary patterns that offer protection and support against cognitive decline
- The role of specific nutrients in protecting brain health and function
- Nutritional recommendations for healthy brain ageing
Intermittent fasting is an Interventional strategy where in individuals are subjected to varying periods of fasting.
It doesn’t specify which foods you should eat but rather when you should eat them.
Intermittent fasting (IF) is an eating pattern that cycles between periods of fasting and eating.
It’s currently very popular in the health and fitness community.
Recently attracted attention because:
1- Its Evidence-Based Health Benefits
2- Its potential for correcting metabolic Abnormalities
3- Better adherence than other methods
While low to moderate doses are generally safe, caffeine is addictive and users can become dependent on it and find it difficult to quit or even cut back.Caffeine dependence was even named as a new mental disorder this year. Anyone who's ever quit cold turkey knows it can trigger pounding headaches, mental fuzziness and fatigue for a couple of days until the body adjusts.
Slide set that accompanied a public lecture on Nutrients and Bone Health held in London September 2011. The lecture focused on the importance of diet and lifestyle in maintaining healthy bone and preventing osteoporosis. Aspects of diagnosis are reviewed and the use of bone markers to indicate bone turnover are discussed in relation to monitoring the response to treatment.
Diet for the brain the right nutrition may prevent dementia rdns.com.aurdnscomau
At RDNS we believe one of the best ways to receive healthcare and remain independent is in the comfort and safety of your own home. That’s why, through life-changing events and throughout life’s changes, RDNS is by your side.
On any given day, we provide home nursing and healthcare to more than 9,500 people throughout Greater Melbourne, parts of regional Victoria, New South Wales and New Zealand. In any given year, we make more than 2 million visits to over 40,000 people, mainly in their own homes.
We offer a wide range of general and specialist care and we operate 24 hours a day, every day of the year. The care we provide enables you to remain in your own home so you can maintain your independence and have some say in your own healthcare.
Home nursing is also beneficial if you’re returning home from hospital. We can ease the transition out of a hospital bed and into the familiarity and comfort of your home environment more quickly.
Your needs are our primary concern, and we consider it a privilege to be allowed into your home to help you. To make sure you get the right care, we will look at your individual situation and prepare a personal, tailored healthcare plan. Where possible, we will also involve your family, friends or carer in planning your healthcare so everyone is part of the plan.
RDNS is also at the forefront of developing innovative home healthcare programs, so we’re always on the lookout for better ways to treat you.
RDNS staff number around 1,600, with over 1,200 nurses and 120 other staff providing personal care, who each year travel in excess of 8 million kilometres to deliver professional nursing and healthcare to those who require it. Basically, we are never far away.
When you need us, whoever you are and wherever you are, we are by your side.
How we are funded
Want to know how a not-for-profit healthcare agency gets to care for so many people? Click the heading to find out more information.
Annual reports
Tune in to what we’ve been doing – the money that’s been raised, how it’s been spent, innovations, celebrations, the works! Click heading for the latest reports.
Dementia introduction slides by swapnakishore released cc-by-nc-saSwapna Kishore
Dementia awareness presentation intended for general public/ patients/ potential and existing caregivers/ volunteers interested in spreading dementia awareness.
Visit my site for more information: http://dementiacarenotes.in
SO GUYS ONCE AGAIN HERE I PRESENT U THE OWN MADE PRESENTATION ON THE TOPIC DEMENTIA I HOPE U LIKE THAT IT IS BEEN USEFUL U WHILE MAKING PSYCHIATRIC PRESENTATION
Relationship of Metabolic syndrome and cognitive impairment has been discussed. Metabolic causes of Dementia and their reversibility has been discussed.
Prof. Dr. Vladimir Trajkovski was key note speaker at ReAttach conference in Eindhoven, Holland. He presented this topic: Medical aspects of Autism Spectrum Disorders
ROLE OF NUTRACEUTICAL IN ALZHEIER'S DISEASEJOSU PJ
Alzheimer's disease (AD) is a progressive, neurocognitive disease characterized by memory loss, language deterioration, impaired ability to mentally manipulate visual information, poor judgment, confusion, restlessness, and mood swings.
A presentation about Alzheimer's disease, it's definition, it's etiology, its mechanism of development as well as actual treatment and developing treatments.
Early-onset Alzheimer's disease occurs in people age 30 to 60.
Rare, representing less than 5 percent of all people who have Alzheimer's Inherited type known as familial Alzheimer's disease (FAD). It caused by mutations in at least 3 genes ( these Mutations increase the production of a Aβ42) :Most cases of Alzheimer's are the late-onset form, which develops after age 60.
The causes include a combination of genetic, environmental, and lifestyle factors .
the increase risk is related to the apolipoprotein E (APOE) found gene on chromosome 19.
APOE contains the instructions for making a protein that helps carry cholesterol and other types of fat in the bloodstream. APOE comes in different forms, or alleles. Three forms—APOE ε2, APOE ε3, and APOE ε4—occur most frequently.
APOE ε2 is relatively rare and may provide some protection against the disease.
If Alzheimer's disease occurs in a person with this allele, it develops later in life than it would in someone with the APOE ε4 gene.
With a growing number of conditions being grouped under the ‘umbrella’ of autoimmune disease, supporting clients who are, increasingly, presenting with various, and often multiple, autoimmune conditions, can appear complex at first glance.
In this webinar, Dr Danielle Crida outlines a clinical protocol that can support most autoimmune conditions, and takes a deep dive into the role of the immune system and key inflammatory processes at play.
Many clients take bone health for granted until they’re presented with a diagnosis of osteoporosis, often following a fracture. Whether your client is nutrient deficient, concerned about bone health, or diagnosed with a metabolic bone disease, adding the right nutrients to a protocol is paramount.
In her latest webinar, Dr Danielle Crida discusses:
- The importance of bone health
- Consequences of low bone mineral density
- The most important nutrients for bone health and their synergistic roles
- Exercise and lifestyle choices for bone strength
- Supplement and dosing recommendations, introducing our new Ca/Mg/D3/K2/Boron product
Did you know that food storage and preparation can hugely affect its nutritional value? For example, the antioxidant capacity of blueberries actually increases with freezing, and letting crushed garlic rest for 10 minutes before cooking allows for the development of compounds with amazing health benefits.
Learn the tricks of the trade for getting the most out of your food in this short webinar with nutritionist Dr Danielle Crida.
Confused about what to eat for better health? Dr Danielle Crida, trained medical doctor and nutritionist, will guide you through the basic ingredients of a nutritious and delicious diet. This short webinar will discuss how to build the foundations of your meals with macronutrients, and provide tips on how to ensure you are meeting your requirements for vitamins and minerals. We know getting started is the hard part, so we’ll provide a free editable shopping list and tips for a kitchen clearout to set you up for success.
Magnesium plays a role in over 300 biochemical reactions, therefore affecting almost every system of the body when levels are insufficient. In her latest webinar, Dr Danielle Crida focuses on the important role magnesium plays in all stages of a woman’s life, supporting:
- Menstrual cramps
- A healthy pregnancy and postpartum
- Menopausal symptoms, such as hot flushes and mood changes
- Women-predominant conditions, e.g. osteoporosis and thyroid conditions
Veganism is on the rise due to growing concerns about the environment and perceived health benefits. However, certain nutrients such as EPA & DHA are difficult to obtain from plant-based diets. Until recently, the only supplemental source of long-chain omega-3s was fish oil. Igennus has recently launched a vegan omega-3 product which combines algae-sourced EPA & DHA with the additional benefit of astaxanthin, a powerful antioxidant.
In this hour-long webinar, Dr Danielle Crida discusses:
- The importance of omega-3s and the omega 6:3 ratio
- Vegan options for omega-3 supplementation
- Our new Vegan Omega-3 & Astaxanthin product
- How to assess omega-3 requirements and measure response to supplementation
- Ensuring optimal nutrition on a plant-based diet: common nutrient deficiencies and how to address them
While Lyme disease is considered to be relatively uncommon in the UK, it is likely that many cases are simply undiagnosed, many of which turn up in our clinics frustrated by conventional approaches to managing their symptoms. Being able to identify clients with suspected Lyme disease is vital, as many cases that present with early or initial symptoms of fever, headache or other neurological symptoms as a consequence of a tick-borne bacterial infection, simply do not relate these symptoms to having been bitten. As such, this highlights the importance of the need to take comprehensive and detailed client history notes, certainly when a client is reporting symptoms that have not responded to conventional interventions.
With appropriate antibiotic treatment, most patients with early-stage Lyme disease recover rapidly and completely. Signs and symptoms of Lyme disease, however, vary by disease stage, and because many individuals who present with symptoms fail to recall a history of a tick bite or to report the classic bulls-eye rash, they often miss out on what is a relatively narrow window of opportunity to prevent the condition from progressing.
As Lyme disease is a multi-system illness, if left untreated, it can progress to affect the skin, joints, immune system, nervous system, or other vital organs, with many of the symptoms becoming indistinguishable from other multi-system conditions such as fibromyalgia or chronic fatigue syndrome.
In this hour-long webinar, Dr Nina Bailey discusses strategies for practitioners to help identify and manage symptoms of Lyme disease.
Around 250,000 people in the UK are currently thought to be affected by CFS/ME. The high level of disability that is often associated with this debilitating condition can be both physically and mentally challenging for patients and appears to stem from a combination of symptoms such as fatigue, pain, sleep disturbance, cognitive impairment, depression and, in many cases, symptoms mirroring those of irritable bowel syndrome.
With no current cure and no validated, universally accepted, ‘one-size-fits-all’ approach to the treatment, many clients are seeking natural alternatives to conventional approaches.
Taking a personalised and functional medicine approach, Dr Nina Bailey reviews the latest science on ME/CFS and the underlying mechanisms that can be targeted with nutritional interventions and explains how to ensure your therapeutic approach is right for your clients.
Covered in the webinar:
1. CFS/ME background /causes/symptoms
2. Update on the mechanisms associated with CFS/ME:
- Immune disturbances
- Oxidative stress and inflammation
- The kynurenine pathway and neurotransmitter dysregulation
- Mitochondrial dysfunction and related mechanisms
* Methylation
* Detoxification
* Glycolysis
* Citric acid cycle/Krebs
* Oxidative phosphorylation
3. An overview of current treatment options
4. Nutritional intervention – an evidence-based approach
5. Nutritional supplementation
As healthcare practitioners, we are well aware of the endless benefits of vitamin C in supporting immune health, antioxidant support, energy production, collagen formation, nervous system function and iron absorption. Faced with a huge array of vitamin C products, however, how can we be confident we’re recommending the best supplement to our clients?
During R&D for our latest addition to the Igennus Healthcare Nutrition synergistic range of supplements, we were impressed by both the high absorption of Ester-C and the unprecedented uptake and retention in immune cells. Ester-C boasts an impressive 10x higher bioavailability in leukocytes, whilst its pH neutral composition means it’s also gentle on the stomach.
In this webinar, Dr Danielle Crida discusses:
- A recap of vitamin C basics
- The research that led to the production of Ester-C
- The case for Ester-C: success in clinical use above standard vitamin C supplements
- Practical applications and dosing
As natural healthcare practitioners, we all understand the pivotal and complex role that magnesium plays. Required for over 300 biochemical reactions and metabolic functions including cellular signalling, function & energy production, it is no surprise magnesium is one of the most used supplements in a clinician’s toolbox.
Magnesium supplementation is, however, not as straightforward as we are led to believe. With considerations such as carrier, dose and bioavailability to consider, are we really doing clients (and magnesium) justice with a standard ‘go-to’ product?
In this educational webinar, Dr Nina Bailey not only discusses magnesium in clinical practice but, importantly, also uncovers the perils and pitfalls of the magnesium supplement ‘scene’, in the quest to provide clinical excellence, and the important supplemental factors that must be considered to optimise magnesium status and provide clinical efficacy.
Dr Bailey discusses:
1. A brief overview of the clinical implications of magnesium deficiency
2. Magnesium in practice:
-Supporting digestive complaints and overcoming
malabsorption
-The importance of magnesium for structural support
-Supporting energy levels and insulin sensitivity
3. How to ensure clinically effective dosing and supplementation
The imbalance between free radical production and endogenous antioxidant defence may result in cellular oxidative stress, causing oxidative damage to various cellular components, such as DNA, proteins and membrane lipids. The human system employs the use of endogenous enzymatic and non-enzymatic antioxidant defence systems against the onslaught of free radicals and oxidative stress.
Unsurprisingly, oxidative damage has been implicated in and is believed to be a key factor causing various pathological conditions, such as cardiovascular disease, neurodegenerative disease, diabetes and cancer. Free radicals can be quenched through a number of mechanisms. Antioxidants directly scavenge free radicals (e.g., via hydrogen atom transfer or electron transfer), prevent free radical formation by chelating metal ions and by interrupting the radical chain reactions of lipid peroxidation, thus retarding its progression. Enzymatic antioxidants include superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. Non-enzymatic antioxidants include vitamins A, C, and E, glutathione, alpha-lipoic acid, carotenoids, and coenzyme Q10. Other antioxidants include polyphenols, minerals (copper, zinc, manganese, and selenium), and cofactors (B-vitamins). Together, antioxidants work synergistically with each other using different mechanisms against different free radicals and stages of oxidative stress.
The benefits associated with antioxidants are numerous and diverse but it can be a minefield when choosing the appropriate antioxidant support for clients. In this hour-long webinar, Dr Nina Bailey discusses the direct and indirect benefits and actions of key antioxidants including (but not limited to) astaxanthin, alpha lipoic acid, polyphenols and co-enzyme Q10, with a focus on:
-Antioxidant sources and benefits
-Mechanisms and actions
-When to combine antioxidants for synergistic effects
-Overcoming bioavailability issues
-Targeted intervention, which antioxidant(s) and why
Astaxanthin, the naturally occurring carotenoid responsible for the pink-red pigmentation of wild salmon and crustaceans such as shrimp and lobsters, is a potent and effective antioxidant that boasts an ability to combat oxidative stress 6000x greater than that of vitamin C, 800x coenzyme Q10, 550x vitamin E and 75x alpha lipoic acid. Naturally, we are very excited to introduce AstaPure astaxanthin to our Pure Essentials range, launching in March!
Most commonly associated with preventing age-related diseases, astaxanthin’s unique chemical structure that spans the cell membrane gives rise to an exciting and diverse array of health benefits. New research is coming out daily suggesting astaxanthin is a highly effective tool in combating age-related diseases and cardiovascular disease, as well as boosting the immune system, liver and brain function.
Join Dr Nina Bailey for this ‘Introductory’ ingredient training webinar and discover:
Astaxanthin’s most exciting mechanisms of action
How its unique structure makes it so potent
An overview of some of the most compelling research into astaxanthin’s health benefits
When to use astaxanthin in clinical practice & dosing guidelines
Fibromyalgia syndrome is a common chronic pain condition that affects at least 2% of the adult population. Chronic widespread pain is the defining feature of FM, but patients may also exhibit a range of other symptoms, including sleep disturbance, fatigue, irritable bowel syndrome, headaches and mood disorders. While the aetiology of the condition is not completely understood, it is believed that a number of factors (rather than one in isolation) are most likely to lead to its development. Thus, the onset of fibromyalgia syndrome can be influenced by hormonal and/or chemical imbalances, chronic stress and/or a traumatic event, genetic predisposition and even pre-existing illness.
In this hour-long webinar, Dr Nina Bailey covers:
• An overview of the aetiology of fibromyalgia
• The signs and symptoms of fibromyalgia
• Factors that can contribute to or exacerbate fibromyalgia syndrome
• Managing symptoms via dietary manipulation and lifestyle change
• Supporting nutrients/supplements for those with fibromyalgia syndrome
Histamine intolerance (which can easily be mistaken for an IgE reaction) results from the imbalance of accumulated histamine and the capacity for histamine degradation. Symptoms of histamine intolerance are diverse in nature because histamine exerts its numerous biological reactions via 4 receptors, located on target cells in various tissues, with the severity of symptoms dependent on circulating histamine levels. The signs and symptoms of histamine intolerance can often be misinterpreted or simply go undetected in many individuals.
In this hour-long webinar, Dr Nina Bailey covers:
· The biological roles of histamine and how/why histamine intolerance arises
· The signs and symptoms of histamine intolerance
· High histamine foods/histamine liberators
· Factors that can contribute to or exacerbate histamine intolerance
· How to optimise your diet to reduce histamine reactions
· Supporting nutrients/supplements for those with histamine intolerance
Polycystic ovary syndrome (PCOS) is a common hormonal disorder, thought to affect between 4%–8% of women of reproductive age. Due to a lack of awareness, and the dramatic variation in the signs and symptoms between individuals, a large number of women may have PCOS without being at all aware of it. Unless help is sought for common symptoms (including oily skin and recurring acne; irregular, infrequent or absent periods; excess facial and body hair growth; head hair loss or thinning; weight gain) a formal diagnosis may never be made and issues can persist unmanaged until menopause. PCOS is most commonly diagnosed in women hoping to become pregnant, but who experience fertility issues as a result of irregular ovulation or miscarriage. In this webinar, Dr Nina Bailey PhD outlines the key mechanisms in the pathophysiology of PCOS, the signs and symptoms that should trigger further investigation, and the key nutritional strategies that can be adopted to help women manage the condition.
During this webinar, Sophie covers the double-edged sword of inflammation and oxidative stress as driving factors in chronic modern illness and why addressing these factors with nutritional intervention does not always produce the desired effects; it may even, in some cases, be harmful. Taking a personalised and functional medicine approach, Sophie reviews the underlying mechanisms that can be targeted with nutritional interventions and explains how to ensure your therapeutic approach is right for your clients.
Igennus are excited to announce the launch of our new product, Longvida® Curcumin. During this webinar, Dr Bailey reviews the research behind the therapeutic use of curcumin and why Longvida is the world’s most advanced formulation of the nutrient.
Curcumin is a polyphenol compound obtained from the rhizome of Curcuma longa, also known as turmeric. This Indian spice has a long history of use in Ayurvedic medicine as a treatment for inflammatory conditions. Curcumin is well documented for its antioxidant, anti-inflammatory and anti-cancer activities. Although it has been shown to be safe at high doses (12g/d), it is poorly absorbed, undergoes rapid intestinal and hepatic metabolism and is rapidly eliminated from the body. As such, standard curcumin demonstrates poor bioavailability, even at high doses, limiting its therapeutic potential.
After much research and discussion (it’s a big and complicated topic!) between the Igennus nutrition scientists, the decision as to which type of curcumin we would use for our Synergistic Nutrients range was actually a very straightforward one. Longvida Curcumin utilises a novel delivery system (SLCP), which protects curcumin from the harsh environment of the stomach and promotes its rapid absorption into the bloodstream and target tissues, even at low doses – resulting in an incredible 285x superior bioavaibility compared with standard curcumin, 65x higher peak plasma levels and 7x longer-lasting action. Longvida is the only formulation proven to deliver high levels of free form, unconjugated curcumin, into the bloodstream. Free form curcumin is the form required for therapeutic benefits, and the only form proven to cross the blood brain barrier.
This webinar covers:
- What curcumin is, what it does and how?
- Why free form curcumin is essential for therapeutic effects
- The research and current evidence for Longvida Curcumin’s unique health benefits
- How Longvida overcomes significant bioavailability issues associated with curcumin use
- To who, why and when you should recommend curcumin
…and more.
Nutrition science seems to change on an almost daily basis and much of what was previously considered mainstream or consensus science is being challenged and changed as the new wave of more personalised intervention trials start to clarify many of the reasons behind why nutrition study results can be so conflicting.
No research area, it seems, is more subject to conflicting and confusing results than that of omega-3s which is why, here at Igennus, we do our best to stay on top of ALL the omega-3 research so we can not only help you unpick the fact from fiction (and answer all your questions about every single product on the market!), but also ensure our formulations and education reflect the most cutting edge and clinically proven ingredient research.
Dr Bailey’s ever-growing brain contains a veritable treasure chest of omega-3 knowledge and as we know you are big fans of the work she does, this webinar is dedicated to Dr Bailey’s brain and sharing with you all the latest updates, innovations and applied therapeutic research that she has been reading about over the last year. We aim to help you separate fish oil fact from fiction by answering as many of your omega-3 and fatty acid therapeutic-related questions as possible. Covering everything from which and how much omega-3 to take for certain conditions, how and when taking omega-3 can affect the benefit and amount absorbed, why very high doses can be dangerous, the truth behind what companies and headlines are telling you about omega-3s, to any other areas you want us to cover! We will do our best to cover the most common and important questions and concerns we hear about from you via phone or email and when out and about training in stores and at events every day. As always, we will also clarify some of the reasons behind the frustratingly confusing conflicts in the research and media and what exciting things are coming out of the omega-3 world.
Catherine Jeans has been working with children’s nutrition for the past six years, specialising in family health, including babies, toddlers and teens. Working with children presents various challenges as a nutritional practitioner – not only getting the child to jump on board with the changes, but as important, making sure the parents are able to motivate their child and make the time to help them prepare the right food.
In this webinar, Catherine will go through:
– Logistical challenges – managing parents and their expectations, at what point to include children in consultations and how to talk to children about weight loss, digestive health and sugar.
-The realities of changing a child’s diet – what can you realistically achieve and how to motivate children to change.
– Case studies from babies to teens – Catherine will go through various case studies from her practice, including allergies, food intolerances, Coeliac disease, weight management and sugar addicts.
This webinar will give you an interesting insight into the practicalities of working with women and couples as they go through their fertility journey, from pre-conception, through to pregnancy and post-natal recovery. Catherine presents this online lecture through the use of key case studies, highlighting:
• The importance of supporting the adrenals for female fertility, and how this may impact on progesterone levels
• Key functional tests which may help you understand what may be preventing conception and successful pregnancy outcomes
• How to work with women going through assisted conception
• How to become a “fertility detective” and support couples with unexplained fertility issues
• Using a 3 month window between trying to conceive again – key supplements for optimal results
• Managing common problems found in pregnancy - iron deficiency anaemia to hyperemesis gravidarum
• How nutritional therapists can support women before birth and the early post-natal recovery – what really needs to go in the hospital bag!
• Preventing post-natal burn out - many women, especially after their second pregnancy, experience post-natal burn out after roughly 6 to 9 months after birth. Why is this and how we can we support women through this?
Ang Chong Yi Navigating Singaporean Flavors: A Journey from Cultural Heritage...Ang Chong Yi
In the heart of Singapore, where tradition meets modernity, He embarks on a culinary adventure that transcends borders. His mission? Ang Chong Yi Exploring the Cultural Heritage and Identity in Singaporean Cuisine. To explore the rich tapestry of flavours that define Singaporean cuisine while embracing innovative plant-based approaches. Join us as we follow his footsteps through bustling markets, hidden hawker stalls, and vibrant street corners.
At Taste Of Middle East, we believe that food is not just about satisfying hunger, it's about experiencing different cultures and traditions. Our restaurant concept is based on selecting famous dishes from Iran, Turkey, Afghanistan, and other Arabic countries to give our customers an authentic taste of the Middle East
Roti Bank Hyderabad: A Beacon of Hope and NourishmentRoti Bank
One of the top cities of India, Hyderabad is the capital of Telangana and home to some of the biggest companies. But the other aspect of the city is a huge chunk of population that is even deprived of the food and shelter. There are many people in Hyderabad that are not having access to
Food and beverage service Restaurant Services notes V1.pptx
Delaying dementia – a case of nutritional inadequacies?
1. Delaying dementia – a case of
nutritional inadequacies?
Nina Bailey
BSc MSc PhD ANutr
2. Defining dementia
• Dementia is an umbrella term, used to describe a syndrome that can
have many different causes and that is characterised by gradual decline in
cognitive abilities and neuropsychiatric symptoms
• The causes are most commonly brain disease including Alzheimer’s
disease, vascular dementia, frontotemporal dementia, Lewy body
dementia, Korsakoff's syndrome, Huntingdon’s chorea, Parkinson's
disease
• These diseases begin to damage the brain many years before symptoms
become apparent and cause a progressive decline in functioning as more
of the brain is damaged
3. Treat, prevent or delay?
• In the last few decades, huge advances have been made in
understanding the neurobiology of dementia, leading to an increase in
trials assessing various treatments
• Drugs used to treat dementia are of limited clinical benefit and so do
not treat the underlying cause
• Preventing or postponing the onset of dementia and delaying or slowing
its progression appear to be required options, leading to a consequent
improvement of health status and quality of life in older age
4. Risk factors for cognitive decline and dementia
Brain function
Higher mental stimulation through education, occupation or leisure is
associated with lower risk
Higher social interaction in later life is associated with lower risk
Lifestyle factors
Regular physical exercise at all ages is associated with lower risk
Current smoking increases risk
Excessive alcohol use increases risk
Diabetes increases risk
Depression increases risk
Elevated homocysteine levels increases risk
High blood pressure increases risk
Elevated cholesterol increases risk
5. The apolipoprotein E (APOE) gene, on chromosome 19, is the major
genetic source of the common forms of late-onset Alzheimer’s disease
APOE carries and delivers cholesterol to the nerve cells which use it for the
repair and establishment of new connections
There are three common variants of the APOE gene:
APOE 3 variant is the most common (neutral)
APOE 2 variant appears to have a protective influence
APOE 4 variant is thought to increase the risk of Alzheimer’s disease
People who inherit one copy of APOE4 are three times more likely to develop
Alzheimer's and people who inherit two copies are 12 times more likely to
develop the disease
6. Mutations in the Amyloid Precursor Protein (APP), Presenilin 1
and Presenilin 2 and inherited Alzheimer's disease
• The APP gene makes a protein that is present on the surface of nerve
cells and may help them grow and move
• The presenilin 1 and 2 genes make proteins that are required for the
correct functioning of the APP protein
• Mutations in any one of these genes can cause the APP protein to be cut
off from the surface of nerve cells, leading to an accumulation in amyloid
plaques which are a hallmark of Alzheimer’s disease
7. Cardiovascular health
Hypertension can cause problems by damaging and narrowing the blood
vessels in the brain, raising the risk of a blood vessel becoming blocked or
bursting, leading to an increased risk of stroke, cognitive impairment and
vascular-related dementia
Hypertension is associated with higher levels of neurofibrillary tangles and
amyloid plaques (poor clearance) and greater hippocampal and cortical
atrophy (loss of neurones)
High blood pressure in mid life rather than late life appears to be associated
with an increased risk of developing dementia (Power et al., 2011)
8. Cardiovascular health
Cholesterol plays an essential role in healthy brain function
High cholesterol in mid life rather than late life appears to be associated with
an increased risk of developing dementia (Anstey et al., 2008)
High cholesterol levels may accelerate the production of beta amyloid,with
autopsy data showing lower midlife cholesterol to be associated with lower
numbers of plaques and tangles (Kivipelto et al., 2006)
Higher HDL is associated with larger hippocampal volume and reduced risk of
cognitive impairment and Alzheimer's disease
10. Elevated homocysteine
Elevated homocysteine levels damage cells directly by promoting oxidative stress
Reduced glutathione production results in compromised detoxification
Reduced methyl donor production
The methylation cycle supplies methyl groups for a large number of methylation-
dependent reactions, including those involved in the synthesis of substances
including creatine, choline, carnitine, coenzyme Q10, melatonin and myelin
proteins
Low SAMe levels also result in a reduction in neurotransmitter production
Methylation is a fundamental process required for normal cell division and DNA
repair
Compromised methylation is also implicated in accelerated ageing!!
12. Homocysteine and dementia
• High values of plasma homocysteine and low levels of vitamin B12
and folate are frequently present in Alzheimer’s patients (Coppede
2010)
• Deficiencies of B vitamins (folate, vitamin B6 and vitamin B12) and
elevated homocysteine levels have been associated with increased
risk of cognitive impairment, Alzheimer’s disease and vascular
dementia (Herrman & Obeid 2011)
• Elevated homocysteine may also increase oxidative stress and the
production of beta-amyloid plaques in the brain (Herrman & Obeid
2011
13. Homocysteine and dementia risk factors
• Elevated homocysteine is also associated with cardiovascular disease,
diabetes and major depression
• As levels of homocysteine in the blood are directly influenced by
levels of the B-complex vitamins (folic acid, vitamin B6 and vitamin
B12), supplementation with these key nutrients offers preventive
strategies for a number of conditions related to high homocysteine
• Studies have shown that supplementing with B6, B12 and folic acid
successfully lowers homocysteine (VITAL 2003; Schnyder et al., 2002;
Lonn et al., 2006; Stanger et al., 2009)
14. Using B vitamins to lower homocysteine as a method to reduce
dementia risk
• Clinical trials in older adults have not shown that increasing B vitamin
intake or using supplements reduces the risk of cognitive decline or
dementia; however, some trials demonstrated slowing of brain atrophy
and improvement in some domains of cognitive function
• It is possible that if such supplementation were begun in midlife, when
chronic elevations in homocysteine could be prevented, they would be
more beneficial, although further research is required to determine this
15. Diabetes, especially type 2, and metabolic syndrome appear to be risk
factors for cognitive impairment and dementia
• Meta-analysis finding suggests that diabetes may be associated with
a 47% increased risk of any dementia, a 39% increased risk of
Alzheimer’s disease, and a 138% increased risk of vascular dementia
(Lu et al., 2009)
• APOE4 genotype combined with diabetes doubles the relative risk of
dementia compared with diabetes alone (Peila et al., 2002; Xu et al.,
2004)
16. Depression is a common comorbidity in dementia
• A history of depression has been associated with an increased risk of
Alzheimer's disease
• A review of epidemiological studies reported that a history of
depression was associated with around double the risk of Alzheimer's
(Ownby et al., 2006)
• Depression is associated with increased inflammation and high
cortisol, both of which have a detrimental impact on brain structure
and function
18. • Dementia is NOT a normal part of ageing, although the risk of
developing dementia increases with age
• Many nutrients, micronutrients and metabolic enzymes known
to be essential for substrate metabolism, substrate utilisation
and energy transfer are known to reduce with age
• Deficiencies in a number of nutrients and micronutrients have
been observed in dementia patients, including omega-3 fatty
acids, vitamin A, vitamin B12, vitamin D, folate, iron, vitamin E
and vitamin C (Lopes da Silva et al., 2013)
19. Oxidative damage and mitochondrial decay in ageing
• Oxidative stress-induced damage in the brain is thought to contribute to
cognitive impairments in ageing humans
• Oxidative stress and lipid peroxidation are believed to be contributing
factors leading to neuronal loss and mitochondrial dysfunction in Parkinson's
disease and may play an early role in the pathogenesis of Alzheimer's
disease
• Several studies show that there is an emerging link between individual
stress and intracellular oxidative stress as measured by
inflammatory cytokine (TNF-α), glycosylated haemoglobin (HbA1C) and
malondialdehyde (MDA) and low levels of enzyme antioxidants superoxide
dismutase (SOD) and glutathione peroxidase (GPX) (Padurariu et al, 2009)
20. • Cognitive decline is correlated with synaptic loss and many of the
components required to maintain optimal synaptic function are
derived from dietary sources
• As synapses are part of the neuronal membrane and are continuously
being remodelled, the availability of sufficient levels of nutritional
precursors to make the phospholipids required to build neuronal
membranes may have beneficial effects
• Oxidative damage, inflammation, demyelination, impaired processing
and metabolic deficits are all associated with the ageing brain
• Could a cocktail of multiple antioxidants with anti-inflammatory
agents be beneficial in the prevention of neurodegenerative disease?
21. Inflammation and dementia
• Inflammation factors are known to be associated with a higher
risk for Alzheimer's disease and cognitive decline (Halliday et al.,
2000)
• Two large-scale prospective studies showed baseline blood
levels of inflammatory markers are associated with higher risk of
incident Alzheimer's disease (Schmidt et al., 2002; Engelhart et
al., 2004)
22. Steps to reducing dementia risk:
Reduce oxidative damage
Increase antioxidant enzymes
Decrease homocysteine and cholesterol levels
Manage blood pressure
Modulate inflammation
Increase cellular energy
Optimise neuroprotection
Enhance neurogenesis
Support cell membrane integrity
Optimise neurotransmitter levels
23. Steps to reducing dementia risk:
Reduce oxidative damage
Alpha lipoic acid
Vitamin E
Vitamin C
Carnosine
Coenzyme Q10
Regulators of antioxidant systems
Superoxide dismutase (SOD) (copper, zinc, manganese & selenium)
Glutathione (Vitamin B6, cysteine)
24. Alpha lipoic acid is an endogenous antioxidant and essential cofactor for
many enzyme complexes that interrupt cellular oxidative processes
Increases acetylcholine production by activation of choline acetyl-
transferase
Increases glucose uptake
Acts as a metal chelator
Down-regulates the expression of redox-sensitive pro-inflammatory
proteins including TNF-a and inducible nitric oxide synthase
Scavenges lipid peroxidation products such as 4-hydroxynonenal and
acrolein
(lui, 2007; Moreira et al., 2007; Maczurek et al., 2008; Salinthone et al., 2008)
25. Carnosine is a naturally occurring antioxidant and metal chelator
• Inhibits lipid peroxidation and the formation of advanced glycation end
products (AGEs) which have been implicated in the progression of
diseases including dementia, cardiovascular disease and stroke
• Inhibits protein glycation and DNA/protein cross-linking which protects
against a beta-amyloid accumulation (Alzheimer’s disease), and alpha-
synuclein accumulation (Parkinson’s disease)
• Carnosine also plays a vital role in carrying fatty acids from the cytosol
into the mitochondria where they are oxidised for energy
26. Coenzyme Q10 has a dual function as it is essential for generating
energy in mitochondria whilst also being a powerful anti-oxidant and
anti-oxidant recycler including vitamin E, vitamin C and lipoic acid
• Its ability to quench free radicals helps to maintain the structural
integrity and stability of mitochondrial and cell membranes
• Supplementation with CoQ10 may have benefits for Huntington's and
neurodegenerative diseases such as Parkinson's and Alzheimer's
• Coenzyme Q10 has been shown to be neuroprotective and dose-
dependently inhibits the formation α-synuclein and β-amyloid fibrils
(Spindler et al., 2009)
• Coenzyme Q10 also has major implications for cardiovascular health
27. Optimising the diet
• At present, for older subjects, healthy diets, antioxidant supplements,
the prevention of nutritional deficiencies, and moderate physical
activity could be considered the first line of defence against the
development and progression of predementia and dementia syndromes
• The Mediterranean-style diet was first described in the Seven-Country
study in the 1950s to 1960s in the south of Europe, where adult life
expectancy was among the highest in the world and rates of coronary
heart disease, certain cancers and other nutrition-related chronic
diseases were among the lowest (Keys et al., 1986)
28. Mediterranean diet
• Dietary patterns characterised by higher intake of fruits, vegetables,
fish, nuts and legumes, and lower intake of meats, high fat dairy and
sweets/sugars seem to be associated with lower risk of cognitive
impairment and dementia (Gu et al., 2011)
Several studies have found a lower risk of dementia is associated with
higher intake of fruit and vegetables and higher adherence to the
Mediterranean diet (Solfrizzi et al., 2011)
29. Mediterranean diet
• A study of 1433 older people showed 6.5% of cases of mild cognitive
impairment or dementia to be attributable to low fruit and vegetable
consumption Ritchie et al., 2010)
• Increasing fruit and vegetable consumption and eliminating depression
and diabetes are likely to have the biggest impact on reducing the
incidence of dementia (Ritchie et al., 2010)
• Another study showed an 88% lower risk of any dementia and 92%
lower risk of Alzheimer’s disease in those with an overall healthy diet at
midlife, compared to those with an unhealthy diet (Eskelinen et al.,
2011)
30. Mediterranean diet
• A 2011 systematic review found that a Mediterranean diet appeared
to be more effective than a low-fat diet in bringing about long-term
changes to cardiovascular risk factors, such as lowering cholesterol
level and blood pressure (Nordman et al., 2011)
• Adherence to the Mediterranean diet may affect not only risk for
Alzheimer’s disease but also subsequent disease course (Scarmeas et
al., 2007)
31. What is the Mediterranean diet?
The principal aspects of this diet include:
• High consumption of olive oil, legumes, unrefined cereals, fruits
and vegetables
• Moderate to high consumption of fish, moderate consumption of dairy
products (mostly as cheese and yoghurt), moderate wine consumption
• Low consumption of meat and meat products
32. Mediterranean diet nutrients
• Low in saturated fat
• High in polyunsaturated and monounsaturated fat
• Rich source of quality protein
• Rich in essential vitamins and minerals
• High in omega-3 fatty acids
• Low in omega-6 fatty acids
• High in dietary fibre
• High in antioxidants
• High in polyphenols and flavonoids
33. Fish consumption and dementia
• High fish consumption tends to be inversely associated with
cognitive impairment and decline (Kalmijn 2000)
• Elderly people who eat fish or seafood at least once a week are at
lower risk of developing dementia, including Alzheimer's disease
(Barberger-Gateau et al., 2002)
• Fish is a unique nutritional package
• Fish is a predominant source of long-chain omega-3 fatty acids
34. Omega-3 and dementia
• Brain lipids contain a high proportion of polyunsaturated fatty acids (PUFA),
which are a main component of cell membranes
• The physiological roles of omega-3 PUFA in the brain include regulation of
cell membrane fluidity, dopaminergic and serotonergic transmission,
regulation of cellular signal transduction, brain glucose metabolism,
eicosanoid synthesis, gene expression and cell cycle control
• Deficiencies in omega-3 fatty acids are observed in dementia patients (Lopes
da Silva et al., 2013)
• A higher plasma EPA concentration is associated with a lower incidence of
dementia (Samieri et al, 2008)
35. • 2012 meta-analysis of 10 studies (including 2,280 subjects)
- EPA and total n-3 PUFAs were decreased in patients with dementia
- levels of EPA, but not DHA or other PUFAs, were significantly lower in
patients with pre-dementia syndrome
- EPA may act as a disease-state marker AND a risk factor for cognitive
impairment (Lin et al, 2012)
• A higher plasma EPA concentration is associated with a lower incidence of
dementia (Samieri et al, 2008)
• High AA:DHA and omega-6:omega-3 is associated with an increased risk of
dementia (Samieri et al., 2008)
• EPA intake is more advantageous than DHA in reducing "brain effort" relative to
cognitive performance (in young adults) (Bauer et al., 2014)
35
36. EPA and brain conditions
• The HPA-axis is the body’s mechanism for dealing with stress
• EPA helps reduce its dysregulation, which plays a role in the onset of
several conditions, including:
⁻ depression
⁻ chronic pain and fatigue syndromes
⁻ neurodegenerative disease such as Huntington’s and Alzheimer's
disease
⁻ reduction in brain grey matter
(Caetano et al, 2007,Burgmer et al, 2009, van Duijn et al, 2010, Puri et al, 2008)
• EPA and not DHA has been shown to reduce the symptoms of these
conditions and support the brain’s natural protective processes
(Salvati et al, 2004; Salvati et al, 2008)
36
37. EPA has several neuroprotective roles in the brain
EPA up-regulates gene expression concerned with neurogenesis
neurotransmission and connectivity, improves endothelial nitric oxide
generation and decreases inflammatory cytokine levels ((Salvati et al, 2004;
Salvati et al, 2008; Calder 1997)
EPA enhances brain acetylcholine levels, and suppresses the production of pro-
inflammatory cytokines such as interleukin-1 (IL-1) and interleukin-6 (IL-
6) (McCarty 1999)
The neuroprotective effect of EPA is also in part, thought to be through its ability
to inhibit neuronal apoptosis (Martin et al, 2002; Lonergan et al, 2004)
GLA in conjunction with EPA, is known to decrease inflammatory leukotriene B4,
IL-1 and IL-6 consequently offers cerebral anti-inflammatory effects (McCarty
1999).
38. Reducing the risk of developing dementia
Keep an active mind
Keep fit and active
Eat a Mediterranean-style diet
Look after cardiovascular health
Reduce the risk of developing diabetes
However, a majority Alzheimer’s disease cases appear to be sporadic and only a small number of cases are known to be inherited
Loss of acetylcholine-producing neurons degradation of cognitive functioningLoss of dopamine-producing neurons is thought to account for the degradation of motor control
Loss of acetylcholine-producing neurons degradation of cognitive functioningLoss of dopamine-producing neurons is thought to account for the degradation of motor control
Loss of acetylcholine-producing neurons degradation of cognitive functioningLoss of dopamine-producing neurons is thought to account for the degradation of motor control