This document discusses and compares tuberculosis and sarcoidosis. Tuberculosis is caused by infection with Mycobacterium tuberculosis and can present as infected sputum or chronic ulcers of the tongue. Sarcoidosis has an unknown cause and results in granuloma formation in the lungs, lymph nodes, salivary glands, and mouth. Both diseases are diagnosed through staining, culturing samples, or biopsy to identify characteristic granulomas, and sarcoidosis can additionally be suggested by raised markers on scans and tests.

1. Granulomatous diseaseTuberculosis & Sarcoidosis

2. Tuberculosis
• A complication of pulmonary disease with
infected sputum.
• Orally: lump or chronic ulcer on the tongue

3. Etiology and
Pathogenesis
• Typical:
Mycobacterium tuberculosis
• Atypical:
M avium-intarcelluler
M scrofulaceum

4. Diagnosis
• Ziehl-Neelsen stain
• Immunofluorescence using
Auramine Rhodamine
• Macubacterium culture
• Macrobacterium DNA
• Tubercalien skin test

5. Clinical changes
• Cervical Mycobacterial Lymphadenitis
unilateral
single or multiple
asymptomatic

6. Histopathology

7. Casation Necrosis

8. Sarcoidosis
• Chronic disease with a unknown
cause, in which granuloma forms in
1- lungs
2- lymph
3- slivery gland
4- mouth
• Heerfordt’s syndrome

9. Clinical changes
• Multisystem granulomatosis disorder
• Cause:
Propiono Bacterium acnes
Propiono Granulosum
Mycobacterium tuberculosis

10. Ddiagnosis
• Minor salivary gland biopsy “granuloma in 20%”
• Chest radiograph
• Gallium scan
• Raised SACE
• Raised adenosine deaminase “ADA test”

11. Histopathology

12. Asteroid bodies Schaumann bodies

13. Sarcoidosis
of a Salivary
gland