Guillain-Barré syndrome is an autoimmune disorder that results from the body's immune system attacking the peripheral nervous system and causing inflammation and damage to the protective covering of nerves. It is characterized by rapidly progressive muscle weakness, loss of reflexes, and sensory disturbances. Common symptoms include numbness or tingling in the legs that ascends to the upper body over days or weeks. The document discusses the causes, pathophysiology, clinical manifestations, diagnosis, and management of Guillain-Barré syndrome.
Guillain-Barré syndrome (GBS) can be described as a collection of clinical syndromes that manifests as an acute inflammatory polyradiculoneuropathy with resultant weakness and diminished reflexes.
Although the classic description of GBS is that of a demyelinating neuropathy with ascending weakness, many clinical variants have been well documented in the medical literature.
Guillain Barre Syndrome (GBS) is a serious disorder that occurs when the body’s defense (immune) system mistakenly attacks part of the nervous system i.e Autoimmune Disorder.
Multiple sclerosis (MS) is a demyelinating disease of central nervous system which includes brain and spinal cord.
it affect the myelin and by damaging the the myelin producing cell -Oligodendrocytes, which leads to sensory, motor and cognitive problems.
Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system). In MS , the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between your brain and the rest of your body.
Guillain-Barré syndrome is a rare but serious autoimmune disorder in which the immune system attacks healthy nerve cells in your peripheral nervous system (PNS).
AUTOIMMUNE DISORDERS OF NERVOUS SYSTEMANILKUMAR BR
Autoimmune disorders of the nervous system can attack the central nervous system (CNS), Autoimmune disorders affecting both the central and peripheral nervous system.) which includes the brain and spinal cord, or the peripheral nervous system, consisting of nerves that connect the CNS with the limbs and organs.
The most common disorders are multiple sclerosis and myasthenia gravis.
Autoimmune nervous system disorders include:
Multiple sclerosis
Myasthenia gravis
Guillain-Barré syndrome. (GB Syndrome)
Guillain-Barré syndrome (GBS) can be described as a collection of clinical syndromes that manifests as an acute inflammatory polyradiculoneuropathy with resultant weakness and diminished reflexes.
Although the classic description of GBS is that of a demyelinating neuropathy with ascending weakness, many clinical variants have been well documented in the medical literature.
Guillain Barre Syndrome (GBS) is a serious disorder that occurs when the body’s defense (immune) system mistakenly attacks part of the nervous system i.e Autoimmune Disorder.
Multiple sclerosis (MS) is a demyelinating disease of central nervous system which includes brain and spinal cord.
it affect the myelin and by damaging the the myelin producing cell -Oligodendrocytes, which leads to sensory, motor and cognitive problems.
Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system). In MS , the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between your brain and the rest of your body.
Guillain-Barré syndrome is a rare but serious autoimmune disorder in which the immune system attacks healthy nerve cells in your peripheral nervous system (PNS).
AUTOIMMUNE DISORDERS OF NERVOUS SYSTEMANILKUMAR BR
Autoimmune disorders of the nervous system can attack the central nervous system (CNS), Autoimmune disorders affecting both the central and peripheral nervous system.) which includes the brain and spinal cord, or the peripheral nervous system, consisting of nerves that connect the CNS with the limbs and organs.
The most common disorders are multiple sclerosis and myasthenia gravis.
Autoimmune nervous system disorders include:
Multiple sclerosis
Myasthenia gravis
Guillain-Barré syndrome. (GB Syndrome)
GBS means Guillain Barre syndrome a disease of neurological system. It often begins with tingling sensation and weakens from the legs and radiating to upper body and arms. there is no known cure for GBS, but treatments can improve symptoms and shorten its duration.
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1. GUI LLAIN-BARR É SYNDROME
DEPARTMENT
OF
MEDICAL SURGICAL NURSING
Smt. Radhikabai Meghe Memorial
College of Nursing
2. Learning Objective
At the end of this lecture, students should be able to:
• Define Guillain-Barré syndrome
• enlist the etiology of Guillain-Barré syndrome.
• enumerate the clinical Manifestations of Guillain-
Barré syndrome
• enlist the diagnostic evaluation of Guillain-Barré
syndrome
• explain the management of Guillain-Barré syndrome
3.
4.
5. DEFINITION (GBS)
• Guillain-Barré syndrome is an autoimmune attack of the
peripheral nerve myelin.
• The result is acute, rapid segmental demyelination of
peripheral nerves and some cranial nerves, producing
ascending weakness with Inability to execute voluntary
movements), hyporeflexia, and paresthesias (numbness).
7. • The antecedent event usually occurs 2 weeks before symptoms
begin.
Weakness usually begins in the legs and progresses upward
for about 1 month.
Maximum weakness varies but usually includes neuromuscular
respiratory failure and bulbar weakness.
• The duration of the symptoms is variable: complete functional
recovery may take up to 2 years (Hickey, 2003).
Any residual symptoms are permanent and reflect axonal damage from
demyelination.
8. • In Guillain-Barré the Schwann cell is spared, allowing for
remyelination in the recovery phase of the disease.
• Guillain-Barré is the result of a cell-mediated immune attack.
9. PATHOPHYSIOLOGY
Guillain-Barré is the result
O f a cell-mediated immune attack
on peripheral nerve myelin proteins (Ho & Griffin, 1999)
The best-accepted theory is that an infectious organism
contains an amino acid that mimics the peripheral
nerve myelin protein
10. With the autoimmune attack there
is an influx of macrophages and other immune-mediated agents
that attack myelin, cause inflammation and destruction, and leave
the axon unable to support nerve conduction.
The immune system cannot distinguish between the two proteins
and
attacks and destroys peripheral nerve myelin
11. Classic Guillain-Barré
• Begins with muscle weakness and diminished reflexes of the
lower extremities.
• Hyporeflexia and weakness progress and may result in
quadriplegia.
• Demyelination of the nerves that innervate the diaphragm and
intercostal muscles results in neuromuscular respiratory
failure.
12. OTHER MANIFESTATIONS :-
Sensory symptoms include paresthesias of the hands and feet and
pain related to the demyelination of sensory fibers.
•Cranial nerve demyelination can result in a variety of clinical
manifestations.
•Optic nerve demyelination may result in blindness.
•Bulbar muscle weakness related to demyelination of the
•glossopharyngeal and vagus nerves results in an inability to swallow or
clear secretions.
13. Vagus nerve demyelination results in manifested by
instability of the cardiovascular system.
tachycardia, bradycardia, hypertension,
or orthostatic hypotension.
14. 1.The patient presents with symmetric weakness,
diminished reflexes,
and upward progression of motor weakness.
2.A history of a viral illness in the previous few weeks
suggests the diagnosis.
3.Changes in vital capacity and negative inspiratory force
are assessed
to identify impending neuromuscular respiratory failure.
4.Serum laboratory tests are not useful in the diagnosis.
However, elevated protein levels are detected in CSF
evaluation, without an increase in other cells.
5. Evoked potential studies demonstrate a progressive
loss of nerve conduction velocity
15. 1.. Respiratory therapy or mechanical ventilation may be
necessary
to support pulmonary function and adequate oxygenation.
2 Preventing the complications of immobility. These may include
the use of anticoagulant agents and thigh-high elastic compression
stockings or sequential compression boots to prevent thrombosis
and pulmonary emboli.
16. 3.. Plasmapheresis and IVIG are used to directly affect the
peripheral nerve myelin antibody level. Both therapies decrease
circulating antibody levels and reduce the amount of time the
patient is immobilized and dependent on mechanical ventilation.
17. The cardiovascular risks posed by autonomic dysfunction require
continuous ECG monitoring.
Tachycardia and hypertension are treated with short-acting
medications such as alpha-adrenergic blocking agents.
Hypotension is managed by increasing the amount of IV fluid
administered. The use of short-acting agents is important because a
18. NURSING DIAGNOSES
• Ineffective breathing pattern and impaired gas exchange
related to rapidly progressive weakness and impending
respiratory failure
• Impaired physical mobility related to paralysis
• Imbalanced nutrition, less than body requirements, related
to inability to swallow
• Impaired verbal communication related to cranial nerve
dysfunction
• Fear and anxiety related to loss of control and paralysis
19. Summary
So far we have discussed about definition, causes,
Pathophysiology clinical manifestations, diagnostic
evaluation and managements of Guillain-Barré
syndrome
20. Bibliography
Lewis et al, Medical Surgical Nursing, Mosby
Elsevier,7th edition.
Joyce.M.Black et al, Medical Surgical Nursing,
Saunders publication.
Brunner and Siddhartha, Medical Surgical Nursing,
Lippincott Williams and Wilkins.
