This document discusses the water-energy-food-environment (WEFE) nexus challenges facing many countries, especially in the context of climate change impacts. It summarizes the goals and workstreams of the NEXUS Gains initiative, which aims to develop integrated solutions and tools to strengthen governance across sectors to boost productivity, access to clean energy, and capacity building in focal regions. Key outcomes include new modeling and decision support tools, improved water security, gender-sensitive clean energy models, and strengthened multi-stakeholder platforms.