Hypertension is defined as a systolic blood pressure equal to or greater than 140 mmHg or a diastolic blood pressure greater than 90 mmHg. Systolic pressure indicates the force of the blood in the arteries as the heart beats. Diastolic pressure is the force of blood in the arteries as the heart relaxes. There are several classes of antihypertensive medications including thiazide-type diuretics, angiotensin-converting enzymes (ACE) inhibitors, angiotensin receptor blockers (ARBs), beta-blockers, renin inhibitors, and calcium channel blockers.
Definition of Hypertension
Hypertension (HTN or HT): is defined as a systolic blood pressure greater than 140 mm Hg and a diastolic pressure greater than 90 mm Hg, based on two or more measurements.
Increase in blood pressure [ Hypertension]
Decrease in blood pressure [ Hypotension]
Blood Pressure: Is the force of blood flow on the walls of blood vessels especially arteries
Diastolic pressure: occur at ventricles rest
Systolic pressure: occur when the ventricles contract
High blood pressure is a treatable condition. It is important to know the risk factors and available treatments for high blood pressure also called hypertension.
Definition of Hypertension
Hypertension (HTN or HT): is defined as a systolic blood pressure greater than 140 mm Hg and a diastolic pressure greater than 90 mm Hg, based on two or more measurements.
Increase in blood pressure [ Hypertension]
Decrease in blood pressure [ Hypotension]
Blood Pressure: Is the force of blood flow on the walls of blood vessels especially arteries
Diastolic pressure: occur at ventricles rest
Systolic pressure: occur when the ventricles contract
High blood pressure is a treatable condition. It is important to know the risk factors and available treatments for high blood pressure also called hypertension.
Hello all, I am Nehal Sharma; owner of this slideshare. I created this slideshare to share my knowledge and experience so i can give wings to all other students aspiring to touch the goal.
Hypertension is also known as high blood pressure. There are mainly two type of blood pressure i.e. systolic and another one is diastolic . The hypertension are categories into two parts that is primary hypertension and secondary hypertension. People are suffering from 3 stage during the condition of hypertension. There are following agents are used to treat hypertension like calcium channel blockers, ACE inhibitors, beta blocker, alpha + beta blockers these are commonly used.
Hypertension or high blood pressure has become a common health problem.
•High blood pressure may cause coronary artery disease, stroke, heart failure, atrial fibrillation, peripheral vascular disease, vision loss, chronic kidney disease and dementia.
•The narrower your arteries are, the higher your blood pressure will be.
•Your blood pressure measurement takes into account how much blood is passing through your blood vessels and the amount of resistance the blood meets while the heart is pumping.
•High blood pressure generally develops over many years, and it affects nearly everyone eventually.
•Fortunately, high blood pressure can be easily detected. And once you know you have high blood pressure, you can work with your doctor to control it.
Get more details @
A blood pressure measurement is always expressed in two numbers. The higher (systolic) number represents the pressure while the heart is beating, and the lower (diastolic) number represents the pressure when the heart is resting between beats.
High Blood Pressure or Hypertension is known as the silent killer. It is a condition that occurs without symptoms for many years and in most cases the cause is unknown. Genetic or environmental are the most explained reasons.
Austin Hypertension is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Hypertension.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of Hypertension. Austin Hypertension accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of hypertension.
Austin Hypertension strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Blood pressure is the force of the blood pushing against the walls of the arteries.
Each time our heart beats pumps blood into the arteries.
Blood pressure is highest when the heart beats, pumping the blood. This is called systolic pressure.
When our heart is at rest, between beats, our blood pressure falls. This is called diastolic pressure.
A blood pressure reading uses these two numbers. Usually, the systolic number comes before or above the diastolic number.
Hello all, I am Nehal Sharma; owner of this slideshare. I created this slideshare to share my knowledge and experience so i can give wings to all other students aspiring to touch the goal.
Hypertension is also known as high blood pressure. There are mainly two type of blood pressure i.e. systolic and another one is diastolic . The hypertension are categories into two parts that is primary hypertension and secondary hypertension. People are suffering from 3 stage during the condition of hypertension. There are following agents are used to treat hypertension like calcium channel blockers, ACE inhibitors, beta blocker, alpha + beta blockers these are commonly used.
Hypertension or high blood pressure has become a common health problem.
•High blood pressure may cause coronary artery disease, stroke, heart failure, atrial fibrillation, peripheral vascular disease, vision loss, chronic kidney disease and dementia.
•The narrower your arteries are, the higher your blood pressure will be.
•Your blood pressure measurement takes into account how much blood is passing through your blood vessels and the amount of resistance the blood meets while the heart is pumping.
•High blood pressure generally develops over many years, and it affects nearly everyone eventually.
•Fortunately, high blood pressure can be easily detected. And once you know you have high blood pressure, you can work with your doctor to control it.
Get more details @
A blood pressure measurement is always expressed in two numbers. The higher (systolic) number represents the pressure while the heart is beating, and the lower (diastolic) number represents the pressure when the heart is resting between beats.
High Blood Pressure or Hypertension is known as the silent killer. It is a condition that occurs without symptoms for many years and in most cases the cause is unknown. Genetic or environmental are the most explained reasons.
Austin Hypertension is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Hypertension.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of Hypertension. Austin Hypertension accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of hypertension.
Austin Hypertension strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Blood pressure is the force of the blood pushing against the walls of the arteries.
Each time our heart beats pumps blood into the arteries.
Blood pressure is highest when the heart beats, pumping the blood. This is called systolic pressure.
When our heart is at rest, between beats, our blood pressure falls. This is called diastolic pressure.
A blood pressure reading uses these two numbers. Usually, the systolic number comes before or above the diastolic number.
With the passage of time, PROTACs technology has entered an unprecedented stage of development in recent years. Scientists gradually see the absolute advantages of this technology, which can not only transform non-drug target (undruggable) into feasible drug target (druggable) but also resolve the problem of drug resistance of existing targets. In recent years, we have made great efforts to develop the (PROTAC) platform of protein degradation technology to provide research tools for small molecules targeting so-called non-proprietary drugs, in order to better help customers and help customers in the process of new drug research and development. According to the different requirements of customers, BOC Sciences can design, synthesize, optimize PROTAC molecules, establish analytical methods and carry out the biological evaluation.
Immunotherapy, a type of cancer treatment designed to eradicate disseminated cancer by harnessing the potential of the immune system. Immunotherapy agents do not directly attack the tumour but instead mobilize the immune system -this can be achieved through various approaches that utilize adaptive or innate immunity. The main types of immunotherapy can be broadly subdivided into non-antigen-specific and antigen-specific categories. Non-antigen-specific strategies include nonspecific immune stimulation and Immune checkpoint inhibitors, whereas antigen-specific strategies include adoptive cell transfer of autologous cancer-specific T cells and various therapeutic vaccination approaches.
Computer-aided drug design (CADD) is a widely used technology using computational tools and resources for the storage, management, analysis and modeling of compounds. It relies on digital repositories for study of designing compounds with physicochemical characteristics, predicting whether a given molecule will be combined with the target, and if so how strongly. Computer based methods can help us to search new hits in drug discovery, screen many irrelevant compounds at the same time and study the structure-activity relationship of drug molecules.
In fact, many of the drugs available today contain active ingredients extracted from natural products. Since 1994, nearly half of all drugs were discovered using natural products. Furthermore, between 2005 and 2007, there were 13 new drugs based on natural products that entered the commercial market, including the following 5 new products: small molecule ixabepilone, retapamulin, trabectedin, and the peptides exenatide and ziconotide. Clearly, natural product drug discovery programs continue to play a significant role in the clinical development of new therapies in the biopharmaceutical industry.
A simplified definition of autophagy is that it is an exceedingly complex process which degrades modifed, superfluous (surplus), or damaged cellular macromolecules and whole organelles using hydrolytic enzymes in the lysosomes. Autophagy can be defined in more detail as a regulated process of degradation and recycling of cellular constituents participating in organelle turnover, resulting in the bioenergetic management of starvation.
Dna encoded library technology-boc sciencesBOC-Sciences
DNA encoded library (DEL) is a new screening platform commonly used to discover small-molecules that interfere with the activity of pharmaceutically relevant proteins. DNA-encoded chemical libraries are hybrid-type collections of combinatorial organic molecules, individually coupled to distinctive DNA fragments.
The inhibition and function of heat shock protein 90BOC-Sciences
Hsp90, short for heat shock protein 90, is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins. In addition to other molecules involved in cell cycle regulation and immune responses. It supports for the appropriately folding of other proteins, offers help in protein degradation and also stabilizes some proteins needed for tumor growth.
Immunotherapy is treatment that uses certain parts of a person’s immune system to fight diseases such as cancer. The main types of immunotherapy now being used to treat cancer include: Immune checkpoint inhibitors, Monoclonal antibodies, Cancer vaccines and Nonspecific immune stimulation.
Antibody-drug conjugates (ADCs) are a very important class of highly potent drugs designed as a targeted therapy for the treatment of people who has cancer. It represents an innovative therapeutic application that includes the unique, high specificity and antitumor activity of monoclonal antibodies which are tumor-specific but not very cytotoxic, with the cell killing activity of small molecule drugs that are too toxic to be used on their own. Scientists could optimize the features of both components by linking monoclonal antibodies with cytotoxic agents.
A coupling reaction in organic chemistry is a general term for a variety of reactions where two hydrocarbon fragments are coupled with the aid of a metal catalyst. Now, we talk about several coupling reactions include (not exhaustive): Wurtz reaction, Glaser coupling, Ullmann reaction, Grignard reaction, Heck reaction, Sonogashira coupling, Stille reaction and Suzuki reaction.
Diabetes describes a group of metabolic diseases in which the person has high blood glucose levels over a prolonged period. Here, we sort out the recent research of diabetes.
New drugs for treating multiple types of cancers boc sciencesBOC-Sciences
Recently, at the annual meeting of the American Society of Clinical Oncology at the United States in 2017, researchers from multinational reported and exchanged their latest study results, the most noteworthy of which was the development of new drugs for the treatment of multiple types of cancers. Here, we sort out about this.
Recent advances of alzheimer's disease boc sciencesBOC-Sciences
Alzheimer's is a type of dementia that causes problems with memory, thinking and behavior. Symptoms usually develop slowly and get worse over time, becoming severe enough to interfere with daily tasks. Here, we sort out the recent advences of Alzheimer's Disease.
The Herpes virus family includes 8 different enveloped DNA-containing viruses that only affect human beings. The viruses are known by numbers as human herpes virus 1 through 8.
Hypotheses and Research of Alzheimer's disease-BOC SciencesBOC-Sciences
There are numerous hypotheses regarding Alzheimer's disease's pathogenesis including formation and metabolic disorders of amyloid-β, cholinergic hypothesis, abnormal Tau protein phosphorylation, the metal ions hypothesis, the involvement of oxidative stress, and others. There are several important targets under research about Alzheimer's disease. They are β-secretase, γ-secretase, Tau, Amyloid-βand Microtubule/Tubulin. BOC Sciences has directed sincere efforts toward providing customers with high quality small molecule reagents for Alzheimer's disease research.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
3. Background1
Hypertension is defined as a systolic blood
pressure equal to or greater than 140 mmHg or a
diastolic blood pressure greater than 90 mmHg.
Systolic pressure indicates the force of the blood
in the arteries as the heart beats.
Diastolic pressure is the force of blood in the
arteries as the heart relaxes.
Increased wall thickness
Reduced interior diameter
Increased resistance, more
force required to move blood
through vessel
6. Control Methods4
The lifestyle modifications include weight
reduction or maintenance of normal weight,
reduced sodium intake, increased physical activity,
reduction in alcohol consumption, and smoking
cessation.
9. BOC Sciences has rich experience in this area and are happy to serve our
customer. Also, BOC Sciences can provide related impurities and metabolites
which can be used in pharmaceutical industry and other research area.
10. Contact us
Email: info@bocsci.com
US & Canada (Toll free): 1-844-BOC(262)-0123
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