Infective endocarditis is a microbial infection of the heart valves or endocardium. It occurs most often in older individuals, those with prosthetic heart valves or congenital heart defects. Common causes are streptococci and staphylococci bacteria entering the bloodstream during medical procedures or dental work. Symptoms can be non-specific but include fever, chills, heart murmur. Diagnosis involves blood cultures, echocardiogram and looking for signs of embolization. Treatment is long-term antibiotics or surgery if the infection damages heart valves severely. Prevention involves good oral hygiene and antibiotic prophylaxis before certain medical procedures to prevent bacteremia.
Cardiomyopathy, or heart muscle disease, is a type of progressive heart disease in which the heart is abnormally enlarged, thickened, and/or stiffened. As a result, the heart muscle's ability to pump blood is less efficient, often causing heart failure and the backup of blood into the lungs or rest of the body. The disease can also cause abnormal heart rhythms.
Cardiomyopathy, or heart muscle disease, is a type of progressive heart disease in which the heart is abnormally enlarged, thickened, and/or stiffened. As a result, the heart muscle's ability to pump blood is less efficient, often causing heart failure and the backup of blood into the lungs or rest of the body. The disease can also cause abnormal heart rhythms.
Rheumatic heart disease is a condition in which the heart valves have been permanently damaged by rheumatic fever. The heart valve damage may start shortly after untreated or under-treated streptococcal infection such as strep throat or scarlet fever.
Cardiomyopathy is a group of disease that affect the heart muscle. Early on there may be few or no symptoms. As the disease worsens, shortness of breath, feeling tired, and swelling of legs may occur, due to the onset of heart failure. An irregular heart beat and fainting may occur.
Cardiomyopathy is a disease of the heart muscles that makes it harder for your heart to pump blood to the rest of your body. Cardiomyopathy can lead to heart failure.
According to the structural and functional abnormalities of the heart muscle
Dilated cardiomyopathy
Hypertrophic cardiomyopathy
Restrictive cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy
Unclassified cardiomyopathy
Rheumatic heart disease is a condition in which the heart valves have been permanently damaged by rheumatic fever. The heart valve damage may start shortly after untreated or under-treated streptococcal infection such as strep throat or scarlet fever.
Cardiomyopathy is a group of disease that affect the heart muscle. Early on there may be few or no symptoms. As the disease worsens, shortness of breath, feeling tired, and swelling of legs may occur, due to the onset of heart failure. An irregular heart beat and fainting may occur.
Cardiomyopathy is a disease of the heart muscles that makes it harder for your heart to pump blood to the rest of your body. Cardiomyopathy can lead to heart failure.
According to the structural and functional abnormalities of the heart muscle
Dilated cardiomyopathy
Hypertrophic cardiomyopathy
Restrictive cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy
Unclassified cardiomyopathy
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. INFECTIVE ENDOCARDITIS
DEFINITION:
It is an inflammatory process of the endocardium,
especially the valves.
is a microbial infection of the valves and endothelial
surface of the heart and usually develops in people with
prosthetic heart valves or cardiac structural defects (e.g.
valve disorders)
3. INCIDENCE
•Each year 15,000 to 20,000 new cases are diagnosed.
•Has high morbidity and death rates.
•Infective endocarditis is more common in older people
•high among IV/injection drug users who most commonly develop
infections of the right-sided heart valves
•Hospital-acquired endocarditis occurs most often in patients with
debilitating disease, those with peripherally inserted central catheters
and those receiving haemodialysis or prolonged intravenous or
4. CONTINUE..
• Patients receiving immunosuppressive medications or
corticosteroids may develop fungal endocarditis.
•Invasive procedures, particularly those involving mucosal
surfaces, can cause a bacteremia.
• If a person has some anatomical cardiac defect, bacteremia
can cause bacterial endocarditis.
• The combination of the invasive procedure, the particular
bacterium introduced into the bloodstream, and the cardiac
defect may result in infective endocarditis.
6. Subacute bacterial endocarditis :
develops gradually over several weeks or months
Usually caused by organisms like: Streptococcus viridans
Acute bacterial endocarditis:
Develops over days or weeks with an erratic course and earlier development
of complications
Commonly caused by Staphylococcus aureus.
Native valve endocarditis:
An infection of a previously normal or damaged valve.
7. Prosthetic valve endocarditis:
An infection of a prosthetic valve.
Non bacterial thrombotic endocarditis:
Caused by sterile thrombotic lesions. ( may be in pts with cancer
or other chronic diseases.)
8. RISK FACTORS
• Prosthetic cardiac valves or prosthetic material used for cardiac
valve repair
• History of bacterial endocarditis (even without heart disease)
• Congenital heart disease
• Unrepaired cyanotic congenital heart disease, including patients
with palliative shunts and conduits
9. • Repaired congenital heart disease with residual defects at
the site or adjacent to the site of a prosthetic patch or
device
• Cardiac transplant recipients with valvulopathy
11. PATHOPHYSIOLOGY
Due to etiological factors
A deformity or an injury of the endocardium leads to
accumulation on the endocardium of fibrin and platelets
(clot formation).
Infectious organisms( staph, strepto…)
The infection most frequently results in platelets, fibrin,
blood cells and microorganisms that cluster as
12. The vegetations may embolise to other tissues throughout the
body.
As the clot on the endocardium continues to expand, the infecting
organism is covered by the new clot and concealed from the
body's normal defenses.
The infection may erode through the endocardium into the
underlying structures (e.g. valve leaflets), causing tears or other
deformities of valve leaflets, dehiscence of prosthetic valves,
13.
14. CLINICAL MANIFESTATIONS
•onset is insidious.
•Systemic emboli occur with left-sided heart infective
endocarditis; pulmonary emboli occur with right-sided heart
infective endocarditis
•Fever
•Chills with sweats
•Malaise
•Weakness
•Anorexia
•Weight loss ……
15. • backache
•Splenomegaly
•Flu like symptoms
•symptoms and signs can be non-specific, diagnosis
requires a high index of suspicion. C/M due to
embolization:
Stroke, TIA, aphasia
Myocardial infarction…..
16.
17.
18. clusters of petechiae may be found on the body.
Small, painful nodules (Osler nodes) may be present in
the pads of fingers or toes.
Finger Clubbing
Arthralgia, proteinuria, hematuria
Pulmonary embolus…..
19. Irregular, red or purple, painless, flat macules (Janeway lesions)
may be present on the palms, fingers, hands, soles and toes.
Haemorrhages with pale centres (Roth spots) caused by emboli
may be observed in the fundi of the eyes.
Vision loss
Splinter haemorrhages (i.e. reddish-brown lines and streaks)
Heart failure, which may result from perforation of a valve leaflet,
rupture of chordae, blood flow obstruction due to vegetations, or
intracardiac shunts from dehiscence of prosthetic valves.
20. ASSESSMENT AND DIAGNOSTIC FINDINGS
•History collection
•Physical examination: A heart murmur may be absent initially but
develops in almost all patients. Murmurs that worsen over time
indicate progressive damage from vegetations or perforation of
the valve or the chordate tendineae.
•fever and no obvious source of infection, particularly if a heart
murmur is present.
•Fever is intermittent and may be absent in patients who are
21. •. Blood culture
• CBC : Patients may have elevated white blood cell (WBC)
counts
•patients may be anaemic and have a positive
rheumatoid factor and an elevated erythrocyte
sedimentation rate (ESR) or (-reactive protein.
22. •Microscopic haematuria
•Doppler echocardiography : may assist in the diagnosis by
demonstrating a mass on the valve, prosthetic valve or supporting
structures and by identifying vegetations, abscesses, new
prosthetic valve dehiscence or new regurgitation
•The echocardiogram may reveal the development of heart failure.
•Chest x ray
23. Prevention:
is rare, infective endocarditis may be life-threatening.
A key strategy is primary prevention in high-risk patients (i.e.
those with prosthetic heart valves).
endocarditis prophylaxis should be given for dental and
respiratory procedures
The list of gastrointestinal and genitourinary procedures is
similarly precise and includes procedures that also have a
24. MANAGEMENT
The severity of oral inflammation and infection is a significant factor in
the incidence and degree of bacteraemia.
•Good oral hygiene is probably the most important factor in reducing
the risk of endocarditis in susceptible individuals, and access to high
quality dental care should be facilitated.
• Once a patient is found to have a cardiac anomaly putting them at risk
of endocarditis, the patient should be referred to have their dental
25. •Prophylaxis is recommended only for those invasive
respiratory tract procedures that involve a high risk of
bacteremia. These include tonsillectomy and
adenoidectomy, bronchoscopy with incision or biopsy and
surgery involving bronchial, sinus, nasal or middle ear
mucosa.
•Regular personal and professional oral healthcare and
rinsing with an antiseptic mouthwash for 30 seconds before
26. PHARMACOLOGICAL MANAGEMENT
•Antibiotic:
•penicillin is usually the medication of choice
•Patients are usually instructed to take 2 g of amoxicillin orally 1
hour before the procedure.
• parenterally in a continuous intravenous infusion for 2 to 6
weeks.
***In fungal endocarditis, an antifungal agent, such as
amphotericin B, is the usual treatment.
27. SURGICAL MANAGEMENT
•if the infection does not respond to medications, the patient has a prosthetic heart
valve endocarditis, has a vegetation larger than 1 cm, or develops complications
such as a septal perforation.
•Surgical interventions include:
• valve debridement or excision,
•debridement of vegetations,
• debridement and closure of an abscess and closure of a fistula.
•The aortic valve may be best treated with an autograft. Most patients who
have prosthetic valve endocarditis require valve replacement.
28. NURSING MANAGEMENT
•monitor the patient's temperature; the patient may have fever for
weeks.
•Heart sounds are assessed; a new murmur may indicate
involvement of the valve leaflets.
•monitor for signs and symptoms of systemic embolisation or for
patients with right-sided heart endocarditis,
• monitor for signs and symptoms of pulmonary infarction and
infiltrates.
•assesse signs and symptoms of organ damage such as stroke,
meningitis, heart failure, myocardial infarction, glomerulonephritis
and splenomegaly.
29. •The patient is started on antibiotics as soon as blood cultures have
been obtained.
•Provide the patient and family with emotional support and facilitate
coping strategies during the prolonged course of the infection and
antibiotic treatment required.
•If the patient receives surgical treatment, the nurse should provide
postoperative care and instruction.
•Encourage to have nutritious diet, adequate fluid, and rest.