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HORMONAL
CONTRACEPTIVES
PRESENTED BY :
GROUP D
MENTORS :
Dr. Santosh Upadhyaya Kafle
Dr. Mrinalini Singh
Learning Objectives :
• Introduction
• Classification
• Mechanism of action
• Method of use
• Advantages
• Disadvantages
• Frequency of use
Introduction :
Hormonal preparation used for reversible suppression of fertility are
hormonal contraceptives.
Over 100 million women worldwide are currently using hormonal
contraceptives for;
• Pregnancy prevention
• Proper birth spacing
• Reduction of pregnancy related morbidity and mortality
• Reduced risk of cancer
Classification :
A. Oral pills
1. Combined pill
2. Phased pill
3. Progestin only pill (Minipill)
4. Emergency pill (post-coital pill)
B. Depot formulations
1. Injectable
2. Subcutaneous implants
3. Vaginal rings
Oral pills :
1. Combined (monophasic) pill:
• Most popular
• Contains an estrogen and progestin in fixed dose
• Common formulation - Ethinylestradiol (0.03mg) + Levonorgestrel (0.15mg)
• A package of 28 pills contains - 21 oral contraceptive pills and 7 brown film
coated ferrous fumarate tablets (60 mg)
• Method - One tablet taken daily for 21 days at night starting on 5th
day of menstruation followed by iron supplement in the gap of 7 days
of menstrual bleeding.
• Withdrawal bleeding
• If one pill missed, two tablets taken on the next day and continued as
usual.
2. Phased pills :
• Permits reduction in total steroid dose without compromising the
efficacy.
• Mimicks normal hormonal pattern in menstrual cycle.
• Estrogen - constant or slightly variable (30-40 mcg)
• Progestin - low in first phase (50-75 mcg)
higher in second and third phases.(125 mcg)
• Recommendation -women over 35 years of age.
-with no withdrawal bleeding on monophasic pill.
-risk factors present.
3. Progestin-only pills(minipill) :
• Eliminates the estrogen because of its many long term risks.
• Efficacy is lower and less popular.
4. Emergency Pill (post coital pill) :
• Standard regimen: Levonorgestrel 0.75mg 2 doses 12 hours apart. Or,
1.5mg single dose as soon as possible.
• Before 72 hours of unprotected intercourse.
Mechanism of action:
• Normal feedback inhibition of Gonadotropin releasing
• Progestin- reduces frequency of LH secretory pulses.
• Estrogen reduces FSH secretion
• Synergism inhibits Midcycle LH surge.
• Failure of ovulation
• Thick cervical mucus secretion
• Post coital pill- interfere with fertilization / implantation.
Depot formulation
1. Injectable
• Developed to obviate the need of daily ingestion of pills
• Long acting progestin only injections are used now.
Compounds marketed are:
(i) Depot medroxyprogesterone acetate 150- one intramuscular injection every 3
months.
(ii) Norethindrone enanthate 200-one intramuscular injection every 2 months.
(iii) Depo-subQ provera 104- one subcutaneous injection every 3 months.
2. Implants
• Known as Norplant.
• Consists of 6 silicon rubber capsule containing 35 mg each of
Levonorgestrel.
• Implanted beneath the skin of fore arm or upper arm.
Drawback: -Irregular menstrual bleeding
-Surgical procedure required
3. Vaginal ring
• Contains Levonergestrel .
• Slowly absorbed as through vaginal mucosa.
• Ring is worn in vagina for 3 weeks of cycle and removed for the
fourth.
Adverse Effects:
(i) Cardiovasular effects.
(ii) Nausea & Vomiting (oral)
(iii) Headache
(iv) Weight gain
(v) Risk of liver diseases
References:
•Park’s textbook of Preventive and Social Medicine (24th
Edition) - K. Park
• Essentials of Medical Pharmacology (7th edition)- K.D
Tripathi
Thankyou!
“Delay the first, postpone the second and prevent the third”

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Hormonal Contraceptives

  • 1. HORMONAL CONTRACEPTIVES PRESENTED BY : GROUP D MENTORS : Dr. Santosh Upadhyaya Kafle Dr. Mrinalini Singh
  • 2. Learning Objectives : • Introduction • Classification • Mechanism of action • Method of use • Advantages • Disadvantages • Frequency of use
  • 3. Introduction : Hormonal preparation used for reversible suppression of fertility are hormonal contraceptives. Over 100 million women worldwide are currently using hormonal contraceptives for; • Pregnancy prevention • Proper birth spacing • Reduction of pregnancy related morbidity and mortality • Reduced risk of cancer
  • 4. Classification : A. Oral pills 1. Combined pill 2. Phased pill 3. Progestin only pill (Minipill) 4. Emergency pill (post-coital pill) B. Depot formulations 1. Injectable 2. Subcutaneous implants 3. Vaginal rings
  • 5. Oral pills : 1. Combined (monophasic) pill: • Most popular • Contains an estrogen and progestin in fixed dose • Common formulation - Ethinylestradiol (0.03mg) + Levonorgestrel (0.15mg) • A package of 28 pills contains - 21 oral contraceptive pills and 7 brown film coated ferrous fumarate tablets (60 mg)
  • 6. • Method - One tablet taken daily for 21 days at night starting on 5th day of menstruation followed by iron supplement in the gap of 7 days of menstrual bleeding. • Withdrawal bleeding • If one pill missed, two tablets taken on the next day and continued as usual.
  • 7. 2. Phased pills : • Permits reduction in total steroid dose without compromising the efficacy. • Mimicks normal hormonal pattern in menstrual cycle. • Estrogen - constant or slightly variable (30-40 mcg) • Progestin - low in first phase (50-75 mcg) higher in second and third phases.(125 mcg) • Recommendation -women over 35 years of age. -with no withdrawal bleeding on monophasic pill. -risk factors present.
  • 8. 3. Progestin-only pills(minipill) : • Eliminates the estrogen because of its many long term risks. • Efficacy is lower and less popular. 4. Emergency Pill (post coital pill) : • Standard regimen: Levonorgestrel 0.75mg 2 doses 12 hours apart. Or, 1.5mg single dose as soon as possible. • Before 72 hours of unprotected intercourse.
  • 9. Mechanism of action: • Normal feedback inhibition of Gonadotropin releasing • Progestin- reduces frequency of LH secretory pulses. • Estrogen reduces FSH secretion • Synergism inhibits Midcycle LH surge. • Failure of ovulation • Thick cervical mucus secretion • Post coital pill- interfere with fertilization / implantation.
  • 10. Depot formulation 1. Injectable • Developed to obviate the need of daily ingestion of pills • Long acting progestin only injections are used now. Compounds marketed are: (i) Depot medroxyprogesterone acetate 150- one intramuscular injection every 3 months. (ii) Norethindrone enanthate 200-one intramuscular injection every 2 months. (iii) Depo-subQ provera 104- one subcutaneous injection every 3 months.
  • 11. 2. Implants • Known as Norplant. • Consists of 6 silicon rubber capsule containing 35 mg each of Levonorgestrel. • Implanted beneath the skin of fore arm or upper arm. Drawback: -Irregular menstrual bleeding -Surgical procedure required
  • 12. 3. Vaginal ring • Contains Levonergestrel . • Slowly absorbed as through vaginal mucosa. • Ring is worn in vagina for 3 weeks of cycle and removed for the fourth.
  • 13. Adverse Effects: (i) Cardiovasular effects. (ii) Nausea & Vomiting (oral) (iii) Headache (iv) Weight gain (v) Risk of liver diseases
  • 14. References: •Park’s textbook of Preventive and Social Medicine (24th Edition) - K. Park • Essentials of Medical Pharmacology (7th edition)- K.D Tripathi
  • 15. Thankyou! “Delay the first, postpone the second and prevent the third”