Empyema is a collection of pus in the cavity between the lung and the membrane that surrounds it (pleural space). Caused by an infection that spreads from the lung and leads to an accumulation of pus in the pleural space, the infected fluid can build up to a quantity of a pint or more, which puts pressure on the lungs, causing shortness of breath and pain. Risk factors include recent lung conditions like bacterial pneumonia, lung abscess, thoracic surgery, trauma or injury to the chest.
“An ENT disease with an ophthalmic manifestation”
Orbital cellulitis (OC) is an inflammatory process that involves the tissues located posterior to the orbital septum within the bony orbit, but the term generally is used to describe infectious inflammation.
It manifests with erythema and edema of the eyelids, vision loss, fever, headache, proptosis, chemosis, and diplopia.
OC usually originates from sinus infection, infection of the eyelids or face, and even hematogenous spread from distant locations.
OC is an uncommon condition that can affect all age groups but is more frequent in the pediatric population.
Empyema is a collection of pus in the cavity between the lung and the membrane that surrounds it (pleural space). Caused by an infection that spreads from the lung and leads to an accumulation of pus in the pleural space, the infected fluid can build up to a quantity of a pint or more, which puts pressure on the lungs, causing shortness of breath and pain. Risk factors include recent lung conditions like bacterial pneumonia, lung abscess, thoracic surgery, trauma or injury to the chest.
“An ENT disease with an ophthalmic manifestation”
Orbital cellulitis (OC) is an inflammatory process that involves the tissues located posterior to the orbital septum within the bony orbit, but the term generally is used to describe infectious inflammation.
It manifests with erythema and edema of the eyelids, vision loss, fever, headache, proptosis, chemosis, and diplopia.
OC usually originates from sinus infection, infection of the eyelids or face, and even hematogenous spread from distant locations.
OC is an uncommon condition that can affect all age groups but is more frequent in the pediatric population.
A detailed description of sarcoidosis, pulmonary in specific but also covering the other systems. a rare entity in india or a better way to say, often an overlooked disease.
A detailed description of sarcoidosis, pulmonary in specific but also covering the other systems. a rare entity in india or a better way to say, often an overlooked disease.
GESTATIONAL DIABETES MELLITUS: “What” and “How” of Insulin administration in the susceptible pregnant population
Prepared for the departmental seminar.
Viswabharathi Medical College, Kurnool.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
2. INTRODUCTION
Hypothyroidism results from low levels of thyroid hormone with varied etiology
and manifestations. Untreated hypothyroidism increases morbidity and mortality.
The patient presentation can vary from asymptomatic disease to myxedema
coma. Today, the diagnosis of hypothyroidism is easily made with simple blood
tests and can be treated with exogenous thyroid hormone.
5. CRETINISM
Cretinism is defined as thyroid hormone deficiency present at fetal / neonatal development
It must be diagnosed promptly because delay in treatment can lead to irreversible
neurological deficits.
Before the newborn screening program, it was one of the most common preventable causes
of intellectual disability. Newborn screening (NBS) programs have led to earlier diagnosis
and treatment, resulting in improved neurodevelopmental outcomes.
6.
7. MANAGEMENT
Treatment with levothyroxine (L-T4) must be started immediately after the diagnosis of
congenital hypothyroidism (CH).
NBS programs and early L-T4 treatment initiation (prior to 2 weeks of life) can prevent
intellectual deficits and optimize neurodevelopmental outcomes. L-T4 alone is the treatment
of choice.
The initial dose depends upon the severity of CH. A higher initial L-T4 dose of 10 to 15
micrograms (ug)/kg/day (50 ug/day for full-term infants with severe CH) is recommended,
especially for neonates with a very low pretreatment T4 level. A high initial L-T4 dose can
normalize serum T4 in 3 days and TSH by two weeks of therapy.
11. MYXOEDEMA
Myxedema is a serious disorder with
high mortality. Most patients die from
GI bleeding, sepsis, or respiratory
failure despite optimal treatment. Poor
prognostic factors include advanced age,
persistent hypothermia, and altered
mental status.
Treatment:
Bolus of 0,5 mcg T4 or 10 mcg T3,
preferably IV over every 4 to 6 hours.
Additionally, IV Broad spectrum
Antibiotics and Hydrocortisone are
recommended
DYSHORMONOGENESIS
Thyroid dyshormonogenesis continues to
be a significant cause of congenital
hypothyroidism because of genetic
deficiencies in enzymes overlooking
hormone synthesis.
Common family history.
Most commonly affects Thyroid
Peroxidase (TPO) and Thyroglobulin
activity. Pendred syndrome is a classical
example of the condition.
15. INTRODUCTION
Follicular adenomas are one subset of benign neoplasms that can occur in the thyroid gland
or ectopic thyroid tissue. They typically present as a solitary thyroid nodule or in
association with nodular hyperplasia or thyroiditis. Thyroid nodules are palpable in 4 to 7
% of individuals, but the prevalence of nodules detected incidentally by ultrasound shows a
higher prevalence of 19 to 67 percent. The majority of thyroid nodules are asymptomatic..
Most of these are benign, although 5% exhibit malignant features. Although the
distinguishing line between the adenoma itself and its malignant counterpart is tricky, this
is for all practical purposes a benign neoplasm.
16.
17. ETIOLOGY
Although follicular adenomas are mostly sporadic, multiple other etiological factors have been identified Other causes
implicated in the development of a follicular adenoma include:
● Iodine deficiency: This is a known risk factor seen in individuals consuming non-iodized sea salt regularly.
● Genetic alterations: PTEN hamartoma tumor syndrome (PHTS) includes several syndromes like Cowden
syndrome and BRRS. Multiple follicular adenomas may occur along with other clinical manifestations. PTHS is
due to mutations causing inactivation of the PTEN tumor suppressor gene. Other genetic mutations in BRAF,
NRAS, RET, and KRAS can also cause unexplained follicular adenomas. Follicular adenomas are also part of
various syndromes like Familial adenomatous polyposis(FAP), Carney Complex syndrome. Genetic
rearrangement of the PAX8-PPAR gene causes loss of follicular growth inhibition, thus facilitating the
development of follicular neoplasms.
● Prior I-131 radiation exposure also increases the risk of malignant lesions of the thyroid.
18.
19. HISTOPATHOLOGY
Follicular adenoma is grossly described as a solitary, encapsulated nodule; the size can be extremely variable,
ranging from a few millimeters to 10-15 cm. The color vary from tan to light brown with solid and fleshy
appearance. It can resemble multinodular goiter due to secondary changes in hemorrhage and cystic
degeneration
The two key characteristics that make the follicular lesion malignant is the evidence of capsular invasion and
angioinvasion.
Histological examination of the nodule reveals a follicular architecture present in the entire or nearly entire
lesion. The nodule can be described as either microfollicular or macrofollicular growth pattern, and the
thyrocytes have a normal cytological appearance.
20.
21. CLINICAL PRESENTATION
● Most patients with a follicular adenoma present with solitary thyroid nodule in an
otherwise normal thyroid gland, however, it may occur in association with
thyroiditis or nodular hyperplasia. while taking history and performing a physical of
a patient with neck swelling, it is imperative to keep in mind the features of
hyperthyroidism or hypothyroidism that could accompany the presentation.
● Family history of Hashimoto disease, Grave disease thyroid carcinoma or familial
syndromes like Gardners all are valid points to consider. Commonly patients
present with and visually describe a slowly growing mass in the neck, pressure
sensation over the neck.
22. CLINICAL PRESENTATION
● Pain seldom accompanies a thyroid nodule unless spontaneous hemorrhage or
cystic degeneration has occurred within the nodule. Pressure symptoms could
cause dyspnea due to tracheal compression, increased coughing, voice hoarseness,
and choking spells due to recurrent laryngeal nerve irritation and dysphagia
secondary to esophagus compression
● Patients with a follicular adenoma present with a thyroid nodule that's palpable on
examination or identified on an imaging study. Nodules less than 1 cm are usually
challenging to palpate unless located anteriorly on the gland. There may be more
than one nodule that is palpated. However, even after neck palpation, nearly half of
these nodules go undetected and can only be picked up on ultrasonography
23. INVESTIGATIONS
● The four main parameters to assess in a thyroid nodule evaluation are detailed patient
history, physical examination, baseline serum TSH assay followed by an ultrasound.
● 5% of microfollicular adenomas, when subjected to histopathological examination, are
reported as follicular cancers
● CT scan and MRI have a limited role in the initial evaluation f solitary thyroid nodule.
Indications for these imaging techniques include suspected tracheal involvement,
either by invasion or compression, extension into the mediastinum, or recurrent
disease.
● FNA is performed to provide a cytological examination of the nodule, and it remains
the mainstay for assessing these lesions, although it may not provide a diagnosis in all
cases. The success rate of FNA is improved when the procedure is done under
ultrasound guidance.
24. MANAGEMENT
Medical Management
● If the patient is not clinically euthyroid, medical therapy done to achieve a
clinically euthyroid state.
● In such lesions, additional, free T3, T4 assay must be done. As mentioned
above, an iodine-123 thyroid scan may help determine the functionality of the
nodule. These patients must be appropriately treated with medication.
● The patient may undergo observation or levothyroxine suppression therapy as
an initial treatment modality. Levothyroxine is administered for six months to
determine if the nodule decreases in size.
25. MANAGEMENT
Surgical Management
● In the case of follicular neoplasms determined by FNA, the risk of malignancy is less than 1% in a
hyperfunctioning nodule, with a higher 20% risk if the nodule is hypo functioning.
● If the FNA result shows a follicular neoplasm, surgical management in the form of a thyroid
lobectomy with isthmusectomy is the norm. If the ultrasound shows suspicious features, the
surgeon should keep in mind the likelihood of malignancy.
● After due consideration of additional risk factors like family history, the presence of other
comorbidities, previous history of neck/head radiation, a decision of performing a total
thyroidectomy may be taken.
● Patients having a solitary toxic nodule, after determination of the functionality of the same, could
undergo therapeutic iodine-131 therapy. Surgically, a unilateral thyroid lobectomy is adequate.
● If the histopathological examination (HPE) examination confirms the Follciular neoplasm as an
adenoma, no further intervention is required.
26. Main Advantages of Surgical Therapy
● Relief from pressure-compressive symptoms like dyspnea,
dysphagia, hoarseness, etc
● Removal of the lesion helps alleviate the patient's anxiety
● Resolves the issues of thyrotoxicosis in a toxic follicular
adenoma
● Avoids unnecessary radiation exposure to the healthy part of
the thyroid
27. PROGNOSIS
● Follicular adenomas are benign neoplasms. They are slow-growing and can progress
to a size that may cause compressive symptoms. The patient should ideally be
reassured that these do not signify a malignant process but rather that the mass is
causing compression on another structure
● 20% of nonfunctioning follicular adenomas have oncogene mutations that may
progress to develop into a follicular carcinoma.
● Thyroxine supplementation is not recommended to suppress the gland unless
hypothyroidism occurs after gland lobectomy.