This document discusses infective hepatitis and cirrhosis of the liver. It defines hepatitis as inflammation of the liver and identifies viruses, alcohol, and toxins as common causes. It describes the different types of viral hepatitis (A, B, C, D, E), their modes of transmission, symptoms, and potential to become chronic. Complications of hepatitis like cirrhosis are explained. Cirrhosis is defined as scarring of the liver leading to loss of function. Common causes and clinical features of cirrhosis are provided. The stages of alcoholic liver disease from fatty liver to hepatitis to cirrhosis are outlined.
Glomerulonephritis is inflammation of the tiny filters in your kidneys (glomeruli). Glomeruli remove excess fluid, electrolytes and waste from your bloodstream and pass them into your urine.
It include the definition , signs and symptoms, types, diagnosis, medical management, Nursing management, preventive measures, complication, Post exposure prophylaxis of Hepatitis.
Glomerulonephritis is inflammation of the tiny filters in your kidneys (glomeruli). Glomeruli remove excess fluid, electrolytes and waste from your bloodstream and pass them into your urine.
It include the definition , signs and symptoms, types, diagnosis, medical management, Nursing management, preventive measures, complication, Post exposure prophylaxis of Hepatitis.
Lung abscess is a type of liquefactive necrosis of the lung tissue and formation of cavities (more than 2 cm) containing necrotic debris or fluid caused by microbial infection.
Encephalitis is a rare yet serious disease that can be life-threatening.
Encephalitis is an inflammation of the brain tissue.
The most common cause is viral infections.
In rare cases it can be caused by bacteria or even fungi.
Encephalitis is an inflammation of the brain tissue.
Primary encephalitis- It occurs when a virus directly infects the brain and spinal cord.
Secondary encephalitis- It occurs when an infection starts elsewhere in the body and then travels to your brain.
Older adults
Children under the age of 1 year
People with weak immune systems
Primary (infectious) encephalitis
Common viruses, including HSV (herpes simplex virus) and EBV (Epstein-Barr virus)
Childhood viruses, including measles and mumps
Arboviruses (spread by mosquitoes, ticks, and other insects), including Japanese encephalitis, West Nile encephalitis, and tick-borne encephalitis
Secondary encephalitis: could be caused by a complication of a viral infection.
Ulcerative colitis (UC) is an inflammatory bowel disease. It causes irritation, inflammation, and ulcers in the lining of your large intestine (also called your colon). There's no cure, and people usually have symptoms off and on for life
Pneumonia is an inflammation of the lung parenchyma caused by various microorganisms, including bacteria, mycobacteria, fungi, and viruses.
Pneumonitis is a more general term that describes the inflammatory process in the lung tissue that may predispose and Pneumonia is an inflammation of the lung parenchyma that is caused by a microbial agent.
place the patient at risk for microbial invasion.
Pneumonia is classified into four: community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP), pneumonia in the immunocompromised host, and aspiration pneumonia.
Chronic obstructive pulmonary disorders COPD is a [preventable and treatable disease with some significant extra pulmonary effects that may contribute to the severity in individual clients.
It is characterized by airflow limitation that is not completely reversible.
A summary of commonly seen symptoms in people suffering with anorexia nervosa. Designed to provide basic information and as the basis for awareness raising sessions with e.g. parents, students or school staff.
There is also an accompanying video and factsheet see: http://www.inourhands.com/anorexia-symptoms-guide/
Lung abscess is a type of liquefactive necrosis of the lung tissue and formation of cavities (more than 2 cm) containing necrotic debris or fluid caused by microbial infection.
Encephalitis is a rare yet serious disease that can be life-threatening.
Encephalitis is an inflammation of the brain tissue.
The most common cause is viral infections.
In rare cases it can be caused by bacteria or even fungi.
Encephalitis is an inflammation of the brain tissue.
Primary encephalitis- It occurs when a virus directly infects the brain and spinal cord.
Secondary encephalitis- It occurs when an infection starts elsewhere in the body and then travels to your brain.
Older adults
Children under the age of 1 year
People with weak immune systems
Primary (infectious) encephalitis
Common viruses, including HSV (herpes simplex virus) and EBV (Epstein-Barr virus)
Childhood viruses, including measles and mumps
Arboviruses (spread by mosquitoes, ticks, and other insects), including Japanese encephalitis, West Nile encephalitis, and tick-borne encephalitis
Secondary encephalitis: could be caused by a complication of a viral infection.
Ulcerative colitis (UC) is an inflammatory bowel disease. It causes irritation, inflammation, and ulcers in the lining of your large intestine (also called your colon). There's no cure, and people usually have symptoms off and on for life
Pneumonia is an inflammation of the lung parenchyma caused by various microorganisms, including bacteria, mycobacteria, fungi, and viruses.
Pneumonitis is a more general term that describes the inflammatory process in the lung tissue that may predispose and Pneumonia is an inflammation of the lung parenchyma that is caused by a microbial agent.
place the patient at risk for microbial invasion.
Pneumonia is classified into four: community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP), pneumonia in the immunocompromised host, and aspiration pneumonia.
Chronic obstructive pulmonary disorders COPD is a [preventable and treatable disease with some significant extra pulmonary effects that may contribute to the severity in individual clients.
It is characterized by airflow limitation that is not completely reversible.
A summary of commonly seen symptoms in people suffering with anorexia nervosa. Designed to provide basic information and as the basis for awareness raising sessions with e.g. parents, students or school staff.
There is also an accompanying video and factsheet see: http://www.inourhands.com/anorexia-symptoms-guide/
10 ideas for supporting recovering anorexics during school mealtimesPooky Knightsmith
Parents and teachers of young people recovering from an eating disorder often find themselves in a situation where they want to offer support at mealtimes, but they don’t know how best to help.
It will depend entirely on the individual and, as long as they are well enough, you should always be guided by the young person in question, but here are ten suggestions to help you on your way.
A summary of commonly seen warning signs in people suffering with anorexia nervosa. Designed to provide basic information and as the basis for awareness raising sessions with e.g. parents, students or school staff.
There is also an accompanying video and factsheet see: http://www.inourhands.com/anorexia-nervosa-warning-signs
This presentation includes basic important facts about cirrhosis in clinical point of view.This might helpful in clinical management of patient suspecting cirrhosis.
This presentation gives us an insight into liver function, problems that can manifest when the liver is not healthy and how we can improve our liver health.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
2. Infective hepatitis and cirrhosis
• Hepatitis - inflammation and injury of the liver
• Hepatitis may be caused by
– Viruses
– Alcohol
– toxins and drugs
• Liver is inflamed/ injured because of viral infection it is
termed a viral hepatitis (three main virus are hepatitis A, B
and C and other hepatitis D, E and G).
3. Acute Hepatitis
• Acute hepatitis is an inflammatory process
• It cause liver cell death either by:
– necrosis or
– triggering apoptosis (programmed cell death)
• Acute hepatitis is also caused by exposure to:
– drugs (isoniazid) or poisons (e.g. ethanol)
• Manifestations
– relatively asymptomatic
– symptoms and signs, including anorexia, fatigue, weight
loss, nausea, vomiting, right upper quadrant abdominal
pain, jaundice, fever, splenomegaly and ascites
– hepatic dysfunction can also vary tremendously
4. Infective hepatitis
• Primary hepatocyte injury by stimulating host inflammatory
immune reactions
• Secondary hepatocyte injury by viral hepatitis
• The inflammatory reactions involve in
– Mast-cell degranulation
– Histamine release
– Cytokine production
– Complement activation
– Lysis of infected and neighboring cells
– Edema and swelling of the interstitium
• Later immune response supports the inflammatory responses
and
5. Aetiology of Infective hepatitis
• Hepatitis A
– non-enveloped, single-stranded RNA viruses
– transmitted via the fecal/oral route (fecal-contaminated
food, water or shellfish
– highest incidence occurs in children and adolescent
– HAV infection is endemic
– Onset: abrupt
– incubation period: 15–50 days
– Chronic hepatitis: rare
6. Aetiology of Infective hepatitis
• Hepatitis B
– enveloped, polyhedral, double stranded DNA virus
– blood-borne pathogen
– major routes of transmission include intravenous drug use,
unprotected sexual contact and exposure to contaminated
blood products
7. Aetiology of Infective hepatitis
• Hepatitis B:
– approx. 300 million people suffering from chronic infection
– in Southeast Asia, China and Africa, HBV is endemic. More than
8% of the infected population being chronic carriers
Transmission usually occurs by:
– mother to infant before or during birth (or)
– one child to another in early childhood
• Diagnostic method:
– Identification of the core antigen (HBcAg) or the hepatitis DNA
– Blood donations are routinely screened for HBV antigens
– Onset: insidious
– incubation period: 30–180 days
– Chronic hepatitis: possible
8. Aetiology of Infective hepatitis
• Hepatitis C (post-transfusion hepatitis):
• Is an enveloped, polyhedral, single stranded RNA virus
• The virus is present in semen and vaginal secretions.
• Multiple sexual (high risk behavior) partners become infected
• At least 30% of HIV-positive individuals are infected with HCV.
• Transmission: blood and body
fluids
• Onset: insidious
• incubation period: 15–160
days
• Chronic hepatitis: possible
9. Aetiology of Infective hepatitis
• Hepatitis D:
– unusual circular RNA, incomplete virus; delta hepatitis
agent
– Blood-borne pathogen.
– Can only infect individuals with active hepatitis B infection.
– Transmitted through contaminated blood and body fluids.
– The HDV virus is passed similarly to HBV virus.
– Onset: insidious
– incubation period: 30–180 days
– Chronic hepatitis: possible
10. Aetiology of Infective hepatitis
• Hepatitis E: Fecal/oral route of transmission. Outbreaks are
more common in developing nations and refugee camps due
to poor sanitation and fecal contamination of water supplies.
Young children are most frequently affected. The effects of
hepatitis E infection are particularly severe in pregnant
women.
– Onset: abrupt
– incubation period: 10–60 days
– Chronic hepatitis: unlikely
11. Manifestations of viral hepatitis
• Initially a prodromal anicteric phase, i.e. no jaundice, with
nausea, vomiting, headache, malaise, and a varying degree of
fever.
• In moderate to severe disease this is followed by the icteric
phase, with jaundice, dark urine and pale faeces (caused by
intrahepatic cholestasis), abdominal discomfort, hepatomegaly
and enlargement, sometimes splenomegaly and tenderness.
12. Manifestations of viral hepatitis
• Range from asymptomatic to severe
• Fatigue, malaise, anorexia, nausea
• Jaundice
• Liver inflammation and abdominal pain
• Abnormal liver function and enzyme levels
13. Complications of hepatitis
• Chronic active or persistent hepatitis can lead to progressive
liver injury, liver failure and death.
• The chronic form of hepatitis is most common with hepatitis B,
C, D, but rare with hepatitis A and E.
• Chronic active hepatitis is also associated with an increased
incidence of hepatocellular carcinoma.
14. Treatment of hepatitis
• Many hepatitis infections will resolve within 4 to 8 weeks
without treatment.
• Hepatitis A rarely becomes chronic and rarely requires
treatment. The long-term course of hepatitis B and C is less
predictable.
• Alpha interferon is currently approved for treatment of chronic
hepatitis B and C in US.
• Effective vaccines are currently available against hepatitis A, B
and C.
15. Drug induced &Toxic Hepatitis
• The relationship between the liver and drugs is important for
three reasons:
• The liver is the principal site for drug metabolisms
– lipophilic drugs, which are normally metabolized to
hydrophilic compounds for urinary excretion.
• Liver impairment has other physiological effects, which affect
drug handling and disposition.
– Reduced
biliary
excretion
(cholestasis)
causes
hyperbilirubinaemia and reduced excretion, e.g. of
rifampicin and fusidic acid.
• Drugs may cause liver damage
e.g. paracetamol (acetaminophen) and antidepressants.
16. Cirrhosis
• Cirrhosis - destruction or chronic, irreversible degeneration of
the normal liver cells
• characterized by diffuse scarring and fibrosis of the liver in
response to chronic inflammation and injury
• One of the major features of cirrhosis is the replacement of
functional liver tissue by scar tissue
• The most prevalent cause of liver cirrhosis is alcohol abuse.
Alcoholic liver disease presents in three progressive stages.
17. Aetiology of Cirrhosis
•
•
•
•
•
•
•
•
•
•
Common causes : prolonged alcoholism and viral hepatitis
Primary biliary cirrhosis (young female)
Autoimmune hepatitis
haemochromatosis (iron overload caused by repeated blood
transfusions)
Genetic mutations
Haemorrhagic conditions
Impaired erythropoiesis, excessive oral iron intake
Wilson’s disease
Schistosomiasis
Drugs and toxins
18. Clinical features of Cirrhosis
• Clinical features of cirrhosis are numerous and varied, and
depend on both liver failure and past patient history.
• Generalized pruritus may precede jaundice by some years
• Ascites and encephalopathy occur inevitably in the later
stages
• Problems associated with liver cirrhosis:
–
–
–
–
–
–
–
–
Ascites
Portosystemic encephalopathy
Cerebral oedema
Hypoglycaemia, hyperglycaemia
Electrolyte imbalance
Respiratory failure
Anaemia, coagulation disorders
Hepatocellular necrosis
19. Stages of alcoholic liver disease
• Alcoholic steatosis — “Fatty liver.” Accumulation of fat in the
hepatocytes, may results altered fat metabolism in the liver
and increase synthesis of fatty acids and triglycerides.
Enlargement of the liver is accompanied by symptoms that
may include anorexia, nausea and jaundice. At this point the
fatty changes are generally reversible if alcohol consumption
ceases.
20. Stages of alcoholic liver disease
• Alcoholic hepatitis — Inflammation, degeneration and
necrosis of hepatocytes with continued alcohol intake.
Symptoms can range from mild to severe and can include
anorexia and weight loss. Structural changes in alcoholic
hepatitis are also reversible to a large extent if alcohol
consumption ceases.
• Alcoholic cirrhosis — Diffuse scarring and fibrosis of the liver
that occurs after many years of alcohol abuse.
21. Manifestations of alcoholic cirrhosis
• Hepatosplenomegaly
• Ascites - Accumulation of fluid in the peritoneal cavity; results
from portal hypertension and decreased plasma protein
production by the liver; presents with massive distention of
the abdomen
• Portal hypertension
• Hepatorenal syndrome - Renal failure that can accompany
advanced liver disease
• Edema
• Jaundice
22. Manifestations of alcoholic cirrhosis
• Hepatic encephalopathy — Neurologic dysfunction
(accumulation of ammonia and other toxins in the circulation)
• Reduced metabolism of circulating sex hormones can result in
gynecomastia, menstrual irregularities, abnormal sexual
function
• Liver failure
23. Treatment of cirrhosis
• Nutritional and vitamin supplementation. A reduced-protein
diet is useful to decrease ammonia production.
• Diuretics to relieve fluid accumulation.
• Intubation or shunting to relieve bleeding from accessory
blood vessels.
• Management of symptoms of liver failure.