Liver failure occurs when the liver is severely damaged and cannot function properly. There are several types defined by how quickly liver function deteriorates. Causes include hepatitis, alcohol abuse, and acetaminophen overdose. Symptoms range from nausea and fatigue to jaundice and confusion. Diagnostic tests include blood tests, biopsies and imaging scans. Treatment depends on the underlying cause but may include medications to reverse toxins, procedures to reduce brain swelling, screening for infections, blood transfusions, and liver transplantation in severe cases.