The document discusses innate healing from philosophical, physiological, cellular, and psychological perspectives.
Physiologically, innate healing is known as innate immunity, which includes physical barriers like skin, mucous membranes, and cilia. The innate immune system also contains cells and proteins that fight pathogens.
Cellular aspects of innate healing involve phagocytosis, inflammation, cellular adaptation, and cell death. These processes help clear pathogens and promote healing.
Psychologically, the mind employs defense mechanisms unconsciously to reduce anxiety and maintain homeostasis. Innate healing aims to reconnect the body with its inherent self-healing abilities.
CONCEPT OF HEALTH and DISEASE ACCORDING TO NATUROPATHY.pptxDrManjuRater
This slide explains the concept of health and disease according to Naturopathy with scientific evidence-based, this includes health according to western medicine. health according to naturopathy, definitions of health according to naturopathy, vitality, determinants of health according to naturopathy difference between naturopathy and allopathy, characteristics of the human body, and Diagnostic criteria according to Naturopathy. Concept of disease according to western principles and disease according to naturopathy. upas tree, violation of natures law, morbid matter theory, source of toxemia and examples, the primary cause of disease and secondary cause of disease, free radicles acute disease and chronic disease, unity of disease and unity of cure, factor affecting the unity of cure, goals of naturopathy,
# Vitality, # prana shakti, # life energy,# life force, #Energy that sustains...Shweta Mishra
# student description on vitality, # vital economy, # notes on vital force, #compilation of notes on body energy system and its conservation
concept of energy, conservation of energy, prana shakti, the life force or life energy.
CONCEPT OF HEALTH and DISEASE ACCORDING TO NATUROPATHY.pptxDrManjuRater
This slide explains the concept of health and disease according to Naturopathy with scientific evidence-based, this includes health according to western medicine. health according to naturopathy, definitions of health according to naturopathy, vitality, determinants of health according to naturopathy difference between naturopathy and allopathy, characteristics of the human body, and Diagnostic criteria according to Naturopathy. Concept of disease according to western principles and disease according to naturopathy. upas tree, violation of natures law, morbid matter theory, source of toxemia and examples, the primary cause of disease and secondary cause of disease, free radicles acute disease and chronic disease, unity of disease and unity of cure, factor affecting the unity of cure, goals of naturopathy,
# Vitality, # prana shakti, # life energy,# life force, #Energy that sustains...Shweta Mishra
# student description on vitality, # vital economy, # notes on vital force, #compilation of notes on body energy system and its conservation
concept of energy, conservation of energy, prana shakti, the life force or life energy.
If you have health, you probably will be happy, and if you have health and happiness, you have all the wealth you need, even if it is not all you want.
~Elbert Hubbard~
Magnets are available every where. Very little people understands the healing properties of magnets. Dr. Desh Bandhu Bajpai is a medical practitioner and is using magnets for healing purposes. In this slide show , you will find the properties of magnets and other details.
Concept of Panchamahabhutas and their relation to Naturopathy and YogaPrakash Regmi
This Presentation shows the significance of Panchamahabhutas
The Body composition by 5 big elements.
Naturopathic and Yogic Interventions upon theory of Panchamahabhutas
Acupuncture originates from China and has been practiced there for thousands of years. It is really beneficial to treat diseases like Anxiety , Depression, Infertility, Weight loss , Insomnia , Asthma, Nausea, Digestive problems, Pregnancy care and many other conditions. The practitioners of Northside Acupuncture in Northern Beaches treat these problems very successfully. So If you are looking for the best Acupuncture clinic then feel free to contact us.
The biopsychosocial model reflects the development of illness through the complex interaction of biological factors (genetic, biochemical, etc.), psychological factors (mood, personality, behavior, etc.) ... A person may have a genetic predisposition for a disease, but social and cognitive factors must trigger the illness.
If you have health, you probably will be happy, and if you have health and happiness, you have all the wealth you need, even if it is not all you want.
~Elbert Hubbard~
Magnets are available every where. Very little people understands the healing properties of magnets. Dr. Desh Bandhu Bajpai is a medical practitioner and is using magnets for healing purposes. In this slide show , you will find the properties of magnets and other details.
Concept of Panchamahabhutas and their relation to Naturopathy and YogaPrakash Regmi
This Presentation shows the significance of Panchamahabhutas
The Body composition by 5 big elements.
Naturopathic and Yogic Interventions upon theory of Panchamahabhutas
Acupuncture originates from China and has been practiced there for thousands of years. It is really beneficial to treat diseases like Anxiety , Depression, Infertility, Weight loss , Insomnia , Asthma, Nausea, Digestive problems, Pregnancy care and many other conditions. The practitioners of Northside Acupuncture in Northern Beaches treat these problems very successfully. So If you are looking for the best Acupuncture clinic then feel free to contact us.
The biopsychosocial model reflects the development of illness through the complex interaction of biological factors (genetic, biochemical, etc.), psychological factors (mood, personality, behavior, etc.) ... A person may have a genetic predisposition for a disease, but social and cognitive factors must trigger the illness.
Bodhi Wellness Care in Mumabi is dedicated to holistic healing for getting relaxation, rejuvenation and relief. I also give Holistic counseling for stress, anxiety, depression and relationship problems. Call me for a healing demonstration at your place in Mumbai and Navi Mumbai in India. Mob/WhatsApp 9895369280
The storyline behind the modern epidemic of inflammation driven disease goes as follows:
• Chronic degenerative conditions (Diseases of Civilization – DOCs) are on the rise and have overtaken infections as the major source of death and illness.
• This epidemiological transition is due, at least in part, to environmental changes that have increased the disease liability of genetic profiles that were previously benign.
• These DOCs are associated with increased systemic inflammation stemming from inappropriate stressor-response mechanisms.
• Much of this inflammation is generated and/or perpetuated by the gut-brain axis.
• Gut-brain axis derived inflammation leads to disruptions in psycho-neuro-immunological (PNI) balances.
• Pathophysiological mediators of PNI disturbances can be measured and treated.
• A cornerstone of said treatment is the regular consumption of a high quality multi-strain probiotic.
The carefully selected strains in Tri-Flora have been shown to:
• Decrease pro-inflammatory cytokines;
• Increase anti-inflammatory cytokine IL-10;
• Stimulate regulatory immune cells;
• Inhibit immune response to LPS (lipopolysaccharide) transduction;
• Improve intestinal barrier function;
• Enhance mucosal and systemic immune responses;
• Produce and deliver neurotransmitters such as GABA and serotonin.
And in so doing accomplish some very intriguing clinical feats:
1. Lessen symptoms of chronic fatigue syndrome;
2. Act as an adjunct to standard care in the treatment of Major Depressive Disorder;
3. Improve anxiety and reduce brain cell death; and
4. Help women lose weight.
It is for reasons such as this, that my most commonly recommended supplement for most people is a high quality probiotic. Tri-Flora by IP Formulas is my new favorite.
A Multimodal, Regenerative Approach to TBI including HBOT and Adult Stem CellsMegan Hughes
Dr. Hughes presents at the 2018 OMED conference in San Diego about treating TBI using intranasal therapies, hyperbaric oxygen, the ketogenic diet, IV nutrition, and supplementation. He also discusses how HBOT upregulates peripheral blood stem cells.
A Multimodal Regenerative Approach to TBI - ROME 2019Megan Hughes
Dr. Hughes speaks at the Regional Osteopathic Medical Education conference in Keystone on February 8th, 2019. His presentation discusses the Multimodal, Regenerative Approach to TBI This will be his second time presenting with the American Osteopathic Association and his fifth time discussing this approach with brain injury. Treatments include hyperbaric oxygen therapy (HBOT), intranasal PRP and insulin, intranasal adult pluripotent stem cells, the ketogenic diet, IV nutrition, and cranial osteopathy.
A talk I gave on fasting at Phage Camp, Burning Man 2018.
Whether through intermittent fasting or time restricted eating, hundreds of books have been written on how to use fasting to lose weight.
However, rewinding back through thousands of years we see that fasting is a part of almost every major religion and recommended by some of the greatest ancient thinkers. Are we missing the point by just seeing it as another diet? In my presentation, I’ll go through a brief history of fasting and its uses throughout time, before looking at the most recent science which suggests it’s one of the most potent tools we have to stave off modern diseases such as cancer, Alzheimer's and multiple sclerosis and delay the premature aging of our bodies.
Equality in creation
Women in epics
Transformation of women
Milestone in women life
menarche & yoga
menstruation & yoga
pregnancy & yoga
Menopause & yoga
Cancer in women
conclusion
Symptomatology terms
General symptoms
Symptoms related to metabolic
Symptoms related to cardiovascular
Symptoms related to respiratory
Symptoms related to Gastrointestinal
Symptoms related to Dermatology
Symptoms related to neurology
Yoga therapy
Evidences supporting yoga in symptomatology
INTRODUCTION TO YOGA, DEFINITION,ORIGIN,THEORY OF EVOLUTION, ACCORDING TO SANKHY, ACCORDING TO YOGA
THE SCHOOLS OF YOGA, BHAVANA YOG, PRANASAMYAMA YOGA,APPLICATIONS OF YOGA, EDUCATION,THERAPY
STRESS MANAGEMENT
SPORTS
HEALTH PROMOTION
BASIC PRINCIPLES OF YOGA
Defined about Health and Disease according to yogic text Patanjali Yoga Sutra.
SAGE PATANJALI
PATANJALI YOGA SUTRAS EVOLUTION
PATANJALI YOGA SUTRAS
YOGA SUTRAS
PADAS - SAMADHI
SADHANA
VIBHUTI
KAIVALYA
CONCEPT OF DISEASES –ANTARAYAS, SAHABHUVAS, VRITTIS, KLESHAS
CONCEPT OF HEALTH - WAYS TO ATTAIN, MAINTAIN HEALTH AND PREVENT, ELIMINATE AND TREAT DISEASES
CONCLUSION
REFERENCES
Describes all about SARS CoV- 2 its introduction, epidemiology, life cycle of virus, its transmission, pathophysiology of the disease, its complications, diagnostic methods and management through different system of medicines.
ABOUT ACUPUNCTURE ANAESTHESIA, HISTORY, INDICATIONS, CONTRAINDICATIONS, PREPARATION & PROCEDURE, MOST COMMONLY USED POINTS, SELECTION OF THEORIES BASED ON NEEDS.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
3. HEALING MEANS
• The dictionary [Cambridge, Oxford] meaning of healing means - Helping
to make someone well again, esp. after injury
• Also psychologically healing refers to the process by which neuroses or
psychoses are resolved to the degree that leads to normal existence of a
being.[APA]
• According to various studies :
4. Author Definition Themes Sub themes
Cassell “Making whole again” Wholeness Transformation
Kubler-Ross “Becoming whole again” Wholeness Loss/ isolation
Saunders “Finding wholeness” Wholeness Suffering
Inui “Well-being & function” Narrative continuity
Siegel “A state of mind” Narrative Personal
Hammerschlag
“A harmony between the mind, the body & the
spirit”
Spirituality
Reconciliation or
restoration of belief/view
Stephens “A spiritual experience” Spirituality Transcendence
Ref: Egnew T. R. (2005). The meaning of healing: transcending suffering. Annals of family
medicine, 3(3), 255–262. https://doi.org/10.1370/afm.313
5. THEORY OF VITALITY
• Vitality is the innate healing force or self curative force within us.
• It preserves & promotes health
• It prevents and cures diseases
• As we violate ways of natural living, the innate healing mechanism, get
weakened, leading to poor health.
• Revitalising the vital force & strengthening it to restore the self-healing
mechanism of the body are primary steps in nature cure
“Neo Naturopathy”: the New Science of Healing by Louis Kuhne
Benedict Lust - Doctrine of unity of diseases
6. VITAL FORCE
• Vital force or life energy is a manifestation of the measurelessness powers of all
forms of subconsciousness & cosmic consciousness.
• Vital energy/prana is the element of life & the process of circulation of vital energy
is very important.
• As vital energy flows within living organism and help to maintain balance in
physiologically, physically, mentally & emotionally.
• Healing depends on “how much vital nerve energy we have”
• balance of vital energy is must = health
7. THEORY OF SELF- HEALING/ MEDICATRIX NATURAE
• Body has an elaborate healing mechanism that strives to maintain & restore
optimal health.
• This power is an intrinsic part of our being and makes the body capable of self-
healing.
• Adequate rest, which includes physical, physiological, mental, emotional and
sensory rest
• Curative forces carry out the restorative & regenerative processes.
• Naturopathy helps to reconnect with innate healer & the treatment process is
the way to create a conducive environment ideal for self-healing.
Wiley library: application.wiley-vch.de/books
Neo naturopathy -By Louis Kuhne
9. PHILOSOPHICAL CONCEPT OF INNATE
HEALING IN REFERENCE TO MODERN
CONCEPT
• Vital force - efficiency of digestive system & lungs to create energy, blood &
tissue
• Vital essence - balance & harmony of endocrine & neuroendocrine system
• Vital spirit - Strength & connection of spiritual energy within & throughout
• Vital economy - Energy expenditure =energy conserved by the body
10. TYPES OF HEALING
• Healing in human body can be done by 2 means or ways depending on
physiological or pathological demand of the body:
• Regeneration
• Repair
11. LEVELS OF HEALING
• Healing in the either
(repair/regeneration) form
occur in the body at certain
levels.
• Physical or mechanical
• Mental or psychological
• Physiological
14. Table -Components of the innate immune system.
Ref- Aristizábal B, González Á. Innate immune system. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to
Bedside [Internet]. Bogota (Colombia): El Rosario University Press; 2013 Jul 18. Chapter 2. Available from:
https://www.ncbi.nlm.nih.gov/books/NBK459455/
16. • Philosophically - Vitality, vital force etc.
• Physiologically is known as innate immunity or inborn healing capacity
of the body.
• Physical or mechanical innate immunity consists of skin[tight skin
junction], epithelial, mucous membrane, Cilia.
Textbook of Medical Physiology- Guyton & Hall, 19th edition
17. Fig1.Section of Skin
Fig2. How skin protects
Ref: Fitzpatrick’s Dermatology in General Medicine, chapter
22
18. Mucosa- and Skin-Associated Lymphoid
Tissues
The diffuse system of lymphoid tissues that
protect mucosal surfaces lining the
digestive, respiratory, and urogenital
systems is collectively known as MALT
(mucosa-associated lymphoid tissue).
Tissue within the MALT that guards a
particular region of the body may be further
categorized. For example, BALT (bronchi-
associated lymphoid tissue) and NALT
(nasopharynx-associated lymphoid tissue)
together defend the air passages from
foreign attack. GALT (gut-associated
lymphoid tissue) protects the gastrointestinal
tract. SALT is the diffuse collection of
immune cells that protect the skin.
Ref: Nochi T, Kiyono H. Innate immunity in the mucosal immune system. Curr Pharm Des. 2006;12(32):4203-13. doi: 10.2174/138161206778743457. PMID: 17100623.
19. Author & Journal Study Outcome/Conclusion
Zhao W & et al
The Journal of
Immunology, 2005
Cytokine production by skin-derived mast
cells: endogenous proteases are
responsible for degradation of cytokines
Activated Human skin derived mast cells which
produces cytokine.
Human skin derived mast cell that produces alpha-
beta-tryptases cells produce substantial amount of
amounts of IL-5,6,3, TNF-Alpha which results in
degranulation response [immediate response to
wound, injury by releasing performing mediators into
connective tissue resulting in cellular & soluble
effectors]
Wei Zhao & et al
The Journal of
Immunology, 2008
FcγRIIa, Not FcγRIIb, Is Constitutively
and Functionally Expressed on Skin-
Derived Human Mast Cells
This are gene expressed lung mast cells. FcyRIIa
receptors present in human skin mast cells of MT-TC
[mast cell that produces alpha-beta-tryptases] extends
the response capabilities of human mast cells beyond
those associated with the IgE to include those
associated with IgG.
20. Author & Journal Study Outcome/Conclusion
W Zhang
Clinical Journal &
Experimental Immunology,
2010
Transforming growth factor
beta 1 plays an important
role in inducing
CD4+CD25+forhead box P3+
regulatory T cells by mast
cells
Bone marrow derived Mast cell[BMCCs] can also
suppress the immune response through regulatory T
cells. And CD4 T cells can be induced into CD4+,
CD25+, Foxp3+ cells by BMMCs via transforming
growth factor beta.
Margherita Zanetti
The Journal of Leuckocyte
Biology, 2004
Cathelicidins,
multifunctional
peptides of the innate
immunity
Antimicrobial peptide LL-37, PR-39(porcine) (as
discussed earlier) participates in providing innate
immunity by regulating the antimicrobial host defences
21. Author Study Outcome/ conclusion
Elizabeth G. Ibarra-
Coronado & et al
Scientific Reports (Nature),
2017
Innate immunity modulation in
the duodenal mucosa induced
by REM sleep deprivation during
infection with Trichinella spirallis
Sleep is predictor of immunity though it can affect immunity.
Study reported that those rats who were sleep deprived got
affected to Trichinella spiralis (parasite) other developed
immune response of gut mucous membrane against the
parasite.
Troy D. Randall
Elsevier Public health
emergency collection,
2010
Bronchus-
Associated
Lymphoid Tissue
(BALT)
• Dendritic cell in BALT are found in highest concentration in
T cell.
• Role in homeostatic, provides cytokines
• Also have role in neuromodulation which gets stimulated in
viral infections (in rats) leading to leucocyte recruitment to
the airways and BALT hyperplasia {as they have higher
affinity for substance P & neurokinin 1}
• BALT areas have lymphatic vessels from which DC
acquire antigen in the airway through BALT
22. Author Study Outcome/ conclusion
Elisa Casadei & Irene
Salinas
Elsevier Public Emergency
Collection, 2018
Comparative
models for human
nasal infections
and immunity
NALT prevents progression of pathogen to lower respiratory
tract or CNS
Examples are as follows :
23.
24. PHYSIOLOGICAL & CHEMICAL ASPECT
• Homeostasis
• pH - sweat, saliva, HCL, bile, vaginal mucus, urine, tears, gut flora &
fauna
• Certain physiological responses such as diarrhoea, fever
25. Author & Journal Study Outcome/Conclusion
John A Kellum
Springer Critical Care,
2000
Determinants of blood
pH in health & disease
Important in cardiac, pulmonary physiology
Blood pH affects functioning of cell, organ, organism via
local, regional & systemic acid-base balance.
Shu-Hua Kuo & et al
Diagnostics(Basel), 2020
Role of pH value in
clinically relevant
diagnosis
pH affects function & play a critical role in regulating the
activating proteases related to wound healing processes.
pH activity of bacterial entertoxin activity antibacterial
efficacy [Table1 next slide]
Gerry K. Schwarzenberg
Journal of Environmental &
public health, 2012
The alkaline diet: is
there evidence that an
Alkaline pH diet
benefits health?
Alkaline diet = alkaline urine pH =reduced Ca in urine [Ca-
balance because of other buffers like phosphate]=improves
bone health Increased GH= improves CV health.
Increased intracellular Mg = normal functioning of numerous
enzymes, Mg activates Vit.D
[table 2next slide]
26.
27. Author & Journal Study Outcome/Conclusion
Nimshitha
Pavathuparambli Abdul
manaph & et al
Stem cell research &
therapy, 2018
Urine derived cells for
human cell therapy
• Differentiation or transdifferentiation of human urine derived cells can
generate desirable cells for regenerative therapy
• Easy, cost effective, non invasive kind of donor based cells helps:
• Renal reconstruction/kidney bioengineering[good replacement for
epithelial, endothelial & proximal tubule cells which reduces
inflammation & tubular injury by releasing cyokine& growth factor in
turns increases vascularisation by angiogenesis]
• genitourinary repair[as endothelial cells have been known to treat
even end age of bladder disease]
• cardiac repair[induced pluripotent cell,embroyonic stem cell as urine
stem cell have proved to generate mesoderm, endoderm & ectoderm
cells]
• liver reconstruction[renal cells have high expression of the endoderm
marker Sox-17 responsible thyroid, liver, pancreas cells development]
• diabetes treatment [conversion into insulin secreting beta cells]
• neurogeneration[provide functional neurons, esp. dopaminergic which
can help in PD]
• bone engineering[due to proliferative, self-renewal, differentiate
capability of urine stem cell to develop osteoblasts] & many other
conditions
28. Author & Journal Study Outcome/Conclusion
Sahdeo Prasad & et al
Experimental Biology &
medicine, 2016
Detection of
inflammatory
biomarkers in saliva &
urine:Potential in
diagnosis, diagnosis,
prevention & treatment
for chronic diseases
Saliva & urine biomarkers are acting as diagnostic tool as
well as treatment [fig. Next slide] also helps in understanding
disease & body relation.
29.
30.
31. Author & Journal Study Outcome/Conclusion
Hilaire J. Thompson
Journal of Advance
nursing, 2005
Fever: a concept
analysis
Now since past 20 year fever is taken as- acute phase response
Fever is an adaptive, coordinated & systemic response to an immune
stimulus, is a self limiting response in which thermoregulatory control
remains intact & generally requires no treatment.
Misconception about fever Facts
Fevers is a cause of illness Fever is a response to illness
Fever is maladaptive Is an adaptive systemic response to immune stimuli
Fever is solely an increased body temp.
Part of coordinated acute phase response of body including
autonomic, behavioural & neuroendocrine responses
Absolute temp. To define fever (usually 100.4 degree F)
No universal temp. Is defined as is based on individuals
normal diurnal body temp.
Fever requires medical/nursing intervention to prevent
negative consequences
Fever is self-limiting & generally requires no intervention
35. Pro-inflammatory cytokine production
Stimulus
Encourage inflammation
Local redness, swelling, heat, pain, loss of function
Depending on nature & infecting pathogen (no. of leucocytes [mainly neutrophils] arrive at site)
Both macrophage & dendritic cells engulf pathogen & cellular debris through phagocytosis
Neutrophils have 2-5 lobes with nucleus & lysosomes. Lysosomes engulf pathogen
Movement of leucocytes & fluid through increasingly permeable capillaries to infection site
Eosinophils (kind of leukocyte) act in allergic response, surrounds parasite & provide protection
PHAGOCYTOSIS
38. Author & Journal Study Outcome/Conclusion
Cornelia Hahn Martin A.
Arteriosclerosis,Thromb
osis, and Vascular
Biology, 2009
The role of
cellular
adaptation to
Mechanical
forces in
atherosclerosis
• Pressurised vascular system is an efficient, evolutionary to
circulate blood at cell or tissue level to increase metabolic output
• Mechanical pressure is generally required even in normal
conditions of CVS functioning to promote homeostasis
• Adaptive responses leads to disturbed flow later, gene
expression, matrix remodelling further contributes to
inflammatory pathways
• These events synergise with systemic risk factors (smoking,
diabetes)leading to progression of disease
Corbucci G. & et al
Minerva
Anestesiologica, 2005
Mechanism of
cell protection by
adaptation to
chronic & acute
hypoxia:
molecular
biology & clinical
practice
Adaptation to chronic hypoxia - increases tissue toleration to O2
deprivation
Promising protection have been reported by this cell
preconditioning & adaptation mimicking
39. Author & Journal Study Outcome/Conclusion
Valerie M.Weaver
Seminars in Cell &
Division Biology
(Elsevier), 2017
Cellular
adaptation to
biomechanical
stress across
length scales in
tissue
homeostasis &
disease
Mechanotransduction & matrix mechanics should be considered
while designing therapies to treat human conditions.
Extracellular matrix stiffness syngises with chemical cues to drive
single cell & collective cell behaviour in culture & act to establish
homeostasis
Valentina Fodale & et al
Cancer Journal, 2017
Mechanism of
cell adaptation.
When & how do
cancer develop
chemoresistance
?
Tumor cells develop chemoresistance & multiple mechanism can
be activated by single cell at different stages of disease
progression
Certain effects to overcome effect of pharmacological compounds -
alteration in drug metabolism, cross-talk between different
membrane receptors, modification of apoptotic signalling &
interference with cell proliferation
40. Author & Journal Study Outcome/Conclusion
Daniela N. Petrusca &
et al
Americal Journal of
Respiratory Cell &
Molecular Biology
(ATS),2014
Smoking
exposure
induces human
lung endothelial
cell adptation to
apoptotic stress
Non smoker’s certain cells (ceramide16) were introduced in
emphysema patients & found reduction In proliferation, induced
apoptosis via mitochondrial membrane depolarisation, apoptosis
inducing factor translocation, Akt phosphorylation.
Smokers develop apoptosis-resistant phenotype
41. • Mechanistic view of mind - Sigmund freud [earlier k/a the neuro-psychoses of defense]
• Unconscious mental processes employee by the ego to reduce anxiety.
• He defined defense as “in order to ward off unacceptable ideas or feelings that would cause “distressing
effect”, a person unconsciously resorts to certain mental processes that oppose these ideas or feelings and
render them less disturbing. This mental process, which take place outside the person’s awareness is called
defenses.
• Why ? Without defense mechanism people cannot live together it will be a mess if everyone will follow ones
instinctual drive.
• Also it protect our whole society & ego (upto certain level in normal condition) from some displeasure
• Also human biocultural behaviour results in healing behaviour. Which involves 1.emotional distress has
evolutionary origin 2.regulation of emotion evolved within a social context 3. There are motivators &
mechanisms of interpersonal regulation of emotion that results in consoling behaviour.
PSYCHOLOGICAL ASPECT
Ref: The ego & the mechanisms of defense: By Anna Freud
Brandon & et al- Why we heal: the evolution of psychological healing & implications for global mental health, Clinical Psychological review Vol.822020, Elsevier
43. Psychological healing in the form
of interpersonal regulation of
emotion between social group
member
Ref: de Waal & Preston, 2017
44. NATUROPATHY MODEL OF HEALING
[Optimal health]
Normal health
Inflammation
Irritation
Chronic inflammation
Discharge
Disturbance
Ref: Jared Zeff & et al “Naturopathic model of healing- the process of healing revisited”
(tumors, ulceration, scar, atrophy)
Degeneration