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Inflammation terrain

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Inflammation terrain as cause of chronic illnes

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  • DOWNLOAD THIS BOOKS INTO AVAILABLE FORMAT (2019 Update) ......................................................................................................................... ......................................................................................................................... Download Full PDF EBOOK here { https://soo.gd/irt2 } ......................................................................................................................... Download Full EPUB Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download Full doc Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download PDF EBOOK here { https://soo.gd/irt2 } ......................................................................................................................... Download EPUB Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download doc Ebook here { https://soo.gd/irt2 } ......................................................................................................................... ......................................................................................................................... ................................................................................................................................... eBook is an electronic version of a traditional print book THIS can be read by using a personal computer or by using an eBook reader. (An eBook reader can be a software application for use on a computer such as Microsoft's free Reader application, or a book-sized computer THIS is used solely as a reading device such as Nuvomedia's Rocket eBook.) Users can purchase an eBook on diskette or CD, but the most popular method of getting an eBook is to purchase a downloadable file of the eBook (or other reading material) from a Web site (such as Barnes and Noble) to be read from the user's computer or reading device. Generally, an eBook can be downloaded in five minutes or less ......................................................................................................................... .............. Browse by Genre Available eBooks .............................................................................................................................. Art, Biography, Business, Chick Lit, Children's, Christian, Classics, Comics, Contemporary, Cookbooks, Manga, Memoir, Music, Mystery, Non Fiction, Paranormal, Philosophy, Poetry, Psychology, Religion, Romance, Science, Science Fiction, Self Help, Suspense, Spirituality, Sports, Thriller, Travel, Young Adult, Crime, Ebooks, Fantasy, Fiction, Graphic Novels, Historical Fiction, History, Horror, Humor And Comedy, ......................................................................................................................... ......................................................................................................................... .....BEST SELLER FOR EBOOK RECOMMEND............................................................. ......................................................................................................................... Blowout: Corrupted Democracy, Rogue State Russia, and the Richest, Most Destructive Industry on Earth,-- The Ride of a Lifetime: Lessons Learned from 15 Years as CEO of the Walt Disney Company,-- Call Sign Chaos: Learning to Lead,-- StrengthsFinder 2.0,-- Stillness Is the Key,-- She Said: Breaking the Sexual Harassment Story THIS Helped Ignite a Movement,-- Atomic Habits: An Easy & Proven Way to Build Good Habits & Break Bad Ones,-- Everything Is Figureoutable,-- What It Takes: Lessons in the Pursuit of Excellence,-- Rich Dad Poor Dad: What the Rich Teach Their Kids About Money THIS the Poor and Middle Class Do Not!,-- The Total Money Makeover: Classic Edition: A Proven Plan for Financial Fitness,-- Shut Up and Listen!: Hard Business Truths THIS Will Help You Succeed, ......................................................................................................................... .........................................................................................................................
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  • DOWNLOAD THIS BOOKS INTO AVAILABLE FORMAT (2019 Update) ......................................................................................................................... ......................................................................................................................... Download Full PDF EBOOK here { https://soo.gd/irt2 } ......................................................................................................................... Download Full EPUB Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download Full doc Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download PDF EBOOK here { https://soo.gd/irt2 } ......................................................................................................................... Download EPUB Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download doc Ebook here { https://soo.gd/irt2 } ......................................................................................................................... ......................................................................................................................... ................................................................................................................................... eBook is an electronic version of a traditional print book THIS can be read by using a personal computer or by using an eBook reader. (An eBook reader can be a software application for use on a computer such as Microsoft's free Reader application, or a book-sized computer THIS is used solely as a reading device such as Nuvomedia's Rocket eBook.) Users can purchase an eBook on diskette or CD, but the most popular method of getting an eBook is to purchase a downloadable file of the eBook (or other reading material) from a Web site (such as Barnes and Noble) to be read from the user's computer or reading device. Generally, an eBook can be downloaded in five minutes or less ......................................................................................................................... .............. Browse by Genre Available eBooks .............................................................................................................................. Art, Biography, Business, Chick Lit, Children's, Christian, Classics, Comics, Contemporary, Cookbooks, Manga, Memoir, Music, Mystery, Non Fiction, Paranormal, Philosophy, Poetry, Psychology, Religion, Romance, Science, Science Fiction, Self Help, Suspense, Spirituality, Sports, Thriller, Travel, Young Adult, Crime, Ebooks, Fantasy, Fiction, Graphic Novels, Historical Fiction, History, Horror, Humor And Comedy, ......................................................................................................................... ......................................................................................................................... .....BEST SELLER FOR EBOOK RECOMMEND............................................................. ......................................................................................................................... Blowout: Corrupted Democracy, Rogue State Russia, and the Richest, Most Destructive Industry on Earth,-- The Ride of a Lifetime: Lessons Learned from 15 Years as CEO of the Walt Disney Company,-- Call Sign Chaos: Learning to Lead,-- StrengthsFinder 2.0,-- Stillness Is the Key,-- She Said: Breaking the Sexual Harassment Story THIS Helped Ignite a Movement,-- Atomic Habits: An Easy & Proven Way to Build Good Habits & Break Bad Ones,-- Everything Is Figureoutable,-- What It Takes: Lessons in the Pursuit of Excellence,-- Rich Dad Poor Dad: What the Rich Teach Their Kids About Money THIS the Poor and Middle Class Do Not!,-- The Total Money Makeover: Classic Edition: A Proven Plan for Financial Fitness,-- Shut Up and Listen!: Hard Business Truths THIS Will Help You Succeed, ......................................................................................................................... .........................................................................................................................
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  • DOWNLOAD THAT BOOKS INTO AVAILABLE FORMAT (2019 Update) ......................................................................................................................... ......................................................................................................................... Download Full PDF EBOOK here { http://bit.ly/2m6jJ5M } ......................................................................................................................... Download Full EPUB Ebook here { http://bit.ly/2m6jJ5M } ......................................................................................................................... Download Full doc Ebook here { http://bit.ly/2m6jJ5M } ......................................................................................................................... Download PDF EBOOK here { http://bit.ly/2m6jJ5M } ......................................................................................................................... Download EPUB Ebook here { http://bit.ly/2m6jJ5M } ......................................................................................................................... Download doc Ebook here { http://bit.ly/2m6jJ5M } ......................................................................................................................... ......................................................................................................................... ................................................................................................................................... eBook is an electronic version of a traditional print book that can be read by using a personal computer or by using an eBook reader. (An eBook reader can be a software application for use on a computer such as Microsoft's free Reader application, or a book-sized computer that is used solely as a reading device such as Nuvomedia's Rocket eBook.) Users can purchase an eBook on diskette or CD, but the most popular method of getting an eBook is to purchase a downloadable file of the eBook (or other reading material) from a Web site (such as Barnes and Noble) to be read from the user's computer or reading device. Generally, an eBook can be downloaded in five minutes or less ......................................................................................................................... .............. Browse by Genre Available eBooks .............................................................................................................................. Art, Biography, Business, Chick Lit, Children's, Christian, Classics, Comics, Contemporary, Cookbooks, Manga, Memoir, Music, Mystery, Non Fiction, Paranormal, Philosophy, Poetry, Psychology, Religion, Romance, Science, Science Fiction, Self Help, Suspense, Spirituality, Sports, Thriller, Travel, Young Adult, Crime, Ebooks, Fantasy, Fiction, Graphic Novels, Historical Fiction, History, Horror, Humor And Comedy, ......................................................................................................................... ......................................................................................................................... .....BEST SELLER FOR EBOOK RECOMMEND............................................................. ......................................................................................................................... Blowout: Corrupted Democracy, Rogue State Russia, and the Richest, Most Destructive Industry on Earth,-- The Ride of a Lifetime: Lessons Learned from 15 Years as CEO of the Walt Disney Company,-- Call Sign Chaos: Learning to Lead,-- StrengthsFinder 2.0,-- Stillness Is the Key,-- She Said: Breaking the Sexual Harassment Story That Helped Ignite a Movement,-- Atomic Habits: An Easy & Proven Way to Build Good Habits & Break Bad Ones,-- Everything Is Figureoutable,-- What It Takes: Lessons in the Pursuit of Excellence,-- Rich Dad Poor Dad: What the Rich Teach Their Kids About Money That the Poor and Middle Class Do Not!,-- The Total Money Makeover: Classic Edition: A Proven Plan for Financial Fitness,-- Shut Up and Listen!: Hard Business Truths that Will Help You Succeed, ......................................................................................................................... .........................................................................................................................
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Inflammation terrain

  1. 1. Inflammation Terrain. Prof.Dr.med. Arturo O’Byrne Integrative Medicine Professor Universidad Javeriana. Colombia
  2. 2. Objective • Chronic illness are immflamatory processes… –understand Inflammation Terrain.
  3. 3. Introduction. • Fundamental to biological medicine: –The role of the microenvironment as… •Critical supporter of healthy cells.
  4. 4. Bibliographic reference. • Buttle DJ. • Factors controlling matrix turnover in health and disease. • Biochem Soc Trans. Aug 2007;35(Pt 4):643-646.
  5. 5. Introduction. • The treatment could be improved by… –Stimulation or optimization of, •patient’s individual inflammation resolution process.
  6. 6. Bibliographic reference. • Serhan CN, Chiang N. • Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus. • Br J Pharmacol. Mar 2008;153 Suppl 1:S200-215.
  7. 7. Bibliographic reference. • Bannenberg GL. • Resolvins: Current understanding and future potential in the control of inflammation. • Curr Opin Drug Discov Devel. Sep 2009;12(5):644-658.
  8. 8. Inflammatory environment. • Cellular environment (millieu) in which inflammation occurs, influence on the inflammatory process… –Critical importance
  9. 9. Inflammatory environment. • Inflammatory reactions occur within microenvironments tissue specific cells: –Fibroblasts, endothelial cells, macrophages… •Specialized ECM components
  10. 10. Bibliographic reference. • Serhan CN, Brain SD, Buckley CD, et al. • Resolution of inflammation: state of the art, definitions and terms. • Faseb J. Feb 2007;21(2):325-332.
  11. 11. Bibliographic reference. • Buckley CD. • Why does chronic inflammation persist: An unexpected role for fibroblasts. • Immunol Lett. Jul 2011;138(1):12-14.
  12. 12. Inflammatory environment. • Fibroblasts –Play an active role in chronic inflammation!!.
  13. 13. Inflammatory environment. • Disordered fibroblast behavior… –Can lead to sustained recruitment, •Inappropriate retention of leukocytes.
  14. 14. Bibliographic reference. • Buckley CD, Pilling D, Lord JM, Akbar AN, Scheel-Toellner D, Salmon M. • Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. • Trends Immunol. Apr 2001;22(4):199-204.
  15. 15. Inflammatory environment. • First Target: the tissue microenvironment, in addition to: • Second target: the stressor and infiltrating immune cells –In treating chronic inflammation.
  16. 16. Inflammatory environment. • Chronic inflammation is associated with most age- related diseases including: –Alzheimer’s, –Atherosclerosis, –Osteoarthritis, cancer.
  17. 17. Inflammatory environment. • Throughout lifetime, –Regularly encounter internal and external antigenic stress, •which activates the immune system.
  18. 18. Inflammatory environment. • Throughout lifetime, –Over time… –Leads to the accumulation of antigenic burden.
  19. 19. Bibliographic reference. • Freund A, Orjalo AV, Desprez PY, Campisi J. • Inflammatory networks during cellular senescence: causes and consequences. • Trends Mol Med. May 2010;16(5):238-246.
  20. 20. Inflammatory environment. • Persistent, low-level immune activation, • Increase of the basal expression of inflammatory factors… –can initiate and maintain substantial chronic inflammation.
  21. 21. Bibliographic reference. • Vasto S, Candore G, Balistreri CR, et al. • Inflammatory networks in ageing, age-related diseases and longevity. • Mech Ageing Dev. Jan 2007;128(1):83-91.
  22. 22. Bibliographic reference. • Caruso C, Lio D, Cavallone L, Franceschi C. • Aging, longevity, inflammation, and cancer. • Ann N Y Acad Sci. Dec 2004;1028:1-13.
  23. 23. Bibliographic reference. • Franceschi C, Bonafe M, Valensin S, et al. • Inflamm-aging. An evolutionary perspective on immunosenescence. • Ann N Y Acad Sci. Jun 2000;908:244-254.
  24. 24. Inflammation / stressors. • Only when the stressors are addressed… –Can chronic inflammation be resolved.
  25. 25. Lymphatic / stressors. • Lymphatic system that promotes lymphatic drainage and cell migration… –is essential to help the body to eliminate or minimize those stressors.
  26. 26. ECM and Cells. • Biological medicine considers the cell and its ECM… –As the collective functional unit in higher organisms. •Not the cell alone.
  27. 27. ECM and Cells. • Communication between a cell and its microenvironment is bidirectional… –Forms the basis of the homeodinamic tissues control.
  28. 28. Inflammation / body functions. • Changes in the microenvironment, • Inflammation, –Significant impact on many bodily functions.
  29. 29. Inflammation / body functions. • Changes at the ECM level can drive systemic chronic inflammatory disorders: –Disturbed stem cell function. –Promotion of tumorigenesis.
  30. 30. Bibliographic reference. • Bhatia A, Kumar Y. • Cancer-immune equilibrium: questions unanswered. Cancer Microenviron. • Aug 2011;4(2):209-217.
  31. 31. Bibliographic reference. • Grivennikov SI, Greten FR, Karin M. • Immunity, inflammation, and cancer. • Cell. Mar 19 2010;140(6):883-899.
  32. 32. Inflammation and ECM. • The ECM is also directly involved… –In the initiation and resolution of inflammatory responses.
  33. 33. Bibliographic reference. • Sorokin L. • The impact of the extracellular matrix on inflammation. • Nat Rev Immunol. Oct 2010;10(10):712-723.
  34. 34. Inflammation and ECM. • Metabolic waste products, • Exogenous particles that accumulate in the ECM… –can function as inflammatory inducers.
  35. 35. Inflammation factors. • Environmental factors: –Diet, –Exercise, –Lifestyle, •Affect metabolic pathways
  36. 36. Bibliographic reference. • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER • An obesity-associated gut microbiome with increased capacity for energy harvest. • Nature. Dec 21 2006;444(7122):1027-1031.
  37. 37. Inflammation factors. • Intestinal mucosal permeability.
  38. 38. Bibliographic reference. • Conterno L, Fava F, Viola R, Tuohy KM. • Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease? • Genes Nutr. Aug 2011;6(3):241- 260.
  39. 39. Bibliographic reference. • Cani PD, Amar J, Iglesias MA, et al. • Metabolic endotoxemia initiates obesity and insulin resistance. • Diabetes. Jul 2007;56(7):1761-1772.
  40. 40. Inflammation factors. • Intestinal mucosal permeability. –Potentially inducing mucosal inflammation
  41. 41. Bibliographic reference. • Cani PD, Neyrinck AM, Fava F, et al. • Selective increases of bifidobacteria in gut microflora improve high-fat- diet-induced diabetes in mice through a mechanism associated with endotoxaemia. • Diabetologia. Nov 2007;50(11):2374-2383.
  42. 42. Bibliographic reference. • de La Serre CB, Ellis CL, Lee J, Hartman AL, Rutledge JC, Raybould HE. • Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. • Am J Physiol Gastrointest Liver Physiol. Aug 2010;299(2):G440-448.
  43. 43. Inflammation factors. • Obesity often causes physiological perturbations such as: –Oxidative stress, –Chronic systemic inflammation.
  44. 44. Bibliographic reference. • Conterno L, Fava F, Viola R, Tuohy KM. • Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease? • Genes Nutr. Aug 2011;6(3):241- 260.
  45. 45. Inflammation terrain. • Consideration of the “terrain” –Targeting the causes of conditions associated with chronic inflammation, •beyond targeting symptoms.
  46. 46. Inflammation terrain. • Biological complexity of chronic inflammation, –The same intervention could produce different effects… •In different patients •At different times
  47. 47. Bibliographic reference. • Nathan C, Ding A. • Nonresolving inflammation. • Cell. Mar 19 2010; 140 (6): 871-882.
  48. 48. Inflammatory patient profile. • Therapeutic systems would benefit… –from the ability to assess an inflammatory patient profile.
  49. 49. Inflammatory patient profile. • Inflammatory individual profile, –Help to identify and locate resolution blockages and underlying pathologies.
  50. 50. Inflammatory patient profile. • Clinical history –Individual evaluation of causes… •Individual treatment of the inflammatory status in every patient.
  51. 51. Inflammatory patient profile. • The real possibility of an individual’s inflammation resolution over time.
  52. 52. Bibliographic reference. • Nathan C, Ding A. • Nonresolving inflammation. • Cell. Mar 19 2010;140(6):871-882.
  53. 53. Living matrix. • The ECM, intracellular cytoskeleton and nuclear matrix, –Are directly interconnected through a chain of commonly utilized molecules.
  54. 54. Bibliographic reference. • Huang S, Ingber DE. • A non-genetic basis for cancer progression and metastasis: self-organizing attractors in cell regulatory networks. • Breast Dis. 2006;26:27-54.
  55. 55. ECM as “body terrain”. • Cellular Microenvironment Information Regulation –Considers the tissue microenvironment •The terrain of the body.
  56. 56. Bibliographic reference. • Genuis SJ. • What's out there making us sick? • J Environ Public Health. 2012;2012:605137.
  57. 57. Conclusion. • Cardinal role of the microenvironment as –Cellular information exchange center positions •ECM as a point of intervention.

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