Hello everyone.....I shared a pdf file containing the deep knowledge about HYPERLIPIDEMIA AND THE PHARMACOLOGY OF ANTI-HYPERLIPIDEMIC DRUGS . In the B.pharma 5th semester...there is an most important topic ANTI-HYPERLIPIDEMIC DRUGS in the subject Pharmacology -II so i uploaded this file to help the students about this most important topic.....if u want this assignment in any format....feel free to DM me on my gmail id.....careof22@gmail.com.....THANK YOU
Overview of Discussion-
Anti-rheumatoid drugs
Classification of anti-rheumatoid drugs
Pharmacology of disease modifying anti-rheumatic drugs (DMARDs)
Pharmacology of adjuvant drugs
Hello everyone.....I shared a pdf file containing the deep knowledge about HYPERLIPIDEMIA AND THE PHARMACOLOGY OF ANTI-HYPERLIPIDEMIC DRUGS . In the B.pharma 5th semester...there is an most important topic ANTI-HYPERLIPIDEMIC DRUGS in the subject Pharmacology -II so i uploaded this file to help the students about this most important topic.....if u want this assignment in any format....feel free to DM me on my gmail id.....careof22@gmail.com.....THANK YOU
Overview of Discussion-
Anti-rheumatoid drugs
Classification of anti-rheumatoid drugs
Pharmacology of disease modifying anti-rheumatic drugs (DMARDs)
Pharmacology of adjuvant drugs
Hypolipidemic agents, also known as cholesterol-lowering drugs or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). They are also called lipid-lowering drugs.
Principles of cancer chemotherapy: a deep insight by RxVichuZ!RxVichuZ
This powerpoint deals with principles of cancer chemotherapy, that includes headings regarding cancer definition, its etiology, diagnostic measures and general considerations to be observed while initiating anti-cancer regimens in patients.
Detailed information of all terms like Thyroid gland, Thyroxine, Triidothyronine, Calcitonine, growth and development , propylthiouracil, Calorigenesis, tadpole to frog, Oligomenorrhoea, snehal chakorkar, pharmacology, Cretinism, Myxoedema coma, Graves disease, Thiocynates, Perchlorate, Nitrates.
Radioactive iodine, I131
Also termed as “Amrit” or the elixir of life, Giloy harmonizes the three “Doshas” making it such a potent herb for rejuvenation, treating ailments, and for boosting immunity. A great detoxification agent, Tinospora cleanses the micro circulatory system and has the unique ability to remove toxins from both exogenous and endogenous sources. Giloy protects the body and helps in its proper functioning under stress. Giloy is present in Medhya’s Total Cleanse and Build Cognition bites.
Hypolipidemic agents, also known as cholesterol-lowering drugs or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). They are also called lipid-lowering drugs.
Principles of cancer chemotherapy: a deep insight by RxVichuZ!RxVichuZ
This powerpoint deals with principles of cancer chemotherapy, that includes headings regarding cancer definition, its etiology, diagnostic measures and general considerations to be observed while initiating anti-cancer regimens in patients.
Detailed information of all terms like Thyroid gland, Thyroxine, Triidothyronine, Calcitonine, growth and development , propylthiouracil, Calorigenesis, tadpole to frog, Oligomenorrhoea, snehal chakorkar, pharmacology, Cretinism, Myxoedema coma, Graves disease, Thiocynates, Perchlorate, Nitrates.
Radioactive iodine, I131
Also termed as “Amrit” or the elixir of life, Giloy harmonizes the three “Doshas” making it such a potent herb for rejuvenation, treating ailments, and for boosting immunity. A great detoxification agent, Tinospora cleanses the micro circulatory system and has the unique ability to remove toxins from both exogenous and endogenous sources. Giloy protects the body and helps in its proper functioning under stress. Giloy is present in Medhya’s Total Cleanse and Build Cognition bites.
[VISITA: http://ymedicinanatural.com/pielblanca/ ] Emparejar el tono de la piel : Emparejar la Piel
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ANTIOXIDANT ACTIVITY AND HEPATOPROTECTIVE EFFECTOF POMEGRANATE PEEL AND WHEY...Anurag Raghuvanshi
The antioxidant activity of pomegranate peel powder (PPP) and whey powder (WP) was evaluated, their hepatoprotective effect of each alone or in combination (PPWP) at equal levels was also evaluated in Wistar rats against carbon tetrachloride (CCL4) induced liver injury.
The hepatoprotective activity was assessed using various biochemical parameters and histopathological studies.
Uk Data Centre Cleaning commercial cleaning technicians have a reputation for being highly professional, pleasant and very efficient in the way they perform their duties.
Medications and Lactation: Principles for Safe Practice for the Clinician – E...ErikaAGoyer
NATIONAL PERINATAL ASSOCIATION CONFERENCE 2014 - Medications and Lactation: Principles for Safe Practice for the Clinician – Evelyn Fulmore, Pharm.D., McLeod Regional Medical Center
Introduction, definition, common adulterants and diseases caused, simple tests to identify the adulterants in food products, Government acts to control the adulteration.
Antiseptic - Modern and Ayurvedic ConceptsAbhilash Mu
A brief presentation on Anti-septics, Detailing history, Classification, Indications, Side effects,uses and an Ayurvedic introduction to this topic.It gives detailed description of Hydrogen peroxide, Chloroxylenol, Ethanol, Cetrimide etc. And Details Neem, Brahmi and Triphala as Ayurvedic anti-septics.
Hypolipidaemics pharmacology with a note on Statins /Fibrates/ Sterol absorption Inhibitors/ CETP Inhibitors / Lipoprotein Lipase activators and Bile acid sequestrants
Hyperlipidemia , dyslipidemia , and drug therapy
also Fat transport and metabolisim and pathophysiology of lipoprotein
clincal importance of
1. Hypertriglycredemia
2. Hypercholesterolemia
3.Combined hyperlipidemia
4. Some other lipoprotein disorders
Including disorder of HDL_C
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. HYPOLIPIDAMIC DRUGS
Drugs which lower the levels of lipids & lipoproteins in
blood.
Prevent cardiovascular disease by retarding the
accelerated atherosclerosis in hyperlipidaemic
individuals.
3.
4. Lipids are carried in plasma in lipoproteins after
getting associated with several apoproteins;
plasma lipid concentrations are dependent on the
concentration of lipoproteins.
The core of lipoprotein globules consists of
triglycerides (TGs) or cholesteryl esters (CHEs)
while the outer polar layer has phospholipids, free
cholesterol (CH) & apoproteins.
The lipoproteins have been divided into 6
classes on the basis of their particle size & density.
They also differ in the nature of apoproteins, the
ratio of TG & CHE, tissue of origin & fate.
5. Source of lipid & Function
1. Chy. Diet Dietary TG transport
2. Chy. Rem. Diet, Chy. Dietary CH transport
3. VLDL Liver Endogenous TG transport
4. IDL VLDL Transport CHE & TG to liver,
source of LDL
5. LDL IDL TransportCH to tissues & liver
6. HDL Tissues, cell memb. Removal of CH from tissues
6. Dietary lipids are absorbed in the intestine
with the help of bile acids. Chylomicrons
(Chy) are formed & passed into lacteals-
reach blood stream via thoracic duct.
During their passage through capillaries,
the endothelium bound lipoprotein lipase
hydrolyses the TGs into fatty acids which
pass into muscle cells to be utilized as
energy source & in fat cells to be
reconverted into TGs & stored.
7. The remaining part-chylomicron
remnant (chy. Rem.) containing mainly
CHE & little TG is engulfed by liver cells,
which have receptors for the surface
apoproteins of Chy. Rem., & digested.
Free CH that is liberated is either stored
in liver cells after reesterification or
incorporated into a different lipoprotein
& released in blood or excreted in bile as
CH/bile acids.
8. Liver secretes VLDL containing mainly TG &
some CHE into blood. VLDL is acted upon by
endothelial lipoprotein lipase in the same way as
on Chy & the fatty acids pass into adipose tissue
& muscle; the remnant called IDL now contains
more CHE than TG. About half of the IDL is taken
back by the liver cells by attachment to another
receptor (LDL receptor), while the rest loses the
remaining TGs gradully & becomes LDL
containing only CHE. The LDL circulates in
plasma for long time; its uptake into liver & other
tissues is dependent on the need for CH.
9. The CHE of LDL is deesterified & used
mainly for cell membrane formation.
The CH released into blood from
degradation of membranes is rapidly
incorporated in HDL, esterified with
the help of an enzyme lecithin;
cholesterol acyltransferase (LCAT) &
transferred back to VLDL or IDL,
completing the cycle.
10. The excess lipoproteins in plasma are
phagocytosed by macrophages for disposal.
When too much of lipoproteins have to be
degraded in this manner, CH is deposited
in arterial walls (atheromas) & in skin &
tendons ( xanthomas). Raised levels of
VLDL, IDL & LDL (rarely Chy & Chy. Rem.
also) are atherogenic, while HDL may be
protective, because HDL facilitates
removal of CH from tissues.
11. Hyperlipoproteinaemias
I. Secondary : Diabetes, myxoedema, nephrotic
syndrome,chronic alcoholism,drugs (corticosteroids,
oral contraceptives, β blockers) etc.
II. Primary: due to
a) A single gene defect
b) Multiple genetic, dietary & physical activity related
causes.
13. Mechanism of action
HMG-CoA reductase inhibitors: ↓ CH synthesis
by inhibition of rate limiting HMG-CoA reductase.
Bile acid sequestrants: ↓ bile acid absorption, ↑
hepatic conversion of CH to bile acids, ↑ LDL
receptors on hepatocytes.
Fibric acid derivatives: ↑ activity of lipoprotein
lipase, ↓ release of fatty acids from adipose tissue.
Nicotinic acid: ↓ Production of VLDL, ↓ lipolysis
in adipocytes.
14. HMG-CoA REDUCTASE INHIBITORS
(STATINS)
Introduced in the 1980s,
Most efficacious
Best tolerated
Because HMG-CoA reductase activity is
maximum at midnight, all statins are
administered at bed time to obtain maximum
effectiveness. However, this is not necessary for
atorvastatin & rosuvastatin, which have long
plasma half life.
15. Lovastatin : orally given. Absorption is
incomplete . Liphophilic , half life is short (1-4
hrs).
Simvastatin : twice as potent as lovastatin. More
efficacious. Liphophilic , oral absorption is better.
Half life is 2-3 hr.
Pravastatin : it is hydrophilic & given in the active
form. At low doses it is equipotent to lovastatin,
but at higher doses (40-80 mg/day). Half life is 1-3
hrs.
16. Atorvastatin: This newer statin is more
potent & appears to have highest LDL-CH
lowering efficacy. Longer half life of 18-24 hr
then other statin & additional antioxidant
property.
Rosuvastatin : This is the latest & the most
potent statin , with half life of 18-24 hrs.
17. Adverse effects
Headache, nausea, bowel upset, rashes.
Sleep disturbances
Rise in serum transaminase can occur, but liver damage is
rare.
Muscle tenderness & rise in CPK levels occurs
infrequently.
Myopathy is the only serious reaction, but is rare. Few
fatalities due to rhabdomyolysis are on record. It is more
common when nicotinic acid/gemfibrozil or CYP3A4
inhibitor- ketoconazole/erythromycin/cyclosporine/HIV
protease inhibitor is given concurrently.
18. Use
Statins are the first choice drugs for
primary hyperlipidaemias with raised
LDL & total CH levels, with or without
raised Tg levels (Type iia, iib, v), as well
as for secondary (diabetes, nephrotic
syndrome) hypercholesterolaemia.
Efficacy of statins in reducing raised
LDL-CH associated mortality &
morbidity is now well established.
19. Beneficial effects in subjects who have raised CH
levels, reducing chances of plaque rupture &
thrombus formation.
Improvement in endothelial function in LDL
oxidation are proposed as additional
mechanisms by which statins may exert
antiatherosclerotic action.
On the basis of these results as well as the excellent
patient acceptability, the statins are being
increasingly used for primary & secondary
hypercholesterolaemia with or without raised TG
levels. They are the first choice drugs for
dyslipidaemia in diabetics.
20. Bile acid sequestrants (Resins)
Resins have been shown to retard
atherosclerosis, but are not popular
clilically because they are unpalatable,
inconvenient, have to be taken in large
doses, cause flatulence & other g.i.
symptoms, interfere with absorption of
many drugs and have poor patient
acceptability.
21. FIBRIC ACID DERIVATIVES
The fibrates primarily activate lipoprotein lipase
which is a key enzyme in the degradation of VLDL
resulting in lowering of circulating TGs.
This effect is exerted through PPARα (paroxisome
proliferator activated receptor α) that is gene
transcription regulating receptor expressed in liver,
fat & muscles.
Activation of PPARα enhances lipoprotein lipase
synthesis & fatty acid oxidation also enhanced LDL
receptor expression in liver.
22. Clofibrate : It does not prevent atherosclerosis,
therefore has gone out of use.
Gemfibrozil : Besides high efficacy in type iii
hyperlipoproteinemia, gemfibrozil has shown action
in subjects with raised blood CH in addition.
In the ‘Helsinki Heart Study’ men without known CAD
treated with gemfibrozil had a 34% reduction in fatal
& nonfatal MI, though overall mortality was not
affected.
Decrease the level of clotting factor vii-phospholipid
complex & promotion of fibrinolysis have been
observed, which may contribute to the
antiatherosclerotic effect.
23. Pharmacokinetics : orally absorbable. Half life is
1-2 hrs.
A/E: epigastric distress, loose motions, skin rashes,
body ache, eosinophilia, impotence, headache,
blurred vision. Myopathy is uncommon.
Gemfrozil + statin increases risk of myopathy.
Incidence of gallstone is not increased as seen with
clofibrate.
It is contraindicated during pregnancy.
24. In dose of 600 mg BD taken before meals,
gemfibrozil is the drug of choice for
patients with markedly raised TG levels,
whether or not CH levels are also raised.
Episodes of acute pancreatitis are prevented in
patients with chylomicronaemia & severe
hypertriglyceridaemia.
It is most effective in type iii
hyperlipoproteinaemia; also a first line drug in
type iv & type v disease.
it may be used as adjuvant drug in type iib
patients.
25. Nicotinic Acid (NIACIN)
Most effective drug to raise HDL-CH. TGs & VLDL
decrease rapidly, followed by a modest fall in LDL-
CH & total CH.
A/E: Flushing, heat, itching, dyspepsia, vomiting,
diarrhoea, peptic ulcer, dryness,
hyperpigmentation of skin, liver disfunction &
jaundice.
Hyperglycaemia, precipitation of diabetes,
hyperuricaemia & gout, atrial arrhythmias.
It is contraindicated during pregnancy & in
children.
26. Interaction & use
Postural hypotension may occur in pts on
antihypertensives when they take nicotinic
acid. Risk of myopathy due to statins is
increased.
Use : it is a wide spectrum hypolipidaemic
drug.
27. Highly efficacious in hypertriglyceridaemia (type iii, iv,
v) whether associated with raised CH level or not. It is
mostly used to lower VLDL & raise HDL levels, & as an
adjunctive drug to statins/fibrates.
It is the most effective drug in reducing plasma TG
levels & controlling pancreatitis in genetic type iv & type
v disorders.
Given over long-term in post- MI patients, reduce
recurrences of MI & overall mortality. However, because
of marked side effects, use of it is restricted to high risk
only.
28. Comments on the use of
hypolipidaemic drugs
Lifestyle modification, such as low fat, low
cholesterol diet, limitation of saturated &
transfats, regular exercise, body weight
control, smoking cessation, restriction of
alcohol are the primary approach, whether
drugs are used or not.
29. The decision to prescribe hypolipidaemic
drugs depends not only on the LDL-CH
level & the type of lipid abnormality, but
also on associated CAD risk factors or
existing CAD or its equivalent like diabetes,
peripheral / cerebral vascular disease,etc. in
individual pt.
30. Risk factors for coronary artery disease
Men > 45 years, Women > 55yrs.
Family history of MI/sudden cardiac death before 55
year (men), 65 year (women) age in first degree
relative
Smoking
Hypertension (BP > 140/90 or use of
antihypertensive medication)
Diabetes mellitus
Low HDL-CH (< 40 mg/dl in men, < 50 mg/dl in
women)
High LDL-CH (≥ 160 mg/dl) or total CH ≥ 240 mg/dl
Obesity (BMI > 25 Kg/m2) or Waist > 40’’ (men), > 35”
(women)
31. Treatment based on LDL-CH level
According to the the revised NCEP-ATP III guidelines
all subjects should receive statin (or statin based
combination) therapy if LDL-CH is ≥ 190 mg/dl. The
dose should be titrated to achieve the goal LDL-CH
level or 30-40% reduction, which ever is lower.
For subjects who already have CAD or CAD equivalent,
there is no lower threshold LDL-CH level; all subjects
should receive lipid lowering drug.
Though, LDL-CH value upto 100 mg/dl is considered
optimal for non-CAD subjects, the goal for CAD pts
has been lowered to 70 mg/dl.
32. Treatment of low HDL-CH level
Epidemiological data has shown that most pts with
premature CAD have low HDL-CH level.
The total CH:HDL-CH ratio has been recognized as a
more important determinant of CAD risk.
Recent trials have shown that statin therapy reduces
CAD endpoints in subjects with low HDL-CH even
though LDL-CH subjects have metabolic syndrome
(obesity, hypertriglyceridaemia, insulin resistance /
diabetes, hypertension).
33. In addition to these measures, the primary approach
of therapy in subjects with low HDL-CH is to reduce
LDL-CH to the target level as per their LDL-CH risk
category or to achieve a total CH: HDL-CH ratio of ≤
3.5, whichever is more intensive.
None of the currently available lipid modifying drugs
has a marked effect to raise HDL-CH, but nicotinic
acid has the highest efficacy followed by fibrates.
These drugs may be usefully combined with the statin,
watching for signs of myositis.
34. Treatment of raised TG level
On the basis of metaanalysis of studies, the NCEP have
recognized elevated TGs to be an independent CAD
risk factor.
Treatment strategy for hypertriglyceridaemia depends
on its cause (obesity, physical inactivity, smoking,
alcohol, high carbohydrate diet, diabetes, renal failure,
drugs like corticosteroids, estrogens, high dose β
blockers & genetic disorders) & its severity.
35. Initial treatment is directed to achieving the target
LDL-CH level appropriate for the pts CAD risk
category (by using a statin).
This may itself lower the TG level.
The primary TG lowering drugs are fibrates & nicotinic
acid.
In case of failure to reduce serum TG to < 200 mg/dl, a
fibrate (preferably fenofibrate) or nicotinic acid may
be added to the statin regimen, with extra vigilance to
guard against the increased risk of myopathy.