External ear,tympanic membrane and auditory tube Dr.N.Mugunthan.M.S.,mgmcri1234
External ear,tympanic membrane and auditory tube - Lecture by Dr.N.Mugunthan.M.S.,Associate Professor, Mahatma Gandhi Medical College & Research Institute, Pondicherry,
Sri Balaji Vidyapeeth University.
I have tried my level best to complete this one. Basics & subjective details as much possible, are included here with understandable diagrams, CT-scans & charts. Clinical associations with possible anatomical structures are also touched . Frequent questions based on the topic discussed, will be there at the middle & end of presentation.
If you find it helpful then please like it & if any query regarding this ppt or upcoming ppts then mail me
drsuraj1997@gmail.com
Development of the middle ear is not covered in this presentation. If you are interested then please mail me. I will try to upload it as a separate one.
THE POWER POINT PRESENTATION OF ANATOMY AND PHYSIOLOGY OF THE EAR (SENSE OF HEARING) IS JUST TO EQUIP READERS WITH SOME BASIC UNDERSTANDING ON THE ORGAN.
HOW IT OPERATES AND CONNECTED TO THE CENTRAL NERVOUS SYSTEM IN ORDER TO PERCEIVE SOUND AND AID IN BALANCE.
External ear,tympanic membrane and auditory tube Dr.N.Mugunthan.M.S.,mgmcri1234
External ear,tympanic membrane and auditory tube - Lecture by Dr.N.Mugunthan.M.S.,Associate Professor, Mahatma Gandhi Medical College & Research Institute, Pondicherry,
Sri Balaji Vidyapeeth University.
I have tried my level best to complete this one. Basics & subjective details as much possible, are included here with understandable diagrams, CT-scans & charts. Clinical associations with possible anatomical structures are also touched . Frequent questions based on the topic discussed, will be there at the middle & end of presentation.
If you find it helpful then please like it & if any query regarding this ppt or upcoming ppts then mail me
drsuraj1997@gmail.com
Development of the middle ear is not covered in this presentation. If you are interested then please mail me. I will try to upload it as a separate one.
THE POWER POINT PRESENTATION OF ANATOMY AND PHYSIOLOGY OF THE EAR (SENSE OF HEARING) IS JUST TO EQUIP READERS WITH SOME BASIC UNDERSTANDING ON THE ORGAN.
HOW IT OPERATES AND CONNECTED TO THE CENTRAL NERVOUS SYSTEM IN ORDER TO PERCEIVE SOUND AND AID IN BALANCE.
hey Guys ,
here u get the detail anatomy of vestibular system for Bachelors level . if have any suggestion or want any topic PPT , Mail me - anantarun27@gmail,com
Inner ear is a complex structure of human body.
It is situated in the petrous temporal bone.
It contains the structures associated with hearing and balance mechanisms.
The vestibule and semicircular canals are associated with balance and the cochlea is associated with hearing .
I have tried my best to make it simple in my presentation.
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Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
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Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
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NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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2. Inner ear
• There are actually two labyrinths of the
inner ear, one inside the other, the
membranous labyrinth contained within
the bony labyrinth.
• The bony labyrinth consists of:
–A central chamber called the vestibule,
–The three semicircular canals, and
–The spirally coiled cochlea.
3.
4.
5.
6. Internal Ear
• Osseous labyrinth: a complex
system of cavities in the
substance of the petrous
bone.
• Membranous labyrinth: filled
with endolymph, bathed in
perilymph.
11. Bony Labyrinth
• The bony labyrinth consists of three
parts:
–The vestibule,
–The semicircular canals, and
–The cochlea.
• These are cavities situated in the
substance of dense bone.
• They are lined by endosteum and contain
a clear fluid, the perilymph, in which is
suspended the membranous labyrinth.
12. The vestibule
• The central part of the bony labyrinth, lies
posterior to the cochlea and anterior to the
semicircular canals. In its lateral wall are the
fenestra vestibuli, which is closed by the base
of the stapes and its anular ligament, and the
fenestra cochleae, which is closed by the
secondary tympanic membrane.
• Lodged within the vestibule are the saccule
and utricle of the membranous labyrinth.
13. Semicircular canals
• The three semicircular canals: superior, posterior, and
lateral open into the posterior part of the vestibule.
• Each canal has a swelling at one end called the ampulla.
The canals open into the vestibule by five orifices, one of
which is common to two of the canals.
• Lodged within the canals are the semicircular ducts.
– The superior semicircular canal is vertical and placed at right
angles to the long axis of the petrous bone.
– The posterior canal is also vertical but is placed parallel with the
long axis of the petrous bone.
– The lateral canal is set in a horizontal position, and it lies in the
medial wall of the aditus to the mastoid antrum, above the facial
nerve canal.
14. The cochlea
• The cochlea resembles a snail shell.
• It opens into the anterior part of the vestibule.
• Basically, it consists of a central pillar, the modiolus, around
which a hollow bony tube makes two and one half spiral
turns. Each successive turn is of decreasing radius so that
the whole structure is conical.
• The apex faces anterolaterally and the base faces
posteromedially.
• The first basal turn of the cochlea is responsible for the
promontory seen on the medial wall of the middle ear.
15. The modiolus
• The modiolus has a broad base, which is situated at the
bottom of the internal acoustic meatus.
• It is perforated by branches of the cochlear nerve. A spiral
ledge, the spiral lamina, winds around the modiolus and
projects into the interior of the canal and partially divides
it.
• The basilar membrane stretches from the free edge of the
spiral lamina to the outer bony wall, thus dividing the
cochlear canal into the scala vestibuli above and the scala
tympani below.
• The perilymph within the scala vestibuli is separated from the
middle ear by the base of the stapes and the anular ligament at
the fenestra vestibuli. The perilymph in the scala tympani is
separated from the middle ear by the secondary tympanic
membrane at the fenestra cochleae.
18. Membranous Labyrinth
• The membranous labyrinth is lodged within the
bony labyrinth. It is filled with endolymph and
surrounded by perilymph.
• It consists of
– The utricle
– Saccule , both are lodged in the bony vestibule;
– The three semicircular ducts, which lie within the bony
semicircular canals; and
– The duct of the cochlea, which lies within the bony
cochlea.
• All these structures freely communicate with one
another.
19. The utricle & The saccule
• The utricle is the larger of the two vestibular sacs. It is
indirectly connected to the saccule and the ductus
endolymphaticus by the ductus utriculosaccularis.
• The saccule is globular and is connected to the utricle. The
ductus endolymphaticus, after being joined by the ductus
utriculosaccularis, passes on to end in a small blind pouch,
the saccus endolymphaticus. This lies beneath the dura on
the posterior surface of the petrous part of the temporal
bone.
• Located on the walls of the utricle and saccule are
specialized sensory receptors, which are sensitive to the
orientation of the head to gravity or other acceleration
forces.
20. The semicircular ducts
• The semicircular ducts, although much smaller in
diameter than the semicircular canals, have the
same configuration.
• They are arranged at right angles to each other so
that all three planes are represented.
• Whenever the head begins or ceases to move, or
whenever a movement of the head accelerates or
decelerates, the endolymph in the semicircular
ducts changes its speed of movement relative to
that of the walls of the semicircular ducts.
• This change is detected in the sensory receptors in
the ampullae of the semicircular ducts.
21. The duct of the cochlea
• The duct of the cochlea is triangular in
cross section and is connected to the
saccule by the ductus reuniens.
• The highly specialized epithelium that
lies on the basilar membrane forms the
spiral organ of Corti and contains the
sensory receptors for hearing
22.
23.
24.
25.
26.
27.
28.
29. Motion Sickness
• The maculae of the membranous labyrinth are
primarily static organs, which have small dense
particles (otoliths) embedded among hair cells.
• Under the influence of gravity, the otoliths cause
bending of the hair cells, which stimulate the
vestibular nerve and provide awareness of the
position of the head in space; the hairs also respond
to quick tilting movements and to linear
acceleration and deceleration.
• Motion sickness results from discordance between
vestibular and visual stimulation.
30. Dizziness and Hearing Loss
• Injuries of the peripheral auditory
system cause three major symptoms:
–Hearing loss (usually conductive hearing
loss),
–Vertigo (dizziness) when the injury involves
the semicircular ducts, and
–Tinnitus (buzzing or ringing) when the
injury is localized in the cochlear duct.
• Tinnitus and hearing loss may result from
lesions anywhere in the peripheral or central
auditory pathways.
31. Menier Syndrome
• Meniere syndrome is related to blockage of
the cochlear aqueduct and is characterized by
recurrent attacks of tinnitus, hearing loss, and
vertigo.
• These symptoms are accompanied by a sense
of pressure in the ear, distortion of sounds,
and sensitivity to noises .
• A characteristic sign is ballooning of the
cochlear duct, utricle, and saccule caused by
an increase in endolymphatic volume.
32. Otic Barotrauma
• Injury caused to the ear by an
imbalance in pressure between
ambient (surrounding) air and the
air in the middle ear is called otic
barotrauma.
• This type of injury usually occurs
in fliers and divers.