This document summarizes eight recent research articles on progress in diabetes treatment and understanding. Article 1 finds that enhanced natriuretic peptide signaling protects against obesity and insulin resistance. Article 2 investigates using stem cells to engineer pancreatic islets outside the body. Article 3 examines if obesity/diabetes drugs can reduce brain pressure. Article 4 links less sleep to higher diabetes risk factors in children. Article 5 describes a tissue engineering approach for under-skin transplants to treat type 1 diabetes. Article 6 shows immunotherapy may help treat type 1 diabetes. Article 7 finds a drug relieves diabetes but causes heart issues. Article 8 reviews the relationship between oxidative metabolism and systemic F2-isoprostane levels as linked to obesity and type 2 diabetes

1. Resent Researches
About Diabetes
Diabetes

2. Eight Articles Give You a
Better Understanding of the
Progress of Diabetes

3. es protect against obesity and insulin resistance
1 Heart Hormones Protect Against Obesity
and Insulin Resistance
Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and Fudan
University have shown that enhanced natriuretic peptide (NP) signaling in adipose tissue
protects against obesity and insulin resistance. This finding suggest that boosting levels
of NPs in adipose tissue may be an important avenue to combating metabolic disease.

4. 2 Treating Type I Diabetes by Engineering
Pancreatic Islets Outside the Body
To explore that potential, the National Science Foundation has funded a multi-
university study led by researchers at the University of Pittsburgh Swanson
School of Engineering who are investigating the use of human pluripotent stem
cells (hPSCs) to engineer pancreatic islets in the lab. A major goal of the
research is to develop a method of vascularizing islets in vitro, which studies
suggest will result in higher viability and enhanced function after the transplant.

5. Common Obesity and
Diabetes Drug Could
Reduce Rise in Brain
Pressure
Over a three-year period, researchers at the
University of Birmingham examined the GLP-
1 agonist drugs which used in the treatment
of diabetes and obesity could reduce
intracranial pressure in an animal model of
raised brain pressure.

6. Sleep Duration and Risk of Type 2 Diabetes
A study has found that children who slept on
average one hour less a night had higher risk
factors for type 2 diabetes, including higher
levels of blood glucose and insulin resistance.

7. Under-skin Transplants Show
Promise for Type 1 Diabetes
In theory, transplanting insulin-producing cells into the body
should work as a treatment for type 1 diabetes. However, in
practice, researchers face many challenges, especially in
finding a non-hostile environment for the cells. Now, a new
study describes a tissue engineering approach that may create
a suitable environment under the skin.

8. Immunotherapy Shows Promise in Type 1 Diabetes
The term “immunotherapy” means modifying the action of the
immune system is order to treat disease. It’s often used in
reference to cancer treatment, which is another exciting
application of the therapy. Researchers from King’s College
London and Cardiff University have published the results of a
clinical trial which shows that the therapy also has potential in
the treatment of Type 1 diabetes.

9. es protect against obesity and insulin resistance
7 MK-8722 Reliefs Diabetes but Induces
Cardiac Hypertrophy
Researchers from Merck & Company developed MK-8722, a potent, direct, allosteric
activator of all 12 mammalian AMPK complexes. In rodents and rhesus monkeys, MK-
8722-mediated AMPK activation in skeletal muscle induced robust, durable, insulin-
independent glucose uptake and glycogen synthesis, with resultant improvements in
glycemia and no evidence of hypoglycemia.

10. 8 Systemic F2-Isoprostane Levels in
Predisposition to Obesity and Type 2 Diabetes
The review summarizes new findings from epidemiological studies and a novel
interpretation of metabolic determinants of systemic F2-isoprostane levels as a
favorable phenotype. Multiple observations indicate that systemic F2-
isoprostane levels reflect intensity of oxidative metabolism, a major endogenous
source of reactive oxygen species, and specifically, the intensity of fat utilization.

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