1. The inner ear consists of the bony labyrinth within the temporal bone and the membranous labyrinth contained within.
2. The bony labyrinth is composed of the vestibule, semicircular canals, and cochlea. The membranous labyrinth contains the cochlear duct, utricle, saccule, and semicircular ducts filled with endolymph.
3. Within the cochlea, the organ of Corti transduces sound into electrical signals via inner and outer hair cells. The hair cells sit on the basilar membrane and are stimulated by the overlying tectorial membrane.
I have tried my level best to complete this one. Basics & subjective details as much possible, are included here with understandable diagrams, CT-scans & charts. Clinical associations with possible anatomical structures are also touched . Frequent questions based on the topic discussed, will be there at the middle & end of presentation.
If you find it helpful then please like it & if any query regarding this ppt or upcoming ppts then mail me
drsuraj1997@gmail.com
Development of the middle ear is not covered in this presentation. If you are interested then please mail me. I will try to upload it as a separate one.
I have tried my level best to complete this one. Basics & subjective details as much possible, are included here with understandable diagrams, CT-scans & charts. Clinical associations with possible anatomical structures are also touched . Frequent questions based on the topic discussed, will be there at the middle & end of presentation.
If you find it helpful then please like it & if any query regarding this ppt or upcoming ppts then mail me
drsuraj1997@gmail.com
Development of the middle ear is not covered in this presentation. If you are interested then please mail me. I will try to upload it as a separate one.
hey Guys ,
here u get the detail anatomy of vestibular system for Bachelors level . if have any suggestion or want any topic PPT , Mail me - anantarun27@gmail,com
human's inner ear ,which is third part of ear, Having cochlea and vestibular system.in this slide we will discuss about the anatomy and physiology of inner ear.
Cochlear Fluid is the one of the most important fluid not only for hearing sensation but also for the balance of human body. It is very important to know the embryology, anatomy, and physiology of cochlear fluid mechanism to know the various pathological conditions of inner ear.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
2. Questions in previous Presentation
Malleus
o Weight-23mg
o Length-9mm
Incus
o Weight-25-30 mg
o Length of long process -7 mm
o Length along short process-5mm
Stapes
o Weight-2.86 mg
o Height-3.26 mm
3. Inner Ear/Labyrinth
• Development of Inner ear starts by 3rd week of IUL and
completes by 16th week.
• Cochlea sufficiently developed by 20th week (fetus can
hear in the womb)
• Lies in the petrous part of the temporal bone.
• Is an important organ of hearing and balance.
• 2 Parts
• Bony Labyrinth
• Membranous Labyrinth
5. Vestibule
• Small Ovoid bony chamber measuring 4mm
• situated between
o Laterally - Medial wall of the middle ear
• is the opening of the oval window which is closed by the
footplate of the stapes
o medially - by Internal auditory meatus .
• Medially(inner Surface)-2 recesses
o Spherical recesses-lodges the sacule
o Elliptical recesses-lodges the utricle
• Below elliptical recesses-opening of endolymphatic duct
• Postero superior
o 5 openings of SCC
6.
7. Semi Circular Canals
• 3 semi circular canals
o Superior
o Posterior
o Lateral
• They lie in planes at right angle to each other.
• Each canal got ampullary end ,which open in the
vestibule.
• Non-ampullary end of Lateral SCC open
independently
• Post. SCC and Sup. SCC form a common opening
Called CRUS COMMUNE
8.
9. Cochlea
• Coiled tube – 35mm.
• Two and half turns around a central bone called
Modiolus
MODIOLUS
• Pyramidal Shaped
• Base directed towards Internal Acoustic Meatus
• Vessels and Nerves enter cochlea via modiolus
• Around modiolus -thin plate of bone winding spirally
is a called – Osseous Spiral lamina
10.
11. • The Osseous Spiral lamina divides the bony cochlea
(incompletely) into
o Scala Vestibuli
o Scala Tympani.
• And gives attachment to a membrane called
Basilar membrane.
• Above the Osseous Spiral lamina and the Basilar
membrane lies the Scala Media which contains the
endolymph and Organ of Cori.
12.
13. • The scala vestibuli and scala tympani are filled with
perilymph and communicate with each other at
the apex of cochlea through an opening called
HELICOTREMA
• Scala vestibuli
o closed by the foot plate of stapes
• scala tympani
o Closed round window membrane (secondary tympanic
membrane)
• Connected to Sub arachnoid space by aqueduct
of choclea
14.
15.
16. Membranous Labyrinth
• It lies within the bony labyrinth
• Filled with Endolymph.
• Space between membranous
labyrinth and bony labyrinth-
Perilymph.
• It contains
o Cochlear Duct
o Utricle and Saccule(otolith organs)
o Semi circular Duct
o Endolymphatic Duct and Sac
17. Cochlear duct
• It is a blind coiled tube.
o called as Scala Media/membranous cochlea
• It appears triangular on cross-section-
o One wall of triangle is the basilar membrane
o Another wall of triangle is the Reissner's membrane
o And the third wall is the stria vascularis,
• Cochlear duct is connected to the saccule by
Ductus reuniens
18.
19. • Utricle
o lies in the posterior part of bony vestibule.
o It receives the five openings of the three semicircular ducts.
o It is also connected to the saccule through utriculosaccular
duct.
o sensory epithelium of the utricle is called the macula
• Saccule
o Lies anterior to urticle
o sensory epithelium of the saccule is called the macula
o Responds to linear acceleration and deceleration
o In Meniere’s disease –distented saccule lies against stapes
foot plate
20. • Semicircular ducts.
o three in number and correspond exactly to the three bony
canals.
o They open in the utricle.
o The ampullated end of each duct contains a thickened
ridge of neuroepithelium called crista ampullaris.
21. • . Endolymphatic duct and sac.
o the union of two ducts, one each from the saccule and
the utricle.
o It passes through the vestibular aqueduct.
o Its terminal part is dilated to form ENDOLYMPHATIC SAC
which lies between the two layers of dura on the posterior
surface of the petrous bone.
22. Fluid System
• Perilymph
o Present in btw memb. Labyrinth and bony labyrinth
o Present in inside the scala vestibuli and Scala tympani
o Rich in sodium (Na+)
o Like extra cellular fluid
o It communicates with CSF through the aqueduct of
cochlea.
o Formation of perilymph:
• It is a filtrate of blood serum and is formed by capillaries of the
spiral ligament
• a direct continuation of CSF and reaches the labyrinth via
aqueduct of cochlea.
23. • Endolymph
o fills the membranous labyrinth
o resembles intracellular fluid,
o rich in Potassium (K+) ions.
o It is secreted by
• secretory cells of the stria vascularis of the cochlea
• the dark cells (present in the utricle and the ampullated
ends of semicircular ducts) .
25. ORGAN OF CORTI
• Organ of hearing,
• Situated on basilar membrane of cochlea
• 3 parts
o Sensory Hair cells
o Supporting cells
o Tectorial Membrane
26. Hair Cells
• Transduce sound energy to Electrical Energy.
• 1 row of flask shaped inner hair cells
• 3 or 4 rows of cylindrical shaped outer hair cells.
• Situated around the tunnel of corti
27.
28. Inner Hair cells Outer Hair cells
• Total No : 3500
• Arranged in single row
• Flask shaped
• 95% afferent from
Cochlear nerve (8th
CN)
• Stereocilia arranged in
V or W format
• More resistent
• Transmit auditory stimuli
• 12,000 [ 1:4 ratio]
• Multiple rows
• Cylindrical
• Efferent from Sup.
Olivary complex
• Stereo cilia single
continous layer.
• Easily damaged to
drugs & loud sound
• Modulate the IHC.
29. Supporting cells
• Stabilize and support the organ of corti
• Supply nutrient to the highly specialized sensory
cells(inner and outer hair cells)
• Includes
o Hensen's Cell
o Claudius Cells
o Deiters Cells
o Boettcher’s Cell
30. Tectorial Membrane
• It over hangs the organ of corti
• Gelatinous – Spread over the hair cells.
• The shearing force between Hair cells and Tectorial
membrane produces the stimulus in hair cells.
31.
32. Cristae
Crista Ampullaris
• Seen in the ampullated end
of 3 SCC
• thickened ridge - covered
by a gelatinous matrix
called Cupula
• Two type of hair cells
• Type 1 – Flask shaped
• Type 2 – Cylindrical
• The cilia of sensory hair cells
are present in cupula.
33. Maculae
• Located in otolith organs
• Sense the position of Head
in response to gravity
• Hair cells
• Type 1
• Type 2
• Supporting cells
• Otolithic membrane
• Gelatinous layer
• Otoconia [Ca(CO ) ]
• Cilia of hair cells in gelatinous
layer – Senses linear,
gravitational & head tilt
movements.
•
34. Ant. Inferior Cerebellar
Art
Labyrinthine/Intern
al Auditory art.
Ant.
Vestibular
A
(to utricle &
LSCC, SSCC)
Common
Cochlear
Vestibulo
Cochlear
Main Cochlear
80%
Cochlear
branch
(20%)
Post. Vestibular
A
(to saccule & PSCC)
Blood Supply
Arterial
35. Venous Drainage
• 3 Veins
o Internal auditory vein
o Vein of cochlear aqueduct
o Veins from the vestibular aqueduct
36. Applied Anatomy
Presbycusis
o Sensory hearing loss associated with physiological ageing
process in ear.
o 4 Pathological type
• Sensory-degenaration of organ of corti
• Neural-degenartion of spiral ganglion
• Straial-Atropy of stria vascuaris
• Cochlear-Stiffing of Basilar membrane
Noise induced hearing loss
o Damages the Hair cell-outer hair cells are affected more
37. Ototoxicity
o Damage inner ear and cause SNHL,Tinnitus and vertigo.
o Aminoglycoside-destroy type-1 hair cell in crista Ampularis and
outer hair cells.
o Diuretics-edema and cystic changes in stria Vascularis.
o Quinine-causes vasoconstriction of small vessels of cochlea and
stria vascularis.
o NSAIDs-Piroxicam,Ketorolac
Meniere’s disease(Endolymphatic Hydrops)
o Endolymphatic distention mainly in scala media,saccule,Utricle
o Leads to bulging of Reissner’s Membrane and saccule and
utricle.
Editor's Notes
Laterally
is the opening of the oval window which is closed by the footplate of the stapes
Medially-2 recesses
Spherical recesses-lodges the sacule
Elliptical recesses-lodges the utricle
Below elliptical recesses-opening of endolymphatic duct
Postero superior
5 openings of SCC
Non-ampullary end of Lateral SCC open independently and Post. SCC and Sup. SCC form a common opening Called CRUS COMMUNE
They lie in planes at right angle to each other.
Each canal got ampullary end ,which open in the vestibule.
Non-ampullary end of Lateral SCC open independently and Post. SCC and Sup. SCC form a common opening Called CRUS COMMUNE
Coiled tube – 35mm
Its central axis is perpendicular to axis of skull.
2.5 – 2.75 turns around a central bone called MODIOLUS
Pyramidal Shaped
Base directed towards Internal Acoustic Meatus
Vessels and Nerves enter cochlea via modiolus
Around modilus -winding spirally is a thin plate of bone called – Osseous Spiral lamina
Scala vestibuli is closed by the foot plate of stapes
which separates it from the air-filled middle ear
The scala vestibuli and scala tympani are filled with peri- lymph and communicate with each other at the apex of cochlea through an opening called HELICOTREMA
Scala vestibuli
closed by the foot plate of stapes
scala tympani
by secondary tympanic membrane(Mem. Of RW)
Connected to Sub arachnoid space by aqueduct of choclea
Cochlear duct
membranous cochlea or the scala media.
It is a blind coiled tube.
It appears triangular on cross-section and its three walls are formed by:
the basilar membrane, which supports the organ of corti,
the Reissner's membrane which separates it from the scala vestibuli,
the stria vascularis, which contains vascular epithelium and is concerned with secretion of endolymph.
Cochlear duct is connected to the saccule by Ductus reuniens
Transduce sound energy to Electrical Energy.
1 row of flask shaped inner cells
3 or 4 rows of cylindrical shaped outer hair cells.
Situated around the tunnel of corti,which contains cortilymph-resembles perilymph.
or Hensen's ‘s Cell or Claudius Cells
Stabilize and support the organ of corti
Supply nutrient to the highly specialized sensory cells
For the balancing function
A macula consists mainly of two parts: (a) a sensory neuroepithelium, made up of type I and type II cells, similar to those in the crista; (b) an otolithic membrane, \vhich is made up of a gelatinous mass and on the top, the crystals of calcium carbonate called otoliths or otoconia (Fig. 2.8). The cilia of hair cells project into the gelatinous layer. The linear, gravitational and head tilt movements cause displacement of otolithic membrane and thus stimulate the hair cells which lie in different planes.