There are numerous hypotheses regarding Alzheimer's disease's pathogenesis including formation and metabolic disorders of amyloid-β, cholinergic hypothesis, abnormal Tau protein phosphorylation, the metal ions hypothesis, the involvement of oxidative stress, and others. There are several important targets under research about Alzheimer's disease. They are β-secretase, γ-secretase, Tau, Amyloid-βand Microtubule/Tubulin. BOC Sciences has directed sincere efforts toward providing customers with high quality small molecule reagents for Alzheimer's disease research.

2. What is Alzheimer's disease ?
Mild disease Severe diseaseHealthy Brain

3. Others
5%5%
Frontotemporal
dementia
15%
Dementia with
lewy bodies
20%
Vascular dementia
55%
Alzheimer’s disease
Types of Dementia

4. I can't say the
words I want.
I can't spell
the word.Who am I?
Who are
you?
What did I
eat for my
lunch?
What's
this?
banana or
apple?

5. Cause of Alzheimer's disease
Amyloid hypothesis01
Tau hypothesis03
Cholinergic hypothesis02
The metal ions hypothesis
The involvement of oxidative
Stress and others
04
Senile plaques Neurofibrillary tangles

6. NH2 COOH
sAPPβ CTF-β sAPPα CTF-α
β-secretase α-secretase
Aβ (40/42) CTF-γ CTF-γP3
γ-secretase
γ-secretase
Amyloid hypothesis
Amyloid Precursor Protein (APP)

7. Amyloid-β Aβ oligomer formation Senile plaques

8. Kinase
Phosphatase
Tau stabilizes
microtubules
(normal)
Tauhyperphosphorylat
ion causes
microtubule
depolymerisation
Tau oligomers
aggregation
Formation of
paired helical
filament
Formation of
neurofibrillary
tangles
Tau protein
Tau hypothesis

9. Cholinergic hypothesis

10. Important targets
Alzheimer's
disease
γ-secretase
Tau
Amyloid-β
Microtubule
/Tubulin
β-secretase

11. BOC Sciences has directed sincere efforts toward providing
customers with high quality small molecule reagents for Alzheimer's
disease research.
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