Outline of beneficial effect of inflammation

1. MOHAMMED MUNEER MOHSIN
SECOND STAGE – COLLEGE OF
MEDICINE
UNIVERSITY OF KARBALA

2. The effects of inflammation can be both local 
and systemic. The systemic effects of acute
inflammation include fever, leukocytosis and
vascular changes.. The local effects are
usually clearly beneficial, for example the
destruction of invading microorganism, but at
other times they appear to serve no obvious
function, or may even be harmful.

3. Beneficial effects 
Both the fluid and cellular exudates may
have useful effects. Beneficial effects of the
fluid exudate are as follows

4. Entry of antibodies
Increased vascular permeability allows antibodies to
enter the extravascular space, where they may lead
either to lysis of microorganisms, through the
participation of complement, or to phagocytosis by
opsonization. Antibodies are also important in
neutralization of toxins.

6. Fibrin formation
Fibrin formation from exuded fibrinogen may
mechanically impede the movement of micro-organisms,
trapping them and so facilitating
phagocytosis.

8. Stimulation of immune response
The drainage of this fluid exudate into the lymphatic
allows particulate and soluble antigens to reach the
local lymph nodes where they may stimulate the
immune response.