Tooth abnormality in systemic disease (Doctor Faris Alabeedi MSc, MMedSc, PgDip, BDS.)

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This document discusses tooth abnormalities that can be caused by systemic diseases and conditions. It covers syndromes like Down syndrome and Ehlers Danlos syndrome that can cause developmental disturbances in tooth structure. Inherited conditions like epidermolysis bullosa and acquired diseases like rickets can also impact tooth development. Other sections discuss systemic causes of intrinsic tooth staining from things like jaundice or porphyria, abnormalities from medications like tetracycline, and other medical conditions and bone diseases that may affect the teeth.

Health & Medicine

CONTENTS
Syndromes
Developmental
disturbance in
tooth structure
Systemic cause
of intrinsic
staining
Abnormality
related to
medication
Medical causes
Psychological
causes
Bone pathology

Syndromes
Ectodermal dysplasia
Down syndrome
Ehlers Danlo syndrome
Syndromic craniosynstoses
Tricho-Dento-Oseus syndrome

Developmental
disturbance in tooth
structure

Inherited and acquired
chronic diseases
• Epidermolysis bullosa
• Coeliac disease

Inherited and acquired
chronic diseases
•Rickets
Bone disease of children
demineralization and defective bone growth

Inherited and acquired
chronic diseases
• X-linked hypophosphatemia
(PHEX)

Inherited and acquired
chronic diseases
• X-linked hypophosphatasia
(TNSALP)

Systemic cause of intrinsic
staining
• Neonatal jaundice
• Porphyria
• Alkaptonuria

Abnormality
related to
medication
• Tetracycline
• Minocycline hydrochloride
• Cytotoxic chemotherapy

Other Medical
causes
• Diabetes
• Gastroesophageal reflux

Psychological
causes
• Bulimia and anorexia
• Drugs abuse

Bone
pathology
• Ewing's sarcoma
• Histiocytosis X
• pseudotumor of haemophilia

References
• Burgess, J. (2015) ‘Oral Manifestations of Systemic
Disease’, Ada Cerp, pp. 1–12.
• Hunter, K. D. and Brierley, D. (2017) ‘Pathology of
the teeth: an update’, Diagnostic Histopathology.
Elsevier Ltd, 23(6), pp. 275–283. doi:
10.1016/j.mpdhp.2017.04.005.
• Sharma, U. and Bhalla, S. (2010) ‘Oral
manifestations of a systemic disease.’, American
Family Physician, 82, pp. 1381–1388. doi:
10.1016/S0733-8635(02)00066-9.
• Regezi, J., 2012. Oral Pathology clinical pathological
correlation. 6th ed. Missoury: Elsevier.

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