This document discusses the importance of nexus thinking in addressing global challenges at the intersection of water, energy, food, and the environment. It notes that food, fuel, and fertilizer crises are increasing in frequency and severity. Climate change is exacerbating water stress and declining water storage. There is a growing need for integrated approaches that consider these interconnected systems. The NEXUS Gains initiative aims to develop and scale innovations through five workstreams, including boosting water productivity, energizing food systems sustainably, and strengthening cross-sectoral governance.