Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
Platelet Rich Fibrin (PRF) in Dentistry, What is PRF ? , What are the difference between PRP,PRGF and PRF ?, Preparation of PRF , shapes of PRF, Role of PRF in wound healing, APPLICATIONS OF PRF, Applications of PRF In Oral and Maxillofacial Surgery, Applications of PRF In Periodontics, Applications of PRF In Endodontics, Applications of PRF In Tissue Engineering
Certains medications have been associated with gingival enlargement.
the seminar gives a complete analysis of etilogy and pathogenesis involved in digo as well as sequlae of it
The content narrates about commercially available disclosing agents for the detection of dental plaque. It holds its significance from both clinician and patient viewpoint, especially in reinforcing oral hygiene measures and early detection of inflammatory changes in the gums.
Platelet Rich Fibrin (PRF) in Dentistry, What is PRF ? , What are the difference between PRP,PRGF and PRF ?, Preparation of PRF , shapes of PRF, Role of PRF in wound healing, APPLICATIONS OF PRF, Applications of PRF In Oral and Maxillofacial Surgery, Applications of PRF In Periodontics, Applications of PRF In Endodontics, Applications of PRF In Tissue Engineering
Certains medications have been associated with gingival enlargement.
the seminar gives a complete analysis of etilogy and pathogenesis involved in digo as well as sequlae of it
The content narrates about commercially available disclosing agents for the detection of dental plaque. It holds its significance from both clinician and patient viewpoint, especially in reinforcing oral hygiene measures and early detection of inflammatory changes in the gums.
Various Plaque Hypothesis are proposed to prove how plaque becomes pathogenic and cause periodontitis. Helpful in understanding pathogenesis of periodontitis especially how Gingivitis change to Periodontitis. All the details have been added and made in easy language to understand.
Useful for BDS and MDS students
Teeth don’t possess regenerative ability found in most other tissues. Therefore, once enamel & dentin are lost as a result of caries, trauma or wear, restorative material must be used, to reestablish form & function.
Teeth require preparation to receive restoration & these preparations must be based on fundamental principles, which are discussed in this presentation, from which basic criteria can be developed to help predict the success of prosthodontic treatment.
Corticosteroids in Dentistry| Application and Adverse Effect of CorticosteroidDr. Rajat Sachdeva
Corticosteroids are very similar to Steroid hormones produced naturally in Adrenal Cortex of humans.
Protein, Carbohydrates and Fat metabolism, maintenance of fluid electrolytes and adapting the body to stress.
Corticosteroids are antinflammatory, analgesics, effective on ulceration promotes the healing of nerve injuries.
Oral Sub-mucus Fibrosis, Central Giant Cell Granuloma, Lichen Planus (for 5 min, 0.5% application of Clobetasol Propionates with Nystatin) in a Gingival Tray.
Bullous and Mucous Pemphigoid, Melkerson Rosenthal syndrome, Bell's Palsy, Post-Herpetic neuralgia.
Periodontitis is a complex infection initiated by bacteria –tissue destruction.
Host: the organism from which a parasite obtains its nourishment/ an individual who receives a graft
Modulation: the alteration of function or status of something in response to a stimulus or an altered physical or chemical environment
A brief description of all topics to recent advances,SDD, host modulation and diabetes, host modulation in smokers, chemically modified tetracyclines, bisphosphonates
This easy and fresh lecture explain to undergraduate and newly-graduated dentists an important topic in dentistry, pain-relievers. Analgesics are used very often in dentistry and a clinical guide seems necessary.
Various Plaque Hypothesis are proposed to prove how plaque becomes pathogenic and cause periodontitis. Helpful in understanding pathogenesis of periodontitis especially how Gingivitis change to Periodontitis. All the details have been added and made in easy language to understand.
Useful for BDS and MDS students
Teeth don’t possess regenerative ability found in most other tissues. Therefore, once enamel & dentin are lost as a result of caries, trauma or wear, restorative material must be used, to reestablish form & function.
Teeth require preparation to receive restoration & these preparations must be based on fundamental principles, which are discussed in this presentation, from which basic criteria can be developed to help predict the success of prosthodontic treatment.
Corticosteroids in Dentistry| Application and Adverse Effect of CorticosteroidDr. Rajat Sachdeva
Corticosteroids are very similar to Steroid hormones produced naturally in Adrenal Cortex of humans.
Protein, Carbohydrates and Fat metabolism, maintenance of fluid electrolytes and adapting the body to stress.
Corticosteroids are antinflammatory, analgesics, effective on ulceration promotes the healing of nerve injuries.
Oral Sub-mucus Fibrosis, Central Giant Cell Granuloma, Lichen Planus (for 5 min, 0.5% application of Clobetasol Propionates with Nystatin) in a Gingival Tray.
Bullous and Mucous Pemphigoid, Melkerson Rosenthal syndrome, Bell's Palsy, Post-Herpetic neuralgia.
Periodontitis is a complex infection initiated by bacteria –tissue destruction.
Host: the organism from which a parasite obtains its nourishment/ an individual who receives a graft
Modulation: the alteration of function or status of something in response to a stimulus or an altered physical or chemical environment
A brief description of all topics to recent advances,SDD, host modulation and diabetes, host modulation in smokers, chemically modified tetracyclines, bisphosphonates
This easy and fresh lecture explain to undergraduate and newly-graduated dentists an important topic in dentistry, pain-relievers. Analgesics are used very often in dentistry and a clinical guide seems necessary.
A powerpoint program describing the energy system of the human body and how energy therapy can help "tune-up" this system and assist you in feeling better. By Kathy Arneson.
Here is a trusted brand with a range flavours in their oral care products that keeps your smile bright and clean. It also protects your mouth from bacteria and germs!
These are the best and powerful Home Remedies for common ailments. These homemade remedies are Natural , Herbal and Safe.
For more natural remedies you can check 1800Remedies.com website
Comparative Evaluation of the Effect of Doxycycline As An Adjunct to Non-Surg...QUESTJOURNAL
Background: The association between diabetes and periodontal disease has long been discussed with conflicting conclusions. Earlier studies demonstrating the relationship between diabetes and severity of periodontal disease has been equivocal. However, recent studies have clearly proven that diabetes increases the risk of periodontal disease progression. Less clear is the impact of periodontal disease on diabetes. It has been hypothesised that periodontal therapy may improve the metabolic control of diabetes. Aim: To determine the effect of doxycycline as an adjunct to non-surgical periodontal therapy in improving the metabolic control of poorly controlled type 2 diabetic subjects with chronic generalized periodontitis. Method: 30 poorly controlled type 2 diabetic subjects with chronic generalized periodontitis and receiving antidiabetic therapy were selected for the study. The subjects were randomly allotted to either of two treatment groups containing 15 subjects each: Group 1 (scaling and root planing(SRP)+ 15 days Doxycycline) or Group 2 (scaling and root planing(SRP). The Glycated haemoglobin (HbA1c) values, Gingival Index(GI), and Probing pocket depth of both the groups were assessed at baseline and after 3 months. Results: Both the treatment groups exhibited reductions in HbA1c, G I and Probing pocket depth compared to baseline over time. The amount of reduction in the glycated haemoglobin and gingival parameters was higher in Group I compared to group 2 after 3 months. Conclusion: Both treatments improved glycemic control in patients with type 2 diabetes; however, the reduction in HbA1c values reached statistical significance only in the group receiving doxycycline as an adjunct to scaling and root planing.
Long term clinical and bacterial effetcx of xylitol on paitnets with fixed or...EdwardHAngle
Background: The objective of this study was to evaluate long-term clinical and bacterial effects of using 6 g of
xylitol per day for 3 months on patients with full fixed orthodontic appliances.
Methods: The study was a pilot clinical trial that included 41 subjects who were undergoing orthodontic
treatment. The subjects were randomly divided into three groups. Group A received xylitol chewing gum, group B
received xylitol dissolvable chewable tablets, and Group C served as the control group and did not receive xylitol
gums or tablets. Clinical examination and the collection of plaque and saliva samples were carried out at baseline
and 3, 6, and 12 months. All three groups were given oral hygiene instruction and were put on a 6-month cleaning
and topical fluoride schedule. Plaque scores and bacterial counts were used to evaluate the effectiveness of the
different approaches at reducing the caries risk.
Results: Xylitol groups did not experience any more reduction in plaque score, plaque MS counts, or salivary MS
counts than the control group nor did they have lower values at any of the time points. Chewing gum did not
significantly increase the incidence of debonded brackets over the other groups.
Conclusions: Xylitol does not have a clinical or bacterial benefit in patients with fixed orthodontic appliances. Oral
hygiene instructions and 6-month topical fluoride application were effective at reducing plaque scores and bacterial
counts in patients with full fixed appliances regardless of whether or not xylitol was used.
Postoperative recovery after mandibular third molar surgery. By Dr. Akhila Damodar { dr.akhila.n@gmail.com }
This study sought to evaluate postoperative recovery after mandibular third molar surgery, with and without the use of sutures.
This trial aimed to evaluate the efficacy and safety of vitamin D supplementation on the residual moderate and deep pockets following nonsurgical periodontal therapy.
A comparative evaluation of 0.33% Sodium Fluoride (Iontophoresis) and Novamin...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
“Desquamative Gingivitis Treated By An Antioxidant Therapy- A Case Report”inventionjournals
Desquamative gingivitis is described as an erythematous, desquamated or eroded gingival lesion. Various etiologic factors are present for the appearance of such lesions. Despite of considering etiology, treatment is oftenly provided by systemic or topical corticosteroids. Apart from steroid application, another optionable treatment is antioxidant therapy which provides rapid healing of the tissue. As antioxidants posses various advantageous properties, it can be considered as a first treatment option for desquamative gingivitis. The presented case report of desquamative gingivitis is successfully treated using systemic antioxidants in the form of commercially available „oxitard capsule‟.
“Desquamative Gingivitis Treated By An Antioxidant Therapy- A Case Report”inventionjournals
Desquamative gingivitis is described as an erythematous, desquamated or eroded gingival lesion. Various etiologic factors are present for the appearance of such lesions. Despite of considering etiology, treatment is oftenly provided by systemic or topical corticosteroids. Apart from steroid application, another optionable treatment is antioxidant therapy which provides rapid healing of the tissue. As antioxidants posses various advantageous properties, it can be considered as a first treatment option for desquamative gingivitis. The presented case report of desquamative gingivitis is successfully treated using systemic antioxidants in the form of commercially available „oxitard capsule‟.
“Desquamative Gingivitis Treated By An Antioxidant Therapy- A Case Report”inventionjournals
Desquamative gingivitis is described as an erythematous, desquamated or eroded gingival lesion. Various etiologic factors are present for the appearance of such lesions. Despite of considering etiology, treatment is oftenly provided by systemic or topical corticosteroids. Apart from steroid application, another optionable treatment is antioxidant therapy which provides rapid healing of the tissue. As antioxidants posses various advantageous properties, it can be considered as a first treatment option for desquamative gingivitis. The presented case report of desquamative gingivitis is successfully treated using systemic antioxidants in the form of commercially available „oxitard capsule‟
Opportunity for Dentists (BDS/MDS )to relocate to United kingdom -Register as a DENTAL HYGIENIST/ DENTAL THERAPIST without Board exams and after approval you can register in GDC as a DH/DT and start working as a DH/DT Immediately and get paid.
You can complete the whole process in 3-4 months.Salary range for DH/DT is around 2500-3500 Pounds per month.
Eligibility / requirements-
1. An International English Language Testing System (IELTS) certificate
at the appropriate level.(Within 2 yrs of application date )
2: A recent primary dental qualification that has been taught and examined in English..(Within 2 yrs of application date )
3: A recent pass in a language test for registration with a regulatory authority in a country where the first language is English.
If you are interested Please contact us for more details.
1ST, 2ND AND 3RD ORDER BENDS IN STANDARD EDGEWISE APPLIANCE SYSTEM /Fixed ort...Indian dental academy
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals
who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry,
Periodontics and General Dentistry.
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
I –Aligners are made with FDA approved transparent thermoplastic materials using 3D scanning, 3D Printing and finally Trays with Pressure vacuum formers.
Dear Doctor,
Indian Dental Academy Now offers comprehensive online Orthodontics course.
Course includes:
1.whiteboard lecture presentations
2.Case Discussions
3.with hundreds of pictures.
4.Demo on Models
5.Demo on Patients
6. subtitles in your own language
12 months unlimited access and support @350 USD only.
For Demo please visit :www.idalectures.com/preview/
For more details visit: www.idalectures.com
Please contact us for any clarifications:
idalectures@gmail.com
indiandentalacademy@gmail.com
Thanks & Regards
Indian Dental Academy
--
Indian Dental Academy
Leader in continuing dental education
www.indiandentalacademy.com
skype:indiandentalacademy
+919248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Cytotoxicity of silicone materials used in maxillofacial prosthesis / dental ...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Diagnosis and treatment planning in completely endntulous arches/dental coursesIndian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Properties of Denture base materials /rotary endodontic coursesIndian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Use of modified tooth forms in complete denture occlusion / dental implant...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
1. GUM ASTRINGENTS – MYTH OR REALITY ?
Dr. Richard Pereira* Dr. Soumya J. Shetty* Dr. Vijay K. Chava**
Abstract
Plaque and calculus are established local etiologic factors resulting
in periodontal disease. Removal of these local irritants and oral hygiene
maintenance are the mainstay of routine periodontal therapy. Several
measures in the form of astringents are also available and are promoted to
serve as adjuncts to oral prophylaxis. The purpose of our study was to
compare 2 proprietary gum astringents and evaluate their efficacy and
also to find out whether these astringents are useful adjuncts to scaling
and root planing. 30 patients were divided into 3 groups using the 2
different astringents and this was compared to a control group of 10
patients who underwent only oral prophylaxis. The results after the 6 day
study showed that gum astringents can serve as useful adjuncts to routine
scaling and root planing.
Introduction
It has been well documented that local factors especially dental
plaque is one of the main factors for the initiation of gingival and
periodontal disease2
. Supragingival plaque control is undoubtedly an
effective method of controlling gingivitis (Loe et al 1965)1
and is an
important component of periodontal therapy. However, there are also
several chemotherapeutic astringents available in the market which are
routinely promoted as effective adjuncts to oral prophylaxis and
mechanical plaque control3
. Zinc sulphate is available as 2% solution
while. Gum gel is a herbal formulation, both of which are recommended as
anti-inflammatory drugs for gingivitis.
1
* Postgraduate students
**Reader
S.D.M. College of Dental Sciences, Dharwad
2. The aim of the study was therefore to evaluate and compare the
efficacy of a 2% zinc sulfate lotion and Gum gel as adjuncts to therapy
over a one week period.
Materials and Methods
Each tube of Gum gel (Himalaya Drug Co.) contained a formulation
with potent herbs, comprising mainly of Xanthoxylym alatum, Triphala,
Punica granatum, Vitex negunda, Embelia ribes and Alpenia galanga.
The 2% zinc sulphate lotion used was marketed under the name of
Zingisol (20ml, ICPA health products Ltd.).
Experimental design
3 groups of 30 subjects were entered into a randomized double
blind, parallel design type of study. The sextant under study was the (L)
anteriors (33 to 43).
Subject selection criteria: The following subjects were entered into the
study; subjects with:
- No history of systemic disease.
- No history of any drug intake in the last 3 months.
- No history of any local drug application in last 3 months.
- Moderate gingivitis with a gingival index score of 1.1-2.1. (Loe and
Silness)
After selection, subjects received oral prophylaxis and were
randomly allotted to one of the following groups:
Group I – Control : Oral prophylaxis + gum massage with water.
Group II – Test A : Oral prophylaxis + ZnSO4 application.
Group III – Test B : Oral prophylaxis + Gum gel application.
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3. The patients were then instructed in the Bass method of brushing, to
be practiced twice daily along with the appropriate instructions according
to the group allotted.
Method and duration of application of astringents:
The appropriate subjects were instructed to use either the zinc
sulfate / gum gel thrice daily by massaging the same on the gums for 1
minute daily. They were instructed not to eat, drink or rinse for 30 minutes
after application.
Compliance was maintained by asking the patient to return with the
allotted samples, during recall visits.
Clinical indices
Clinical index scoring was carried out by one investigator. The area
assessed was the lower anterior region from 33 to 43. All patients were
assessed at baseline 1 / 2 / 3 / 6 days for the gingival index (Loe and
Silness, 1963).
Gingival index (Loe and Silness, 1963)
0 - Normal gingiva.
1 - Mild inflammation, slight change in colour, slight edema; no
bleeding on palpation.
2 - Moderate inflammation, redness, edema and glazing; bleeding on
palpation.
3 - Severe inflammation, marked redness and edema, ulcerations;
tendency to spontaneous bleeding.
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4. Results
Comparing the results on day 1 after application we found that there
was a significant difference between the gum paint group (GP) and control
group. There was highly significant difference between Gum gel (GG) and
control groups. However there was no significant difference between the
two astringents namely GG and GP groups.
Table showing comparison of mean difference between groups from
baseline to day 1
Period Group Mean S.D. p-value Significance
0-1
I
II
0.26
0.36
0.084
0.096
<0.05 S
I
III
0.26
0.49
0.084
0.207
<0.001 HS
II
III
0.36
0.49
0.096
0.207
>0.05 NS
4
0.26
0.36
0.49
0
0.05
0.1
0.15
0.2
0.25
0.3
0.35
0.4
0.45
0.5
Mean
Group I Group II Group III
Groups
Graph I : Showing comparison of mean difference between
groups from baseline to day 1
0.26
0.36
0.49
0
0.05
0.1
0.15
0.2
0.25
0.3
0.35
0.4
0.45
0.5
Mean
Group I Group II Group III
Groups
Graph I : Showing comparison of mean difference between
groups from baseline to day 1
5. Similarly on day 2 after application, there was significant difference
between gum astringents and control group while again there was no
significant difference between either gum astringents.
Table showing comparison of mean difference between groups from
baseline to day 2
Period Group Mean S.D. p-value Significance
0-2
I
II
0.61
0.84
0.213
0.227
<0.05 S
I
III
0.61
0.80
0.213
0.133
<0.05 S
II
III
0.84
0.80
0.227
0.133
>0.05 NS
5
0.61
0.84
0.8
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
Mean
Group I Group II Group III
Groups
Graph II : Showing comparison of mean difference between
groups from baseline to day 2
0.61
0.84
0.8
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
Mean
Group I Group II Group III
Groups
Graph II : Showing comparison of mean difference between
groups from baseline to day 2
6. On day 3, once again similar results were observed, with gum
astringents proving to be better than the control group.
Table showing comparison of mean difference between groups from
baseline to day 2
Period Group Mean S.D. p-value Significance
0-3
I
II
0.82
0.99
0.198
0.196
<0.05 S
I
III
0.82
1.03
0.198
0.094
<0.10 S
II
III
0.99
1.03
0.196
0.094
>0.05 NS
6
0.82
0.99
1.03
0
0.2
0.4
0.6
0.8
1
1.2
Mean
Group I Group II Group III
Groups
Graph III : Showing comparison of mean difference
between groups from baseline to day 3
0.82
0.99
1.03
0
0.2
0.4
0.6
0.8
1
1.2
Mean
Group I Group II Group III
Groups
0.82
0.99
1.03
0
0.2
0.4
0.6
0.8
1
1.2
Mean
Group I Group II Group III
Groups
Graph III : Showing comparison of mean difference
between groups from baseline to day 3
7. After 1 week of application yet again, gum astringents consistently
offered significantly better results than the control group but again, no
difference in efficacy was seen between either gum gel or ZnSo4.
Table showing comparison of mean difference between groups from
baseline to day 2
Period Group Mean S.D. p-value Significance
0-6
I
II
1.08
1.35
0.209
0.150
<0.001 S
I
III
1.08
1.29
0.209
0.185
<0.05 S
II
III
1.35
1.29
0.150
0.185
>0.05 NS
7
1.08
1.35
1.29
0
0.2
0.4
0.6
0.8
1
1.2
1.4
Mean
Group I Group II Group III
Groups
Graph IV : Showing comparison of mean difference between
groups from baseline to day 6
1.08
1.35
1.29
0
0.2
0.4
0.6
0.8
1
1.2
1.4
Mean
Group I Group II Group III
Groups
Graph IV : Showing comparison of mean difference between
groups from baseline to day 6
8. Discussion
Astringents are agents which act by precipitating blood proteins,
causing a mechanical obstruction to hemorrhage from injured blood
vessels. Various astringents like tannic acid, zinc sulphate and herbal
formulations are promoted in the market to aid as adjuncts to routine oral
prophylaxis.
Zinc salts possess astringent, corrosive and weak antiseptic
properties. Externally zinc sulphate is used as an astringent lotion to assist
granulation formation. Gum gel is a herbal formulation also promoted to
have an astringent effect and meant for treatment for gingivitis. Being a
herbal derivative, it is believed to be safer with lesser adverse effects.
Removal of local irritants by scaling and root planing is
undoubtedly the mainstay of initial periodontal therapy. The aim of this
study was to evaluate whether these astringents could be used as adjuncts
to therapy. Interestingly results showed that astringents did show a
significant reduction in inflammation as compared to only oral prophylaxis.
However there was no significant difference between the 2 astringents at
any point in time during the 6 day study period.
Conclusion
Astringents showed significant reduction inflammation as compared
to plain oral prophylaxis but no significant difference was seen between the
two astringents tested. These findings from the above study go to prove
that gum astringents can serve as effective adjuncts to therapy. They may
therefore not be a plain myth but possibly a reality.
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9. References
1. Loe H., Theilade E., James S.B. : Experimental gingivitis in man.
Journal of Periodontology, 1965; 36 : 177-187.
2. Listgarten M.A. : The role of dental plaque in gingivitis and
periodontitis. Journal of Clinical Periodontology, 1988; 15 : 485-
487.
3. Mandel I.D. (1988) : Chemotherapeutic agents for controlling
plaque and gingivitis. Journal of Clinical Periodontology, 15 : 488-
498.
4. Satoskar R.S., Bhandarkar S.D., Ainapure S.S. : Pharmacology
and Pharmacotherapeutics. 16th
Edition, 1999.
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10. References
1. Loe H., Theilade E., James S.B. : Experimental gingivitis in man.
Journal of Periodontology, 1965; 36 : 177-187.
2. Listgarten M.A. : The role of dental plaque in gingivitis and
periodontitis. Journal of Clinical Periodontology, 1988; 15 : 485-
487.
3. Mandel I.D. (1988) : Chemotherapeutic agents for controlling
plaque and gingivitis. Journal of Clinical Periodontology, 15 : 488-
498.
4. Satoskar R.S., Bhandarkar S.D., Ainapure S.S. : Pharmacology
and Pharmacotherapeutics. 16th
Edition, 1999.
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