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By
Kanchan Devi
Assistant Professor
SCPM college of nursing Gonda

Liver failure is an uncommon condition in which rapid
deterioration of liver function results in coagulopathy
and alteration in the mental status( encephalopathy).
Liver failure indicates that liver has sustained injury
Introduction

 FULMINANT HEPATIC FAILURE -
Encephalopathy starts within 8 weeks
 ACUTE LIVER FAILURE -(ALF) is a rare condition
characterized by the abrupt onset of severe liver
injury.
 LATE ONSET HEPATIC FAILURE – subacute FHF
 CHRONIC DECOMPENSATED HEPATIC
FAILURE – over six month latent period
TYPES OF LIVER FAILURE

 Large part of liver damaged beyond repair and liver
no longer able to work
 Hepatitis B, C
 Long term alcohol consumption
 Cirrhosis of liver
 Malnutrition
 Acetaminophen
 Ingestion of poison
 Hepatocellular carcinoma
Causes and risk factor


Early symptoms
 Nausea
 Loss of appetite
 Fatigue
 Diarrhea
Urgent treatment
 Jaundice
 Bleeding
 easily Swollen abdomen
 Mental disorientation or confusion (known as hepatic
encephalopathy)
 Sleepiness
 Coma
Clinical manifestation

 Blood test
 Liver tissue biopsy
 Doppler ultrasound
 CT scan
 MRI
 Electroencephalography
Diagnostic Evaluation

Acute liver failure treatments may include:
1. Medications to reverse poisoning:
 Liver failure caused by acetaminophen overdose
mushroom poisoning is treated with drugs that can
reverse the effects of the toxin.
 Antidotes such as penicillin G, activated charcoal,
N-acetylcysteine neutralize toxic agents and
neutralize or counteract any form of poisoning.
 Hemodialysis can be used to remove toxins from the
body.
Management

2. Relieving excess fluid in the brain:
 Cerebral edema caused by liver failure can increase
pressure on brain.
 Osmnotic diuretics such as mannitol can help reduce
the fluid buildup in brain.
 Administration of intravenous mannitol (in a bolus
dose of 0.5-1 g/kg or 50-100 g) is recommended to
treat cerebral edema in liver failure
Cont….

3. Screening for infections:
 periodic samples of blood and urine to be tested for
signs of infection.
 If suspects an infection, patient receives antibiotic
medications to treat the infection
4. If patient lost lots of blood than blood transfusion
needed
Cont….

 Liver transplant
Replace damage liver with healthy liver
Surgical management

Thank you

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Hepatic Failure.pptx

  • 1. By Kanchan Devi Assistant Professor SCPM college of nursing Gonda
  • 2.  Liver failure is an uncommon condition in which rapid deterioration of liver function results in coagulopathy and alteration in the mental status( encephalopathy). Liver failure indicates that liver has sustained injury Introduction
  • 3.   FULMINANT HEPATIC FAILURE - Encephalopathy starts within 8 weeks  ACUTE LIVER FAILURE -(ALF) is a rare condition characterized by the abrupt onset of severe liver injury.  LATE ONSET HEPATIC FAILURE – subacute FHF  CHRONIC DECOMPENSATED HEPATIC FAILURE – over six month latent period TYPES OF LIVER FAILURE
  • 4.   Large part of liver damaged beyond repair and liver no longer able to work  Hepatitis B, C  Long term alcohol consumption  Cirrhosis of liver  Malnutrition  Acetaminophen  Ingestion of poison  Hepatocellular carcinoma Causes and risk factor
  • 5.
  • 6.  Early symptoms  Nausea  Loss of appetite  Fatigue  Diarrhea Urgent treatment  Jaundice  Bleeding  easily Swollen abdomen  Mental disorientation or confusion (known as hepatic encephalopathy)  Sleepiness  Coma Clinical manifestation
  • 7.   Blood test  Liver tissue biopsy  Doppler ultrasound  CT scan  MRI  Electroencephalography Diagnostic Evaluation
  • 8.  Acute liver failure treatments may include: 1. Medications to reverse poisoning:  Liver failure caused by acetaminophen overdose mushroom poisoning is treated with drugs that can reverse the effects of the toxin.  Antidotes such as penicillin G, activated charcoal, N-acetylcysteine neutralize toxic agents and neutralize or counteract any form of poisoning.  Hemodialysis can be used to remove toxins from the body. Management
  • 9.  2. Relieving excess fluid in the brain:  Cerebral edema caused by liver failure can increase pressure on brain.  Osmnotic diuretics such as mannitol can help reduce the fluid buildup in brain.  Administration of intravenous mannitol (in a bolus dose of 0.5-1 g/kg or 50-100 g) is recommended to treat cerebral edema in liver failure Cont….
  • 10.  3. Screening for infections:  periodic samples of blood and urine to be tested for signs of infection.  If suspects an infection, patient receives antibiotic medications to treat the infection 4. If patient lost lots of blood than blood transfusion needed Cont….
  • 11.   Liver transplant Replace damage liver with healthy liver Surgical management