The document defines inflammation and its advantages and disadvantages. It discusses the players involved in the inflammatory response, including circulating cells, vascular wall cells, and the extracellular matrix. It describes acute and chronic inflammation, distinguishing their features. Chronic inflammation arises from acute inflammation when the stimulus cannot be resolved. It involves macrophages, lymphocytes, eosinophils, and mast cells and can be granulomatous or non-granulomatous.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
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The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
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Difference between reversible and irreversible cell injury,Mechanism of cell ...Rukhshanda Ramzaan
Cell Injury: Any change resulting in loss of the ability to maintain the normal or adapted homeostatic state.
Agents that cause cell injury
• Hypoxia / Ischemia (loss of blood supply)
• Microbial
• Parasitic
• Chemical
• Physical
• Trauma
• Genetic
• Nutritious
• Environmental
Types of Cell injury
Reversible Cell Injury
Pathologic changes that can be reversed in mild cellular injury when the stimulus is removed. Cell injury is reversible only up to a certain point otherwise it will be irreversible.
Changes in reversible cell injury
Cellular Swelling: Due to accumulation of intracellular water and endoplasmic reticulum & mitochondria.
Clumping of chromatin.
Irreversible Cell injury
Pathologic changes that are permanent and cause cell death, they cannot be reversed to normal state.
Changes in irreversible cell injury
Irreversible injury is marked by severe mitochondrial vacuolization, extensive damage to plasma membranes, detachment of ribosomes from the granular endoplasmic reticulum (ER). Injury to lysosomal bodies leads to leakage of lysosomal enzymes into the cytoplasm and condensation, fragmentation and lysis of nuclei.
Inflammation- General Pathology seminar PG 1st yearDr. Ritu Gupta
this seminar includes general inflammation, its etiology, acute inflammation, features, events, fate, chronic inflammation, causes, features, types, granulomatous inflammation, acute v/s chronic inflammation, inflammatory disorders of pulp and periradicular tissues
A. There are three types of immunological disorders
1. Hypersensitivity
2. Autoimmune disease
3. Immunodeficiency
B. Hypersensitivity reactions to usually harmless substances are often called allergies or allergic reactions
Inflammation is a fundamental process for human survival, this lecture covers the basics of the process, its components and affects. Developing an understanding of this process will enable the student to comprehend this omnipresent process and how it is directly linked to our survival.
Difference between reversible and irreversible cell injury,Mechanism of cell ...Rukhshanda Ramzaan
Cell Injury: Any change resulting in loss of the ability to maintain the normal or adapted homeostatic state.
Agents that cause cell injury
• Hypoxia / Ischemia (loss of blood supply)
• Microbial
• Parasitic
• Chemical
• Physical
• Trauma
• Genetic
• Nutritious
• Environmental
Types of Cell injury
Reversible Cell Injury
Pathologic changes that can be reversed in mild cellular injury when the stimulus is removed. Cell injury is reversible only up to a certain point otherwise it will be irreversible.
Changes in reversible cell injury
Cellular Swelling: Due to accumulation of intracellular water and endoplasmic reticulum & mitochondria.
Clumping of chromatin.
Irreversible Cell injury
Pathologic changes that are permanent and cause cell death, they cannot be reversed to normal state.
Changes in irreversible cell injury
Irreversible injury is marked by severe mitochondrial vacuolization, extensive damage to plasma membranes, detachment of ribosomes from the granular endoplasmic reticulum (ER). Injury to lysosomal bodies leads to leakage of lysosomal enzymes into the cytoplasm and condensation, fragmentation and lysis of nuclei.
Inflammation- General Pathology seminar PG 1st yearDr. Ritu Gupta
this seminar includes general inflammation, its etiology, acute inflammation, features, events, fate, chronic inflammation, causes, features, types, granulomatous inflammation, acute v/s chronic inflammation, inflammatory disorders of pulp and periradicular tissues
A. There are three types of immunological disorders
1. Hypersensitivity
2. Autoimmune disease
3. Immunodeficiency
B. Hypersensitivity reactions to usually harmless substances are often called allergies or allergic reactions
Inflammation is a fundamental process for human survival, this lecture covers the basics of the process, its components and affects. Developing an understanding of this process will enable the student to comprehend this omnipresent process and how it is directly linked to our survival.
Multipex for viral and atypical pneumoniaPathKind Labs
Diagnosis of pneumonia can be challeging, especially if pathogens other than Streptococcus pneumoniae are involved Multiplex PCR with results available within the same day can investigate the presence or absence of 16 viruses and 5 bacteria, enablng the physician to make informed decisions about treatment, prognosis and public health and infection control measures.
Chronic inflammation /orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
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8 OUT COMES OF ACUTE INFLAMMATION.8 OUT COMES OF ACUTE INFLAMMATION.ssuser12303b
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This is about inflammation in immunology. Types of inflammation, causes, signs, events and mechanisms are mentioned briefly and it focuses on the cytokines associated with inflammatory and anti-inflammatory responses. Inflammation topic on immunology is the focus point.
concise lecture with tables and pictures about chronic inflammation, its mediators, mechanism and sequele. Granulomatous inflammation with different types of granulomas along with histopathology pictures and description.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
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Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Executive Directors Chat Leveraging AI for Diversity, Equity, and InclusionTechSoup
Let’s explore the intersection of technology and equity in the final session of our DEI series. Discover how AI tools, like ChatGPT, can be used to support and enhance your nonprofit's DEI initiatives. Participants will gain insights into practical AI applications and get tips for leveraging technology to advance their DEI goals.
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
2. Definition:
Inflammation is a protective response intended to
remove injurious stimuli as well as the necrotic cells
and tissues resulting from original insert.
OR
Repair process that causes the replacement of damaged
tissues by regeneration of parenchyma cells or by
filling of any residual defect by firous scar tissues.
3. ADVANTAGES:
It causes destruction of microbes.
Causes detoxification of toxins.
Clears infections.
Helps in healing process.
Causes repair of damaged tissues.
4. DISADVANTAGES:
Inflammatory responses are sometimes harmful as they
cause:
Life threatening anaphylactic reactions to insects
bites, drugs and other chronic diseases like
Rheumatoid arthritis, Atherosclerosis etc.
Inflammation of peritoneum leads to firous bands that
causes obstruction of intestines.
Pericardial inflammation causes the formation of
dense pericardium that impairs cardiac functions.
5. PLAYERS OF INFLAMMATION:
The inflammatory responses have many players. They
include:
1) CIRCULATING CELLS:
I. Bone marrow derived polymorph nuclear leukocytes
e.g., Basophils, Esinophils and Neutrophils.
II. Lymphocytes
III. Monocytes
IV. Platelets.
2) CIRCULATING PROTEINS:
I. Clotting factors
II. Kininogens
III. Complement proteins
6. 3) VASCULAR WALL CELLS:
I. Connective tissue cells
II. Smooth muscle cells
III. Epithelial cells
4) EXTRA CELLULAR MATRIX:
I. Fibrous structural proteins e.g., Elastin & Fibrinogen
II. Gel-forming proteoglycans
III. Adhesive glycoprotein e.g., Fibronectin, that are cell-
ECM and ECM-ECM connectors.
7. Inflammatory stimulus Chemical mediators
Inflammatory response until
injurious stimulus is removed
When the inflammatory stimulus is removed these
mediators are then dissipated, catabolized or removed.
TYPES OF INFLAMMATION:
Acute inflammation
And
Chronic inflammation
8. Chronic inflammation is the inflammation with
prolonged duration usually from weeks to months and
sometimes to years in which active inflammation,
tissue injury and healing process proceed
simultaneously.
DISTINGUISHING FEATURES:
Infiltration of mono-nuclear cells like lymphocytes,
macrophages and plasma cells.
Destruction of tissue by inflammatory cells.
Proliferation of new vessels leading to repair
(angiogenesis & fibrosis).
9. ORIGIN AND PROCESS:
Chronic inflammation arises from acute inflammation.
This transition takes place if the acute responses cannot
be resolved either because of the persistence e.g., of
injurious stimuli or by interference of the normal
healing process e.g., peptic ulcer.
Some types of injuries engender responses with chronic
inflammation initially e.g., viral infections.
SETTINGS LEADING TO CHRONIC INFLAMMATION:
I. Viral infections
II. Persistent microbial infections
III. Prolonged exposure to potentially toxic materials
IV. Autoimmune diseases
10. It is joined by lymphocytes and plasma cells,
however mast cells and eosinophils are as well involved
in chronic allergic diseases
Blood monocytes Tissue macrophage (RES)migrate into
tissue
within 48 hours
after injury
and differentiate
Kupffer cell
(liver)
Microglia (CNS)
Histiocytes
(spleen)
Alveolar macs
(lung)
Lymphocyte Plasma cell
11. CHRONIC INFLAMMATORY CELLS & MEDIATORS:
1) MACROPHAGES:
Macrophages are white blood cells within tissues, produced
by the division of monocytes.
A majority of macrophages are stationed at strategic points
where microbial invasion or accumulation of dust is likely
to occur. Each type of macrophage, determined by its
location, has a specific name:
In liver Kupffer cells
Spleen and lymph nodes Sinus histocytes
Nervous system Microglial cells
Lungs Alveolar macrophages
12. During chronic inflammation macrophages serve to eliminate injurious
agents and initiate repair- however, they are as well responsible for much
of the tissue injury that occurs
IFN-g
Activated T cell or NK cell
Tissue macrophage
Activated macrophage
Non Immune activation:
Endotoxins,
fibronectin,
chemical mediators
Tissue injury
Toxic oxygen metabolites
Metallo-proteases
Coagulation factors
AA metabolites and NO
Fibrosis (Scaring)
Growth factors involved
in fibroblast proliferation
(PDGF,TGFb,FGF)
Angiogenesis factors
(FGF,VEGF)
Collagen deposition
(IL-13 and TGFb)
13. FUNCTIONS OF MACROPHAGES:
They help to:
Filter the particulate matter
Kill microbes
Alert immune system of the body.
Their life is 1-2 days.
ACTIVATION OF MACROPHAGES:
Activation of macrophages means:
Increase in size
Increase in lysosomal content
Increase in metabolism
Increase in microbial killing activity
14. ACTIVATION SIGNALS:
Different signals required to activate macrophages are:
Cytokines produced by T-lymphocytes
Bacterial endotoxins
Different mediators produced during acute
inflammation
Extra cellular matrix proteins e.g., Fibrinogen
When macrophages become activated they produce
different type of biologically active substances that
either cause ;
Cell injury
OR
Fibrosis.
16. 2) LYMPHOCYTES:
Both T- & B-lymphocytes are involved in chronic
inflammation. Their migration is brought about by
specific adhesion molecules and cytokines. The T-
lymphocytes work in reciprocal with B-lymphocytes in
chronic inflammation. The already activated
macrophages release TNF & IL1 and activate the
inactive lymphocytes which then produce different
antibodies that cause destruction of antigens at the
inflammatory site.
3) ESINOPHILS:
They are usually found in parasitic infections and IgE
mediated allergic reactions. Their migration is brought
about by adhesion molecules produced by leukocytes
and epithelial cells. Esinophils specific granules
contain Major Basic Proteins which is highly cationic
&toxic for parasites.
17. 4) MAST CELLS:
Mast cells are tissue cells which are like basophils in
shape. They are present in bone marrow and around
blood vessels and do not enter the blood. They are
specifically armed with IgE antibodies against certain
antigens. When these antigens are encountered, they
release histamines and amino acid metabolites. They
cause initial vascular changes in acute inflammation
and also cause anaphylactic reactions.
18. TYPES OF CHRONIC INFLAMMATION:
1) AGRANULOMATOUS:
Granuloma is not formed,
Inflammation is characterized by all features of chronic
inflammation.
Examples:
Chronic viral infections e.g., Hepatitis
Chronic autoimmune diseases e.g., Rheumatoid
arthritis and Ulcerative colitis
Chronic chemical intoxication e.g., Chronic
alcoholic liver disease
Allergic reactions e.g., Bronchial asthma
19. 2) GRANULOMATOUS INFLAMMATION:
Characterized by aggregates of activated macrophages
that assume a squamous cell like epithelloid
appearance.
GRANULOMA is defined as aggregates of macrophages
formed due persistant response of T-lymphocytes to
particular antigens.
This has a granular cheesy appearance called as caseous
necrosis.
Examples are:
Bacterial:
Tuberculosis , Leprosy, Syphilis gumma etc.